-
1
-
-
24944497786
-
Non-Smad TGF-β signals
-
Moustakas, A. & Heldin, C.-H. Non-Smad TGF-β signals. J. Cell Sci. 118, 3573-3584 (2005).
-
(2005)
J. Cell Sci
, vol.118
, pp. 3573-3584
-
-
Moustakas, A.1
Heldin, C.-H.2
-
2
-
-
23044466047
-
Specificity and versatility in TGF-β signaling through Smads
-
Feng, X.-H. & Derynck, R. Specificity and versatility in TGF-β signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693 (2005).
-
(2005)
Annu. Rev. Cell Dev. Biol
, vol.21
, pp. 659-693
-
-
Feng, X.-H.1
Derynck, R.2
-
3
-
-
27644494876
-
Smad transcription factors
-
Massagué, J., Seoane, J. & Wotton, D. Smad transcription factors. Genes Dev. 19, 2783-2810 (2005).
-
(2005)
Genes Dev
, vol.19
, pp. 2783-2810
-
-
Massagué, J.1
Seoane, J.2
Wotton, D.3
-
4
-
-
24644495693
-
The role of Smad signaling in hematopoiesis
-
Larsson, J. & Karlsson, S. The role of Smad signaling in hematopoiesis. Oncogene 24, 5676-5692 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 5676-5692
-
-
Larsson, J.1
Karlsson, S.2
-
5
-
-
33646164362
-
Transforming growth factor-β regulation of immune responses
-
Li, M. O., Wan, Y. Y., Sanjabi, S., Robertson, A. K. & Flavell, R. A. Transforming growth factor-β regulation of immune responses. Annu. Rev. Immunol. 24, 99-146 (2006).
-
(2006)
Annu. Rev. Immunol
, vol.24
, pp. 99-146
-
-
Li, M.O.1
Wan, Y.Y.2
Sanjabi, S.3
Robertson, A.K.4
Flavell, R.A.5
-
6
-
-
33845972599
-
Bone morphogenetic protein pleiotropism in neural stem cells and their derivatives - alternative pathways, convergent signals
-
Chen, H. L. & Panchision, D. M. Bone morphogenetic protein pleiotropism in neural stem cells and their derivatives - alternative pathways, convergent signals. Stem Cells 25, 63-68 (2007).
-
(2007)
Stem Cells
, vol.25
, pp. 63-68
-
-
Chen, H.L.1
Panchision, D.M.2
-
7
-
-
0035810944
-
Genetic programs of epithelial cell plasticity directed by transforming growth factor-β
-
Zavadil, J. et al. Genetic programs of epithelial cell plasticity directed by transforming growth factor-β. Proc. Natl Acad. Sci. USA 98, 6686-6691 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 6686-6691
-
-
Zavadil, J.1
-
8
-
-
16344378397
-
TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
-
Valcourt, U., Kowanetz, M., Niimi, H., Heldin, C.-H. & Moustakas, A. TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol. Biol. Cell 16, 1987-2002 (2005).
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 1987-2002
-
-
Valcourt, U.1
Kowanetz, M.2
Niimi, H.3
Heldin, C.-H.4
Moustakas, A.5
-
9
-
-
65249085245
-
TGF-β signaling in epithelial-mesenchymal transition and invasion/metastasis
-
eds Derynck, R. & Miyazono, K, Cold Spring Harbor Press, Cold Spring Harbor, NY
-
Akhurst, R. J. TGF-β signaling in epithelial-mesenchymal transition and invasion/metastasis. The TGF-β Family (eds Derynck, R. & Miyazono, K.) (Cold Spring Harbor Press, Cold Spring Harbor, NY, 2007).
-
(2007)
The TGF-β Family
-
-
Akhurst, R.J.1
-
10
-
-
0036304111
-
Metastasis is driven by sequential elevation of H-Ras and Smad2 levels
-
Oft, M., Akhurst, R. J. & Balmain, A. Metastasis is driven by sequential elevation of H-Ras and Smad2 levels. Nature Cell Biol. 4, 487-494 (2002).
-
(2002)
Nature Cell Biol
, vol.4
, pp. 487-494
-
-
Oft, M.1
Akhurst, R.J.2
Balmain, A.3
-
11
-
-
0034785496
-
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
-
Yang, J. & Liu, Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am. J. Pathol. 159, 1465-1475 (2001).
-
(2001)
Am. J. Pathol
, vol.159
, pp. 1465-1475
-
-
Yang, J.1
Liu, Y.2
-
12
-
-
33750936779
-
-
Gadue, P., Huber, T. L., Paddison, P. J. & Keller, G. M. Wnt and TGF-β signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc. Natl Acad. Sci. USA 103, 16806-16811 (2006).
-
Gadue, P., Huber, T. L., Paddison, P. J. & Keller, G. M. Wnt and TGF-β signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells. Proc. Natl Acad. Sci. USA 103, 16806-16811 (2006).
-
-
-
-
13
-
-
33846974670
-
Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation
-
Cordenonsi, M. et al. Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation. Science 315, 840-843 (2007).
-
(2007)
Science
, vol.315
, pp. 840-843
-
-
Cordenonsi, M.1
-
14
-
-
15444348295
-
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
-
Sirard, C. et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 12, 107-119 (1998).
-
(1998)
Genes Dev
, vol.12
, pp. 107-119
-
-
Sirard, C.1
-
15
-
-
33750825092
-
Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
-
Wang, J. et al. Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev. Biol. 6, 51 (2006).
-
(2006)
BMC Dev. Biol
, vol.6
, pp. 51
-
-
Wang, J.1
-
16
-
-
33947095941
-
Endoglin and ALK5 regulate epithelial-mesenchymal transformation during cardiac valve formation
-
Mercado-Pimentel, M. E., Hubbard, A. D. & Runyan, R. B. Endoglin and ALK5 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 304, 420-432 (2007).
-
(2007)
Dev. Biol
, vol.304
, pp. 420-432
-
-
Mercado-Pimentel, M.E.1
Hubbard, A.D.2
Runyan, R.B.3
-
17
-
-
14844293126
-
Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation
-
Desgrosellier, J. S., Mundell, N. A., McDonnell, M. A., Moses, H. L. & Barnett, J. V. Activin receptor-like kinase 2 and Smad6 regulate epithelial-mesenchymal transformation during cardiac valve formation. Dev. Biol. 280, 201-210 (2005).
-
(2005)
Dev. Biol
, vol.280
, pp. 201-210
-
-
Desgrosellier, J.S.1
Mundell, N.A.2
McDonnell, M.A.3
Moses, H.L.4
Barnett, J.V.5
-
18
-
-
0028972869
-
Transforming growth factor-β3 is required for secondary palate fusion
-
Proetzel, G. et al. Transforming growth factor-β3 is required for secondary palate fusion. Nature Genet. 11, 409-414 (1995).
-
(1995)
Nature Genet
, vol.11
, pp. 409-414
-
-
Proetzel, G.1
-
19
-
-
0036322007
-
Evidence that fibroblasts derive from epithelium during tissue fibrosis
-
Iwano, M. et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J. Clin. Invest. 110, 341-350 (2002).
-
(2002)
J. Clin. Invest
, vol.110
, pp. 341-350
-
-
Iwano, M.1
-
20
-
-
33748375828
-
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
-
Kim, K. K. et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl Acad. Sci. USA 103, 13180-13185 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 13180-13185
-
-
Kim, K.K.1
-
21
-
-
17844384822
-
Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: Potential role in idiopathic pulmonary fibrosis
-
Willis, B. C. et al. Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-β1: Potential role in idiopathic pulmonary fibrosis. Am. J. Pathol. 166, 1321-1332 (2005).
-
(2005)
Am. J. Pathol
, vol.166
, pp. 1321-1332
-
-
Willis, B.C.1
-
22
-
-
33749676226
-
Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-β2
-
Paruchuri, S. et al. Human pulmonary valve progenitor cells exhibit endothelial/mesenchymal plasticity in response to vascular endothelial growth factor-A and transforming growth factor-β2. Circ. Res. 99, 861-869 (2006).
-
(2006)
Circ. Res
, vol.99
, pp. 861-869
-
-
Paruchuri, S.1
-
23
-
-
30644479959
-
Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
-
Ju, W. et al. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol. Cell. Biol. 26, 654-67 (2006).
-
(2006)
Mol. Cell. Biol
, vol.26
, pp. 654-667
-
-
Ju, W.1
-
24
-
-
30944466813
-
Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis
-
Roberts, A. B. et al. Smad3 is key to TGF-β-mediated epithelial-to-mesenchymal transition, fibrosis, tumor suppression and metastasis. Cytokine Growth Factor Rev. 17, 19-27 (2006).
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 19-27
-
-
Roberts, A.B.1
-
25
-
-
0037148532
-
Ras and TGF-β cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
-
Janda, E. et al. Ras and TGF-β cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways. J. Cell Biol. 156, 299-313 (2002).
-
(2002)
J. Cell Biol
, vol.156
, pp. 299-313
-
-
Janda, E.1
-
26
-
-
1642488263
-
Histopathology of cutaneous squamous cell carcinoma and its variants
-
Kane, C. L., Keehn, C. A., Smithberger, E. & Glass, L. F. Histopathology of cutaneous squamous cell carcinoma and its variants. Semin. Cutan. Med. Surg. 23, 54-61 (2004).
-
(2004)
Semin. Cutan. Med. Surg
, vol.23
, pp. 54-61
-
-
Kane, C.L.1
Keehn, C.A.2
Smithberger, E.3
Glass, L.F.4
-
27
-
-
0035147248
-
Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: Correlation with histopathological parameters, hormone receptors, and oncoproteins
-
Dandachi, N. et al. Co-expression of tenascin-C and vimentin in human breast cancer cells indicates phenotypic transdifferentiation during tumour progression: Correlation with histopathological parameters, hormone receptors, and oncoproteins. J. Pathol. 193 181-189 (2001).
-
(2001)
J. Pathol
, vol.193
, pp. 181-189
-
-
Dandachi, N.1
-
28
-
-
8844266086
-
Spindle cell metaplasia in follicular adenoma of the thyroid gland: Case report and review of the literature
-
Aker, F. V., Bas, Y., Ozkara, S. & Peker, O. Spindle cell metaplasia in follicular adenoma of the thyroid gland: Case report and review of the literature. Endocr. J. 51, 457-461 (2004).
-
(2004)
Endocr. J
, vol.51
, pp. 457-461
-
-
Aker, F.V.1
Bas, Y.2
Ozkara, S.3
Peker, O.4
-
29
-
-
0037331707
-
Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma
-
Petersen, O. W. et al. Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am. J. Pathol. 162, 391-402 (2003).
-
(2003)
Am. J. Pathol
, vol.162
, pp. 391-402
-
-
Petersen, O.W.1
-
30
-
-
2942707848
-
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
-
Yang, J. et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117, 927-939 (2004).
-
(2004)
Cell
, vol.117
, pp. 927-939
-
-
Yang, J.1
-
31
-
-
4944266313
-
High interstitial fluid pressure - an obstacle in cancer therapy
-
Heldin, C.-H., Rubin, K., Pietras, K. & Ostman, A. High interstitial fluid pressure - an obstacle in cancer therapy. Nature Rev. Cancer 4, 806-813 (2004).
-
(2004)
Nature Rev. Cancer
, vol.4
, pp. 806-813
-
-
Heldin, C.-H.1
Rubin, K.2
Pietras, K.3
Ostman, A.4
-
32
-
-
17144428081
-
Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma
-
Salnikov, A. V. et al. Inhibition of TGF-β modulates macrophages and vessel maturation in parallel to a lowering of interstitial fluid pressure in experimental carcinoma. Lab. Invest. 85, 512-521 (2005).
-
(2005)
Lab. Invest
, vol.85
, pp. 512-521
-
-
Salnikov, A.V.1
-
33
-
-
33847635618
-
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling
-
Kano, M. R. et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling. Proc. Natl Acad. Sci. USA 104, 3460-3465 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 3460-3465
-
-
Kano, M.R.1
-
34
-
-
34548298781
-
Smads in mesenchymal differentiation
-
eds ten Dijke, P. & Heldin, C.-H, Springer, The Netherlands
-
Derynck, R., Choy, L. & Alliston, T. Smads in mesenchymal differentiation. In Smad Signal Transduction (eds ten Dijke, P. & Heldin, C.-H.) 93-112 (2006). (Springer, The Netherlands)
-
(2006)
Smad Signal Transduction
, pp. 93-112
-
-
Derynck, R.1
Choy, L.2
Alliston, T.3
-
35
-
-
27144559149
-
Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination
-
Hjelmeland, A. B., Schilling, S. H., Guo, X., Quarles, D. & Wang, X. F. Loss of Smad3-mediated negative regulation of Runx2 activity leads to an alteration in cell fate determination. Mol. Cell. Biol. 25, 9460-9468 (2005).
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 9460-9468
-
-
Hjelmeland, A.B.1
Schilling, S.H.2
Guo, X.3
Quarles, D.4
Wang, X.F.5
-
36
-
-
8444243360
-
Regulation of muscle mass by myostatin
-
Lee, S.-J. Regulation of muscle mass by myostatin. Annu. Rev. Cell Dev. Biol. 20, 61-86 (2004).
-
(2004)
Annu. Rev. Cell Dev. Biol
, vol.20
, pp. 61-86
-
-
Lee, S.-J.1
-
37
-
-
13844282120
-
Myostatin and its implications on animal breeding: A review
-
Bellinge, R. H., Liberles, D. A., Iaschi, S. P., O'Brien, P. A. & Tay, G. K. Myostatin and its implications on animal breeding: A review. Anim. Genet. 36, 1-6 (2005).
-
(2005)
Anim. Genet
, vol.36
, pp. 1-6
-
-
Bellinge, R.H.1
Liberles, D.A.2
Iaschi, S.P.3
O'Brien, P.A.4
Tay, G.K.5
-
38
-
-
2942735123
-
Myostatin mutation associated with gross muscle hypertrophy in a child
-
Schuelke, M. et al. Myostatin mutation associated with gross muscle hypertrophy in a child. N. Engl. J. Med. 350, 2682-2688 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, pp. 2682-2688
-
-
Schuelke, M.1
-
39
-
-
0141768237
-
Myostatin negatively regulates satellite cell activation and self-renewal
-
McCroskery, S., Thomas, M., Maxwell, L., Sharma, M. & Kambadur, R. Myostatin negatively regulates satellite cell activation and self-renewal. J. Cell Biol. 162, 1135-1147 (2003).
-
(2003)
J. Cell Biol
, vol.162
, pp. 1135-1147
-
-
McCroskery, S.1
Thomas, M.2
Maxwell, L.3
Sharma, M.4
Kambadur, R.5
-
40
-
-
14044279926
-
Muscle regeneration in the prolonged absence of myostatin
-
Wagner, K. R., Liu, X., Chang, X. & Allen, R. E. Muscle regeneration in the prolonged absence of myostatin. Proc. Natl Acad. Sci. USA 102, 2519-2524 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 2519-2524
-
-
Wagner, K.R.1
Liu, X.2
Chang, X.3
Allen, R.E.4
-
41
-
-
33745805890
-
Myostatin: Biology and clinical relevance
-
Carnac, G., Ricaud, S., Vernus, B. & Bonnieu, A. Myostatin: Biology and clinical relevance. Mini Rev. Med. Chem. 6, 765-770 (2006).
-
(2006)
Mini Rev. Med. Chem
, vol.6
, pp. 765-770
-
-
Carnac, G.1
Ricaud, S.2
Vernus, B.3
Bonnieu, A.4
-
42
-
-
0027946689
-
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
-
Katagiri, T. et al. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol. 127, 1755-1766 (1994).
-
(1994)
J. Cell Biol
, vol.127
, pp. 1755-1766
-
-
Katagiri, T.1
-
43
-
-
14344284361
-
BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis
-
Nakashima, K. et al. BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc. Natl Acad. Sci. USA 98, 5868-5873 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 5868-5873
-
-
Nakashima, K.1
-
44
-
-
12344291865
-
Bone morphogenetic proteins
-
Chen, D., Zhao, M. & Mundy, G. R. Bone morphogenetic proteins. Growth Factors. 22, 233-241 (2004).
-
(2004)
Growth Factors
, vol.22
, pp. 233-241
-
-
Chen, D.1
Zhao, M.2
Mundy, G.R.3
-
45
-
-
0029746491
-
Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva
-
Shafritz, A. B. et al. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. N. Engl. J. Med. 335 555-561 (1996).
-
(1996)
N. Engl. J. Med
, vol.335
, pp. 555-561
-
-
Shafritz, A.B.1
-
46
-
-
33646348736
-
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
-
Shore, E. M. et al. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nature Genet. 38, 525-527 (2006).
-
(2006)
Nature Genet
, vol.38
, pp. 525-527
-
-
Shore, E.M.1
-
47
-
-
0037078328
-
Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes
-
Skillington, J., Choy, L. & Derynck, R. Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J. Cell Biol. 159, 135-146 (2002).
-
(2002)
J. Cell Biol
, vol.159
, pp. 135-146
-
-
Skillington, J.1
Choy, L.2
Derynck, R.3
-
48
-
-
33747618270
-
Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling
-
Wan, D. C. et al. Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling. Proc. Natl Acad. Sci. USA 103, 12335-12340 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 12335-12340
-
-
Wan, D.C.1
-
49
-
-
23344450107
-
Adipose-derived mesenchymal cells as a potential cell source for skeletal regeneration
-
Xu, Y., Malladi, P., Wagner, D. R. & Longaker, M. T. Adipose-derived mesenchymal cells as a potential cell source for skeletal regeneration. Curr. Opin. Mol. Ther. 7, 300-305 (2005).
-
(2005)
Curr. Opin. Mol. Ther
, vol.7
, pp. 300-305
-
-
Xu, Y.1
Malladi, P.2
Wagner, D.R.3
Longaker, M.T.4
-
50
-
-
2342586660
-
Adipose-derived adult stromal cells heal critical-size mouse calvarial defects
-
Cowan, C. M. et al. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nature Biotechnol. 22 560-567 (2004).
-
(2004)
Nature Biotechnol
, vol.22
, pp. 560-567
-
-
Cowan, C.M.1
-
51
-
-
11044234825
-
Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: Case report
-
Lendeckel, S. et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: Case report. J. Craniomaxillofac. Surg. 32, 370-373 (2004).
-
(2004)
J. Craniomaxillofac. Surg
, vol.32
, pp. 370-373
-
-
Lendeckel, S.1
-
52
-
-
0141959179
-
Revisiting the role of retinoid signaling in skeletal development
-
Weston, A. D., Hoffman, L. M. & Underhill, T. M. Revisiting the role of retinoid signaling in skeletal development. Birth Defects Res. C Embryo Today 69, 156-173 (2003).
-
(2003)
Birth Defects Res. C Embryo Today
, vol.69
, pp. 156-173
-
-
Weston, A.D.1
Hoffman, L.M.2
Underhill, T.M.3
|