-
1
-
-
0034785348
-
TGF-β signaling in tumor suppression and cancer progression
-
Derynck R, Akhurst RJ, Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat Genet 2001;29:117-29.
-
(2001)
Nat Genet
, vol.29
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
2
-
-
0033565626
-
Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
-
Engle SJ, Hoying JB, Boivin GP, Ormsby I, Gartside PS, Doetschman T. Transforming growth factor β1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res 1999;59:3379-86.
-
(1999)
Cancer Res
, vol.59
, pp. 3379-3386
-
-
Engle, S.J.1
Hoying, J.B.2
Boivin, G.P.3
Ormsby, I.4
Gartside, P.S.5
Doetschman, T.6
-
3
-
-
0037012009
-
Consequences of altered TGF-β expression and responsiveness in breast cancer: Evidence for autocrine and paracrine effects
-
Tobin SW, Douville K, Benbow U, Brinckerhoff CE, Memoli VA, Arrick BA. Consequences of altered TGF-β expression and responsiveness in breast cancer: evidence for autocrine and paracrine effects. Oncogene 2002;21:108-18.
-
(2002)
Oncogene
, vol.21
, pp. 108-118
-
-
Tobin, S.W.1
Douville, K.2
Benbow, U.3
Brinckerhoff, C.E.4
Memoli, V.A.5
Arrick, B.A.6
-
4
-
-
33845209913
-
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
-
Neve RM, Chin K, Fridlyand J, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006;10:515-27.
-
(2006)
Cancer Cell
, vol.10
, pp. 515-527
-
-
Neve, R.M.1
Chin, K.2
Fridlyand, J.3
-
5
-
-
0030044330
-
MCF10AT: A model for the evolution of cancer from proliferative breast disease
-
Dawson PJ, Wolman SR, Tait L, Heppner GH, Miller FR. MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am J Pathol 1996;148:313-9.
-
(1996)
Am J Pathol
, vol.148
, pp. 313-319
-
-
Dawson, P.J.1
Wolman, S.R.2
Tait, L.3
Heppner, G.H.4
Miller, F.R.5
-
6
-
-
0035129885
-
Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells
-
Santner SJ, Dawson PJ, Tait L, et al. Malignant MCF10CA1 cell lines derived from premalignant human breast epithelial MCF10AT cells. Breast Cancer Res Treat 2001;65:101-10.
-
(2001)
Breast Cancer Res Treat
, vol.65
, pp. 101-110
-
-
Santner, S.J.1
Dawson, P.J.2
Tait, L.3
-
7
-
-
0030978315
-
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF- b in cells lacking the CDK inhibitor p15
-
Iavarone A, Massague J. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF- b in cells lacking the CDK inhibitor p15. Nature 1997;387:417-22.
-
(1997)
Nature
, vol.387
, pp. 417-422
-
-
Iavarone, A.1
Massague, J.2
-
8
-
-
0034534734
-
Progression of premalignant MCF10AT generates heterogeneous malignant variants with characteristic histologic types and immunohistochemical markers
-
Strickland LB, Dawson PJ, Santner SJ, Miller FR. Progression of premalignant MCF10AT generates heterogeneous malignant variants with characteristic histologic types and immunohistochemical markers. Breast Cancer Res Treat 2000;64:235-40.
-
(2000)
Breast Cancer Res Treat
, vol.64
, pp. 235-240
-
-
Strickland, L.B.1
Dawson, P.J.2
Santner, S.J.3
Miller, F.R.4
-
9
-
-
0029002907
-
Aberrant function of the Ras signal transduction pathway in human breast cancer
-
Clark GJ, Der CJ. Aberrant function of the Ras signal transduction pathway in human breast cancer. Breast Cancer Res Treat 1995;35:133-44.
-
(1995)
Breast Cancer Res Treat
, vol.35
, pp. 133-144
-
-
Clark, G.J.1
Der, C.J.2
-
10
-
-
1642503735
-
Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program
-
Crawford YG, Gauthier ML, Joubel A, et al. Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program. Cancer Cell 2004;5:263-73.
-
(2004)
Cancer Cell
, vol.5
, pp. 263-273
-
-
Crawford, Y.G.1
Gauthier, M.L.2
Joubel, A.3
-
12
-
-
33644560281
-
Cancer stem cells: An old idea - a paradigm shift
-
Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res 2006;66:1883-90.
-
(2006)
Cancer Res
, vol.66
, pp. 1883-1890
-
-
Wicha, M.S.1
Liu, S.2
Dontu, G.3
-
13
-
-
30644471961
-
Stem cells in the etiology and treatment of cancer
-
Zhang M, Rosen JM. Stem cells in the etiology and treatment of cancer. Curr Opin Genet Dev 2006;16:60-4.
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 60-64
-
-
Zhang, M.1
Rosen, J.M.2
-
14
-
-
0242285692
-
TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
-
Tang B, Vu M, Booker T, et al. TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J Clin Invest 2003;112:1116-24.
-
(2003)
J Clin Invest
, vol.112
, pp. 1116-1124
-
-
Tang, B.1
Vu, M.2
Booker, T.3
-
15
-
-
0034161969
-
A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells
-
Lin CQ, Singh J, Murata K, et al. A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. Cancer Res 2000;60:1332-40.
-
(2000)
Cancer Res
, vol.60
, pp. 1332-1340
-
-
Lin, C.Q.1
Singh, J.2
Murata, K.3
-
16
-
-
19444378108
-
The mammary gland "side population": A putative stem/progenitor cell marker?
-
Smalley MJ, Clarke RB. The mammary gland "side population": a putative stem/progenitor cell marker? J Mammary Gland Biol Neoplasia 2005;10:37-47.
-
(2005)
J Mammary Gland Biol Neoplasia
, vol.10
, pp. 37-47
-
-
Smalley, M.J.1
Clarke, R.B.2
-
17
-
-
21344454219
-
Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
-
Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005;65:5506-11.
-
(2005)
Cancer Res
, vol.65
, pp. 5506-5511
-
-
Ponti, D.1
Costa, A.2
Zaffaroni, N.3
-
18
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sorlie T, Perou CM, Tibshirani R, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-74.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10869-10874
-
-
Sorlie, T.1
Perou, C.M.2
Tibshirani, R.3
-
19
-
-
9244239811
-
G1 cell-cycle control and cancer
-
Massague J. G1 cell-cycle control and cancer. Nature 2004;432:298-306.
-
(2004)
Nature
, vol.432
, pp. 298-306
-
-
Massague, J.1
-
20
-
-
16544368308
-
Gene expression analysis in SV40-immortalized human breast luminal epithelial cells with stem cell characteristics using a cDNA microarray
-
Park JS, Noh DY, Kim SH, et al. Gene expression analysis in SV40-immortalized human breast luminal epithelial cells with stem cell characteristics using a cDNA microarray. Int J Oncol 2004;24:1545-58.
-
(2004)
Int J Oncol
, vol.24
, pp. 1545-1558
-
-
Park, J.S.1
Noh, D.Y.2
Kim, S.H.3
-
21
-
-
0037478605
-
Repeated observation of breast tumor subtypes in independent gene expression data sets
-
Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 2003;100:8418-23.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 8418-8423
-
-
Sorlie, T.1
Tibshirani, R.2
Parker, J.3
-
22
-
-
21044455192
-
Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer
-
Gusterson BA, Ross DT, Heath VJ, Stein T. Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer. Breast Cancer Res 2005;7:143-8.
-
(2005)
Breast Cancer Res
, vol.7
, pp. 143-148
-
-
Gusterson, B.A.1
Ross, D.T.2
Heath, V.J.3
Stein, T.4
-
23
-
-
0025415270
-
Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium
-
Smith GH, Mehrel T, Roop DR. Differential keratin gene expression in developing, differentiating, preneoplastic, and neoplastic mouse mammary epithelium. Cell Growth Differ 1990;1:161-70.
-
(1990)
Cell Growth Differ
, vol.1
, pp. 161-170
-
-
Smith, G.H.1
Mehrel, T.2
Roop, D.R.3
-
24
-
-
0348134978
-
Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: A new progenitor (adult stem) cell concept
-
Boecker W, Buerger H. Evidence of progenitor cells of glandular and myoepithelial cell lineages in the human adult female breast epithelium: a new progenitor (adult stem) cell concept. Cell Prolif 2003;36 Suppl 1:73-84.
-
(2003)
Cell Prolif
, vol.36
, Issue.SUPPL. 1
, pp. 73-84
-
-
Boecker, W.1
Buerger, H.2
-
25
-
-
0347634454
-
Defining the epithelial stem cell niche in skin
-
Tumbar T, Guasch G, Greco V, et al. Defining the epithelial stem cell niche in skin. Science 2004;303:359-63.
-
(2004)
Science
, vol.303
, pp. 359-363
-
-
Tumbar, T.1
Guasch, G.2
Greco, V.3
-
26
-
-
0037131389
-
Stemness: Transcriptional profiling of embryonic and adult stem cells
-
Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science 2002;298:597-600.
-
(2002)
Science
, vol.298
, pp. 597-600
-
-
Ramalho-Santos, M.1
Yoon, S.2
Matsuzaki, Y.3
Mulligan, R.C.4
Melton, D.A.5
-
27
-
-
0034795256
-
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
-
Zhou S, Schuetz JD, Bunting KD, et al. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 2001;7:1028-34.
-
(2001)
Nat Med
, vol.7
, pp. 1028-1034
-
-
Zhou, S.1
Schuetz, J.D.2
Bunting, K.D.3
-
28
-
-
4644306516
-
A distinct "side population" of cells with high drug efflux capacity in human tumor cells
-
Hirschmann-Jax C, Foster AE, Wulf GG, et al. A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A 2004;101:14228-33.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 14228-14233
-
-
Hirschmann-Jax, C.1
Foster, A.E.2
Wulf, G.G.3
-
29
-
-
25444482608
-
Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines
-
Locke M, Heywood M, Fawell S, Mackenzie IC. Retention of intrinsic stem cell hierarchies in carcinoma-derived cell lines. Cancer Res 2005;65:8944-50.
-
(2005)
Cancer Res
, vol.65
, pp. 8944-8950
-
-
Locke, M.1
Heywood, M.2
Fawell, S.3
Mackenzie, I.C.4
-
30
-
-
22244433866
-
Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG- cells are similarly tumorigenic
-
Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG- cells are similarly tumorigenic. Cancer Res 2005;65:6207-19.
-
(2005)
Cancer Res
, vol.65
, pp. 6207-6219
-
-
Patrawala, L.1
Calhoun, T.2
Schneider-Broussard, R.3
Zhou, J.4
Claypool, K.5
Tang, D.G.6
-
31
-
-
0037948854
-
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
-
Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003;17:1253-70.
-
(2003)
Genes Dev
, vol.17
, pp. 1253-1270
-
-
Dontu, G.1
Abdallah, W.M.2
Foley, J.M.3
-
32
-
-
0034471262
-
ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
-
Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 2000;113:3897-905.
-
(2000)
J Cell Sci
, vol.113
, pp. 3897-3905
-
-
Norton, J.D.1
-
33
-
-
0038369998
-
A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
-
Kang Y, Chen CR, Massague J. A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 2003;11:915-26.
-
(2003)
Mol Cell
, vol.11
, pp. 915-926
-
-
Kang, Y.1
Chen, C.R.2
Massague, J.3
-
34
-
-
0344845415
-
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
-
Ying QL, Nichols J, Chambers I, Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003;115:281-92.
-
(2003)
Cell
, vol.115
, pp. 281-292
-
-
Ying, Q.L.1
Nichols, J.2
Chambers, I.3
Smith, A.4
-
35
-
-
0033572467
-
Transforming growth factor-β and breast cancer risk in women with mammary epithelial hyperplasia
-
Gobbi H, Dupont WD, Simpson JF, et al. Transforming growth factor-β and breast cancer risk in women with mammary epithelial hyperplasia. J Natl Cancer Inst 1999;91:2096-101.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 2096-2101
-
-
Gobbi, H.1
Dupont, W.D.2
Simpson, J.F.3
-
36
-
-
0034004714
-
Loss of expression of transforming growth factor β type II receptor correlates with high tumor grade in human breast in-situ and invasive carcinomas
-
Gobbi H, Arteaga CL, Jensen RA, et al. Loss of expression of transforming growth factor β type II receptor correlates with high tumor grade in human breast in-situ and invasive carcinomas. Histopathology 2000;36:168-77.
-
(2000)
Histopathology
, vol.36
, pp. 168-177
-
-
Gobbi, H.1
Arteaga, C.L.2
Jensen, R.A.3
-
37
-
-
26444585020
-
Transforming growth factor-β signaling in stem cells and cancer
-
Mishra L, Derynck R, Mishra B. Transforming growth factor-β signaling in stem cells and cancer. Science 2005;310:68-71.
-
(2005)
Science
, vol.310
, pp. 68-71
-
-
Mishra, L.1
Derynck, R.2
Mishra, B.3
-
38
-
-
30144433093
-
Generation of a functional mammary gland from a single stem cell
-
Shackleton M, Vaillant F, Simpson KJ, et al. Generation of a functional mammary gland from a single stem cell. Nature 2006;439:84-8.
-
(2006)
Nature
, vol.439
, pp. 84-88
-
-
Shackleton, M.1
Vaillant, F.2
Simpson, K.J.3
-
39
-
-
30144432901
-
Purification and unique properties of mammary epithelial stem cells
-
Stingl J, Eirew P, Ricketson I, et al. Purification and unique properties of mammary epithelial stem cells. Nature 2006;439:993-7.
-
(2006)
Nature
, vol.439
, pp. 993-997
-
-
Stingl, J.1
Eirew, P.2
Ricketson, I.3
-
40
-
-
0028986768
-
Ectopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population
-
Kordon EC, McKnight RA, Jhappan C, Hennighausen L, Merlino G, Smith GH. Ectopic TGFβ1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev Biol 1995;168:47-61.
-
(1995)
Dev Biol
, vol.168
, pp. 47-61
-
-
Kordon, E.C.1
McKnight, R.A.2
Jhappan, C.3
Hennighausen, L.4
Merlino, G.5
Smith, G.H.6
-
41
-
-
0035953393
-
Reducing mammary cancer risk through premature stem cell senescence
-
Boulanger CA, Smith GH. Reducing mammary cancer risk through premature stem cell senescence. Oncogene 2001;20:2264-72.
-
(2001)
Oncogene
, vol.20
, pp. 2264-2272
-
-
Boulanger, C.A.1
Smith, G.H.2
-
42
-
-
0029010734
-
Mammary tumor suppression by transforming growth factor β1 transgene expression
-
Pierce DF, Jr., Gorska AE, Chytil A, et al. Mammary tumor suppression by transforming growth factor β1 transgene expression. Proc Natl Acad Sci U S A 1995;92:4254-8.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 4254-4258
-
-
Pierce Jr., D.F.1
Gorska, A.E.2
Chytil, A.3
-
43
-
-
0141537150
-
Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-β receptor exhibit impaired mammary development and enhanced mammary tumor formation
-
Gorska AE, Jensen RA, Shyr Y, Aakre ME, Bhowmick NA, Moses HL. Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-β receptor exhibit impaired mammary development and enhanced mammary tumor formation. Am J Pathol 2003;163:1539-49.
-
(2003)
Am J Pathol
, vol.163
, pp. 1539-1549
-
-
Gorska, A.E.1
Jensen, R.A.2
Shyr, Y.3
Aakre, M.E.4
Bhowmick, N.A.5
Moses, H.L.6
-
44
-
-
0031441041
-
Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene
-
Bottinger EP, Jakubczak JL, Haines DC, Bagnall K, Wakefield LM. Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor β receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene. Cancer Res 1997;57:5564-70.
-
(1997)
Cancer Res
, vol.57
, pp. 5564-5570
-
-
Bottinger, E.P.1
Jakubczak, J.L.2
Haines, D.C.3
Bagnall, K.4
Wakefield, L.M.5
-
45
-
-
6944224156
-
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling
-
He XC, Zhang J, Tong WG, et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling. Nat Genet 2004;36:1117-21.
-
(2004)
Nat Genet
, vol.36
, pp. 1117-1121
-
-
He, X.C.1
Zhang, J.2
Tong, W.G.3
-
46
-
-
0035901594
-
c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny
-
Arnold I, Watt FM. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 2001;11:558-68.
-
(2001)
Curr Biol
, vol.11
, pp. 558-568
-
-
Arnold, I.1
Watt, F.M.2
-
47
-
-
23144464750
-
Id family of helix-loop-helix proteins in cancer
-
Perk J, Iavarone A, Benezra R. Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer 2005;5:603-14.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 603-614
-
-
Perk, J.1
Iavarone, A.2
Benezra, R.3
-
48
-
-
0029024931
-
Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1
-
Desprez PY, Hara E, Bissell MJ, Campisi J. Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1. Mol Cell Biol 1995;15:3398-404.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3398-3404
-
-
Desprez, P.Y.1
Hara, E.2
Bissell, M.J.3
Campisi, J.4
-
49
-
-
0345669748
-
Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer
-
Schoppmann SF, Schindl M, Bayer G, et al. Overexpression of Id-1 is associated with poor clinical outcome in node negative breast cancer. Int J Cancer 2003;104:677-82.
-
(2003)
Int J Cancer
, vol.104
, pp. 677-682
-
-
Schoppmann, S.F.1
Schindl, M.2
Bayer, G.3
-
50
-
-
0021922710
-
Increased secretion of type β transforming growth factor accompanies viral transformation of cells
-
Anzano MA, Roberts AB, De Larco JE, et al. Increased secretion of type β transforming growth factor accompanies viral transformation of cells. Mol Cell Biol 1985;5:242-7.
-
(1985)
Mol Cell Biol
, vol.5
, pp. 242-247
-
-
Anzano, M.A.1
Roberts, A.B.2
De Larco, J.E.3
|