Abnormal angiogenesis but intact hematopoietic potential in TGF-β type I receptor-deficient mice

EMBO Journal

Volumn 20, Issue 7, 2001, Pages 1663-1673

  Larsson, Jonas ^a   Goumans, Marie José ^b   Sjöstrand, Lottie Jansson ^a   Van Rooijen, Marga A ^c   Ward, Dorien ^c   Levéen, Per ^a   Xu, Xiufeng ^a   Ten Dijke, Peter ^b   Mummery, Christine L ^c   Karlsson, Stefan ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c HUBRECHT INSTITUTE   (Netherlands)

Author keywords

Endothelial cell; Hematopoiesis; Serine; Signal transduction; TGF ; Threonine kinase receptor

Indexed keywords

ACTIVIN; FIBRONECTIN; PROTEIN ALK1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CLONOGENIC ASSAY; EMBRYO; GENE DELETION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; RECEPTOR DENSITY;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; CELL DIVISION; CELL MOVEMENT; EMBRYONIC AND FETAL DEVELOPMENT; ENDOTHELIUM, VASCULAR; ERYTHROID PROGENITOR CELLS; FIBRONECTINS; HEMATOPOIESIS; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 17744397294     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.7.1663     Document Type: Article

References (54)

1. Identification of human activin and TGF-β type I receptors that form heteromeric kinase complexes with type II receptors
2. Early embryonic vascular development
3. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
4. Implantation and the placenta: Key pieces of the development puzzle
5. Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura
6. Direct binding of Smad3 and Smad4 to critical TGF-β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
7. Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice
8. Transforming growth factor-β (TGF-β), a potent inhibitor of erythropoiesis: Neutralizing TGF-β antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burstpromoting activity
9. Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins
10. Transforming growth factor-β: Pleiotropic role in the regulation of hematopoiesis
11. Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor
12. Inhibition of transforming growth factor-induced cell growth in soft agar by oxidized polyamines
13. Functional analysis of the TGF-β receptor/Smad pathway through gene ablation in mice
14. Transforming growth factor-β signalling in extraembryonic mesoderm is required for yolk sac vasculogenesis in mice
15. Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-β
16. 2 homeostasis by hypoxia-inducible factor 1
17. Large T antigens of simian vires 40 and polyomavirus efficiently establish primary fibroblasts
18. Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2
19. Abnormal lung development and cleft palate in mice lacking TGF-β3 indicates defects of epithelial-mesenchymal interaction
20. Transforming growth factor-β: A bidirectional regulator of hematopoietic cell growth
21. Transforming growth factor-β1 null mutation in mice causes excessive inflammatory response and early death
22. Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and II
23. Maternal rescue of transforming growth factor-β1 null mice
24. Defective angiogenesis in mice lacking endoglin
25. Assignment of transforming growth factor β1 and β3 and a third new ligand to the type I receptor ALK-1
26. TGF-β signal transduction
27. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
28. Transforming growth factor-β: A matter of life and death
29. Vascular cells respond differentially to transforming growth factors β1 and β2 in vitro
30. Inhibitory action of transforming growth factor-β on endothelial cells
31. Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis
32. TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
33. Transforming growth factor-β: Vasculogenesis, angiogenesis and vessel wall integrity
34. The L45 loop in type I receptors for TGF-β family members is a critical determinant in specifying Smad isoform activation
35. Expression of transforming-growth-factor (TGF)-β receptors and Smad proteins in glioblastoma cell lines with distinct responses to TGF-β1
36. Transforming growth factor-β3 is required for secondary palate fusion
37. Mechanisms of angiogenesis
38. The transforming growth factors-β
39. Expression of ALK-1, a type 1 serine/threonine kinase receptor, coincides with sites of vasculogenesis and angiogenesis in early mouse development
40. TGF-β2 knockout mice have multiple developmental defects that are non-overlapping with other TGF-β knockout phenotypes
41. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
42. Transforming growth factor β1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells
43. Peptide growth factors are multifunctional
44. A mouse TGF-β type I receptor that requires type II receptor for ligand binding
45. Characterization of type I receptors for transforming growth factor-β and activin
46. Restricted expression of type-II TGF-β receptor in murine embryonic development suggests a central role in tissue modeling and CNS patterning
47. GS domain mutations that constitutively activate TβR-I, the downstream signalling component in the TGF-β receptor complex
48. Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene
49. Properties of the earliest clonogenic hemopoietic precursors to appear in the developing murine yolk sac
50. Mechanism of activation of the TGF-β receptor
51. Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β
52. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
53. Autoimmune manifestations in the transforming growth factor β1 knockout mouse
54. Ectopic expression of the transforming growth factor-β type II receptor disrupts mesoderm organization during mouse gastrulation