메뉴 건너뛰기




Volumn 96, Issue 3, 1999, Pages 319-328

The integrin αvβ6 binds and activates latent TGFβ1: A mechanism for regulating pulmonary inflammation and fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; GENE PRODUCT; INTEGRIN; LATENCY ASSOCIATED PEPTIDE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 0033524949     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80545-0     Document Type: Article
Times cited : (1769)

References (42)
  • 1
    • 0028328817 scopus 로고
    • An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct
    • Abe, M., Harpel, J.G., Metz, C.N., Nunes, I., Loskutoff, D.J., and Rifkin, D.B. (1994). An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal. Biochem. 216, 276-284.
    • (1994) Anal. Biochem. , vol.216 , pp. 276-284
    • Abe, M.1    Harpel, J.G.2    Metz, C.N.3    Nunes, I.4    Loskutoff, D.J.5    Rifkin, D.B.6
  • 2
    • 0029736871 scopus 로고    scopus 로고
    • Redox-mediated activation of latent transforming growth factor-beta 1
    • Barcellos-Hoff, M.H., and Dix, T.A. (1996). Redox-mediated activation of latent transforming growth factor-beta 1. Mol. Endocrinol. 10, 1077-1083.
    • (1996) Mol. Endocrinol. , vol.10 , pp. 1077-1083
    • Barcellos-Hoff, M.H.1    Dix, T.A.2
  • 3
    • 0028177037 scopus 로고
    • Transforming growth factor-beta activation in irradiated murine mammary gland
    • Barcellos-Hoff, M.H., Derynck, R., Tsang, M.L., and Weatherbee, J.A. (1994). Transforming growth factor-beta activation in irradiated murine mammary gland. J. Clin. Invest. 93, 892-899.
    • (1994) J. Clin. Invest. , vol.93 , pp. 892-899
    • Barcellos-Hoff, M.H.1    Derynck, R.2    Tsang, M.L.3    Weatherbee, J.A.4
  • 4
    • 0028881813 scopus 로고
    • Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue
    • Barcellos-Hoff, M.H., Ehrhart, E.J., Kalia, M., Jirtle, R., Flanders, K., and Tsang, M.L (1995). Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue. Am. J. Pathol. 747, 1228-1237.
    • (1995) Am. J. Pathol. , vol.747 , pp. 1228-1237
    • Barcellos-Hoff, M.H.1    Ehrhart, E.J.2    Kalia, M.3    Jirtle, R.4    Flanders, K.5    Tsang, M.L.6
  • 5
    • 0026676859 scopus 로고
    • Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease
    • Border, W.A., Noble, N.A., Yamamoto, Y., Harper, J.R., Yamaguchi, Y., Pierschbacher, M.D., and Ruoslahti, E. (1992). Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature 360, 361-364.
    • (1992) Nature , vol.360 , pp. 361-364
    • Border, W.A.1    Noble, N.A.2    Yamamoto, Y.3    Harper, J.R.4    Yamaguchi, Y.5    Pierschbacher, M.D.6    Ruoslahti, E.7
  • 7
    • 0026010305 scopus 로고
    • Transforming growth factor-beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis
    • Broekelmann, T., Limper, A.H., Colby, T.V., and McDonald, J.A. (1991 ). Transforming growth factor-beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc. Natl. Acad. Sci. USA 88, 6642-6646.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 6642-6646
    • Broekelmann, T.1    Limper, A.H.2    Colby, T.V.3    McDonald, J.A.4
  • 8
    • 0026660349 scopus 로고
    • Characterization of the integrin αvβ6 as a fibronectin-binding protein
    • Busk, M., Pytela, R., and Sheppard, D. (1992). Characterization of the integrin αvβ6 as a fibronectin-binding protein. J. Biol. Chem. 267, 5790-5796.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5790-5796
    • Busk, M.1    Pytela, R.2    Sheppard, D.3
  • 9
    • 0028225614 scopus 로고
    • Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts
    • Cone, R.I., Weinacker, A., Chen, A., and Sheppard, D. (1994). Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts. Cell Adhes. Commun. 2, 101-113.
    • (1994) Cell Adhes. Commun. , vol.2 , pp. 101-113
    • Cone, R.I.1    Weinacker, A.2    Chen, A.3    Sheppard, D.4
  • 11
    • 0026059613 scopus 로고
    • Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose-6- phosphate/insulin-like growth factor type II receptor
    • Dennis, P.A., and Rifkin, D.B. (1991). Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose-6- phosphate/insulin-like growth factor type II receptor. Proc. Natl. Acad. Sci. USA 88, 580-584.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 580-584
    • Dennis, P.A.1    Rifkin, D.B.2
  • 12
    • 0027425864 scopus 로고
    • Effect of antibody to transforming growth factor-beta on bleomycin induced accumulation of lung collagen in mice
    • Giri, S., Hyde, D.M., and Hollinger, M.A. (1993). Effect of antibody to transforming growth factor-beta on bleomycin induced accumulation of lung collagen in mice. Thorax 48, 959-966.
    • (1993) Thorax , vol.48 , pp. 959-966
    • Giri, S.1    Hyde, D.M.2    Hollinger, M.A.3
  • 13
    • 0029029807 scopus 로고
    • Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin
    • G rainger, D.U., Wakefield, L, Bethell, H.W., Farndale R.W., and Metcalfe, U.C. (1995). Release and activation of platelet latent TGF-beta in blood clots during dissolution with plasmin. Nat. Med. 1, 932-937.
    • (1995) Nat. Med. , vol.1 , pp. 932-937
    • Grainger, D.U.1    Wakefield, L.2    Bethell, H.W.3    Farndale, R.W.4    Metcalfe, U.C.5
  • 14
    • 0025373853 scopus 로고
    • Requirement for activin A and transforming growth factor-beta 1 pro-region in homodimer assembly
    • Gray, A., and Mason, A. (1990). Requirement for activin A and transforming growth factor-beta 1 pro-region in homodimer assembly. Science 247, 1328-1330.
    • (1990) Science , vol.247 , pp. 1328-1330
    • Gray, A.1    Mason, A.2
  • 15
    • 15844376477 scopus 로고    scopus 로고
    • Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin
    • Huang, X.Z., Wu, J.F., Cass, D., Erle, D.J., Corry, D., Young, S.G., Farese, R.V.J., and Sheppard, D. (1996). Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J. Cell Biol. 133, 921-928.
    • (1996) J. Cell Biol. , vol.133 , pp. 921-928
    • Huang, X.Z.1    Wu, J.F.2    Cass, D.3    Erle, D.J.4    Corry, D.5    Young, S.G.6    Farese, R.V.J.7    Sheppard, D.8
  • 16
    • 0031696891 scopus 로고    scopus 로고
    • The integrin alphavbetae is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin
    • Huang, X.Z., Wu, J.F., Spong, S., and Sheppard, D. (1998a). The integrin alphavbetae is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin. J. Cell Sci. 111, 2189-2195.
    • (1998) J. Cell Sci. , vol.111 , pp. 2189-2195
    • Huang, X.Z.1    Wu, J.F.2    Spong, S.3    Sheppard, D.4
  • 17
    • 0032186263 scopus 로고    scopus 로고
    • Expression of the human integrin betas subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in betas knockout mice
    • Huang, X.Z., Wu, J.F., Zhu, W., Pytela, R., and Sheppard, D. (1998b). Expression of the human integrin betas subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in betas knockout mice. Am. J. Respir. Cell. Mol. Biol. 19, 636-642.
    • (1998) Am. J. Respir. Cell. Mol. Biol. , vol.19 , pp. 636-642
    • Huang, X.Z.1    Wu, J.F.2    Zhu, W.3    Pytela, R.4    Sheppard, D.5
  • 18
    • 0028806184 scopus 로고
    • Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction
    • Kaartinen, V., Voncken, J.W., Shuler, C., Warburton, D., Bu, D. Heisterkamp, N., and Groffen, J. (1995). Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat. Genet. 11, 415-421.
    • (1995) Nat. Genet. , vol.11 , pp. 415-421
    • Kaartinen, V.1    Voncken, J.W.2    Shuler, C.3    Warburton, D.4    Bu, D.5    Heisterkamp, N.6    Groffen, J.7
  • 19
    • 0027419881 scopus 로고
    • Requirement for transglutaminase in the activation of latent transforming growth factorbeta in bovine endothelial cells
    • Kojima, S., Nara, K., and Rifkin, D.B. (1993). Requirement for transglutaminase in the activation of latent transforming growth factorbeta in bovine endothelial cells. J. Cell Biol. 121, 439-448.
    • (1993) J. Cell Biol. , vol.121 , pp. 439-448
    • Kojima, S.1    Nara, K.2    Rifkin, D.B.3
  • 21
    • 0025215307 scopus 로고
    • Mechanism of activation of latent recombinant transforming growth factor-beta 1 by plasmin
    • Lyons, R.M., Gentry, L.E., Purchio, A.F., and Moses, H.L (1990). Mechanism of activation of latent recombinant transforming growth factor-beta 1 by plasmin. J. Cell Biol. 770, 1361-1367.
    • (1990) J. Cell Biol. , vol.770 , pp. 1361-1367
    • Lyons, R.M.1    Gentry, L.E.2    Purchio, A.F.3    Moses, H.L.4
  • 22
    • 0030022404 scopus 로고    scopus 로고
    • Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide
    • McMahon, G.A., Dignam, J.D., and Gentry, L.E. (1996). Structural characterization of the latent complex between transforming growth factor beta 1 and beta 1-latency-associated peptide. Biochem. J. 373, 343-351.
    • (1996) Biochem. J. , vol.373 , pp. 343-351
    • McMahon, G.A.1    Dignam, J.D.2    Gentry, L.E.3
  • 23
    • 0027451706 scopus 로고
    • The extracellular matrix as a cell survival factor
    • Meredith, U.E., Jr., Fazeli, B., and Schwartz, M.A. (1993). The extracellular matrix as a cell survival factor. Mol. Biol. Cell 4, 953-961.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 953-961
    • Meredith Jr., U.E.1    Fazeli, B.2    Schwartz, M.A.3
  • 24
    • 0031670654 scopus 로고    scopus 로고
    • Interactions between growth factors and integrins: Latent forms of transforming growth factor-β are ligands for the integrin αvβ1
    • Munger, U.S., Harpel, J.G., Giancotti, F.G., and Rifkin, D.B. (1998). Interactions between growth factors and integrins: latent forms of transforming growth factor-β are ligands for the integrin αvβ1. Mol. Biol. Cell 9, 2627-2638.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 2627-2638
    • Munger, U.S.1    Harpel, J.G.2    Giancotti, F.G.3    Rifkin, D.B.4
  • 25
    • 0030974902 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta
    • Nunes, I., Gleizes, P.E., Metz, C.N., and Rifkin, D.B. (1997). Latent transforming growth factor-beta binding protein domains involved in activation and transglutaminase-dependent cross-linking of latent transforming growth factor-beta. J. Cell Biol. 736, 1151-1163.
    • (1997) J. Cell Biol. , vol.736 , pp. 1151-1163
    • Nunes, I.1    Gleizes, P.E.2    Metz, C.N.3    Rifkin, D.B.4
  • 26
    • 0027364324 scopus 로고
    • Multiple integrins mediate cell attachment to cytotactin tenascin
    • Prieto, A.L, Edelman, G.M., and Crossin, K.L. (1993). Multiple integrins mediate cell attachment to cytotactin tenascin. Proc. Natl. Acad. Sci. USA 90, 10154-10158.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10154-10158
    • Prieto, A.L.1    Edelman, G.M.2    Crossin, K.L.3
  • 27
    • 0022000778 scopus 로고
    • Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor
    • Pytela, R., Pierschbacher, M.D., and Ruoslahti, E. (1985). Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Cell 40, 191-198.
    • (1985) Cell , vol.40 , pp. 191-198
    • Pytela, R.1    Pierschbacher, M.D.2    Ruoslahti, E.3
  • 29
    • 0025310993 scopus 로고
    • Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: A self-regulating system
    • Sato, Y., Tsuboi, R., Moses, H., and Rifkin, D.B. (1990). Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system. J. Cell Biol. 111, 757-763.
    • (1990) J. Cell Biol. , vol.111 , pp. 757-763
    • Sato, Y.1    Tsuboi, R.2    Moses, H.3    Rifkin, D.B.4
  • 30
    • 0027305971 scopus 로고
    • Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism
    • Schultz-Cherry, S., and Murphy-Ullrich, J.E. (1993). Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J. Cell Biol. 722, 923-932.
    • (1993) J. Cell Biol. , vol.722 , pp. 923-932
    • Schultz-Cherry, S.1    Murphy-Ullrich, J.E.2
  • 31
    • 0028138619 scopus 로고
    • The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta
    • Schultz-Cherry, S., Lawler, J., and Murphy-Ullrich, J.E. (1994). The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta. J. Biol. Chem. 269, 26783-26788.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26783-26788
    • Schultz-Cherry, S.1    Lawler, J.2    Murphy-Ullrich, J.E.3
  • 33
    • 0026794061 scopus 로고
    • Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells
    • Sheppard, D., Cohen, D.S., Wang, A., and Busk, M. (1992). Transforming growth factor beta differentially regulates expression of integrin subunits in guinea pig airway epithelial cells. J. Biol. Chem. 267, 17409-17414.
    • (1992) J. Biol. Chem. , vol.267 , pp. 17409-17414
    • Sheppard, D.1    Cohen, D.S.2    Wang, A.3    Busk, M.4
  • 34
  • 35
    • 0030800795 scopus 로고    scopus 로고
    • Adenovector-mediated gene transfer of active transforming growth factor-β1 induces prolonged severe fibrosis in rat lung
    • Sime, P.J., Xing, Z., Graham, F.L, Csaky K.G., and Gauldie, J. (1997). Adenovector-mediated gene transfer of active transforming growth factor-β1 induces prolonged severe fibrosis in rat lung. J. Clin. Invest. 100, 768-776.
    • (1997) J. Clin. Invest. , vol.100 , pp. 768-776
    • Sime, P.J.1    Xing, Z.2    Graham, F.L.3    Csaky, K.G.4    Gauldie, J.5
  • 36
    • 0029813731 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils
    • Taipale, J., Saharinen, J., Hedman K., and Keski-Oja, J. (1996). Latent transforming growth factor-beta 1 and its binding protein are components of extracellular matrix microfibrils. J. Histochem. Cytochem. 44, 875-889.
    • (1996) J. Histochem. Cytochem. , vol.44 , pp. 875-889
    • Taipale, J.1    Saharinen, J.2    Hedman, K.3    Keski-Oja, J.4
  • 37
    • 0031684855 scopus 로고    scopus 로고
    • Extracellular matrix-associated transforming growth factor-beta: Role in cancer cell growth and invasion
    • Taipale, J., Saharinen, J., and Keski-Oja, J. (1998). Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion. Adv. Cancer. Res. 75, 87-134.
    • (1998) Adv. Cancer. Res. , vol.75 , pp. 87-134
    • Taipale, J.1    Saharinen, J.2    Keski-Oja, J.3
  • 38
    • 0024278715 scopus 로고
    • Transforming growth factor-betal positively regulates its own expression in normal and transformed cells
    • Van Obberghen-Schilling, E., Roche, N.S., Flanders, K.C, Sporn, M.B., and Roberts, A.B. (1988). Transforming growth factor-betal positively regulates its own expression in normal and transformed cells. J. Biol. Chem. 263, 7741-7746.
    • (1988) J. Biol. Chem. , vol.263 , pp. 7741-7746
    • Van Obberghen-Schilling, E.1    Roche, N.S.2    Flanders, K.C.3    Sporn, M.B.4    Roberts, A.B.5
  • 40
    • 0028173629 scopus 로고
    • Role of the integrin alphaVbeta6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor
    • Weinacker, A., Chen, A., Agrez, M., Cone, R.I., Nishimura, S., Wayner, E., Pytela, R., and Sheppard, D. (1994). Role of the integrin alphaVbeta6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor. J. Biol. Chem. 269, 6940-6948.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6940-6948
    • Weinacker, A.1    Chen, A.2    Agrez, M.3    Cone, R.I.4    Nishimura, S.5    Wayner, E.6    Pytela, R.7    Sheppard, D.8
  • 41
    • 0024335963 scopus 로고
    • Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression
    • Werb, Z., Tremble, P.M., Behrendtsen, O., Crowley, E., and Damsky, C.H. (1989). Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression. J. Cell. Biol. 109, 877-889.
    • (1989) J. Cell. Biol. , vol.109 , pp. 877-889
    • Werb, Z.1    Tremble, P.M.2    Behrendtsen, O.3    Crowley, E.4    Damsky, C.H.5
  • 42
    • 33745996622 scopus 로고
    • The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid
    • Woessner, J.F. (1961 ). The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid. Arch. Biochem. Biophys. 93, 440-447.
    • (1961) Arch. Biochem. Biophys. , vol.93 , pp. 440-447
    • Woessner, J.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.