메뉴 건너뛰기




Volumn 119, Issue 11, 2009, Pages 3408-3419

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

Author keywords

[No Author keywords available]

Indexed keywords

FANCONI ANEMIA PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 70449338760     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI38854     Document Type: Article
Times cited : (190)

References (60)
  • 1
    • 13544270249 scopus 로고    scopus 로고
    • Profiling early head and neck cancer
    • DOI 10.1038/nrc1548
    • Hunter, K.D., Parkinson, E.K., and Harrison, P.R. 2005. Profiling early head and neck cancer. Nat. Rev. Cancer. 5:127-135. (Pubitemid 40220338)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.2 , pp. 127-135
    • Hunter, K.D.1    Parkinson, E.K.2    Harrison, P.R.3
  • 5
    • 0031946721 scopus 로고    scopus 로고
    • Presence of multiple incontiguous deleted regions at the long arm of chromosome 18 in head and neck cancer
    • Papadimitrakopoulou, V.A., et al. 1998. Presence of multiple incontiguous deleted regions at the long arm of chromosome 18 in head and neck cancer. Clin. Cancer Res. 4:539-544.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 539-544
    • Papadimitrakopoulou, V.A.1
  • 7
    • 33749354957 scopus 로고    scopus 로고
    • Mouse models for human head and neck squamous cell carcinomas
    • DOI 10.1002/hed.20397
    • Lu, S.L., Herrington, H., and Wang, X.J. 2006. Mouse models for human head and neck squamous cell carcinomas. Head Neck. 28:945-954. (Pubitemid 44497871)
    • (2006) Head and Neck , vol.28 , Issue.10 , pp. 945-954
    • Lu, S.-L.1    Herrington, H.2    Wang, X.-J.3
  • 8
    • 33646537475 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma
    • Lu, S.L., et al. 2006. Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev. 20:1331-1342.
    • (2006) Genes Dev. , vol.20 , pp. 1331-1342
    • Lu, S.L.1
  • 9
    • 3442883361 scopus 로고    scopus 로고
    • Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity
    • DOI 10.1158/0008-5472.CAN-04-1488
    • Caulin, C., et al. 2004. Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity. Cancer Res. 64:5054-5058. (Pubitemid 39006517)
    • (2004) Cancer Research , vol.64 , Issue.15 , pp. 5054-5058
    • Caulin, C.1    Nguyen, T.2    Longley, M.A.3    Zhou, Z.4    Wang, X.-J.5    Roop, D.R.6
  • 12
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
    • DOI 10.1038/383168a0
    • Zhang, Y., Feng, X., We, R., and Derynck, R. 1996. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. Nature. 383:168-172. (Pubitemid 26303979)
    • (1996) Nature , vol.383 , Issue.6596 , pp. 168-172
    • Zhang, Y.1    Feng, X.-H.2    Wu, R.-Y.3    Derynck, R.4
  • 13
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel, P.M., and Massague, J. 2003. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat. Rev. Cancer. 3:807-821. (Pubitemid 37376979)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.11 , pp. 807-820
    • Siegel, P.M.1    Massague, J.2
  • 16
    • 0032489508 scopus 로고    scopus 로고
    • Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    • DOI 10.1016/S0092-8674(00)81132-0
    • Takaku, K., et al. 1998. Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes. Cell. 92:645-656. (Pubitemid 28141513)
    • (1998) Cell , vol.92 , Issue.5 , pp. 645-656
    • Takaku, K.1    Oshima, M.2    Miyoshi, H.3    Matsui, M.4    Seldin, M.F.5    Taketo, M.M.6
  • 19
    • 33746919897 scopus 로고    scopus 로고
    • Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse
    • DOI 10.1158/0008-5472.CAN-06-0507
    • Teng, Y., et al. 2006. Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse. Cancer Res. 66:6972-6981. (Pubitemid 44197672)
    • (2006) Cancer Research , vol.66 , Issue.14 , pp. 6972-6981
    • Teng, Y.1    Sun, A.-N.2    Pan, X.-C.3    Yang, G.4    Yang, L.-L.5    Wang, M.-R.6    Yang, X.7
  • 22
    • 30544444184 scopus 로고    scopus 로고
    • Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin
    • DOI 10.1038/sj.onc.1209029, PII 1209029
    • Qiao, W., et al. 2006. Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Oncogene. 25:207-217. (Pubitemid 43083682)
    • (2006) Oncogene , vol.25 , Issue.2 , pp. 207-217
    • Qiao, W.1    Li, A.G.2    Owens, P.3    Xu, X.4    Wang, X.-J.5    Deng, C.-X.6
  • 24
    • 25444473619 scopus 로고    scopus 로고
    • Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors
    • DOI 10.1158/0008-5472.CAN-05-0800
    • Yang, L., et al. 2005. Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors. Cancer Res. 65:8671-8678. (Pubitemid 41377354)
    • (2005) Cancer Research , vol.65 , Issue.19 , pp. 8671-8678
    • Yang, L.1    Mao, C.2    Teng, Y.3    Li, W.4    Zhang, J.5    Cheng, X.6    Li, X.7    Han, X.8    Xia, Z.9    Deng, H.10    Yang, X.11
  • 25
    • 20544465379 scopus 로고    scopus 로고
    • Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma
    • Snijders, A.M., et al. 2005. Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma. Oncogene. 24:4232-4242.
    • (2005) Oncogene , vol.24 , pp. 4232-4242
    • Snijders, A.M.1
  • 26
    • 0037103055 scopus 로고    scopus 로고
    • Decreased Smad4 expression in the transforming growth factor-beta signaling pathway during progression of esophageal squamous cell carcinoma
    • DOI 10.1002/cncr.10727
    • Fukuchi, M., et al. 2002. Decreased Smad4 expression in the transforming growth factor-beta signaling pathway during progression of esophageal squamous cell carcinoma. Cancer. 95:737-743. (Pubitemid 34839664)
    • (2002) Cancer , vol.95 , Issue.4 , pp. 737-743
    • Fukuchi, M.1    Masuda, N.2    Miyazaki, T.3    Nakajima, M.4    Osawa, H.5    Kato, H.6    Kuwano, H.7
  • 28
    • 0031850583 scopus 로고    scopus 로고
    • Gene expression of differentiation-specific keratins (4/13 and 1/10) in normal human buccal mucosa
    • Bloor, B.K., Su, L., Shirlaw, P.J., and Morgan, P.R. 1998. Gene expression of differentiation-specific keratins (4/13 and 1/10) in normal human buccal mucosa. Lab. Invest. 78:787-795. (Pubitemid 28347876)
    • (1998) Laboratory Investigation , vol.78 , Issue.7 , pp. 787-795
    • Bloor, B.K.1    Su, L.2    Shirlaw, P.J.3    Morgan, P.R.4
  • 30
    • 0345304254 scopus 로고    scopus 로고
    • Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells
    • DOI 10.1038/sj.onc.1206998
    • Bertrand, P., Lambert, S., Joubert, C., and Lopez, B.S. 2003. Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant- negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells. Oncogene. 22:7587-7592. (Pubitemid 37464091)
    • (2003) Oncogene , vol.22 , Issue.48 , pp. 7587-7592
    • Bertrand, P.1    Lambert, S.2    Joubert, C.3    Lopez, B.S.4
  • 31
  • 32
    • 36448987217 scopus 로고    scopus 로고
    • Oncogenes and tumour suppressors take on centrosomes
    • DOI 10.1038/nrc2249, PII NRC2249
    • Fukasawa, K. 2007. Oncogenes and tumour suppressors take on centrosomes. Nat. Rev. Cancer. 7:911-924. (Pubitemid 350165854)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.12 , pp. 911-924
    • Fukasawa, K.1
  • 36
    • 29144506137 scopus 로고    scopus 로고
    • The Fanconi Anemia/BRCA pathway: New faces in the crowd
    • Kennedy, R.D., and D'Andrea, A.D. 2005. The Fanconi Anemia/BRCA pathway: new faces in the crowd. Genes Dev. 19:2925-2940.
    • (2005) Genes Dev. , vol.19 , pp. 2925-2940
    • Kennedy, R.D.1    D'Andrea, A.D.2
  • 37
    • 33845683318 scopus 로고    scopus 로고
    • Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4
    • DOI 10.1016/j.canlet.2006.01.003, PII S0304383506000279
    • Qiu, W., Schonleben, F., Li, X., and Su, G.H. 2007. Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4. Cancer Lett. 245:163-170. (Pubitemid 44959352)
    • (2007) Cancer Letters , vol.245 , Issue.1-2 , pp. 163-170
    • Qiu, W.1    Schonleben, F.2    Li, X.3    Su, G.H.4
  • 38
    • 0037268338 scopus 로고    scopus 로고
    • The Fanconi anaemia/BRCA pathway
    • D'Andrea, A.D., and Grompe, M. 2003. The Fanconi anaemia/BRCA pathway. Nat. Rev. Cancer. 3:23-34.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 23-34
    • D'Andrea, A.D.1    Grompe, M.2
  • 40
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan, P.R., et al. 2006. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 441:231-234.
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1
  • 41
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • DOI 10.1016/j.immuni.2006.01.001, PII S1074761306000045
    • Veldhoen, M., Hocking, R.J., Atkins, C.J., Locksley, R.M., and Stockinger, B. 2006. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 24:179-189. (Pubitemid 43214587)
    • (2006) Immunity , vol.24 , Issue.2 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 42
    • 2442548490 scopus 로고    scopus 로고
    • Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder
    • DOI 10.1038/sj.emboj.7600183
    • Li, A.G., Wang, D., Feng, X.H., and Wang, X.J. 2004. Latent TGFbeta1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J. 23:1770-1781. (Pubitemid 38649640)
    • (2004) EMBO Journal , vol.23 , Issue.8 , pp. 1770-1781
    • Li, A.G.1    Wang, D.2    Feng, X.-H.3    Wang, X.-J.4
  • 43
    • 3042778716 scopus 로고    scopus 로고
    • Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation
    • Lu, S.L., et al. 2004. Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation. Cancer Res. 64:4405-4410.
    • (2004) Cancer Res. , vol.64 , pp. 4405-4410
    • Lu, S.L.1
  • 44
    • 7444272649 scopus 로고    scopus 로고
    • Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis
    • DOI 10.1158/0008-5472.CAN-04-1331
    • Li, A.G., Lu, S.L., Zhang, M.X., Deng, C., and Wang, X.J. 2004. Smad3 knockout mice exhibit a resistance to skin chemical carcinogenesis. Cancer Res. 64:7836-7845. (Pubitemid 39446916)
    • (2004) Cancer Research , vol.64 , Issue.21 , pp. 7836-7845
    • Li, A.G.1    Lu, S.-L.2    Zhang, M.-X.3    Deng, C.4    Wang, X.-J.5
  • 45
    • 34250658382 scopus 로고    scopus 로고
    • Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma
    • DOI 10.1159/000101542
    • Wreesmann, V.B., Estilo, C., Eisele, D.W., Singh, B., and Wang, S.J. 2007. Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. ORL J. Otorhinolaryngol. Relat. Spec. 69:218-225. (Pubitemid 46934196)
    • (2007) ORL , vol.69 , Issue.4 , pp. 218-225
    • Wreesmann, V.B.1    Estilo, C.2    Eisele, D.W.3    Singh, B.4    Wang, S.J.5
  • 46
    • 1342301467 scopus 로고    scopus 로고
    • Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: Implications for treatment and survival
    • Marsit, C.J., et al. 2004. Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene. 23:1000-1004.
    • (2004) Oncogene , vol.23 , pp. 1000-1004
    • Marsit, C.J.1
  • 48
    • 0036500132 scopus 로고    scopus 로고
    • Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair
    • DOI 10.1093/emboj/21.5.1219
    • Kanamoto, T., Hellman, U., Heldin, C.H., and Souchelnytskyi, S. 2002. Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair. EMBO J. 21:1219-1230. (Pubitemid 34206195)
    • (2002) EMBO Journal , vol.21 , Issue.5 , pp. 1219-1230
    • Kanamoto, T.1    Hellman, U.2    Heldin, C.-H.3    Souchelnytskyi, S.4
  • 51
    • 33745578957 scopus 로고    scopus 로고
    • Smad4 signalling in T cells is required for suppression of gastrointestinal cancer
    • Kim, B.G., et al. 2006. Smad4 signalling in T cells is required for suppression of gastrointestinal cancer. Nature. 441:1015-1019.
    • (2006) Nature , vol.441 , pp. 1015-1019
    • Kim, B.G.1
  • 53
    • 40949083607 scopus 로고    scopus 로고
    • Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype
    • Bharathy, S., Xie, W., Yingling, J.M., and Reiss, M. 2008. Cancer-associated transforming growth factor beta type II receptor gene mutant causes activation of bone morphogenic protein-Smads and invasive phenotype. Cancer Res. 68:1656-1666.
    • (2008) Cancer Res. , vol.68 , pp. 1656-1666
    • Bharathy, S.1    Xie, W.2    Yingling, J.M.3    Reiss, M.4
  • 54
    • 58749089988 scopus 로고    scopus 로고
    • TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch
    • Liu, I.M., et al. 2009. TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch. EMBO J. 28:88-98.
    • (2009) EMBO J. , vol.28 , pp. 88-98
    • Liu, I.M.1
  • 55
    • 34547857048 scopus 로고    scopus 로고
    • Distinct roles of individual Smads in skin carcinogenesis
    • DOI 10.1002/mc.20336
    • Bornstein, S., Hoot, K., Han, G.W., Lu, S.L., and Wang, X.J. 2007. Distinct roles of individual Smads in skin carcinogenesis. Mol. Carcinog. 46:660-664. (Pubitemid 47255184)
    • (2007) Molecular Carcinogenesis , vol.46 , Issue.8 , pp. 660-664
    • Bornstein, S.1    Hoot, K.2    Han, G.-W.3    Lu, S.-L.4    Wang, X.-J.5
  • 56
    • 0035125764 scopus 로고    scopus 로고
    • A distinct expression of CC chemokines by macrophages in nasopharyngeal carcinoma: Implication for the intense tumor infiltration by T lymphocytes and macrophages
    • Tang, K.F., et al. 2001. A distinct expression of CC chemokines by macrophages in nasopharyngeal carcinoma: implication for the intense tumor infiltration by T lymphocytes and macrophages. Hum. Pathol. 32:42-49.
    • (2001) Hum. Pathol. , vol.32 , pp. 42-49
    • Tang, K.F.1
  • 57
    • 34548262577 scopus 로고    scopus 로고
    • Clinical significance of MMP-2 and MMP-9 in patients with oral cancer
    • DOI 10.1002/hed.20561
    • Patel, B.P., Shah, S.V., Shukla, S.N., Shah, P.M., and Patel, P.S. 2007. Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head Neck. 29:564-572. (Pubitemid 47324773)
    • (2007) Head and Neck , vol.29 , Issue.6 , pp. 564-572
    • Patel, B.P.1    Shah, S.V.2    Shukla, S.N.3    Shah, P.M.4    Patel, P.S.5
  • 58
    • 47849098044 scopus 로고    scopus 로고
    • Inflammation: Gearing the journey to cancer
    • Kundu, J.K., and Surh, Y.J. 2008. Inflammation: gearing the journey to cancer. Mutat. Res. 659:15-30.
    • (2008) Mutat. Res. , vol.659 , pp. 15-30
    • Kundu, J.K.1    Surh, Y.J.2
  • 60
    • 33947380240 scopus 로고    scopus 로고
    • Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology
    • DOI 10.1158/1078-0432.CCR-06-2260
    • Ratnam, K., and Low, J.A. 2007. Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. Clin. Cancer Res. 13:1383-1388. (Pubitemid 46450426)
    • (2007) Clinical Cancer Research , vol.13 , Issue.5 , pp. 1383-1388
    • Ratnam, K.1    Low, J.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.