SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

Molecular Pharmacology

Volumn 62, Issue 1, 2002, Pages 65-74

  Inman, Gareth J ^a,b,c,d   Nicolás, Francisco J ^a,b,c,d   Callahan, James F ^a,b,c,d   Harling, John D ^a,b,c,d   Gaster, Laramie M ^a,b,c,d   Reith, Alastair D ^a,b,c,d   Laping, Nicholas J ^a,b,c,d   Hill, Caroline S ^a,b,c,d  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c GLAXOSMITHKLINE   (United Kingdom)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ACTIVIN RECEPTOR; ACTIVIN RECEPTOR LIKE KINASE; BONE MORPHOGENETIC PROTEIN; PHOSPHOTRANSFERASE; PROTEIN ALK4; PROTEIN ALK7; RECEPTOR BLOCKING AGENT; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL SURVIVAL; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; EMBRYO; GROWTH REGULATION; MOUSE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BLOCKING; SIGNAL TRANSDUCTION;

3T3 CELLS; ACTIVATING TRANSCRIPTION FACTOR 2; ACTIVIN RECEPTORS, TYPE I; ACTIVINS; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA-BINDING PROTEINS; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; OSMOTIC PRESSURE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEINS; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0036085920     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.1.65     Document Type: Article

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