Pretranscriptional regulation of Tgf-Β1 by PI polyamide prevents scarring and accelerates wound healing of the cornea after exposure to alkali

Molecular Therapy

Volumn 18, Issue 3, 2010, Pages 519-527

  Chen, Min ^a   Matsuda, Hiroyuki ^a,b,c   Wang, Linghua ^b,e   Watanabe, Takayoshi ^b   Kimura, Makoto T ^b,d   Igarashi, Jun ^a   Wang, Xiaofei ^a   Sakimoto, Tohru ^b   Fukuda, Noboru ^a   Sawa, Mitsuru ^b   Nagase, Hiroki ^a,b,d  

^a NIHON UNIVERSITY   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^d ROSWELL PARK CANCER INSTITUTE   (United States)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE EARTH METAL; DNA; GB 1201; IMIDAZOLE DERIVATIVE; MESSENGER RNA; POLYAMIDE; PYRROLE DERIVATIVE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BURN SCAR; CELL STRAIN HEK293; CONTROLLED STUDY; CORNEA BURN; DNA BINDING; DNA SEQUENCE; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; MALE; NONHUMAN; PROMOTER REGION; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; UPREGULATION; WOUND HEALING;

ANIMALS; BINDING SITES; CICATRIX; CORNEA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; NYLONS; PROMOTER REGIONS, GENETIC; PYRROLES; RATS; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1; WOUND HEALING;

RATTUS;

EID: 77649269818     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2009.263     Document Type: Article

References (31)

1. Peate, WF (2007). Work-related eye injuries and illnesses. Am Fam Physician 75: 1017-1022.
2. McGwin, G Jr, Xie, A and Owsley, C (2005). Rate of eye injury in the United States. Arch Ophthalmol 123: 970-976.
3. Wagoner, MD (1997). Chemical injuries of the eye: current concepts in pathophysiology and therapy. Surv Ophthalmol 41: 275-313.
4. Saika, S (2004). TGF-beta signal transduction in corneal wound healing as a therapeutic target. Cornea 23 (8 suppl.): S25-S30.
5. Saika, S, Ikeda, K, Yamanaka, O, Miyamoto, T, Ohnishi, Y, Sato, M et al. (2005). Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol 166: 1405-1418.
6. Zieske, JD, Hutcheon, AE, Guo, X, Chung, EH and Joyce, NC (2001). TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair. Invest Ophthalmol Vis Sci 42: 1465-1471.
7. Jester, JV, Moller-Pedersen, T, Huang, J, Sax, CM, Kays, WT, Cavangh, HD et al. (1999). The cellular basis of corneal transparency: evidence for 'corneal crystallins'. J Cell Sci 112 (Pt 5): 613-622.
8. Takahashi, H, Igarashi, T, Fujimoto, C, Ozaki, N and Ishizaki, M (2007). Immunohistochemical observation of amniotic membrane patching on a corneal alkali burn in vivo. Jpn J Ophthalmol 51: 3-9.
9. Dervan, PB, Doss, RM and Marques, MA (2005). Programmable DNA binding oligomers for control of transcription. Curr Med Chem Anticancer Agents 5: 373-387.
10. Matsuda, H, Fukuda, N, Ueno, T, Tahira, Y, Ayame, H, Zhang, W et al. (2006). Development of gene silencing pyrrole-imidazole polyamide targeting the TGF-beta1 promoter for treatment of progressive renal diseases. J Am Soc Nephrol 17: 422-432.
11. Yao, EH, Fukuda, N, Ueno, T, Matsuda, H, Nagase, H, Matsumoto, Y et al. (2009). A pyrrole-imidazole polyamide targeting transforming growth factor-beta1 inhibits restenosis and preserves endothelialization in the injured artery. Cardiovasc Res 81: 797-804.
12. Sakimoto, T, Shoji, J and Sawa, M (2003). Active form of gelatinases in tear fuid in patients with corneal ulcer or ocular burn. Jpn J Ophthalmol 47: 423-426.
13. Di Girolamo, N, McCluskey, P, Lloyd, A, Coroneo, MT and Wakefeld, D (2000). Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells. Invest Ophthalmol Vis Sci 41: 671-679.
14. Fini, ME, Cook, JR and Mohan, R (1998). Proteolytic mechanisms in corneal ulceration and repair. Arch Dermatol Res 290 (suppl.): S12-S23.
15. Matsubara, M, Girard, MT, Kublin, CL, Cintron, C and Fini, ME (1991). Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea. Dev Biol 147: 425-439.
16. Liu, B and Kodadek, T (2009). Investigation of the relative cellular permeability of DNA-binding pyrrole-imidazole polyamides. J Med Chem 52: 4604-4612.
17. Best, TP, Edelson, BS, Nickols, NG and Dervan, PB (2003). Nuclear localization of pyrrole-imidazole polyamide-fuorescein conjugates in cell culture. Proc Natl Acad Sci USA 100: 12063-12068.
18. Trauger, JW, Baird, EE and Dervan, PB (1996). Recognition of DNA by designed ligands at subnanomolar concentrations. Nature 382: 559-561.
19. Sugiyama, H, Lian, C, Isomura, M, Saito, I and Wang, AH (1996). Distamycin A modulates the sequence specifcity of DNA alkylation by duocarmycin A. Proc Natl Acad Sci USA 93: 14405-14410.
20. Arcamone, F, Penco, S, Orezzi, P, Nicolella, V and Pirelli, A (1964). Structure and synthesis of distamycin A. Nature 203: 1064-1065.
21. White, S, Baird, EE and Dervan, PB (1997). On the pairing rules for recognition in the minor groove of DNA by pyrrole-imidazole polyamides. Chem Biol 4: 569-578. (Pubitemid 27398760)
22. Pertovaara, L, Sistonen, L, Bos, TJ, Vogt, PK, Keski-Oja, J and Alitalo, K (1989). Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation. Mol Cell Biol 9: 1255-1262.
23. Kim, SJ, Denhez, F, Kim, KY, Holt, JT, Sporn, MB and Roberts, AB (1989). Activation of the second promoter of the transforming growth factor-beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences. J Biol Chem 264: 19373-19378.
24. Turner, JM, Swalley, SE, Baird, EE and Dervan, PB (1998). Aliphatic/aromatic amino acid pairings for polyamide recognition in the minor groove of DNA. J Am Chem Soc 120: 6219-6226.
25. Schultz, GS, Strelow, S, Stern, GA, Chegini, N, Grant, MB, Galardy, RE et al. (1992). Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci 33: 3325-3331.
26. Kato, T, Saika, S and Ohnishi, Y (2006). Effects of the matrix metalloproteinase inhibitor GM6001 on the destruction and alteration of epithelial basement membrane during the healing of post-alkali burn in rabbit cornea. Jpn J Ophthalmol 50: 90-95.
27. Paterson, CA, Wells, JG, Koklitis, PA, Higgs, GA and Docherty, AJ (1994). Recombinant tissue inhibitor of metalloproteinases type 1 suppresses alkali-burn-induced corneal ulceration in rabbits. Invest Ophthalmol Vis Sci 35: 677-684.
28. Yang, Y, Mumy, M, Romeo, D and Wakefeld, LM (1998). Identifcation of the start sites for the 1.9-and 1.4-kb rat transforming growth factor-beta1 transcripts and their effect on translational effciency. Gene 219: 81-89.
29. Bando, T, Narita, A, Saito, I and Sugiyama, H (2002). Molecular design of a pyrrole-imidazole hairpin polyamides for effective DNA alkylation. Chemistry 8: 4781-4790.
30. Murty, MS and Sugiyama, H (2004). Biology of N-methylpyrrole-N- methylimidazole hairpin polyamide. Biol Pharm Bull 27: 468-474.
31. Fantes, FE, Hanna, KD, Waring, GO 3rd, Pouliquen, Y, Thompson, KP and Savoldelli, M (1990). Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys. Arch Ophthalmol 108: 665-675.