Gene transfer of soluble transforming growth factor type II receptor by in vivo electroporation attenuates lung injury and fibrosis

Journal of Clinical Pathology

Volumn 60, Issue 8, 2007, Pages 916-920

  Yamada, Mizuho ^a   Kuwano, Kazuyoshi ^a   Maeyama, Takashige ^a   Yoshimi, Michihiro ^a   Hamada, Naoki ^a   Fukumoto, Jutaro ^a   Egashira, Kensuke ^a   Hiasa, Kenichi ^a   Takayama, Koichi ^a   Nakanishi, Yoichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; IMMUNOGLOBULIN G; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; VIRUS VECTOR;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ELECTROPORATION; GENE TRANSFER; GENETIC TRANSFECTION; LUNG FIBROSIS; LUNG INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SKELETAL MUSCLE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLEOMYCIN; DISEASE MODELS, ANIMAL; ELECTROPORATION; GENE THERAPY; IN SITU NICK-END LABELING; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; MUSCLE, SKELETAL; PULMONARY FIBROSIS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SOLUBILITY; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 34547755121     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2006.039396     Document Type: Article

References (22)

1. American Thoracic Society and European Respiratory Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. Am J Respir Crit Care Med 2000;161:646-64.
2. Khalil N, O'Connor RN, Unruh HW, et al. Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 1991;5:155-62.
3. Sime PJ, Xing Z, Graham FL, et al. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 1997;100:768-76.
4. Khalil N, Bereznay O, Sporn M, et al. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J Exp Med 1989;170:727-37.
5. Pittet JF, Griffiths MJ, Geiser T, et al. TGF-beta is a critical mediator of acute lung injury. J Clin Invest 2001;107:1537-44.
6. Hagimoto N, Kuwano K, Inoshima I, et al. TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells. J Immunol 2002;168:6470-8.
7. Inoshima I, Kuwano K, Hamada N, et al. Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol, 2004;286:L1038-44.
8. Lawson BR, Prud'homme GJ, Chang Y, et al. Treatment of murine lupus with cDNA encoding IFN-γR/Fc. J Clin Invest 2000;106:207-15.
9. Wang Q, Wang Y, Hyde DM, et al. Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters. Thorax 1999;54:805-12.
10. Maeyama T, Kuwano K, Kawasaki M, et al. Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12. Am J Physiol Lung Cell Mol Physiol 2001;280:L1128-37.
11. Tsuburai T, Suzuki M, Nagashima Y, et al. Adenovirus-mediated transfer and overexpression of heme oxygen 1 cDNA in lung prevents bleomycin-induced pulmonary fibrosis via a Fas-Fas ligand-independent pathway. Hum Gene Ther 2002;13:1945-60.
12. Smith RE, Strieter RM, Zhang K, et al. A role for C-C chemokines in fibrotic lung disease. J Leukoc Biol 1995;57:782-7.
13. Chandler DB, Hyde DM, Giri SN. Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters. Am J Pathol 1983;112:170-7.
14. Wrana JL, Attisano L, Wieser R, et al. Mechanism of activation of the TGF-beta receptor. Nature 1994;370:341-7.
15. Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-71.
16. Kulkarni AB, Huh CG, Becker D, et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 1993;90:770-4.
17. Selman M, Pardo A. The epithelial/fibroblastic pathway in the pathogenesis of idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol 2003;29:593-7.
18. Bonniaud P, Margetts PJ, Ask K, et al. TGF-beta and Smad3 signaling link inflammation to chronic fibrogenesis. J Immunol 2005;175:5390-5.
19. Kuwano K, Kawasaki M, Maeyama T, Soluble form of fas and fas ligand in BAL fluid from patients with pulmonary fibrosis and bronchiolitis obliterans organizing pneumonia, et al. Chest 2000;118:451-8.
20. Spurzem JR, Sacco O, Rickard KA, et al. Transforming growth factor-beta increases adhesion but not migration of bovine bronchial epithelial cells to matrix proteins. J Lab Clin Med 1993;122:92-102.
21. Neurohr C, Nishimura SL, Sheppard D. Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am J Respir Cell Mol Biol 2006;35:252-9.
22. Khalil N, Whitman C, Zuo L, et al. Regulation of alveolar macrophage transforming growth factor-beta secretion by corticosteroids in bleomycin-induced pulmonary inflammation in the rat. J Clin Invest 1993;92:1812-18.