Hypoxia-inducible factor prolyl hydroxylase inhibition: Robust new target or another big bust for stroke therapeutics

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 7, 2012, Pages 1347-1361

  Karuppagounder, Saravanan S ^a,b   Ratan, Rajiv R ^a,b  

^a BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Gene expression; hypoxia; hypoxia inducible factor proly hydroxylase domain inhibitors; iron; neuroprotection; stroke

Indexed keywords

2 OXOGLUTARIC ACID; 2,2' BIPYRIDINE; DEFERASIROX; DEFEROXAMINE; ENZYME INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITOR; IRON CHELATE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROTOCATECHUIC ACID; UNCLASSIFIED DRUG;

ADAPTATION; BRAIN ISCHEMIA; CONTINUOUS INFUSION; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYPOXIA; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; STROKE; TREATMENT OUTCOME;

ANIMALS; CELL HYPOXIA; ENZYME INHIBITORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; NEUROPROTECTIVE AGENTS; PROCOLLAGEN-PROLINE DIOXYGENASE; STROKE;

EID: 84863483418     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.28     Document Type: Review

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