The role of hypoxia-inducible transcription factors in the hypoxic neonatal brain

Brain and Development

Volumn 31, Issue 7, 2009, Pages 503-509

  Trollmann, Regina ^a   Gassmann, Max ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Developing brain; Hypoxic ischemic encephalopathy; Mouse placenta; Neuroprotection; VEGF

Indexed keywords

ERYTHROPOIETIN; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; RECOMBINANT ERYTHROPOIETIN; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

ANEMIA; APOPTOSIS; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN MATURATION; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; DRUG MEGADOSE; HUMAN; LOW DRUG DOSE; NEUROPROTECTION; NEWBORN HYPOXIA; NONHUMAN; OXIDATIVE STRESS; PROGNOSIS; REVIEW;

ANIMALS; ANIMALS, NEWBORN; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL MARKERS; BRAIN; HUMANS; HYPOXIA, BRAIN; HYPOXIA-INDUCIBLE FACTOR 1; INFANT, NEWBORN; NEUROPROTECTIVE AGENTS;

EID: 67649427346     PISSN: 03877604     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.braindev.2009.03.007     Document Type: Review

References (39)

1. Terzidou V., and Bennet P. Maternal risk factors for fetal and neonatal brain damage. Biol Neonate 79 (2001) 157-162
2. Rutherford M., Srinivasan L., Dyet L., Ward P., Allsop J., Counsell S., et al. Magnetic resonance imaging in perinatal brain injury: clinical presentation, lesions and outcome. Pediatr Radiol 36 (2006) 582-592
3. Jensen F.E. Developmental factors regulating susceptibility to perinatal brain injury and seizures. Curr Opin Pediatr 18 (2001) 628-633
4. Northington F.J., Ferriero D.M., Flock D.L., and Marin L.J. Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis. J Neurosci 21 (2001) 1931-1938
5. Fandrey J., Gorr T.A., and Gassmann M. Regulating cellular oxygen sensing by hydroxylation. Cardiovasc Res 71 (2006) 642-651
6. D'Angelo G., Duplan E., Boyer N., Vigne P., and Frelin C. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation. J Biol Chem 278 (2003) 38183-38187
7. Wang G.L., Jiang B.H., Rue E.A., and Semenza G.L. Hypoxia-inducible factor 1 is a basic helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92 (1995) 5510-5514
8. 2 homeostasis by hypoxia inducible factor 1α. Genes Dev 12 (1998) 149-162
9. Chavez J.C., Baranova O., Lin J., and Pichiule P. The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J Neurosci 26 (2006) 9471-9481
10. Stroka D.M., Burkhardt T., Desbaillets I., Wenger R.H., Neil D.A.H., Bauer C., et al. HIF-1 is expressed in normoxic tissues and displays an organ-specific regulation under systemic hypoxia. FASEB J 15 (2001) 2445-2453
11. Wiesener M.S., Jurgensen J.S., Rosenberger C., Scholze C.K., Horstrup J.H., Warnecke C., et al. Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J 17 (2003) 271-273
12. Mense S.M., Sengupta A., Zhou M., Lan C., Bentsman G., Volsky D.J., et al. Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes. Physiol Genomics 25 (2006) 435-449
13. Bani Hashemi S., Braun J., Bernhardt W.M., Rascher W., Dötsch J., and Trollmann R. HIF-1alpha subunit and vasoactive HIF-1-dependent genes are involved in carbon monoxide-induced cerebral hypoxic stress response. Eur J Appl Physiol 104 (2008) 95-102
14. Lee Y.M., Jeong C.H., Koo S.Y., Son M.J., Song H.S., Bae S.K., et al. Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development. Dev Dyn 220 (2001) 175-186
15. Yu X., Shacka J.J., Eells J.B., Suarez-Quian C., Przygodzki R.M., Beleslin-Cokic B., et al. Erythropoietin receptor signaling is required for normal brain development. Development 129 (2002) 505-516
16. Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola OO, et al. Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Am J Physiol Regul Integr Comp Physiol 2008 [epub ahead of print].
17. Trollmann R., Schneider J., Keller S., Strasser K., Wenzel D., Rascher W., et al. HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam. Brain Res 1199 (2008) 27-36
18. Knabe W., Knerlich F., Washausen S., Kietzmann T., Siren A.L., Brunnett G., et al. Expression patterns of erythropoietin and its receptor in the developing midbrain. Anat Embryol 207 (2004) 503-512
19. Bergeron M., Gidday J.M., Yu A.Y., Semenza G.L., Ferriero D.M., and Sharp F.R. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 48 (2000) 285-296
20. Bernaudin M., Tang Y., Reilly M., Petit E., and Sharp F.R. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. J Biol Chem 277 (2002) 39728-39738
21. Van den Tweel E.R., Kavelaars A., Lombardi M.S., Nijboer C.H., Groenendaal F., van Bel F., et al. Bilateral molecular changes in a neonatal rat model of unilateral hypoxic-ischemic brain damage. Pediatr Res 59 (2006) 434-439
22. Dobbing J., and Sands J. Comparative aspects of the brain growth spurt. Early Hum Dev 3 (1979) 79-83
23. Bergeron M., Yu A.Y., Solway K.E., Semenza G.L., and Sharp F.R. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci 11 (1999) 4159-4170
24. Sun Y., Jin K., Xie L., Childs J., Mao X.O., Logvinova A., et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 111 (2003) 1843-1851
25. Ogunshola O.O., Antic A., Donoghue M.J., Fan S.Y., Kim H., Stewart W.B., et al. Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system. J Biol Chem 277 (2002) 11410-11415
26. Chow J., Ogunshola O., Fan S.Y., Li Y., Ment L.R., and Madri J.A. Astrocyte-derived VEGF mediates survival and tube stabilization of hypoxic brain microvascular endothelial cells in vitro. Brain Res Dev Brain Res 130 (2001) 123-132
27. Thorngren-Jerneck K., Alling C., Herbst A., Amer-Wahlin I., and Marsal K. S100 protein in serum as a prognostic marker for cerebral injury in term newborn infants with hypoxic ischemic encephalopathy. Pediatr Res 55 (2004) 406-412
28. Gazzolo D., Marinoni E., Giovannini L., Letizia C., Serra G., and Di Iorio R. Circulating adrenomedullin is increased in newborns developing intraventricular hemorrhage. Pediatr Res 50 (2001) 544-547
29. Di Iorio R., Marinoni E., Lituania M., Serra G., Letizia C., Cosmi E.V., et al. Adrenomedullin increases in term asphyxiated newborns developing intraventricular hemorrhage. Clin Biochem 37 (2004) 1112-1116
30. Trollmann R., Amann K., Schoof E., Beinder E., Wenzel D., Rascher W., et al. Hypoxia activates human placental VEGF system in vitro and in vivo: up-regulation of placental VEGF system in clinically relevant hypoxic ischemia in birth asphyxia. Am J Obstet Gynecol 188 (2003) 517-523
31. Marchini G., Hagenäs L., Kocoska-Maras L., Berggren V., and Hansson L.O. Insulin-like growth factor binding protein-1 and interleukin-6 are markers of fetal stress during parturition at term gestation. J Pediatr Endocrinol Metab 18 (2005) 777-783
32. Trollmann R., Klingmüller K., Schild R.L., Rascher W., and Dötsch J. Differential gene expression of somatotrophic and growth factors in response to in vivo hypoxia in human placenta. Am J Obstet Gynecol 197 601 (2007) e1-e6
33. Grimm C., Wenzel A., Acar N., Keller S., Seeliger M., and Gassmann M. Hypoxic preconditioning and erythropoietin protect retinal neurons from degeneration. Adv Exp Med Biol 588 (2006) 119-131
34. Sun Y., Calvert J.W., and Zhang J.H. Neonatal hypoxia/ischemia is associated with decreased inflammatory mediators after erythropoietin administration. Stroke 36 (2005) 1672-1678
35. Viviani B., Bartesaghi S., Corsini E., Villa P., Ghezzi P., Garau A., et al. Erythropoietin protects primary hippocampal neurons increasing the expression of brain-derived neurotrophic factor. J Neurochem 93 (2005) 412-421
36. Noguchi C.T., Asavaritikrai P., Teng R., and Jia Y. Role of erythropoietin in the brain. Crit Rev Oncol Hematol 64 (2007) 159-171
37. Bierer R., Peceny M.C., Hartenberger H.C., and Ohls R.K. Erythropoietin concentrations and neurodevelopmental outcome in preterm infants. Pediatrics 118 (2006) e635-e640
38. Fauchère J.C., Dame C., Vonthein R., Koller B., Arri S., Wolf M., et al. An approach to using recombinant erythropoietin for neuroprotection in very preterm infants. Pediatrics 122 (2008) 375-382
39. Siddiq A., Ayoub I.A., Chavez J.C., Aminova L., Shah S., LaManna J.C., et al. Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J Biol Chem 280 (2005) 41732-41743