Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin

Journal of Neuroscience

Volumn 19, Issue 22, 1999, Pages 9821-9830

  Zaman, Khalequz ^a   Ryu, Hoon ^a   Hall, David ^a   O'Donovan, Kevin ^c   Lin, Kuo I ^a   Miller, Matthew P ^a   Marquis, John C ^b   Baraban, Jay M ^c   Semenza, Gregg L ^c   Ratan, Rajiv R ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Apoptosis; ATF 1 CREB; Glutathione; HIF 1; Iron chelators; Oxidative stress

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ERYTHROPOIETIN; GLYCOLYTIC ENZYME; HYPOXIA INDUCIBLE FACTOR 1; IRON CHELATING AGENT; PROTEIN P21;

ANIMAL CELL; APOPTOSIS; ARTICLE; DNA BINDING; GENE EXPRESSION SYSTEM; NERVE CELL CULTURE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

EID: 0033571939     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-22-09821.1999     Document Type: Article

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