Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 26, 2006, Pages 9814-9819

  McDonough, Michael A ^a   Li, Vivian ^c   Flashman, Emily ^a   Chowdhury, Rasheduzzaman ^a   Mohr, Christopher ^c   Liénard, Benoît M R ^a   Zondlo, James ^c   Oldham, Neil J ^a   Clifton, Ian J ^a   Lewis, Jeffrey ^c   McNeill, Luke A ^b   Kurzeja, Robert J M ^c   Hewitson, Kirsty S ^a,b   Yang, Evelyn ^c   Jordan, Steven ^c   Syed, Rashid S ^c   Schofield, Christopher J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ReOx Ltd   (United Kingdom)

^c AMGEN INC   (United States)

Author keywords

2 oxoglutarate; Dioxygenase; Erythropoietin; Hypoxic response

Indexed keywords

2 OXOGLUTARIC ACID; [[(4 HYDROXY 8 IODOISOQUINOLIN 3 YL)CARBONYL]AMINO]ACETIC ACID; ENZYME INHIBITOR; ERYTHROPOIETIN; FERROUS ION; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOQUINOLINE DERIVATIVE; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE DERIVATIVE; PROTEASOME; UNCLASSIFIED DRUG;

ALPHA HELIX; ANEMIA; ARTICLE; BETA SHEET; CELL HYPOXIA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DICTYOSTELIUM; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME STRUCTURE; ERYTHROCYTOSIS; ESCHERICHIA COLI; HYDROXYLATION; ISCHEMIA; NONHUMAN; OXYGEN SENSING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PSEUDOMONAS AERUGINOSA; TRANSCRIPTION REGULATION; VIBRIO CHOLERAE;

BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HIPPEL-LINDAU DISEASE; HUMANS; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN CONFORMATION;

METAZOA;

EID: 33745614894     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601283103     Document Type: Article

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