Oxygen-regulated β2-Adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

Science Signaling

Volumn 2, Issue 78, 2009, Pages

  Xie, Liang ^a   Xiao, Kunhong ^a   Whalen, Erin J ^a   Forrester, Michael T ^a   Freeman, Robert S ^b   Fong, Guohua ^c   Gygi, Steven P ^d   Lefkowitz, Robert J ^a,e   Stamler, Jonathan S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HYPOXIA INDUCIBLE FACTOR; PROLINE DERIVATIVE; RADIOLIGAND; UBIQUITIN PROTEIN LIGASE E3; VON HIPPEL LINDAU PROTEIN; DIOXYGENASE; EGLN3 PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLINE;

ANIMAL TISSUE; ARTICLE; BETA CHAIN; CELL STRAIN HEK293; CONFOCAL MICROSCOPY; GENETIC TRANSFECTION; HOMEOSTASIS; HYDROXYLATION; IMMUNOFLUORESCENCE; LIGAND BINDING; LIQUID CHROMATOGRAPHY; LYSOSOME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; TANDEM MASS SPECTROMETRY; UBIQUITINATION; CELL LINE; DOWN REGULATION; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN BINDING;

CELL LINE; DIOXYGENASES; DOWN-REGULATION; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; OXYGEN; PROCOLLAGEN-PROLINE DIOXYGENASE; PROLINE; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-2; UBIQUITINATION; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 70249122059     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000444     Document Type: Article

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45. This work was supported by P01-HL075443, U19-ES012496, RO1-NS034400 and an RJL Award for Scientific Innovation. We thank D. T. Hess for discussion, advice, and assistance with the manuscript and L. A. Desouza for technical help. The authors have no conflicting financial interests.