Regulation of cytosolic and mitochondrial oxidation via malate-aspartate shuttle: An observation using dynamic 13C NMR spectroscopy

Advances in Experimental Medicine and Biology

Volumn 701, Issue , 2011, Pages 185-192

  Lu, Ming ^a,c   Banerjee, Suhanti ^a   Saidel, Gerald M ^a,c   Yu, Xin ^a,b,c  

^a Case Western Reserve University   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; FATTY ACID; GLUCOSE; GLUTAMIC ACID; LACTIC ACID; MALIC ACID; PALMITIC ACID; TRICARBOXYLIC ACID;

ANIMAL TISSUE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL COMPARTMENTALIZATION; CONFERENCE PAPER; CONTROLLED STUDY; FATTY ACID METABOLISM; HEART MUSCLE METABOLISM; HEART MUSCLE OXYGEN CONSUMPTION; HEART MUSCLE PERFUSION; HEART RATE; HEART VOLUME; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY ANALYSIS; UPREGULATION;

EID: 84934441350     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-7756-4_25     Document Type: Conference Paper

References (6)

1. LaNoue, K. F. and Williamson, J. R. (1971) Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria, Metabolism 20, 119-140.
2. Malloy, C. R., Sherry, A. D., and Jeffrey, F. M. (1988) Evaluation of carbon flux and substrate selection through alternate pathways involving the citric acid cycle of the heart by 13C NMR spectroscopy, J Biol Chem. 263, 6964-6971.
3. Chance, E. M., Seeholzer, S. H., Kobayashi, K., and Williamson, J. R. (1983) Mathematical analysis of isotope labeling in the citric acid cycle with applications to 13C NMR studies in perfused rat hearts, J Biol Chem. 258, 13785-13794. (Pubitemid 14212024)
4. Yu,X.,White, L. T.,Doumen,C.,Damico, L.A., LaNoue,K. F.,Alpert,N.M., andLewandowski, E. D. (1995) Kinetic analysis of dynamic 13C NMR spectra: Metabolic flux, regulation, and compartmentation in hearts, Biophys. J. 69, 2090-2102.
5. Lu, M., Zhou, L., Stanley, W. C., Cabrera, M. E., Saidel, G. M., and Yu, X. (2008) Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia, J Theor. Biol 254, 466-475.
6. Shulman, R. G., Rothman, D. L., Behar, K. L., and Hyder, F. (2004) Energetic basis of brain activity: Implications for neuroimaging, Trends Neurosci. 27, 489-495. (Pubitemid 38951042)