Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways

Journal of Neuroscience

Volumn 29, Issue 27, 2009, Pages 8828-8838

  Siddiq, Ambreena ^a,b   Aminova, Leila R ^c   Troy, Carol M ^d   Suh, Kyungsun ^a,b   Messer, Zachary ^a   Semenza, Gregg L ^e   Ratan, Rajiv R ^a,b  

^a BURKE MEDICAL RESEARCH INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d College of Physicians and Surgeons ^*  (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEFEROXAMINE; DIMETHYLOXALYLGLYCINE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON CHELATING AGENT; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL 4 HYDROXYLASE ISOFORM 1; PROLYL 4 HYDROXYLASE ISOFORM 2; PROLYL 4 HYDROXYLASE ISOFORM 3; PROTOCATECHUIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME INHIBITION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; IRON CHELATION; NERVE CELL; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE;

AMINO ACID SEQUENCE; ANIMALS; CELL DEATH; CELL LINE, TRANSFORMED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIOXYGENASES; HYPOXIA-INDUCIBLE FACTOR 1; IRON CHELATING AGENTS; MICE; MOLECULAR SEQUENCE DATA; NEURONS; NUCLEAR PROTEINS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 67650481882     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1779-09.2009     Document Type: Article

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