Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Nature Genetics

Volumn 40, Issue 2, 2008, Pages 170-180

  Aragonés, Julián ^a,b   Schneider, Martin ^a,b,m   Van Geyte, Katie ^a,b   Fraisl, Peter ^a,b   Dresselaers, Tom ^a   Mazzone, Massimiliano ^a,b   Dirkx, Ruud ^a   Zacchigna, Serena ^a,b   Lemieux, Hélène ^c   Jeoung, Nam Ho ^d   Lambrechts, Diether ^a,b   Bishop, Tammie ^e   Lafuste, Peggy ^a,b   Diez Juan, Antonio ^a,b   Harten, Sarah K ^f   Van Noten, Pieter ^a   De Bock, Katrien ^a   Willam, Carsten ^e,n   Tjwa, Marc ^a,b   Grosfeld, Alexandra ^e   Navet, Rachel ^g   Moons, Lieve ^a,b   Vandendriessche, Thierry ^a,b   Deroose, Christophe ^h   Wijeyekoon, Bhathiya ^e   Nuyts, Johan ^h   Jordan, Benedicte ⁱ   Silasi Mansat, Robert ^j   Lupu, Florea ^j   Dewerchin, Mieke ^a,b   Pugh, Chris ^e   Salmon, Phil ^k   Mortelmans, Luc ^h   Gallez, Bernard ⁱ   Gorus, Frans ^l   Buyse, Johan ^a   Sluse, Francis ^g   Harris, Robert A ^d   Gnaiger, Erich ^c   Hespel, Peter ^a   Van Hecke, Paul ^a   Schuit, Frans ^a   Van Veldhoven, Paul ^a   Ratcliffe, Peter ^e   Baes, Myriam ^a   Maxwell, Patrick ^f   Carmeliet, Peter ^a,b   more..

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d INDIANA UNIVERSITY   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF LIÈGE   (Belgium)

^h UNIVERSITY HOSPITALS LEUVEN   (Belgium)

ⁱ UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^j OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^k SkyScan Belgium   (Belgium)

^l FREE UNIVERSITY OF BRUSSELS   (Belgium)

^m UNIVERSITY OF HEIDELBERG   (Germany)

ⁿ UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROPYLHYDROXYLASE 1; PYRUVIC ACID; UNCLASSIFIED DRUG;

ADAPTATION; ANAEROBIC METABOLISM; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL METABOLIC RATE; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME MECHANISM; ERYTHROPOIESIS; GANGRENE; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HYPOXIA; ISCHEMIA; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE CELL; MUSCLE FUNCTION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SKELETAL MUSCLE; VASODILATATION; WILD TYPE;

ANIMALS; ANOXIA; BASAL METABOLISM; CARBON DIOXIDE; CARBON ISOTOPES; CARBON RADIOISOTOPES; EMBRYO, MAMMALIAN; ENERGY METABOLISM; FIBROBLASTS; GLUCOSE; GLUTAMATES; HOMOZYGOTE; IMMUNOHISTOCHEMISTRY; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; PROCOLLAGEN-PROLINE DIOXYGENASE; TOMOGRAPHY, X-RAY COMPUTED;

MUS;

EID: 38649143118     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.2007.62     Document Type: Article

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