Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators

Chemistry and Biology

Volumn 18, Issue 6, 2011, Pages 752-765

  Smirnova, Natalya A ^a   Haskew Layton, Renee E ^a   Basso, Manuela ^a   Hushpulian, Dmitry M ^b   Payappilly, Jimmy B ^a   Speer, Rachel E ^a   Ahn, Young Hoon ^c   Rakhman, Ilay ^a   Cole, Philip A ^c   Pinto, John T ^d   Ratan, Rajiv R ^a   Gazaryan, Irina G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MOSCOW STATE UNIVERSITY   (Russian Federation)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FISETIN; FLAVONOID; GEDUNIN; HYBRID PROTEIN; KEAP1 PROTEIN, HUMAN; LIMONOID; LUCIFERASE; NORDIHYDROGUAIARETIC ACID; SIGNAL PEPTIDE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ARTICLE; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG POTENTIATION; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; KINETICS; METABOLISM; OXIDATIVE STRESS; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; RNA INTERFERENCE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; UBIQUITINATION;

BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; FLAVONOIDS; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; LIMONINS; LUCIFERASES; NF-E2-RELATED FACTOR 2; NORDIHYDROGUAIARETIC ACID; OXIDATIVE STRESS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITINATION;

EID: 79959532959     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.03.013     Document Type: Article

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