2-Oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 16, 2003, Pages 2677-2680

  Mole, David R ^a   Schlemminger, Imre ^b   McNeill, Luke A ^b   Hewitson, Kirsty S ^a   Pugh, Christopher W ^a   Ratcliffe, Peter J ^a   Schofield, Christopher J ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; DRUG ANALOG; HYPOXIA INDUCIBLE FACTOR 1; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

ARTICLE; CATALYSIS; CELL FREE SYSTEM; CONTROLLED STUDY; DRUG INHIBITION; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROXYLATION; IRON CHELATION;

EID: 0038825680     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00539-0     Document Type: Article

References (29)

1. Wang G.L., Jiang B.H., Rue E.A., Semenza G.L. Proc. Natl. Acad. Sci. U.S.A. 92:1995;5510.
2. Bruick R.K., McKnight S.L. Science. 294:2001;1337.
3. Epstein A.C.R., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., Mukherji M., Metzen E., Wilson M.I., Dhanda A., Tian Y.M., Masson N., Hamilton D.L., Jaakkola P., Barstead R., Hodgkin J., Maxwell P.H., Pugh C.W., Schofield C.J., Ratcliffe P.J. Cell. 107:2001;43.
4. Masson N., Willam C., Maxwell P.H., Pugh C.W., Ratcliffe P.J. Embo J. 20:2001;5197.
5. Yu F., White S.B., Zhao Q., Lee F.S. Proc. Natl. Acad. Sci. U.S.A. 98:2001;9630.
6. Ivan M., Kondo K., Yang H.F., Kim W., Valiando J., Ohh M., Salic A., Asara J.M., Lane W.S., Kaelin W.G. Science. 292:2001;464.
7. Jaakkola P., Mole D.R., Tian Y.M., Wilson M.I., Gielbert J., Gaskell S.J., von Kriegsheim A., Hebestreit H.F., Mukherji M., Schofield C.J., Maxwell P.H., Pugh C.W., Ratcliffe P.J. Science. 292:2001;468.
8. Hon W.C., Wilson M.I., Harlos K., Claridge T.D.W., Schofield C.J., Pugh C.W., Maxwell P.H., Ratcliffe P.J., Stuart D.I., Jones E.Y. Nature. 417:2002;975.
9. Min J.H., Yang H.F., Ivan M., Gertler F., Kaelin W.G., Pavletich N.P. Science. 296:2002;1886.
10. Maxwell P.H., Pugh C.W., Ratcliffe P.J. Exp. Nephrol. 9:2001;235.
11. Cockman M.E., Masson N., Mole D.R., Jaakkola P., Chang G.W., Clifford S.C., Maher E.R., Pugh C.W., Ratcliffe P.J., Maxwell P.H. J. Biol. Chem. 275:2000;25733.
12. Lando D., Peet D.J., Whelan D.A., Gorman J.J., Whitelaw M.L. Science. 295:2002;858.
13. Lando D., Peet D.J., Gorman J.J., Whelan D.A., Whitelaw M.L., Bruick R.K. Genes Dev. 16:2002;1466.
14. Hewitson K.S., McNeill L.A., Riordan M.V., Tian Y.M., Bullock A.N., Welford R.W.D., Elkins J.M., Oldham N.J., Battacharya S., Gleadle J., Ratcliffe P.J., Pugh C.W., Schofield C.J. J. Biol. Chem. 277:2002;26351.
15. Dames S.A., Martinez-Yamout M., De Guzman R.N., Dyson H.J., Wright P.E. Proc. Natl. Acad. Sci. U.S.A. 99:2002;5271.
16. Freedman S.J., Sun Z.-Y.J., Poy F., Kung A.L., Livingston D.M., Wagner G., Eck M.J. Proc. Natl. Acad. Sci. U.S.A. 99:2002;5367.
17. Prescott A.G., Lloyd M.D. Nat. Prod. Rep. 17:2000;367.
18. Myllyharju J., Kivirikko K.I. Ann. Med. 33:2001;7.
19. Elkins J.M., Hewitson K.S., McNeill L.A., Seibel J.F., Schlemminger I., Pugh C.W., Ratcliffe P.J., Schofield C.J. J. Biol. Chem. 278:2003;1802.
20. Schlemminger I., Mole D.R., McNeill L.A., Dhanda A., Hewitson K.S., Tian Y.M., Ratcliffe P.J., Pugh C.W., Schofield C.J. Bioorg. Med. Chem. Lett. 13:2003;1451.
21. McNeill L.A., Hewitson K.S., Gleadle J., Horsfall L.E., Oldham N.J., Maxwell P., Pugh C.W., Ratcliffe P.J., Schofield C.J. Bioorg. Med. Chem. Lett. 12:2002;1547.
22. Cunliffe C.J., Franklin T.J., Hales N.J., Hill G.B. J. Med. Chem. 35:1992;2652.
23. Harris P.A. Sulphur Lett. 10:1989;117.
24. Danielli J.F., Danielli M., Fraser J.B., Mitchell P.D., Owen L.N., Shaw G. Biochem. J. 41:1947;325.
25. Battersby A.R., Cardwell K.S., Leeper F.J.J.C.S. J. Chem. Soc., Perkin Trans 1. 1986;1565.
26. Ondetti, M. A. and Cushman, D. W. U. S. Patent 4053651, 1977; Chem. Abstr. 1977 88 136977.
27. Kinder D.H., Ames M.M. J. Org. Chem. 52:1987;2452.
28. Doi J.T., Luehr G.W., Musker W.K. J. Org. Chem. 50:1985;5716.
29. Welford R.W.D., Schlemminger I., McNeill L.A., Hewitson K.S., Schofield C.J. J. Biol. Chem. 278:2003;10157.