Novel multi-modal strategies to promote brain and spinal cord injury recovery

Stroke

Volumn 40, Issue 3 SUPPL. 1, 2009, Pages

  Ratan, Rajiv R ^a,c   Noble, Mark ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF ROCHESTER   (United States)

^c BURKE MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

Brain recovery; Spinal cord recovery; Treatment

Indexed keywords

GLYCOSAMINOGLYCAN; MYELIN; NUTRACEUTICAL;

ASTROCYTE; BRAIN HYPOXIA; BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; CELL TRANSPLANTATION; CONCEPTUAL FRAMEWORK; CONFERENCE PAPER; DISEASE COURSE; DNA RESPONSIVE ELEMENT; DRUG EFFICACY; HOMEOSTASIS; HUMAN; HYPOGLYCEMIA; INFLAMMATION; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; ROBOTICS; SPINAL CORD INJURY; STROKE; SYSTEM ANALYSIS;

ANIMALS; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; HUMANS; NEUROPROTECTIVE AGENTS; RECOVERY OF FUNCTION; ROBOTICS; SPINAL CORD INJURIES; STROKE; TISSUE THERAPY;

EID: 62949246207     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.534933     Document Type: Conference Paper

References (26)

1. Pappachan J, Kirkham F. Cerebrovascular disease and stroke. Arch Dis Child. 2008;93:890-898.
2. Phillips RA. A review of therapeutic strategies for risk reduction of recurrent stroke. Prog Cardiovasc Dis. 2008;50:264.
3. Cramer SC. Repairing the human brain after stroke. II. Restorative therapies. Ann Neurol. 2008;63:549.
4. Fawcett JW. Overcoming inhibition in the damaged spinal cord. J Neurotrauma. 2006;23:371.
5. Endres M, Engelhardt B, Koistinaho J, Lindvall O, Meairs S, Mohr JP, Planas A, Rothwell N, Schwaninger M, Schwab ME, Vivien D, Wieloch T, Dirnagl U. Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis. 2008;25:268.
6. DeLucia TA, Alexander TD, Fargo KN, Jones KJ. Effects of single versus combinatorial treatment strategies on beta II-tubulin gene expression in axotomized hamster rubrospinal motoneurons. Restor Neurol Neurosci. 2007;25:573.
7. Montaner J. Cholesterol measured before stroke thrombolysis is not associated with tissue plasminogen activator-related hemorrhagic transformation. Stroke. 2008;39:e6.
8. Ferguson JJ, Califf RM, Antman EM, Cohen M, Grines CL, Goodman S. Kereiakes DJ, Langer A, Mahaffey KW, Nessel CC, Armstrong PW, Avezum A, Aylward P, Becker RC, Biasucci L, Borzak S, Col J, Frey MJ, Fry E, Gulba DC, Guneri S, Gurfinkel E, Harrington R, Hochman JS, Kleiman NS, Leon MB, Lopez-Sendon JL, Pepine CJ, Ruzyllo W, Steinhubl SR, Teirstein PS, Toro-Figueroa L, White H. Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial. JAMA. 2004;292:45.
9. Dimyan MA, Dobkin BH, Cohen LG. Emerging subspecialties: neurorehabilitation: training neurologists to retrain the brain. Neurology. 2008;70:e52.
10. Wang Y, Hu F, Wang ZJ, Wang GX, Zhang ZH, Xie P, Cui SP. Administration of bone marrow-derived stem cells suppresses cellular necrosis and apoptosis induced by reperfusion of ischaemic kidneys in rats. Chin Med J (Engl). 2008;121:268.
11. Cao L, Cao W, Zhang W, Lin H, Yang X, Zhen H, Cheng J, Dong W, Huo J, Zhang X. Identification of 14-3-3 protein isoforms in human astrocytoma by immunohistochemistry. Neurosci Lett. 2008;432:94.
12. Ma X, Idle JR, Gonzalez FJ. The pregnane X receptor: from bench to bedside. Expert Opin Drug Metab Toxicol. 2008;4:895.
13. Yin Y, Henzel MT, Lorber B, Nakazawa T, Thomas TT, Jiang F, Langer R, Benowitz LI. Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci. 2006;9:843-852.
14. Gervasi NM, Kwok JC, Fawcett JW. Role of extracellular factors in axon regeneration in the CNS: implications for therapy. Regen Med. 2008;3: 907-923.
15. Hannila SS, Siddiq MM, Filbin MT. Therapeutic approaches to promoting axonal regeneration in the adult mammalian spinal cord. Int Rev Neurobiol. 2007;77:57-105.
16. Ratan RR, Murphy TH, Baraban JM. Oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem. 1994;62:376.
17. Zaman K, Ryu H, Hall D, O'Donovan K, Lin KI, Miller MP, Marquis JC, Baraban JM, Semenza GL, Ratan RR. Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/ cip1), and erythropoietin. J Neurosci. 1999;19:9821.
18. Siddiq A, Ayoub IA, Chavez JC, Aminova L, Shah S, LaManna JC, Patton SM, Connor JR, Cherny RA, Volitakis I, Bush AI, Langsetmo I, Seeley T, Gunzler V, Ratan RR. Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J Biol Chem. 2005;280:41732.
19. Aminova LR, Chavez JC, Lee J, Ryu H, Kung A, Lamanna JC, Ratan RR. Prosurvival and prodeath effects of hypoxia-inducible factor-1 alpha stabilization in a murine hippocampal cell line. J Biol Chem. 2005;280:3996.
20. Aminova LR, Luo S, Bannai Y, Ho M, Wilson BA. The C3 domain of Pasteurella multocida toxin is the minimal domain responsible for activation of Gq-dependent calcium and mitogenic signaling. Protein Sci. 2008;17:945.
21. Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I. Small molecule activation of adaptative gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Ann NY Acad Sci. 2008; in press.
22. Ratan RR, Siddiq A, Aminova L, Lange PS, Langley B, Ayoub I, Gensert J, Chavez J. Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy. Stroke. 2004;35:2687.
23. Davies SL, Ferrer E, Moral MA. Chronicles in drug discovery. Drug News Perspect. 2006;19:295.
24. Dobkin BH. Training and exercise to drive poststroke recovery. Nat Clin Pract Neurol. 2008;4:76.
25. Volpe BT, Lynch D, Rykman-Berland A, Ferraro M, Galgano M, Hogan N, Krebs HI. Intensive sensorimotor arm training mediated by therapist or robot improves hemiparesis in patients with chronic stroke. Neurorehabil Neural Repair. 2008;22:305.
26. Krebs HI, Mernoff S, Fasoli SE, Hughes R, Stein J, Hogan N. A comparison of functional and impairment-based robotic training in severe to moderate chronic stroke: a pilot study. NeuroRehabilitation. 2008;23:81.