메뉴 건너뛰기




Volumn 14, Issue 6, 2009, Pages 228-235

Hemin toxicity: A preventable source of brain damage following hemorrhagic stroke

Author keywords

Catalase; Gsh; Hcp1; Heme; Hydrogen peroxide; Iron; Nadph; Oxidative stress; Protoporphyrin; Reactive oxygen species

Indexed keywords

ALBUMIN; ANTIOXIDANT; GLUTATHIONE; HEME OXYGENASE; HEMIN; HEMOGLOBIN; HEMOPEXIN; HYDROGEN PEROXIDE; HYDROXYL RADICAL; MEMBRANE LIPID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUPEROXIDE;

EID: 73949099862     PISSN: 13510002     EISSN: 17432928     Source Type: Journal    
DOI: 10.1179/135100009X12525712409931     Document Type: Review
Times cited : (159)

References (68)
  • 1
    • 0347453124 scopus 로고    scopus 로고
    • Available from [accessed 17 November 2009]
    • World Health Organization. The World Health Report 2003 - Shaping the Future. 2003; Available from:< http://www.who.int/whr/2003/en/whr03-en. pdf> [accessed 17 November 2009].
    • (2003) The World Health Report 2003- Shaping the Future
  • 2
    • 55449136520 scopus 로고    scopus 로고
    • Australian Institute of Health and Welfare. Canberra: AIHW, Cat. no. AUS 99
    • Australian Institute of Health and Welfare. Australia's Health 2008. Canberra: AIHW, 2008; Cat. no. AUS 99.
    • (2008) Australia's Health 2008
  • 3
    • 0028064265 scopus 로고
    • Spectrum of primary intracerebral haemorrhage in Perth, Western Australia, 1989-1990: Incidence and outcome
    • Anderson CS, Chakera TM, Stewart-Wynne EG, Jamrozik KD. Spectrum of primary intracerebral haemorrhage in Perth, Western Australia, 1989-1990: incidence and outcome. J Neurol Neurosurg Psychiatry 1994; 57: 936-940.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 936-940
    • Anderson, C.S.1    Chakera, T.M.2    Stewart-Wynne, E.G.3    Jamrozik, K.D.4
  • 5
    • 0026512113 scopus 로고
    • The risk of subarachnoid and intracerebral hemorrhages in blacks as compared with whites
    • Broderick JP, Brott T, Tomsick T, Huster G, Miller R. The risk of subarachnoid and intracerebral hemorrhages in blacks as compared with whites. N Engl J Med 1992; 326: 733-736.
    • (1992) N Engl J Med , vol.326 , pp. 733-736
    • Broderick, J.P.1    Brott, T.2    Tomsick, T.3    Huster, G.4    Miller, R.5
  • 6
    • 0032491174 scopus 로고    scopus 로고
    • Prediction of 30-day mortality among patients with thrombolysis-related intracranial hemorrhage
    • Sloan MA, Sila CA, Mahaffey KW et al. Prediction of 30-day mortality among patients with thrombolysis-related intracranial hemorrhage. Circulation 1998; 98: 1376-1382.
    • (1998) Circulation , vol.98 , pp. 1376-1382
    • Sloan, M.A.1    Sila, C.A.2    Mahaffey, K.W.3
  • 7
    • 34247488271 scopus 로고    scopus 로고
    • Inflammation after intracerebral hemorrhage
    • Wang J, Dore S. Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab 2007; 27: 894-908.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 894-908
    • Wang, J.1    Dore, S.2
  • 8
    • 0036460425 scopus 로고    scopus 로고
    • Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia
    • Tang Y, Lu A, Aronow BJ, Wagner KR, Sharp FR. Genomic responses of the brain to ischemic stroke, intracerebral haemorrhage, kainate seizures, hypoglycemia, and hypoxia. Eur J Neurosci 2002; 15: 1937-1952.
    • (2002) Eur J Neurosci , vol.15 , pp. 1937-1952
    • Tang, Y.1    Lu, A.2    Aronow, B.J.3    Wagner, K.R.4    Sharp, F.R.5
  • 11
    • 0034765001 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinases potentiates hemin toxicity in astrocyte cultures
    • Regan RF, Wang Y, Ma X, Chong A, Guo Y. Activation of extracellular signal-regulated kinases potentiates hemin toxicity in astrocyte cultures. J Neurochem 2001; 79: 545-555.
    • (2001) J Neurochem , vol.79 , pp. 545-555
    • Regan, R.F.1    Wang, Y.2    Ma, X.3    Chong, A.4    Guo, Y.5
  • 12
    • 12944252179 scopus 로고    scopus 로고
    • Heme oxygenase-2 gene deletion attenuates oxidative stress in neurons exposed to extracellular hemin
    • Regan RF, Chen J, Benvenisti-Zarom L. Heme oxygenase-2 gene deletion attenuates oxidative stress in neurons exposed to extracellular hemin. BMC Neurosci 2004; 5: 34.
    • (2004) BMC Neurosci , vol.5 , pp. 34
    • Regan, R.F.1    Chen, J.2    Benvenisti-Zarom, L.3
  • 13
    • 62949163677 scopus 로고    scopus 로고
    • Hematoma resolution as a therapeutic target: The role of microglia/macrophages
    • Zhao X, Grotta J, Gonzales N, Aronowski J. Hematoma resolution as a therapeutic target: the role of microglia/macrophages. Stroke 2009; 40: S92-S94.
    • (2009) Stroke , vol.40
    • Zhao, X.1    Grotta, J.2    Gonzales, N.3    Aronowski, J.4
  • 14
    • 0033778283 scopus 로고    scopus 로고
    • Glial swelling with eosinophilia in human post-mortem brains: A change indicative of plasma extravasation
    • Del Bigio MR, Deck JH, Davidson GS. Glial swelling with eosinophilia in human post-mortem brains: a change indicative of plasma extravasation. Acta Neuropathol 2000; 100: 688-694.
    • (2000) Acta Neuropathol , vol.100 , pp. 688-694
    • Del Bigio, M.R.1    Deck, J.H.2    Davidson, G.S.3
  • 15
    • 0002520963 scopus 로고
    • Intracerebral hemorrhage: Pathology of selected topics
    • Kase CS, Caplan LR. (eds) Boston, MA: Butterworth-Heinemann
    • Garcia JH, Ho KL, Caccamo DV. Intracerebral hemorrhage: pathology of selected topics. In: Kase CS, Caplan LR. (eds) Intracerebral Hemorrhage. Boston, MA: Butterworth-Heinemann, 1994; 45-72.
    • (1994) Intracerebral Hemorrhage , pp. 45-72
    • Garcia, J.H.1    Ho, K.L.2    Caccamo, D.V.3
  • 16
    • 68949132988 scopus 로고    scopus 로고
    • Heme oxygenase and iron: From bacteria to humans
    • Li C, Stocker R. Heme oxygenase and iron: from bacteria to humans. Redox Rep 2009; 14: 95-101.
    • (2009) Redox Rep , vol.14 , pp. 95-101
    • Li, C.1    Stocker, R.2
  • 18
    • 0034011593 scopus 로고    scopus 로고
    • Hemoglobin potentiates the production of reactive oxygen species by alveolar macrophages
    • Huffman LJ, Miles PR, Shi X, Bowman L. Hemoglobin potentiates the production of reactive oxygen species by alveolar macrophages. Exp Lung Res 2000; 26: 203-217.
    • (2000) Exp Lung Res , vol.26 , pp. 203-217
    • Huffman, L.J.1    Miles, P.R.2    Shi, X.3    Bowman, L.4
  • 19
    • 0041967387 scopus 로고    scopus 로고
    • Different faces of the heme-heme oxygenase system in inflammation
    • Wagener FA, Volk HD, Willis D et al. Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev 2003; 55: 551-571.
    • (2003) Pharmacol Rev , vol.55 , pp. 551-571
    • Wagener, F.A.1    Volk, H.D.2    Willis, D.3
  • 20
    • 0026318447 scopus 로고
    • Hemin: A possible physiological mediator of low density lipoprotein oxidation and endothelial injury
    • Balla G, Jacob HS, Eaton JW, Belcher JD, Vercellotti GM. Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury. Arterioscler Thromb 1991; 11: 1700-1711.
    • (1991) Arterioscler Thromb , vol.11 , pp. 1700-1711
    • Balla, G.1    Jacob, H.S.2    Eaton, J.W.3    Belcher, J.D.4    Vercellotti, G.M.5
  • 22
    • 0025670315 scopus 로고
    • Hemopexin joins transferrin as representative members of a distinct class of receptor-mediated endocytic transport systems
    • Smith A, Hunt RC. Hemopexin joins transferrin as representative members of a distinct class of receptor-mediated endocytic transport systems. Eur J Cell Biol 1990; 53: 234-245.
    • (1990) Eur J Cell Biol , vol.53 , pp. 234-245
    • Smith, A.1    Hunt, R.C.2
  • 23
    • 65549152427 scopus 로고    scopus 로고
    • Heme-hemopexin complex attenuates neuronal cell death and stroke damage
    • Li RC, Saleem S, Zhen G et al. Heme-hemopexin complex attenuates neuronal cell death and stroke damage. J Cereb Blood FlowMetab 2009; 29: 953-964.
    • (2009) J Cereb Blood FlowMetab , vol.29 , pp. 953-964
    • Li, R.C.1    Saleem, S.2    Zhen, G.3
  • 24
    • 0029143336 scopus 로고
    • Expression and distribution of low density lipoprotein receptor-related protein mRNA in the rat central nervous system
    • Ishiguro M, Imai Y, Kohsaka S. Expression and distribution of low density lipoprotein receptor-related protein mRNA in the rat central nervous system. Brain ResMol Brain Res 1995; 33: 37-46.
    • (1995) Brain ResMol Brain Res , vol.33 , pp. 37-46
    • Ishiguro, M.1    Imai, Y.2    Kohsaka, S.3
  • 25
    • 0031891213 scopus 로고    scopus 로고
    • Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors
    • Taketani S, Immenschuh S, Go S et al. Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors. Hepatology 1998; 27: 808-814.
    • (1998) Hepatology , vol.27 , pp. 808-814
    • Taketani, S.1    Immenschuh, S.2    Go, S.3
  • 26
    • 73349123422 scopus 로고    scopus 로고
    • The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin
    • Dang TN, Bishop GM, Dringen R, Robinson SR. The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin. Glia 2010; 58: 55-65.
    • (2010) Glia , vol.58 , pp. 55-65
    • Dang, T.N.1    Bishop, G.M.2    Dringen, R.3    Robinson, S.R.4
  • 27
    • 0034806977 scopus 로고    scopus 로고
    • Hemopexin a review of biological aspects and the role in laboratory medicine
    • Delanghe JR, LangloisMR. Hemopexin: a review of biological aspects and the role in laboratory medicine. Clin Chim Acta 2001; 312: 13-23.
    • (2001) Clin Chim Acta , vol.312 , pp. 13-23
    • Delanghe, J.R.1    Langlois, M.R.2
  • 28
    • 24144459870 scopus 로고    scopus 로고
    • Identification of an intestinal heme transporter
    • Shayeghi M, Latunde-Dada GO, Oakhill JS et al. Identification of an intestinal heme transporter. Cell 2005; 122: 789-801.
    • (2005) Cell , vol.122 , pp. 789-801
    • Shayeghi, M.1    Latunde-Dada, G.O.2    Oakhill, J.S.3
  • 29
    • 33751244559 scopus 로고    scopus 로고
    • Identification of an intestinal folate transporter and themolecular basis for hereditary folatemalabsorption
    • Qiu A, Jansen M, Sakaris A et al. Identification of an intestinal folate transporter and themolecular basis for hereditary folatemalabsorption. Cell 2006; 127: 917-928.
    • (2006) Cell , vol.127 , pp. 917-928
    • Qiu, A.1    Jansen, M.2    Sakaris, A.3
  • 30
    • 67649443910 scopus 로고    scopus 로고
    • Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1)
    • Laftah AH, Latunde-Dada GO, Fakih S, Hider RC, Simpson RJ, McKie AT. Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1). Br J Nutr 2009; 101: 1150-1156.
    • (2009) Br J Nutr , vol.101 , pp. 1150-1156
    • Laftah, A.H.1    Latunde-Dada, G.O.2    Fakih, S.3    Hider, R.C.4    Simpson, R.J.5    McKie, A.T.6
  • 31
    • 67349265621 scopus 로고    scopus 로고
    • On the fate of extracellular hemoglobin and heme in brain
    • Lara FA, Kahn SA, da Fonseca AC et al. On the fate of extracellular hemoglobin and heme in brain. J Cereb Blood Flow Metab 2009; 29: 1109-1120.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1109-1120
    • Lara, F.A.1    Kahn, S.A.2    Da Fonseca, A.C.3
  • 32
    • 19444386445 scopus 로고    scopus 로고
    • Free heme toxicity and its detoxification systems in human
    • Kumar S, Bandyopadhyay U. Free heme toxicity and its detoxification systems in human. Toxicol Lett 2005; 157: 175-188.
    • (2005) Toxicol Lett , vol.157 , pp. 175-188
    • Kumar, S.1    Bandyopadhyay, U.2
  • 33
    • 0040141555 scopus 로고    scopus 로고
    • Reaction intermediates and single turnover rate constants for the oxidation of heme by human heme oxygenase-1
    • Liu Y, Ortiz de Montellano PR. Reaction intermediates and single turnover rate constants for the oxidation of heme by human heme oxygenase-1. J Biol Chem 2000; 275: 5297-5307.
    • (2000) J Biol Chem , vol.275 , pp. 5297-5307
    • Liu, Y.1    Ortiz De Montellano, P.R.2
  • 34
    • 0029971924 scopus 로고    scopus 로고
    • Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase- 2, protein in rat brain
    • Geddes JW, Pettigrew LC, Holtz ML, Craddock SD, Maines MD. Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase- 2, protein in rat brain. Neurosci Lett 1996; 210: 205-208.
    • (1996) Neurosci Lett , vol.210 , pp. 205-208
    • Geddes, J.W.1    Pettigrew, L.C.2    Holtz, M.L.3    Craddock, S.D.4    Maines, M.D.5
  • 35
    • 0031914726 scopus 로고    scopus 로고
    • Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin
    • Turner CP, Bergeron M, Matz P et al. Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin. J Cereb Blood Flow Metab 1998; 18: 257-273.
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 257-273
    • Turner, C.P.1    Bergeron, M.2    Matz, P.3
  • 36
    • 0036839590 scopus 로고    scopus 로고
    • Gene expression profiles of heme oxygenase isoforms in the rat brain
    • ScapagniniG,D'Agata V, Calabrese V et al.Gene expression profiles of heme oxygenase isoforms in the rat brain. Brain Res 2002; 954: 51-59.
    • (2002) Brain Res , vol.954 , pp. 51-59
    • Scapagnini, G.1    D'agata, V.2    Calabrese, V.3
  • 37
    • 54949143147 scopus 로고    scopus 로고
    • Regulation of haem oxygenase-1 for treatment of neuroinflammation and brain disorders
    • Syapin PJ. Regulation of haem oxygenase-1 for treatment of neuroinflammation and brain disorders. Br J Pharmacol 2008; 155: 623-640.
    • (2008) Br J Pharmacol , vol.155 , pp. 623-640
    • Syapin, P.J.1
  • 38
    • 0029868298 scopus 로고    scopus 로고
    • Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage
    • DOI 10.1016/0006-8993(95)01511-6
    • Matz P, Turner C, Weinstein PR, Massa SM, Panter SS, Sharp FR. Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage. Brain Res 1996; 713: 211-222. (Pubitemid 26114842)
    • (1996) Brain Research , vol.713 , Issue.1-2 , pp. 211-222
    • Matz, P.1    Turner, C.2    Weinstein, P.R.3    Massa, S.M.4    Panter, S.S.5    Sharp, F.R.6
  • 39
    • 0029973893 scopus 로고    scopus 로고
    • Long-term induction of haem oxygenase-1 (HSP-32) in astrocytes andmicroglia following transient focal brain ischaemia in the rat
    • Koistinaho J, Miettinen S, Keinanen R, Vartiainen N, Roivainen R, Laitinen JT. Long-term induction of haem oxygenase-1 (HSP-32) in astrocytes andmicroglia following transient focal brain ischaemia in the rat. Eur J Neurosci 1996; 8: 2265-2272.
    • (1996) Eur J Neurosci , vol.8 , pp. 2265-2272
    • Koistinaho, J.1    Miettinen, S.2    Keinanen, R.3    Vartiainen, N.4    Roivainen, R.5    Laitinen, J.T.6
  • 40
    • 0034677855 scopus 로고    scopus 로고
    • Heme oxygenase-1 induction protects murine cortical astrocytes fromhemoglobin toxicity
    • Regan RF, Guo Y, Kumar N. Heme oxygenase-1 induction protects murine cortical astrocytes fromhemoglobin toxicity.Neurosci Lett 2000; 282: 1-4.
    • (2000) Neurosci Lett , vol.282 , pp. 1-4
    • Regan, R.F.1    Guo, Y.2    Kumar, N.3
  • 42
    • 0031396912 scopus 로고    scopus 로고
    • Histochemical localization of heme oxygenase- 2 protein and mRNA expression in rat brain
    • Ewing JF,MainesMD. Histochemical localization of heme oxygenase- 2 protein and mRNA expression in rat brain. Brain Res Brain Res Protoc 1997; 1: 165-174.
    • (1997) Brain Res Brain Res Protoc , vol.1 , pp. 165-174
    • Ewing, J.F.1    Maines, M.D.2
  • 43
    • 0028073463 scopus 로고
    • Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons
    • Vincent SR,Das S,MainesMD. Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons. Neuroscience 1994; 63: 223-231.
    • (1994) Neuroscience , vol.63 , pp. 223-231
    • Vincent, S.R.1    Das, S.2    Maines, M.D.3
  • 44
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37: 517-554.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 45
  • 46
    • 33750922153 scopus 로고    scopus 로고
    • Carbon monoxide and bilirubin fromheme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction
    • Matsumoto H, Ishikawa K, Itabe H, Maruyama Y. Carbon monoxide and bilirubin fromheme oxygenase-1 suppresses reactive oxygen species generation and plasminogen activator inhibitor-1 induction. Mol Cell Biochem 2006; 291: 21-28.
    • (2006) Mol Cell Biochem , vol.291 , pp. 21-28
    • Matsumoto, H.1    Ishikawa, K.2    Itabe, H.3    Maruyama, Y.4
  • 47
    • 1542314436 scopus 로고    scopus 로고
    • Carbon monoxide in biology and medicine
    • Ryter SW, Otterbein LE. Carbon monoxide in biology and medicine. Bioessays 2004; 26: 270-280.
    • (2004) Bioessays , vol.26 , pp. 270-280
    • Ryter, S.W.1    Otterbein, L.E.2
  • 48
    • 0141749478 scopus 로고    scopus 로고
    • Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicity
    • Rogers B, Yakopson V, Teng ZP, Guo Y, Regan RF. Heme oxygenase-2 knockout neurons are less vulnerable to hemoglobin toxicity. Free Radic BiolMed 2003; 35: 872-881.
    • (2003) Free Radic BiolMed , vol.35 , pp. 872-881
    • Rogers, B.1    Yakopson, V.2    Teng, Z.P.3    Guo, Y.4    Regan, R.F.5
  • 49
    • 2942525556 scopus 로고    scopus 로고
    • Heme oxygenase in experimental intracerebral hemorrhage: The benefit of tin-mesoporphyrin
    • Koeppen AH, Dickson AC, Smith J. Heme oxygenase in experimental intracerebral hemorrhage: the benefit of tin-mesoporphyrin. J Neuropathol Exp Neurol 2004; 63: 587-597.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 587-597
    • Koeppen, A.H.1    Dickson, A.C.2    Smith, J.3
  • 50
    • 33746890907 scopus 로고    scopus 로고
    • Glutathione peroxidase 1 and glutathione are required to protectmouse astrocytes from iron-mediated hydrogen peroxide toxicity
    • Liddell JR, Hoepken HH, Crack PJ, Robinson SR, Dringen R. Glutathione peroxidase 1 and glutathione are required to protectmouse astrocytes from iron-mediated hydrogen peroxide toxicity. J Neurosci Res 2006; 84: 578-586.
    • (2006) J Neurosci Res , vol.84 , pp. 578-586
    • Liddell, J.R.1    Hoepken, H.H.2    Crack, P.J.3    Robinson, S.R.4    Dringen, R.5
  • 51
    • 84875964358 scopus 로고    scopus 로고
    • The cytosolic redox state of astrocytes: Maintenance regulation and functional implications for metabolic trafficking
    • [Epub ahead of print]
    • Hirrlinger J, Dringen R. The cytosolic redox state of astrocytes: maintenance, regulation and functional implications for metabolic trafficking. Brain Res Rev 2009; [Epub ahead of print].
    • (2009) Brain Res Rev
    • Hirrlinger, J.1    Dringen, R.2
  • 52
    • 53049083456 scopus 로고    scopus 로고
    • Hemininduced necroptosis involves glutathione depletion in mouse astrocytes
    • Laird MD, Wakade C, Alleyne Jr CH, Dhandapani KM. Hemininduced necroptosis involves glutathione depletion in mouse astrocytes. Free Radic BiolMed 2008; 45: 1103-1114.
    • (2008) Free Radic BiolMed , vol.45 , pp. 1103-1114
    • Laird, M.D.1    Wakade, C.2    Alleyne Jr, C.H.3    Dhandapani, K.M.4
  • 53
    • 39749124150 scopus 로고    scopus 로고
    • Cytotoxic effects of metal protoporphyrins in glioblastoma cells: Roles of albumin, reactive oxygen species, and heme oxygenase-1.
    • Chow JM,HuangGC, LinHY, Shen SC,Yang LY, ChenYC. Cytotoxic effects of metal protoporphyrins in glioblastoma cells: roles of albumin, reactive oxygen species, and heme oxygenase-1. Toxicol Lett 2008; 177: 97-107.
    • (2008) Toxicol Lett , vol.177 , pp. 97-107
    • Chow, J.M.1    Huang, G.C.2    Lin, H.Y.3    Shen, S.C.4    Yang, L.Y.5    Chen, Y.C.6
  • 54
  • 55
    • 0034284263 scopus 로고    scopus 로고
    • Glycogen is mobilized during the disposal of peroxides by cultured astroglial cells from rat brain
    • Rahman B, Kussmaul L, Hamprecht B, Dringen R. Glycogen is mobilized during the disposal of peroxides by cultured astroglial cells from rat brain. Neurosci Lett 2000; 290: 169-172.
    • (2000) Neurosci Lett , vol.290 , pp. 169-172
    • Rahman, B.1    Kussmaul, L.2    Hamprecht, B.3    Dringen, R.4
  • 56
    • 28544449134 scopus 로고    scopus 로고
    • Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to hememediated oxidative injury
    • Chen-Roetling J, Benvenisti-Zarom L, Regan RF. Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to hememediated oxidative injury. J Neurosci Res 2005; 82: 802-810.
    • (2005) J Neurosci Res , vol.82 , pp. 802-810
    • Chen-Roetling, J.1    Benvenisti-Zarom, L.2    Regan, R.F.3
  • 57
    • 33749080071 scopus 로고    scopus 로고
    • Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin
    • Chen-Roetling J, Regan RF. Effect of heme oxygenase-1 on the vulnerability of astrocytes and neurons to hemoglobin. Biochem Biophys Res Commun 2006; 350: 233-237.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 233-237
    • Chen-Roetling, J.1    Regan, R.F.2
  • 58
    • 34248674094 scopus 로고    scopus 로고
    • Astrocyte-specific heme oxygenase-1 hyperexpression attenuates heme-mediated oxidative injury
    • Benvenisti-Zarom L, Regan RF. Astrocyte-specific heme oxygenase-1 hyperexpression attenuates heme-mediated oxidative injury. Neurobiol Dis 2007; 26: 688-695.
    • (2007) Neurobiol Dis , vol.26 , pp. 688-695
    • Benvenisti-Zarom, L.1    Regan, R.F.2
  • 60
    • 0015245206 scopus 로고
    • The peroxidase activity of deuterohemin
    • Portsmouth D, Beal EA. The peroxidase activity of deuterohemin. Eur J Biochem 1971; 19: 479-487.
    • (1971) Eur J Biochem , vol.19 , pp. 479-487
    • Portsmouth, D.1    Beal, E.A.2
  • 62
    • 0024241523 scopus 로고
    • Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation
    • Gutteridge JM, Smith A. Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation. Biochem J 1988; 256: 861-865.
    • (1988) Biochem J , vol.256 , pp. 861-865
    • Gutteridge, J.M.1    Smith, A.2
  • 64
    • 7244240720 scopus 로고    scopus 로고
    • Heme degradation by reactive oxygen species
    • Nagababu E, Rifkind JM. Heme degradation by reactive oxygen species. Antioxid Redox Signal 2004; 6: 967-978.
    • (2004) Antioxid Redox Signal , vol.6 , pp. 967-978
    • Nagababu, E.1    Rifkind, J.M.2
  • 65
    • 0028828562 scopus 로고
    • Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells
    • Atamna H, Ginsburg H. Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells. J Biol Chem 1995; 270: 24876-24883.
    • (1995) J Biol Chem , vol.270 , pp. 24876-24883
    • Atamna, H.1    Ginsburg, H.2
  • 66
    • 0037103555 scopus 로고    scopus 로고
    • Enhancement of glutathione-dependent haemin degradation by ascorbic acid
    • Zou CG, Agar NS, Jones GL. Enhancement of glutathione-dependent haemin degradation by ascorbic acid. Biochem Pharmacol 2002; 64: 565-572.
    • (2002) Biochem Pharmacol , vol.64 , pp. 565-572
    • Zou, C.G.1    Agar, N.S.2    Jones, G.L.3
  • 67
    • 65549127596 scopus 로고    scopus 로고
    • Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats
    • Okauchi M, Hua Y, Keep RF, Morgenstern LB, Xi G. Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats. Stroke 2009; 40: 1858-1863.
    • (2009) Stroke , vol.40 , pp. 1858-1863
    • Okauchi, M.1    Hua, Y.2    Keep, R.F.3    Morgenstern, L.B.4    Xi, G.5
  • 68
    • 34250657407 scopus 로고    scopus 로고
    • Experimental intracerebral hematoma in the rat: Characterization by sequentialmagnetic resonance imaging, behavior, and histopathology. Effect of albumin therapy
    • Belayev L, Obenaus A, Zhao W et al. Experimental intracerebral hematoma in the rat: characterization by sequentialmagnetic resonance imaging, behavior, and histopathology. Effect of albumin therapy. Brain Res 2007; 1157: 146-155.
    • (2007) Brain Res , vol.1157 , pp. 146-155
    • Belayev, L.1    Obenaus, A.2    Zhao, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.