메뉴 건너뛰기




Volumn 27, Issue 23, 2007, Pages 6320-6332

Neuron-specific inactivation of the hypoxia inducible factor 1α increases brain injury in a mouse model of transient focal cerebral ischemia

Author keywords

Gene expression; HIF; Hypoxia; Neuroprotection; Preconditioning; Stroke

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA;

EID: 34250021865     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0449-07.2007     Document Type: Article
Times cited : (325)

References (56)
  • 1
    • 33646119185 scopus 로고    scopus 로고
    • Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats
    • Althaus J, Bernaudin M, Petit E, Toutain J, Touzani O, Rami A (2006) Expression of the gene encoding the pro-apoptotic BNIP3 protein and stimulation of hypoxia-inducible factor-1alpha (HIF-1alpha) protein following focal cerebral ischemia in rats. Neurochem Int 48:687-695.
    • (2006) Neurochem Int , vol.48 , pp. 687-695
    • Althaus, J.1    Bernaudin, M.2    Petit, E.3    Toutain, J.4    Touzani, O.5    Rami, A.6
  • 2
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurological examination
    • Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurological examination. Stroke 17:472-476.
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.6
  • 3
    • 0033435198 scopus 로고    scopus 로고
    • Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain
    • Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR (1999) Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci 11:4159-4170.
    • (1999) Eur J Neurosci , vol.11 , pp. 4159-4170
    • Bergeron, M.1    Yu, A.Y.2    Solway, K.E.3    Semenza, G.L.4    Sharp, F.R.5
  • 4
    • 0033839757 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
    • Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR (2000) Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 48:285-296.
    • (2000) Ann Neurol , vol.48 , pp. 285-296
    • Bergeron, M.1    Gidday, J.M.2    Yu, A.Y.3    Semenza, G.L.4    Ferriero, D.M.5    Sharp, F.R.6
  • 5
    • 0036211764 scopus 로고    scopus 로고
    • Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain
    • Bernaudin M, Nedelec AS, Divoux D, MacKenzie ET, Petit E, Schumann-Bard P (2002a) Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain. J Cereb Blood Flow Metab 22:393-403.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 393-403
    • Bernaudin, M.1    Nedelec, A.S.2    Divoux, D.3    MacKenzie, E.T.4    Petit, E.5    Schumann-Bard, P.6
  • 6
    • 0037131170 scopus 로고    scopus 로고
    • Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance
    • Bernaudin M, Tang Y, Reilly M, Petit E, Sharp FR (2002b) Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem 277:39728-39738.
    • (2002) J Biol Chem , vol.277 , pp. 39728-39738
    • Bernaudin, M.1    Tang, Y.2    Reilly, M.3    Petit, E.4    Sharp, F.R.5
  • 7
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • Bruick RK (2000) Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA 97:9082-9087.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 8
    • 0242330181 scopus 로고    scopus 로고
    • Oxygen sensing in the hypoxic response pathway: Regulation of the hypoxia-inducible transcription factor
    • Bruick RK (2003) Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor. Genes Dev 17:2614-2623.
    • (2003) Genes Dev , vol.17 , pp. 2614-2623
    • Bruick, R.K.1
  • 9
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick RK, McKnight SL (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294:1337-1340.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 10
    • 0036469146 scopus 로고    scopus 로고
    • Transcription. Oxygen sensing gets a second wind
    • Bruick RK, McKnight SL (2002) Transcription. Oxygen sensing gets a second wind. Science 295:807-808.
    • (2002) Science , vol.295 , pp. 807-808
    • Bruick, R.K.1    McKnight, S.L.2
  • 11
    • 0037109768 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: Potential role of insulin-like growth factor-1
    • Chavez JC, LaManna JC (2002) Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1. J Neurosci 22:8922-8931.
    • (2002) J Neurosci , vol.22 , pp. 8922-8931
    • Chavez, J.C.1    LaManna, J.C.2
  • 12
    • 0033763820 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia
    • Chavez JC, Agani F, Pichiule P, LaManna JC (2000) Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia. J Appl Physiol 89:1937-1942.
    • (2000) J Appl Physiol , vol.89 , pp. 1937-1942
    • Chavez, J.C.1    Agani, F.2    Pichiule, P.3    LaManna, J.C.4
  • 13
    • 33748714735 scopus 로고    scopus 로고
    • The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes
    • Chavez JC, Baranova O, Lin J, Pichiule P (2006) The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J Neurosci 26:9471-9481.
    • (2006) J Neurosci , vol.26 , pp. 9471-9481
    • Chavez, J.C.1    Baranova, O.2    Lin, J.3    Pichiule, P.4
  • 14
    • 10044231587 scopus 로고    scopus 로고
    • Cytoprotective efficacy and mechanisms of the liposoluble iron chelator 2,2′-dipyridyl in the rat photothrombotic ischemic stroke model
    • Demougeot C, Van Hoecke M, Bertrand N, Prigent-Tessier A, Mossiat C, Beley A, Marie C (2004) Cytoprotective efficacy and mechanisms of the liposoluble iron chelator 2,2′-dipyridyl in the rat photothrombotic ischemic stroke model. J Pharmacol Exp Ther 311:1080-1087.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 1080-1087
    • Demougeot, C.1    Van Hoecke, M.2    Bertrand, N.3    Prigent-Tessier, A.4    Mossiat, C.5    Beley, A.6    Marie, C.7
  • 15
    • 0033199996 scopus 로고    scopus 로고
    • Pathobiology of ischaemic stroke: An integrated view
    • Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391-397.
    • (1999) Trends Neurosci , vol.22 , pp. 391-397
    • Dirnagl, U.1    Iadecola, C.2    Moskowitz, M.A.3
  • 16
    • 0033624837 scopus 로고    scopus 로고
    • CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain
    • Dragatsis I, Zeitlin S (2000) CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain. Genesis 26:133-135.
    • (2000) Genesis , vol.26 , pp. 133-135
    • Dragatsis, I.1    Zeitlin, S.2
  • 17
    • 0037470245 scopus 로고    scopus 로고
    • Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)
    • Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, Rauter M, Plate K, Sieweke M, Breier G, Flamme I (2003) Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J Biol Chem 278:7520-7530.
    • (2003) J Biol Chem , vol.278 , pp. 7520-7530
    • Elvert, G.1    Kappel, A.2    Heidenreich, R.3    Englmeier, U.4    Lanz, S.5    Acker, T.6    Rauter, M.7    Plate, K.8    Sieweke, M.9    Breier, G.10    Flamme, I.11
  • 20
    • 33745763116 scopus 로고    scopus 로고
    • Cerebral preconditioning and ischaemic tolerance
    • Gidday JM (2006) Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci 7:437-448.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 437-448
    • Gidday, J.M.1
  • 21
    • 0030693379 scopus 로고    scopus 로고
    • Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats
    • Hayashi T, Abe K, Suzuki H, Itoyama Y (1997) Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke 28:2039-2044.
    • (1997) Stroke , vol.28 , pp. 2039-2044
    • Hayashi, T.1    Abe, K.2    Suzuki, H.3    Itoyama, Y.4
  • 23
    • 0032493368 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
    • Huang LE, Gu J, Schau M, Bunn HF (1998) Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95:7987-7992.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7987-7992
    • Huang, L.E.1    Gu, J.2    Schau, M.3    Bunn, H.F.4
  • 27
    • 0034675037 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor and hypoxia-inducible factor-1alpha by global ischemia in rat brain
    • Jin KL, Mao XO, Nagayama T, Goldsmith PC, Greenberg DA (2000) Induction of vascular endothelial growth factor and hypoxia-inducible factor-1alpha by global ischemia in rat brain. Neuroscience 99:577-585.
    • (2000) Neuroscience , vol.99 , pp. 577-585
    • Jin, K.L.1    Mao, X.O.2    Nagayama, T.3    Goldsmith, P.C.4    Greenberg, D.A.5
  • 29
    • 0033966614 scopus 로고    scopus 로고
    • Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion
    • Lin TN, Wang CK, Cheung WM, Hsu CY (2000) Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 20:387-395.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 387-395
    • Lin, T.N.1    Wang, C.K.2    Cheung, W.M.3    Hsu, C.Y.4
  • 31
    • 0033902012 scopus 로고    scopus 로고
    • Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia
    • Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E, Risau W (2000) Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol 156:965-976.
    • (2000) Am J Pathol , vol.156 , pp. 965-976
    • Marti, H.J.1    Bernaudin, M.2    Bellail, A.3    Schoch, H.4    Euler, M.5    Petit, E.6    Risau, W.7
  • 32
    • 0030909616 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
    • Nogawa S, Zhang F, Ross ME, Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17:2746-2755.
    • (1997) J Neurosci , vol.17 , pp. 2746-2755
    • Nogawa, S.1    Zhang, F.2    Ross, M.E.3    Iadecola, C.4
  • 35
    • 0036707853 scopus 로고    scopus 로고
    • Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia
    • Pichiule P, LaManna JC (2002) Angiopoietin-2 and rat brain capillary remodeling during adaptation and deadaptation to prolonged mild hypoxia. J Appl Physiol 93:1131-1139.
    • (2002) J Appl Physiol , vol.93 , pp. 1131-1139
    • Pichiule, P.1    LaManna, J.C.2
  • 40
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda S, Caro J (1997) Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272:22642-22647.
    • (1997) J Biol Chem , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 41
    • 0033803047 scopus 로고    scopus 로고
    • Surviving ischemia: Adaptive responses mediated by hypoxia-inducible factor 1
    • Semenza GL (2000) Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J Clin Invest 106:809-812.
    • (2000) J Clin Invest , vol.106 , pp. 809-812
    • Semenza, G.L.1
  • 43
    • 2642555563 scopus 로고    scopus 로고
    • HIF1 and oxygen sensing in the brain
    • Sharp FR, Bernaudin M (2004) HIF1 and oxygen sensing in the brain. Nat Rev Neurosci 5:437-448.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 437-448
    • Sharp, F.R.1    Bernaudin, M.2
  • 48
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 49
    • 25844487075 scopus 로고    scopus 로고
    • Apoptotic cell death progression after photothrombotic focal cerebral ischaemia: Effects of the lipophilic iron chelator 2,2′-dipyridyl
    • Van Hoecke M, Prigent-Tessier A, Bertrand N, Prevotat L, Marie C, Beley A (2005) Apoptotic cell death progression after photothrombotic focal cerebral ischaemia: effects of the lipophilic iron chelator 2,2′-dipyridyl. Eur J Neurosci 22:1045-1056.
    • (2005) Eur J Neurosci , vol.22 , pp. 1045-1056
    • Van Hoecke, M.1    Prigent-Tessier, A.2    Bertrand, N.3    Prevotat, L.4    Marie, C.5    Beley, A.6
  • 50
    • 0027427588 scopus 로고
    • Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia
    • Wang GL, Semenza GL (1993) Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 268:21513-21518.
    • (1993) J Biol Chem , vol.268 , pp. 21513-21518
    • Wang, G.L.1    Semenza, G.L.2
  • 51
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor 1
    • Wang GL, Semenza GL (1995) Purification and characterization of hypoxia-inducible factor 1. J Biol Chem 270:1230-1237.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 52
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 92:5510-5514.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 54
    • 9444283176 scopus 로고    scopus 로고
    • Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells
    • Warnecke C, Zaborowska Z, Kurreck J, Erdmann VA, Frei U, Wiesener M, Eckardt KU (2004) Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J 18:1462-1464.
    • (2004) FASEB J , vol.18 , pp. 1462-1464
    • Warnecke, C.1    Zaborowska, Z.2    Kurreck, J.3    Erdmann, V.A.4    Frei, U.5    Wiesener, M.6    Eckardt, K.U.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.