Peripheral neural targets in obesity

British Journal of Pharmacology

Volumn 166, Issue 5, 2012, Pages 1537-1558

  Page, Amanda J ^a,b,c   Symonds, Erin ^c   Peiris, Madusha ^d   Blackshaw, L Ashley ^a,d   Young, Richard L ^a,b,c  

^a Nerve Gut Research Laboratory   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

enteroendocrine cell; nutrient sensing; obesity; vagus nerve

Indexed keywords

CHOLECYSTOKININ; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; LEPTIN; NEUROPEPTIDE; NEUROPEPTIDE W; OREXIN; PEPTIDE YY; SEROTONIN; UNCLASSIFIED DRUG;

APPETITE; BARIATRIC SURGERY; CALCIUM SIGNALING; ENTEROENDOCRINE CELL; FOOD INTAKE; GASTRECTOMY; GASTROINTESTINAL TRACT; HORMONE ACTION; HORMONE RELEASE; HUMAN; INTESTINE INNERVATION; MALABSORPTION; MECHANOTRANSDUCTION; NONHUMAN; NUTRIENT UPTAKE; OBESITY; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SATIETY; STOMACH BYPASS; STOMACH FUNCTION; VAGUS NERVE;

AFFERENT PATHWAYS; ANIMALS; APPETITE REGULATION; BRAIN; GASTROINTESTINAL TRACT; HUMANS; OBESITY; SATIETY RESPONSE; VAGUS NERVE;

EID: 84862743271     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.01951.x     Document Type: Review

References (336)

1. Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JR, et al,. (2005). The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 1044: 127-131.
2. Aja S, (2006). Serotonin-3 receptors in gastric mechanisms of cholecystokinin-induced satiety. Am J Physiol Regul Integr Comp Physiol 291: R112-R114.
3. Akiba Y, Watanabe C, Mizumori M, Kaunitz J, (2009). Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. Am J Physiol Gastrointest Liver Physiol 297: G781-G791.
4. Andrews PL, Sanger GJ, (2002). Abdominal vagal afferent neurones: an important target for the treatment of gastrointestinal dysfunction. Curr Opin Pharmacol 2: 650-656.
5. Anini Y, Brubaker PL, (2003). Role of leptin in the regulation of glucagon-like peptide-1 secretion. Diabetes 52: 252-259.
6. Aramori I, Nakanishi S, (1992). Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron 8: 757-765.
7. Arnold M, Mura A, Langhans W, Geary N, (2006). Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci 26: 11052-11060.
8. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, et al,. (2001). Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120: 337-345.
9. Atkinson TJ, (2008). Central and peripheral neuroendocrine peptides and signalling in appetite regulation: considerations for obesity pharmacotherapy. Obes Rev 9: 108-120.
10. Attoub S, Levasseur S, Buyse M, Goiot H, Laigneau JP, Moizo L, et al,. (1999). Physiological role of cholecystokinin B/gastrin receptor in leptin secretion. Endocrinology 140: 4406-4410.
11. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, et al,. (1998). The stomach is a source of leptin. Nature 394: 790-793.
12. Baggio LL, Drucker DJ, (2007). Biology of incretins: GLP-1 and GIP. Gastroenterology 132: 2131-2157.
13. Baranowska B, Radzikowska M, Wasilewska-Dziubinska E, Roguski K, Borowiec M, (2000). Disturbed release of gastrointestinal peptides in anorexia nervosa and in obesity. Diabetes Obes Metab 2: 99-103.
14. Barrera JG, Sandoval DA, D'Alessio DA, Seeley RJ, (2011). GLP-1 and energy balance: an integrated model of short-term and long-term control. Nat Rev 7: 507-516.
15. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, et al,. (2002). Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418: 650-654.
16. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, et al,. (2003). Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349: 941-948.
17. Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, et al,. (2006). Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 4: 223-233.
18. Becker JM, Kelly KA, (1983). Antral control of canine gastric emptying of solids. Am J Physiol 245: G334-G338.
19. Beglinger C, Degen L, Matzinger D, D'Amato M, Drewe J, (2001). Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans. Am J Physiol Regul Integr Comp Physiol 280: R1149-R1154.
20. Berthoud HR, Kressel M, Neuhuber WL, (1992). An anterograde tracing study of the vagal innervation of rat liver, portal vein and biliary system. Anat Embryol (Berl) 186: 431-442.
21. Berthoud HR, Kressel M, Raybould HE, Neuhuber WL, (1995). Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing. Anat Embryol (Berl) 191: 203-212.
22. Bertrand PP, (2009). The cornucopia of intestinal chemosensory transduction. Front Neurosci 3: 1-9.
23. Bertrand PP, Bertrand RL, (2010). Serotonin release and uptake in the gastrointestinal tract. Auton Neurosci 153: 47-57.
24. Bertrand RL, Senadheera S, Markus I, Liu L, Howitt L, Chen H, et al,. (2011). A Western diet increases serotonin availability in rat small intestine. Endocrinology 152: 36-47.
25. Bezencon C, le Coutre J, Damak S, (2007). Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 32: 41-49.
26. Bi S, Chen J, Behles RR, Hyun J, Kopin AS, Moran TH, (2007). Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors. Am J Physiol Regul Integr Comp Physiol 293: R55-R63.
27. Blackshaw LA, Grundy D, (1989). Responses of vagal efferent fibres to stimulation of gastric mechano- and chemoreceptors in the anaesthetized ferret. J Auton Nerv Syst 27: 39-45.
28. Blackshaw LA, Grundy D, (1990). Effects of cholecystokinin (CCK-8) on two classes of gastroduodenal vagal afferent fibre. J Auton Nerv Syst 31: 191-201.
29. Blackshaw LA, Grundy D, Scratcherd T, (1987). Involvement of gastrointestinal mechano- and intestinal chemoreceptors in vagal reflexes: an electrophysiological study. J Auton Nerv Syst 18: 225-234.
30. Blackshaw LA, Brookes SJ, Grundy D, Schemann M, (2007). Sensory transmission in the gastrointestinal tract. Neurogastroenterol Motil 19: 1-19.
31. Bonini J, Anderson S, Steiner D, (1997). Molecular cloning and tissue expression of a novel orphan G protein-coupled receptor from rat lung. Biochem Biophys Res Commun 234: 190-193.
32. Bozkurt A, Oktar BK, Kurtel H, Alican I, Coskun T, Yegen BC, (1999). Capsaicin-sensitive vagal fibres and 5-HT3-, gastrin releasing peptide- and cholecystokinin A-receptors are involved in distension-induced inhibition of gastric emptying in the rat. Regul Pept 83: 81-86.
33. Brener W, Hendrix TR, McHugh PR, (1983). Regulation of the gastric emptying of glucose. Gastroenterology 85: 76-82.
34. Brennan IM, Little TJ, Feltrin KL, Smout AJ, Wishart JM, Horowitz M, et al,. (2008). Dose-dependent effects of cholecystokinin-8 on antropyloroduodenal motility, gastrointestinal hormones, appetite, and energy intake in healthy men. Am J Physiol Endocrinol Metab 295: E1487-E1494.
35. Briscoe C, Tadayyon M, Andrews J, Benson W, Chambers J, Eilert M, et al,. (2003). The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278: 11303-11311.
36. Broberger C, Hokfelt T, (2001). Hypothalamic and vagal neuropeptide circuitries regulating food intake. Physiol Behav 74: 669-682.
37. Broberger C, Holmberg K, Shi TJ, Dockray G, Hokfelt T, (2001). Expression and regulation of cholecystokinin and cholecystokinin receptors in rat nodose and dorsal root ganglia. Brain Res 903: 128-140.
38. Brown A, Goldsworthy S, Barnes A, Eilert M, Tcheang L, Daniels D, et al,. (2003). The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278: 11312-11319.
39. Bryant MG, Bloom SR, Polak JM, Hobbs S, Domschke W, Domschke S, et al,. (1983). Measurement of gut hormonal peptides in biopsies from human stomach and proximal small intestine. Gut 24: 114-119.
40. Buchan AM, Squires PE, Ring M, Meloche RM, (2001). Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 120: 1128-1139.
41. Bucinskaite V, Tolessa T, Pedersen J, Rydqvist B, Zerihun L, Holst JJ, et al,. (2009). Receptor-mediated activation of gastric vagal afferents by glucagon-like peptide-1 in the rat. Neurogastroenterol Motil 21: e978-e978.
42. Bueter M, le Roux CW, (2011). Gastrointestinal hormones, energy balance and bariatric surgery. Int J Obes (Lond) 35: S35-S39.
43. Burdyga G, Spiller D, Morris R, Lal S, Thompson DG, Saeed S, et al,. (2002). Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience 109: 339-347.
44. Burdyga G, Lal S, Spiller D, Jiang W, Thompson D, Attwood S, et al,. (2003). Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. Gastroenterology 124: 129-139.
45. Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ, (2006a). Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones. Neuroscience 137: 1405-1415.
46. Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ, (2006b). Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance. Am J Physiol Gastrointest Liver Physiol 290: G1289-G1297.
47. Burdyga G, de Lartigue G, Raybould HE, Morris R, Dimaline R, Varro A, et al,. (2008). Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach. J Neurosci 28: 11583-11592.
48. Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ, (2010). Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics, and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol 299: G63-G69.
49. Burns R, Moniri N, (2010). Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. Biochem Biophys Res Commun 396: 1030-1035.
50. Buyse M, Ovesjo ML, Goiot H, Guilmeau S, Peranzi G, Moizo L, et al,. (2001). Expression and regulation of leptin receptor proteins in afferent and efferent neurons of the vagus nerve. Eur J Neurosci 14: 64-72.
51. Bystrova M, Romanov R, Rogachevskaja O, Churbanov G, Kolesnikov S, (2010). Functional expression of the extracellular-Ca2+-sensing receptor in mouse taste cells. J Cell Sci 123: 972-982.
52. Calapai G, Corica F, Corsonello A, Sautebin L, Di Rosa M, Campo GM, et al,. (1999). Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis. J Clin Invest 104: 975-982.
53. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ, (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348: 1625-1638.
54. Caminos JE, Bravo SB, Garcia-Rendueles ME, Ruth Gonzalez C, Garces MF, Cepeda LA, et al,. (2008). Expression of neuropeptide W in rat stomach mucosa: regulation by nutritional status, glucocorticoids and thyroid hormones. Regul Pept 146: 106-111.
55. Cartoni C, Yasumatsu K, Ohkuri T, Shigemura N, Yoshida R, Godinot N, et al,. (2010). Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci 30: 8376-8382.
56. Chan JM, Rimm EB, Colditz GA, Stampfer MJ, Willett WC, (1994). Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men. Diabetes Care 17: 961-969.
57. Chang H, Yoo B, Lim S, Jeong S, Kim W, Park J, (2005). Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance. Clin Cancer Res 11: 3288-3295.
58. Chaudhari N, Yang H, Lamp C, Delay E, Cartford C, Than T, et al,. (1996). The taste of monosodium glutamate: membrane receptors in taste buds. J Neurosci 16: 3817-3826.
59. Chihara K, Arimura A, Schally AV, (1979). Immunoreactive somatostatin in rat hypophyseal portal blood: effects of anesthetics. Endocrinology 104: 1434-1441.
60. Cho YM, Kieffer TJ, (2011). K-cells and glucose-dependent insulinotropic polypeptide in health and disease. Vitam Horm 84: 111-150.
61. Choi S, Lee M, Shiu AL, Yo SJ, Aponte GW, (2007a). Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes. Am J Physiol Gastrointest Liver Physiol 292: G98-112.
62. Choi S, Lee M, Shiu AL, Yo SJ, Hallden G, Aponte GW, (2007b). GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am J Physiol Gastrointest Liver Physiol 292: G1366-G1375.
63. Chu Z, Carroll C, Chen R, Alfonso J, Gutierrez V, He H, et al,. (2010). N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119. Mol Endocrinol 24: 161-170.
64. Cinti S, Matteis RD, Pico C, Ceresi E, Obrador A, Maffeis C, et al,. (2000). Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin. Int J Obes Relat Metab Disord 24: 789-793.
65. Clarke GD, Davison JS, (1975). Tension receptors in the oesophagus and stomach of the rat. J Physiol 244: 41P-42P.
66. Clarke GD, Davison JS, (1978). Mucosal receptors in the gastric antrum and small intestine of the rat with afferent fibres in the cervical vagus. J Physiol 284: 55-67.
67. Colditz GA, Willett WC, Rotnitzky A, Manson JE, (1995). Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 122: 481-486.
68. Conigrave AD, Quinn SJ, Brown EM, (2000). L-amino acid sensing by the extracellular Ca2+-sensing receptor. Proc Natl Acad Sci U S A 97: 4814-4819.
69. Cottrell DF, Iggo A, (1984a). The responses of duodenal tension receptors in sheep to pentagastrin, cholecystokinin and some other drugs. J Physiol 354: 477-495.
70. Cottrell DF, Iggo A, (1984b). Tension receptors with vagal afferent fibres in the proximal duodenum and pyloric sphincter of sheep. J Physiol 354: 457-475.
71. Covasa M, Ritter RC, (1998). Rats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin. Peptides 19: 1407-1415.
72. Covasa M, Marcuson JK, Ritter RC, (2001). Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin. Am J Physiol Regul Integr Comp Physiol 280: R331-R337.
73. Crawley JN, Beinfeld MC, (1983). Rapid development of tolerance to the behavioural actions of cholecystokinin. Nature 302: 703-706.
74. Cummings DE, Overduin J, (2007). Gastrointestinal regulation of food intake. J Clin Invest 117: 13-23.
75. Cunningham KM, Daly J, Horowitz M, Read NW, (1991). Gastrointestinal adaptation to diets of differing fat composition in human volunteers. Gut 32: 483-486.
76. Czech DA, (1996). Possible involvement of nitric oxide in chlordiazepoxide-induced feeding in the mouse. Pharmacol Biochem Behav 55: 327-331.
77. Czech DA, (1998). A nitric oxide synthase inhibitor NG-nitro-L-arginine, attenuates glucoprivic feeding and deprivation-induced drinking in the mouse. Pharmacol Biochem Behav 60: 601-607.
78. Czech DA, Klosterman AE, Le Sueur KT, (1998). N(G)-nitro-L-arginine methyl ester reduces stress-related feeding in the rat tail-pinch model. Pharmacol Biochem Behav 60: 91-96.
79. Daly DM, Park SJ, Valinsky WC, Beyak MJ, (2011). Impaired intestinal afferent nerve satiety signalling and vagal afferent excitability in diet induced obesity in the mouse. J Physiol 589: 2857-2870.
80. Darcel NP, Liou AP, Tome D, Raybould HE, (2005). Activation of vagal afferents in the rat duodenum by protein digests requires PepT1. J Nutr 135: 1491-1495.
81. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, et al,. (2000). Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141: 4255-4261.
82. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, et al,. (2002). The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123: 1120-1128.
83. Daughters RS, Hofbauer RD, Grossman AW, Marshall AM, Brown EM, Hartman BK, et al,. (2001). Ondansetron attenuates CCK induced satiety and c-fos labeling in the dorsal medulla. Peptides 22: 1331-1338.
84. Davison JS, (1972). Response of single vagal afferent fibres to mechanical and chemical stimulation of the gastric and duodenal mucosa in cats. Q J Exp Physiol Cogn Med Sci 57: 405-416.
85. De Lartigue G, Dimaline R, Varro A, Raybould H, De la Serre CB, Dockray GJ, (2011). Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons. Gastroenterology 138: 1479-1490.
86. De Miguel MJ, Burrell MA, (2002). Immunocytochemical detection of orexin A in endocrine cells of the developing mouse gut. J Histochem Cytochem 50: 63-69.
87. Deacon CF, Pridal L, Klarskov L, Olesen M, Holst JJ, (1996). Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig. Am J Physiol 271: E458-E464.
88. Dockray GJ, Burdyga G, (2011). Plasticity in vagal afferent neurones during feeding and fasting: mechanisms and significance. Acta Physiol (Oxf) 201: 313-321.
89. Donovan MJ, Paulino G, Raybould HE, (2009). Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity. Brain Res 1248: 136-140.
90. Drucker DJ, Asa S, (1988). Glucagon gene expression in vertebrate brain. J Biol Chem 263: 13475-13478.
91. Dufner M, Kirchhoff P, Remy C, Hafner P, Müller M, Cheng S, et al,. (2005). The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands. Am J Physiol Gastrointest Liver Physiol 289: G1084-G1090.
92. Dyer J, Salmon KS, Zibrik L, Shirazi-Beechey SP, (2005). Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 33: 302-305.
93. Edfalk S, Steneberg P, Edlund H, (2008). Gpr40 is expressed in enteroendocrine cells and mediates FFA stimulation of incretin secretion. Diabetes 57: 2280-2287.
94. Edholm T, Degerblad M, Gryback P, Hilsted L, Holst JJ, Jacobsson H, et al,. (2011). Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis. Neurogastroenterol Motil 22: 1191-1200.
95. Eissele R, Goke R, Willemer S, Harthus HP, Vermeer H, Arnold R, et al,. (1992). Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man. Eur J Clin Invest 22: 283-291.
96. Elder KA, Wolfe BM, (2007). Bariatric surgery: a review of procedures and outcomes. Gastroenterology 132: 2253-2271.
97. Elliott LA, O'Donnell TA, Isaacs NJ, Blackshaw LA, Page AJ, (2011). Opposite effects of nitric oxide on peripheral vagal afferents in feeding and fasting. Gastroenterology 140: S833-S834.
98. Falken Y, Hellstrom PM, Sanger GJ, Dewit O, Dukes G, Gryback P, et al,. (2010). Actions of prolonged ghrelin infusion on gastrointestinal transit and glucose homeostasis in humans. Neurogastroenterol Motil 22: e192-e200.
99. Farr SA, Banks WA, Kumar VB, Morley JE, (2005). Orexin-A-induced feeding is dependent on nitric oxide. Peptides 26: 759-765.
100. Feltrin KL, Little TJ, Meyer JH, Horowitz M, Smout AJ, Wishart J, et al,. (2004). Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. Am J Physiol Regul Integr Comp Physiol 287: R524-R533.
101. Ferry S, Traiffort E, Stinnakre J, Ruat M, (2000). Developmental and adult expression of rat calcium-sensing receptor transcripts in neurons and oligodendrocytes. Eur J Neurosci 12: 872-884.
102. Fetissov SO, Byrne LC, Hassani H, Ernfors P, Hokfelt T, (2004). Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus. J Comp Neurol 470: 256-265.
103. Fletcher PJ, Burton MJ, (1985). The anorectic action of peripherally administered 5-HT is enhanced by vagotomy. Physiol Behav 34: 861-866.
104. Fletcher PJ, Burton MJ, (1986). Microstructural analysis of the anorectic action of peripherally administered 5-HT. Pharmacol Biochem Behav 24: 1133-1136.
105. Flint A, Raben A, Ersboll AK, Holst JJ, Astrup A, (2001). The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity. Int J Obes Relat Metab Disord 25: 781-792.
106. Flock G, Holland D, Seino Y, Drucker D, (2011). GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms. Endocrinology 152: 374-383.
107. Flor P, Lukic S, Rüegg D, Leonhardt T, Knöpfel T, Kuhn R, (1995). Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4. Neuropharmacology 34: 149-155.
108. Fredriksson R, Höglund P, Gloriam D, Lagerström M, Schiöth H, (2003). Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett 554: 381-388.
109. French SJ, Cecil JE, (2001). Oral, gastric and intestinal influences on human feeding. Physiol Behav 74: 729-734.
110. Fried M, Erlacher U, Schwizer W, Lochner C, Koerfer J, Beglinger C, et al,. (1991). Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide. Gastroenterology 101: 503-511.
111. Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodriguez De Fonseca F, et al,. (2003). Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425: 90-93.
112. Furness JB, Koopmans HS, Robbins HL, Clerc N, Tobin JM, Morris MJ, (2001). Effects of vagal and splanchnic section on food intake, weight, serum leptin and hypothalamic neuropeptide Y in rat. Auton Neurosci 92: 28-36.
113. Gaskin FS, Farr SA, Banks WA, Kumar VB, Morley JE, (2003). Ghrelin-induced feeding is dependent on nitric oxide. Peptides 24: 913-918.
114. Gautron L, Lee C, Funahashi H, Friedman J, Lee S, Elmquist J, (2010). Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions. J Comp Neurol 518: 6-24.
115. Geliebter A, (1988). Gastric distension and gastric capacity in relation to food intake in humans. Physiol Behav 44: 665-668.
116. Gerspach AC, Steinert RE, Schonenberger L, Graber-Maier A, Beglinger C, (2011). The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans. Am J Physiol Endocrinol Metab 301: E317-E325.
117. Glatzle J, Sternini C, Robin C, Zittel TT, Wong H, Reeve JR, et al,. (2002). Expression of 5-HT3 receptors in the rat gastrointestinal tract. Gastroenterology 123: 217-226.
118. Glatzle J, Wang Y, Adelson DW, Kalogeris TJ, Zittel TT, Tso P, et al,. (2003). Chylomicron components activate duodenal vagal afferents via a cholecystokinin A receptor-mediated pathway to inhibit gastric motor function in the rat. J Physiol 550: 657-664.
119. Goke R, Larsen PJ, Mikkelsen JD, Sheikh SP, (1995). Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 7: 2294-2300.
120. Görcs T, Penke B, Böti Z, Katarova Z, Hámori J, (1993). Immunohistochemical visualization of a metabotropic glutamate receptor. Neuroreport 4: 283-286.
121. Grundy D, (2006). Serotonin and sensory signalling from the gastrointestinal lumen. J Physiol (Lond) 575: 1-2.
122. Grundy D, (2008). 5-HT system in the gut: roles in the regulation of visceral sensitivity and motor functions. Eur Rev Med Pharmacol Sci 12: 63-67.
123. Haid D, Widmayer P, Breer H, (2011). Nutrient sensing receptors in gastric endocrine cells. J Mol Histol 42: 355-364.
124. Hansen K, Rosenkilde M, Knop F, Wellner N, Diep T, Rehfeld J, et al,. (2011). 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans. J Clin Endocrinol Metab 96: E1409-E1417.
125. Hansotia T, Maida A, Flock G, Yamada Y, Tsukiyama K, Seino Y, et al,. (2007). Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure. J Clin Invest 117: 143-152.
126. Hass N, Schwarzenbacher K, Breer H, (2010). T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach. Cell Tissue Res 339: 493-504.
127. Hayes MR, Chory FM, Gallagher CA, Covasa M, (2006). Serotonin type-3 receptors mediate cholecystokinin-induced satiation through gastric distension. Am J Physiol Regul Integr Comp Physiol 291: R115-R123.
128. Hayes MR, Skibicka KP, Grill HJ, (2008). Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Endocrinology 149: 4059-4068.
129. Hayes MR, De Jonghe BC, Kanoski SE, (2010). Role of the glucagon-like-peptide-1 receptor in the control of energy balance. Physiol Behav 100: 503-510.
130. Hayes MR, Kanoski SE, De Jonghe BC, Leichner TM, Alhadeff AL, Fortin SM, et al,. (2011). The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like- peptide-1. Am J Physiol Regul Integr Comp Physiol 301: R1479-R1485.
131. Helou N, Obeid O, Azar ST, Hwalla N, (2008). Variation of postprandial PYY 3-36 response following ingestion of differing macronutrient meals in obese females. Ann Nutr Metab 52: 188-195.
132. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, et al,. (2005). Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 11: 90-94.
133. Hoang CJ, Hay M, (2001). Expression of metabotropic glutamate receptors in nodose ganglia and the nucleus of the solitary tract. Am J Physiol Heart Circ Physiol 281: H457-H462.
134. Holmes GM, Browning KN, Tong M, Qualls-Creekmore E, Travagli RA, (2009). Vagally mediated effects of glucagon-like peptide 1: in vitro and in vivo gastric actions. J Physiol 587: 4749-4759.
135. Holst JJ, (2007). The physiology of glucagon-like peptide 1. Physiol Rev 87: 1409-1439.
136. Honda T, Wada E, Battey JF, Wank SA, (1993). Differential gene expression of CCK(A) and CCK(B) receptors in the rat brain. Mol Cell Neurosci 4: 143-154.
137. Horowitz M, Nauck MA, (2006). To be or not to be-an incretin or enterogastrone? Gut 55: 148-150.
138. Houpt TR, Houpt KA, Swan AA, (1983). Duodenal osmoconcentration and food intake in pigs after ingestion of hypertonic nutrients. Am J Physiol 245: R181-R189.
139. Hunt JN, Knox MT, (1968). A relation between the chain length of fatty acids and the slowing of gastric emptying. J Physiol 194: 327-336.
140. Iggo A, (1955). Tension receptors in the stomach and the urinary bladder. J Physiol 128: 593-607.
141. Iggo A, (1958). The electrophysiological identification of single nerve fibres, with particular reference to the slowest-conducting vagal afferent fibres in the cat. J Physiol 142: 110-126.
142. Imeryuz N, Yegen BC, Bozkurt A, Coskun T, Villanueva-Penacarrillo ML, Ulusoy NB, (1997). Glucagon-like peptide-1 inhibits gastric emptying via vagal afferent-mediated central mechanisms. Am J Physiol 273: G920-G927.
143. Inui A, (2001). Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2: 551-560.
144. Ishii M, Fei H, Friedman JM, (2003). Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity. Proc Natl Acad Sci U S A 100: 10540-10545.
145. Jagger A, Grahn J, Ritter RC, (1997). Reduced vagal sensory innervation of the small intestinal myenteric plexus following capsaicin treatment of adult rats. Neurosci Lett 236: 103-106.
146. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, et al,. (2007). Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 104: 15069-15074.
147. Justinich C, Mak N, Pacheco I, Mulder D, Wells R, Blennerhassett M, et al,. (2008). The extracellular calcium-sensing receptor (CaSR) on human esophagus and evidence of expression of the CaSR on the esophageal epithelial cell line (HET-1A). Am J Physiol Gastrointest Liver Physiol 294: G120-G129.
148. Kaemmerer E, Plum P, Klaus C, Weiskirchen R, Liedtke C, Adolf M, et al,. (2010). Fatty acid binding receptors in intestinal physiology and pathophysiology. World J Gastrointest Pathophysiol 1: 147-153.
149. Kaji I, Karaki S, Tanaka R, Kuwahara A, (2011). Density distribution of free fatty acid receptor 2 (FFA2)-expressing and GLP-1-producing enteroendocrine L cells in human and rat lower intestine, and increased cell numbers after ingestion of fructo-oligosaccharide. J Mol Histol 42: 27-38.
150. Kakei M, Yada T, Nakagawa A, Nakabayashi H, (2002). Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons. Auton Neurosci 102: 39-44.
151. Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR, (2011). Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology 152: 3103-3112.
152. Karaki S, Mitsui R, Hayashi H, Kato I, Sugiya H, Iwanaga T, et al,. (2006). Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res 324: 353-360.
153. Karra E, Chandarana K, Batterham RL, (2009). The role of peptide YY in appetite regulation and obesity. J Physiol 587: 19-25.
154. Kentish S, Li H, Philp LK, O'Donnell TA, Isaacs NJ, Young RL, et al,. (2011). Diet induced adaptation of vagal afferent function. J Physiol 590 (Pt 1): 209-221.
155. Kim DY, Camilleri M, Murray JA, Stephens DA, Levine JA, Burton DD, (2001). Is there a role for gastric accommodation and satiety in asymptomatic obese people? Obes Res 9: 655-661.
156. Kim SJ, Nian C, McIntosh CH, (2007). Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade. J Biol Chem 282: 8557-8567.
157. Kirchgessner AL, Liu M, (1999). Orexin synthesis and response in the gut. Neuron 24: 941-951.
158. Koda S, Date Y, Murakami N, Shimbara T, Hanada T, Toshinai K, et al,. (2005). The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 146: 2369-2375.
159. Kotarsky K, Nilsson N, Flodgren E, Owman C, Olde B, (2003). A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem Biophys Res Commun 301: 406-410.
160. Kotarsky K, Boketoft A, Bristulf J, Nilsson N, Norberg A, Hansson S, et al,. (2006). Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes. J Pharmacol Exp Ther 318: 619-628.
161. Kristensen P, Suzdak P, Thomsen C, (1993). Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor. Neurosci Lett 155: 159-162.
162. de Krom M, van der Schouw YT, Hendriks J, Ophoff RA, van Gils CH, Stolk RP, et al,. (2007). Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns. Diabetes 56: 276-280.
163. Kumar KG, Byerley LO, Volaufova J, Drucker DJ, Churchill GA, Li R, et al,. (2008). Genetic variation in Glp1r expression influences the rate of gastric emptying in mice. Am J Physiol Regul Integr Comp Physiol 294: R362-R371.
164. Lacourse KA, Swanberg LJ, Gillespie PJ, Rehfeld JF, Saunders TL, Samuelson LC, (1999). Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol 276: G1302-G1309.
165. Lal S, Kirkup AJ, Brunsden AM, Thompson DG, Grundy D, (2001). Vagal afferent responses to fatty acids of different chain length in the rat. Am J Physiol Gastrointest Liver Physiol 281: G907-G915.
166. Lang PM, Grafe P, (2007). Chemosensitivity of unmyelinated axons in isolated human gastric vagus nerve. Auton Neurosci 136: 100-104.
167. Laskiewicz J, Krolczyk G, Zurowski G, Sobocki J, Matyja A, Thor PJ, (2003). Effects of vagal neuromodulation and vagotomy on control of food intake and body weight in rats. J Physiol Pharmacol 54: 603-610.
168. Lassman DJ, McKie S, Gregory LJ, Lal S, D'Amato M, Steele I, et al,. (2010). Defining the role of cholecystokinin in the lipid-induced human brain activation matrix. Gastroenterology 138: 1514-1524.
169. Leckstrom A, Kim ER, Wong D, Mizuno TM, (2009). Xenin, a gastrointestinal peptide, regulates feeding independent of the melanocortin signaling pathway. Diabetes 58: 87-94.
170. Levine AS, Winsky-Sommerer R, Huitron-Resendiz S, Grace MK, de Lecea L, (2005). Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake. Am J Physiol Regul Integr Comp Physiol 288: R1727-R1732.
171. Li H, Kentish S, O'Donnell TA, Witten G, Blackshaw LA, Page AJ, (2011). Modulatory effect of NPW on mechanosensitivity of vagal afferents in obesity. Gastroenterology 140: S34-S34.
172. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E, (2002). Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 99: 4692-4696.
173. Li Y, Hao Y, Zhu J, Owyang C, (2000). Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin-stimulated pancreatic secretion in rats. Gastroenterology 118: 1197-1207.
174. Li Y, Wu XY, Owyang C, (2004). Serotonin and cholecystokinin synergistically stimulate rat vagal primary afferent neurones. J Physiol (Lond) 559: 651-662.
175. Liddle RA, Goldfine ID, Rosen MS, Taplitz RA, Williams JA, (1985). Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest 75: 1144-1152.
176. Lieverse RJ, Jansen JB, Masclee AA, Rovati LC, Lamers CB, (1994). Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide. Gut 35: 501-505.
177. Liou AP, Chavez DI, Espero E, Hao S, Wank SA, Raybould HE, (2011). Protein hydrolysate-induced cholecystokinin secretion from enteroendocrine cells is indirectly mediated by the intestinal oligopeptide transporter PepT1. Am J Physiol Gastrointest Liver Physiol 300: G895-G902.
178. Little TJ, Feinle-Bisset C, (2011a). Effects of dietary fat on appetite and energy intake in health and obesity-oral and gastrointestinal sensory contributions. Physiol Behav 104: 613-620.
179. Little TJ, Feinle-Bisset C, (2011b). Oral and gastrointestinal sensing of dietary fat and appetite regulation in humans: modification by diet and obesity. Front Neurosci 4: 1-9.
180. Little TJ, Doran S, Meyer JH, Smout AJ, O'Donovan DG, Wu KL, et al,. (2006). The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed. Am J Physiol Endocrinol Metab 291: E647-E655.
181. Little TJ, Gopinath A, Patel E, McGlone A, Lassman DJ, d'amato M, et al,. (2010). Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK receptor. Neurogastroenterol Motil 22: 1183-1190.
182. Llewellyn-Smith IJ, Reimann F, Gribble FM, Trapp S, (2011). Preproglucagon neurons project widely to autonomic control areas in the mouse brain. Neuroscience 180: 111-121.
183. Lo CM, Ma L, Zhang DM, Lee R, Qin A, Liu M, et al,. (2007). Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Am J Physiol Regul Integr Comp Physiol 292: R268-R273.
184. Lo CM, King A, Samuelson LC, Kindel TL, Rider T, Jandacek RJ, et al,. (2011). Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity. Gastroenterology 138: 1997-2005.
185. Lorenz DN, (1983). Effects of gastric filling and vagotomy on ingestion, nipple attachment, and weight gain by suckling rats. Dev Psychobiol 16: 469-483.
186. Luo J, Liu Z, Liu J, Eugene C, (2010). Distribution pattern of GPRC6A mRNA in mouse tissue by in situ hybridization. Zhong Nan Da Xue Xue Bao Yi Xue Ban 35: 1-10.
187. Ma D, Tao B, Warashina S, Kotani S, Lu L, Kaplamadzhiev D, et al,. (2007). Expression of free fatty acid receptor GPR40 in the central nervous system of adult monkeys. Neurosci Res 58: 394-401.
188. Mace OJ, Affleck J, Patel N, Kellett GL, (2007). Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol 582: 379-392.
189. Madsen AN, Hansen G, Paulsen SJ, Lykkegaard K, Tang-Christensen M, Hansen HS, et al,. (2011). Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome. J Endocrinol 206: 287-296.
190. Makoff A, Lelchuk R, Oxer M, Harrington K, Emson P, (1996). Molecular characterization and localization of human metabotropic glutamate receptor type 4. Brain Res Mol Brain Res 37: 239-248.
191. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, et al,. (2007). T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A 104: 15075-15080.
192. Martin L, Blackstone C, Huganir R, Price D, (1992). Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron 9: 259-270.
193. Matsumura K, Miki T, Jhomori T, Gonoi T, Seino S, (2005). Possible role of PEPT1 in gastrointestinal hormone secretion. Biochem Biophys Res Commun 336: 1028-1032.
194. Matsumura S, Mizushige T, Yoneda T, Iwanaga T, Tsuzuki S, Inoue K, et al,. (2007). GPR expression in the rat taste bud relating to fatty acid sensing. Biomed Res 28: 49-55.
195. Matzinger D, Degen L, Drewe J, Meuli J, Duebendorfer R, Ruckstuhl N, et al,. (2000). The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans. Gut 46: 688-693.
196. Mau M, Mielenz M, Südekum K, Obukhov A, (2011). Expression of GPR30 and GPR43 in oral tissues: deriving new hypotheses on the role of diet in animal physiology and the development of oral cancers. J Anim Physiol Anim Nutr (Berl) 95: 280-285.
197. McIntyre A, Vincent RM, Perkins AC, Spiller RC, (1997). Effect of bran, ispaghula, and inert plastic particles on gastric emptying and small bowel transit in humans: the role of physical factors. Gut 40: 223-227.
198. McLaughlin J, Grazia Luca M, Jones MN, D'Amato M, Dockray GJ, Thompson DG, (1999). Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 116: 46-53.
199. Mei N, (1978). Vagal glucoreceptors in the small intestine of the cat. J Physiol 282: 485-506.
200. Mei N, Garnier L, (1986). Osmosensitive vagal receptors in the small intestine of the cat. J Auton Nerv Syst 16: 159-170.
201. Mei N, Perrin J, Crousillat J, Boyer A, (1984). Comparison between the properties of the vagal and splanchnic glucoreceptors of the small intestine. Involvement in insulin release. J Auton Nerv Syst 10: 275-278.
202. Meier JJ, Goetze O, Anstipp J, Hagemann D, Holst JJ, Schmidt WE, et al,. (2004). Gastric inhibitory polypeptide does not inhibit gastric emptying in humans. Am J Physiol Endocrinol Metab 286: E621-E625.
203. Merchenthaler I, Lane M, Shughrue P, (1999). Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol 403: 261-280.
204. Miyauchi S, Hirasawa A, Iga T, Liu N, Itsubo C, Sadakane K, et al,. (2009). Distribution and regulation of protein expression of the free fatty acid receptor GPR120. Naunyn Schmiedebergs Arch Pharmacol 379: 427-434.
205. Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, et al,. (2002). Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 8: 738-742.
206. Mondal MS, Yamaguchi H, Date Y, Shimbara T, Toshinai K, Shimomura Y, et al,. (2003). A role for neuropeptide W in the regulation of feeding behavior. Endocrinology 144: 4729-4733.
207. Mondal MS, Yamaguchi H, Date Y, Toshinai K, Kawagoe T, Tsuruta T, et al,. (2006). Neuropeptide W is present in antral G cells of rat, mouse, and human stomach. J Endocrinol 188: 49-57.
208. Morales M, Wang SD, (2002). Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system. J Neurosci 22: 6732-6741.
209. Moran AW, Al-Rammahi MA, Arora DK, Batchelor DJ, Coulter EA, Daly K, et al,. (2010a). Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners. Br J Nutr 104: 637-646.
210. Moran AW, Al-Rammahi MA, Arora DK, Batchelor DJ, Coulter EA, Ionescu C, et al,. (2010b). Expression of Na+/glucose co-transporter 1 (SGLT1) in the intestine of piglets weaned to different concentrations of dietary carbohydrate. Br J Nutr 104: 647-655.
211. Moran TH, Smith GP, Hostetler AM, McHugh PR, (1987). Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches. Brain Res 415: 149-152.
212. Moran TH, Ameglio PJ, Schwartz GJ, McHugh PR, (1992). Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am J Physiol 262: R46-R50.
213. Moran TH, Kornbluh R, Moore K, Schwartz GJ, (1994). Cholecystokinin inhibits gastric emptying and contracts the pyloric sphincter in rats by interacting with low affinity CCK receptor sites. Regul Pept 52: 165-172.
214. Morley JE, Alshaher MM, Farr SA, Flood JF, Kumar VB, (1999). Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding. Peptides 20: 595-600.
215. Morley JE, Farr SA, Sell RL, Hileman SM, Banks WA, (2011). Nitric oxide is a central component in neuropeptide regulation of appetite. Peptides 32: 776-780.
216. Nagell CF, Wettergren A, Ãrskov C, Holst JJ, (2006). Inhibitory effect of GLP-1 on gastric motility persists after vagal deafferentation in pigs. Scand J Gastroenterol 41: 667-672.
217. Nakabayashi M, Suzuki T, Takahashi K, Totsune K, Muramatsu Y, Kaneko C, et al,. (2003). Orexin-A expression in human peripheral tissues. Mol Cell Endocrinol 205: 43-50.
218. Nakade Y, Tsukamoto K, Pappas TN, Takahashi T, (2006). Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats. Brain Res 1111: 117-121.
219. Nakagawa A, Satake H, Nakabayashi H, Nishizawa M, Furuya K, Nakano S, et al,. (2004). Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells. Auton Neurosci 110: 36-43.
220. Nakagawa Y, Nagasawa M, Yamada S, Hara A, Mogami H, Nikolaev VO, et al,. (2009). Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS ONE 4: e5106.
221. Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, Goto K, (1999). Distribution of orexin neurons in the adult rat brain. Brain Res 827: 243-260.
222. Naveilhan P, Hassani H, Canals JM, Ekstrand AJ, Larefalk A, Chhajlani V, et al,. (1999). Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat Med 5: 1188-1193.
223. Neary NM, Small CJ, Druce MR, Park AJ, Ellis SM, Semjonous NM, et al,. (2005). Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively. Endocrinology 146: 5120-5127.
224. Nefti W, Chaumontet C, Fromentin G, Tome D, Darcel N, (2009). A high-fat diet attenuates the central response to within-meal satiation signals and modifies the receptor expression of vagal afferents in mice. Am J Physiol Regul Integr Comp Physiol 296: R1681-R1686.
225. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS, (2001). Mammalian sweet taste receptors. Cell 106: 381-390.
226. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, et al,. (2002). An amino-acid taste receptor. Nature 416: 199-202.
227. Neuhuber WL, (1987). Sensory vagal innervation of the rat esophagus and cardia: a light and electron microscopic anterograde tracing study. J Auton Nerv Syst 20: 243-255.
228. Nilsson N, Kotarsky K, Owman C, Olde B, (2003). Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. Biochem Biophys Res Commun 303: 1047-1052.
229. Ning Y, Wang L, Giovannucci EL, (2010). A quantitative analysis of body mass index and colorectal cancer: findings from 56 observational studies. Obes Rev 11: 19-30.
230. Nishizawa M, Nakabayashi H, Uchida K, Nakagawa A, Niijima A, (1996). The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-1, but not to glucose-dependent insulinotropic polypeptide, in the portal vein. J Auton Nerv Syst 61: 149-154.
231. Oh D, Yoon J, Moon M, Hwang J, Choe H, Lee J, et al,. (2008). Identification of farnesyl pyrophosphate and N-arachidonylglycine as endogenous ligands for GPR92. J Biol Chem 283: 21054-21064.
232. Overton H, Babbs A, Doel S, Fyfe M, Gardner L, Griffin G, et al,. (2006). Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 3: 167-175.
233. Ozaki N, Gebhart GF, (2001). Characterization of mechanosensitive splanchnic nerve afferent fibers innervating the rat stomach. Am J Physiol Gastrointest Liver Physiol 281: G1449-G1459.
234. Page AJ, Blackshaw LA, (1998). An in vitro study of the properties of vagal afferent fibres innervating the ferret oesophagus and stomach. J Physiol (Lond) 512: 907-916.
235. Page AJ, Martin CM, Blackshaw LA, (2002). Vagal mechanoreceptors and chemoreceptors in mouse stomach and esophagus. J Neurophysiol 87: 2095-2103.
236. Page AJ, Brierley SM, Martin CM, Price MP, Symonds E, Butler R, et al,. (2005). Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut 54: 1408-1415.
237. Page AJ, Slattery JA, Milte C, Laker R, O'Donnell TA, Dorian C, et al,. (2007). Ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents. Am J Physiol Gastrointest Liver Physiol 292: G1376-G1384.
238. Page AJ, O'Donnell TA, Cooper NJ, Young RL, Blackshaw LA, (2009). Nitric oxide as an endogenous peripheral modulator of visceral sensory neuronal function. J Neurosci 29: 7246-7255.
239. Parker HE, Habib AM, Rogers GJ, Gribble FM, Reimann F, (2009). Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia 52: 289-298.
240. Partosoedarso ER, Young RL, Blackshaw LA, (2001). GABA(B) receptors on vagal afferent pathways: peripheral and central inhibition. Am J Physiol Gastrointest Liver Physiol 280: G658-G668.
241. Paschetta E, Hvalryg M, Musso G, (2011). Glucose-dependent insulinotropic polypeptide: from pathophysiology to therapeutic opportunities in obesity-associated disorders. Obes Rev 12: 813-828.
242. Perrin J, Crousillat J, Mei N, (1981). Assessment of true splanchnic glucoreceptors in the jejuno-ileum of the cat. Brain Res Bull 7: 625-628.
243. Peters JH, McKay BM, Simasko SM, Ritter RC, (2005). Leptin-induced satiation mediated by abdominal vagal afferents. Am J Physiol Regul Integr Comp Physiol 288: R879-R884.
244. Phifer CB, Berthoud HR, (1998). Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem. Am J Physiol 274: R1725-R1733.
245. Pilichiewicz AN, Chaikomin R, Brennan IM, Wishart JM, Rayner CK, Jones KL, et al,. (2007a). Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men. Am J Physiol Endocrinol Metab 293: E743-E753.
246. Pilichiewicz AN, Papadopoulos P, Brennan IM, Little TJ, Meyer JH, Wishart JM, et al,. (2007b). Load-dependent effects of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 293: R2170-R2178.
247. Powley TL, Phillips RJ, (2011). Vagal intramuscular array afferents form complexes with interstitial cells of Cajal in gastrointestinal smooth muscle: analogues of muscle spindle organs? Neuroscience 186: 188-200.
248. Punjabi M, Arnold M, Geary N, Langhans W, Pacheco-Lopez G, (2011). Peripheral glucagon-like peptide-1 (GLP-1) and satiation. Physiol Behav 105: 71-76.
249. Raliou M, Boucher Y, Wiencis A, Bézirard V, Pernollet J, Trotier D, et al,. (2009). Tas1R1-Tas1R3 taste receptor variants in human fungiform papillae. Neurosci Lett 451: 217-221.
250. Ranieri F, Mei N, Crousillat J, (1973). Splanchnic afferents arising from gastro-intestinal and peritoneal mechanoreceptors. Exp Brain Res 16: 276-290.
251. Ray J, Squires P, Curtis S, Meloche M, Buchan A, (1997). Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest 99: 2328-2333.
252. Raybould HE, (1998). Does your gut taste? Sensory transduction in the gastrointestinal tract. News Physiol Sci 13: 275-280.
253. Raybould HE, (2009). Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci 153: 41-46.
254. Raybould HE, Holzer H, (1992). Dual capsaicin-sensitive afferent pathways mediate inhibition of gastric emptying in rat induced by intestinal carbohydrate. Neurosci Lett 141: 236-238.
255. Raybould HE, Glatzle J, Robin C, Meyer JH, Phan T, Wong H, et al,. (2003). Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. Am J Physiol Gastrointest Liver Physiol 284: G367-G372.
256. Rehfeld JF, (1978). Immunochemical studies on cholecystokinin. II. Distribution and molecular heterogeneity in the central nervous system and small intestine of man and hog. J Biol Chem 253: 4022-4030.
257. Reidelberger RD, Hernandez J, Fritzsch B, Hulce M, (2004). Abdominal vagal mediation of the satiety effects of CCK in rats. Am J Physiol Regul Integr Comp Physiol 286: R1005-R1012.
258. Reimann F, (2010). Molecular mechanisms underlying nutrient detection by incretin-secreting cells. Int Dairy J 20: 236-242.
259. Ren X, Zhou L, Terwilliger R, Newton SS, de Araujo IE, (2009). Sweet taste signaling functions as a hypothalamic glucose sensor. Front Integr Neurosci 3: 1-15.
260. Renshaw D, Batterham RL, (2005). Peptide YY: a potential therapy for obesity. Curr Drug Targets 6: 171-179.
261. Rindi G, Leiter AB, Kopin AS, Bordi C, Solcia E, (2004). The 'normal' endocrine cell of the gut: changing concepts and new evidences. Ann N Y Acad Sci 1014: 1-12.
262. Ritter RC, (2004). Gastrointestinal mechanisms of satiation for food. Physiol Behav 81: 249-273.
263. le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, et al,. (2006). Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147: 3-8.
264. Roze C, Couturier D, Chariot J, Debray C, (1977). Inhibition of gastric electrical and mechanical activity by intraduodenal agents in pigs and the effects of vagotomy. Digestion 15: 526-539.
265. Ruat M, Molliver M, Snowman A, Snyder S, (1995). Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proc Natl Acad Sci U S A 92: 3161-3165.
266. Rubino F, Schauer PR, Kaplan LM, Cummings DE, (2010). Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action. Annu Rev Med 61: 393-411.
267. Sakamoto Y, Inoue H, Kawakami S, Miyawaki K, Miyamoto T, Mizuta K, et al,. (2006). Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: predominant localization in pancreatic polypeptide-secreting PP-cells. Biochem Biophys Res Commun 351: 474-480.
268. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al,. (1998). Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92: 573-585.
269. Samuel B, Shaito A, Motoike T, Rey F, Backhed F, Manchester J, et al,. (2008). Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A 105: 16767-16772.
270. San Gabriel A, Maekawa T, Uneyama H, Yoshie S, Torii K, (2007). mGluR1 in the fundic glands of rat stomach. FEBS Lett 581: 1119-1123.
271. Savastano DM, Carelle M, Covasa M, (2005). Serotonin-type 3 receptors mediate intestinal Polycose- and glucose-induced suppression of intake. Am J Physiol Regul Integr Comp Physiol 288: R1499-R1508.
272. Savastano DM, Hayes MR, Covasa M, (2007). Serotonin-type 3 receptors mediate intestinal lipid-induced satiation and Fos-like immunoreactivity in the dorsal hindbrain. Am J Physiol Regul Integr Comp Physiol 292: R1063-R1070.
273. Schick RR, Harty GJ, Yaksh TL, Go VL, (1990). Sites in the brain at which cholecystokinin octapeptide (CCK-8) acts to suppress feeding in rats: a mapping study. Neuropharmacology 29: 109-118.
274. Schirra J, Goke B, (2005). The physiological role of GLP-1 in human: incretin, ileal brake or more? Regul Pept 128: 109-115.
275. Schoepp D, Goldsworthy J, Johnson B, Salhoff C, Baker S, (1994). 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J Neurochem 63: 769-772.
276. Schwartz GJ, Berkow G, McHugh PR, Moran TH, (1993). Gastric branch vagotomy blocks nutrient and cholecystokinin-induced suppression of gastric emptying. Am J Physiol 264: R630-R637.
277. Schwartz GJ, Whitney A, Skoglund C, Castonguay TW, Moran TH, (1999). Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors. Am J Physiol 277: R1144-R1151.
278. Sclafani A, Ackroff K, Schwartz GJ, (2003). Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients. Physiol Behav 78: 285-294.
279. Scott V, Kimura N, Stark JA, Luckman SM, (2005). Intravenous peptide YY3-36 and Y2 receptor antagonism in the rat: effects on feeding behaviour. J Neuroendocrinol 17: 452-457.
280. Shen T, Kaya N, Zhao FL, Lu SG, Cao Y, Herness S, (2005). Co-expression patterns of the neuropeptides vasoactive intestinal peptide and cholecystokinin with the transduction molecules alpha-gustducin and T1R2 in rat taste receptor cells. Neuroscience 130: 229-238.
281. Shimomura Y, Harada M, Goto M, Sugo T, Matsumoto Y, Abe M, et al,. (2002). Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8. J Biol Chem 277: 35826-35832.
282. Smith GP, Jerome C, Norgren R, (1985). Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am J Physiol 249: R638-R641.
283. Sobhani I, Bado A, Vissuzaine C, Buyse M, Kermorgant S, Laigneau JP, et al,. (2000). Leptin secretion and leptin receptor in the human stomach. Gut 47: 178-183.
284. Sobhani I, Buyse M, Goiot H, Weber N, Laigneau JP, Henin D, et al,. (2002). Vagal stimulation rapidly increases leptin secretion in human stomach. Gastroenterology 122: 259-263.
285. Soga T, Ohishi T, Matsui T, Saito T, Matsumoto M, Takasaki J, et al,. (2005). Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem Biophys Res Commun 326: 744-751.
286. Spannagel AW, Nakano I, Tawil T, Chey WY, Liddle RA, Green GM, (1996). Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats. Am J Physiol 270: G128-G135.
287. Steinert R, Beglinger C, (2011). Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides. Physiol Behav 105: 62-70.
288. Stephan D, Bon C, Holzwarth J, Galvan M, Pruss R, (1996). Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants. Neuropharmacology 35: 1649-1660.
289. Strader AD, Woods SC, (2005). Gastrointestinal hormones and food intake. Gastroenterology 128: 175-191.
290. Sullivan CN, Raboin SJ, Gulley S, Sinzobahamvya NT, Green GM, Reeve JJR, et al,. (2007). Endogenous cholecystokinin reduces food intake and increases Fos-like immunoreactivity in the dorsal vagal complex but not in the myenteric plexus by CCK1 receptor in the adult rats. Am J Physiol Regul Integr Comp Physiol 292: R1071-R1080.
291. Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, et al,. (2011). Long-term persistence of hormonal adaptations to weight loss. N Engl J Med 365: 1597-1604.
292. Sutherland K, Brierley SM, Horowitz M, Rayner CK, Blackshaw LA, Young RL, (2007). Sweet taste transduction molecules are expressed in the upper gastrointestinal tract in humans. Gastroenterology 132: A587.
293. Takahashi N, Okumura T, Yamada H, Kohgo Y, (1999). Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem Biophys Res Commun 254: 623-627.
294. Tanabe Y, Nomura A, Masu M, Shigemoto R, Mizuno N, Nakanishi S, (1993). Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4. J Neurosci 13: 1372-1378.
295. Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, et al,. (2003). Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc Natl Acad Sci U S A 100: 6251-6256.
296. Tanaka T, Katsuma S, Adachi T, Koshimizu T, Hirasawa A, Tsujimoto G, (2007). Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedebergs Arch Pharmacol 377: 523-527.
297. Taylor AI, Irwin N, McKillop AM, Patterson S, Flatt PR, Gault VA, (2011). Evaluation of the degradation and metabolic effects of the gut peptide xenin on insulin secretion, glycaemic control and satiety. J Endocrinol 207: 87-93.
298. Tazoe H, Otomo Y, Karaki S, Kato I, Fukami Y, Terasaki M, et al,. (2009). Expression of short-chain fatty acid receptor GPR41 in the human colon. Biomed Res 30: 149-156.
299. Testa C, Standaert D, Young A, Penney J, (1994). Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat. J Neurosci 14: 3005-3018.
300. Thomsen C, Suzdak P, (1993). Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport 4: 1099-1101.
301. Tolhurst G, Reimann F, Gribble FM, (2009). Nutritional regulation of glucagon-like peptide-1 secretion. J Physiol 587: 27-32.
302. Tomas E, Wood JA, Stanojevic V, Habener JF, (2011). Glucagon-like peptide-1(9-36)amide metabolite inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice. Diabetes Obes Metab 13: 26-33.
303. Toouli J, Collins J, Wray N, Billington C, Knudson M, Pulling C, et al,. (2007). Vagal blocking for obesity control (VBLOC): effects on excess weight loss, calorie intake, satiation and satiety. Obes Surg 17: 1043-1043.
304. Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K, (2003). Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell Tissue Res 313: 29-35.
305. Tuleu C, Andrieux C, Boy P, Chaumeil JC, (1999). Gastrointestinal transit of pellets in rats: effect of size and density. Int J Pharm 180: 123-131.
306. Vahl TP, Tauchi M, Durler TS, Elfers EE, Fernandes TM, Bitner RD, et al,. (2007). Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats. Endocrinology 148: 4965-4973.
307. Vrang N, Madsen AN, Tang-Christensen M, Hansen G, Larsen PJ, (2006). PYY(3-36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 291: R367-R375.
308. Vrang N, Hansen M, Larsen PJ, Tang-Christensen M, (2007). Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei. Brain Res 1149: 118-126.
309. Wadden TA, Butryn ML, Byrne KJ, (2004). Efficacy of lifestyle modification for long-term weight control. Obes Res 12: 151S-162S.
310. Walls EK, Phillips RJ, Wang FB, Holst MC, Powley TL, (1995). Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation. Am J Physiol 269: R1410-R1419.
311. Wan S, Browning KN, Coleman FH, Sutton G, Zheng H, Butler A, et al,. (2008). Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons. J Neurosci 28: 4957-4966.
312. Wang J, Wu X, Simonavicius N, Tian H, Ling L, (2006). Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem 281: 34457-34464.
313. Wang Y, Chandra R, Samsa L, Gooch B, Fee B, Cook J, et al,. (2011). Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. Am J Physiol Gastrointest Liver Physiol 300: G528-G537.
314. Wellendorph P, Bräuner-Osborne H, (2004). Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene 335: 37-46.
315. Wellendorph P, Hansen K, Balsgaard A, Greenwood J, Egebjerg J, Bräuner-Osborne H, (2005). Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Mol Pharmacol 67: 589-597.
316. West DB, Fey D, Woods SC, (1984). Cholecystokinin persistently suppresses meal size but not food intake in free-feeding rats. Am J Physiol 246: R776-R787.
317. Whited KL, Thao D, Lloyd KCK, Kopin AS, Raybould HE, (2006). Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function. Am J Physiol Gastrointest Liver Physiol 291: G156-G162.
318. Wilkinson AR, Johnston D, (1973). Effect of truncal, selective and highly selective vagotomy on gastric emptying and intestinal transit of a food-barium meal in man. Ann Surg 178: 190-193.
319. Williams DL, Baskin DG, Schwartz MW, (2009). Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 150: 1680-1687.
320. Wolf G, (1998). Orexins: a newly discovered family of hypothalamic regulators of food intake. Nutr Rev 56: 172-173.
321. World Health Organization (2011). Obesity and Overweight. Fact Sheet No. 311, updated March 2011. Available at:.
322. Wu XY, Zhu JX, Gao J, Owyang C, Li Y, (2005). Neurochemical phenotype of vagal afferent neurons activated to express C-FOS in response to luminal stimulation in the rat. Neuroscience 130: 757-767.
323. Xiong Y, Miyamoto N, Shibata K, Valasek M, Motoike T, Kedzierski R, et al,. (2004). Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A 101: 1045-1050.
324. Yamada K, Emson P, Hokfelt T, (1996). Immunohistochemical mapping of nitric oxide synthase in the rat hypothalamus and colocalization with neuropeptides. J Chem Neuroanat 10: 295-316.
325. Yip RG, Boylan MO, Kieffer TJ, Wolfe MM, (1998). Functional GIP receptors are present on adipocytes. Endocrinology 139: 4004-4007.
326. Yoshioka M, Doucet E, Drapeau V, Dionne I, Tremblay A, (2001). Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br J Nutr 85: 203-211.
327. Young RL, (2011). Sensing via intestinal sweet taste pathways. Front Neurosci 5: 1-13.
328. Young RL, Sutherland K, Pezos N, Brierley SM, Ma J, Rayner CK, et al,. (2010). Control of intestinal sweet taste receptor expression is impaired in type 2 diabetes. Neurogastroenterol Motil 22 (Suppl 1): 31.
329. Yox DP, Ritter RC, (1988). Capsaicin attenuates suppression of sham feeding induced by intestinal nutrients. Am J Physiol 255: R569-R574.
330. Yox DP, Brenner L, Ritter RC, (1992). CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients. Am J Physiol 262: R554-R561.
331. Zagorodnyuk V, Chen B, Brookes S, (2001). Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach. J Physiol 534: 255-268.
332. Zaibi M, Stocker C, O'Dowd J, Davies A, Bellahcene M, Cawthorne M, et al,. (2010). Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids. FEBS Lett 584: 2381-2386.
333. Zhang LL, Yan Liu D, Ma LQ, Luo ZD, Cao TB, Zhong J, et al,. (2007). Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity. Circ Res 100: 1063-1070.
334. Zhang X, Ji RR, Arvidsson J, Lundberg JM, Bartfai T, Bedecs K, et al,. (1996). Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions. Exp Brain Res 111: 393-404.
335. Zhang X, Shi T, Holmberg K, Landry M, Huang W, Xiao H, et al,. (1997). Expression and regulation of the neuropeptide Y Y2 receptor in sensory and autonomic ganglia. Proc Natl Acad Sci U S A 94: 729-734.
336. Zhu J, Zhu X, Owyang C, Li Y, (2001). Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J Physiol 530: 431-442.