Inhibition of gastric inhibitory polypeptide signaling prevents obesity

Nature Medicine

Volumn 8, Issue 7, 2002, Pages 738-742

  Miyawaki, Kazumasa ^a   Yamada, Yuichiro ^a   Ban, Nobuhiro ^a   Ihara, Yu ^a   Tsukiyama, Katsushi ^a   Zhou, Heying ^a   Fujimoto, Shimpei ^a   Oku, Akira ^a   Tsuda, Kinsuke ^a   Toyokuni, Shinya ^a   Hiai, Hiroshi ^a   Mizunoya, Wataru ^a   Fushiki, Tohru ^a   Holst, Jens Juul ^b   Makino, Mitsuhiro ^c   Tashita, Akira ^c   Kobara, Yukari ^c   Tsubamoto, Yoshiharu ^c   Jinnouchi, Takayoshi ^c   Jomori, Takahito ^c   Seino, Yutaka ^a   more..

^a KYOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c SANWA KAGAKU KENKYUSHO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAT; GASTRIC INHIBITORY POLYPEPTIDE; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROSS BREEDING; ENERGY CONSUMPTION; FEEDING; HOMOZYGOSITY; HORMONE INHIBITION; HORMONE RELEASE; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; MOUSE; NONHUMAN; OBESITY; OVERNUTRITION; PRIORITY JOURNAL; PROTECTION; RESPIRATORY QUOTIENT; SIGNAL TRANSDUCTION; SUBCUTANEOUS FAT; WEIGHT GAIN; WILD TYPE;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; CROSSES, GENETIC; DIETARY FATS; GASTRIC INHIBITORY POLYPEPTIDE; MICE; MICE, KNOCKOUT; OBESITY; RECEPTORS, GASTROINTESTINAL HORMONE; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0036068322     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm727     Document Type: Article

References (24)

1. Diabetes mellitus: A thrifty genotype rendered detrimental by progress
2. The "thrifty genotype" in 1998
3. Obesity and the regulation of energy balance
4. The role of dietary fat in obesity
5. Dietary fat intake does affect obesity
6. Gastric inhibitory polypeptide (GIP) stimulated by fat ingestion in man
7. Glucose intolerance caused by a defect in the entero-insular axis: A study in gastric inhibitory polypeptide receptor knockout mice
8. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
9. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
10. Obesity and insulin resistance
11. The hormone resistin links obesity to diabetes
12. Positional cloning of the mouse obese gene and its human homologue
13. Weight-reducing effects of the plasma protein encoded by the obese gene
14. Comparative determinations of rat body composition by chemical, near infrared reflectance and total body electrical conductivity analyses
15. Comparison of TOBEC-derived total body fat with fat pad weights
16. Gastric inhibitory polypeptide
17. Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
18. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion
19. Lipoprotein lipase and lipolysis: Central roles in lipoprotein metabolism and atherogenesis
20. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat
21. Development of leptin resistance in rat soleus muscle in response to high-fat diets
22. Peptides and the control of meal size
23. A single oral administration of conjugated linoleic acid enhanced energy metabolism in mice
24. Diminished immunoreactive gastric inhibitory polypeptide response to a meal in newly diagnosed type I (insulin-dependent) diabetics