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Volumn 152, Issue 8, 2011, Pages 3103-3112

Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN (9-39); EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; LIRAGLUTIDE; PROTEIN INHIBITOR; SALCATONIN; UNCLASSIFIED DRUG;

EID: 79960741385     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-0174     Document Type: Article
Times cited : (276)

References (53)
  • 1
    • 79952531665 scopus 로고    scopus 로고
    • Center for Disease Control and Prevention
    • Center for Disease Control and Prevention 2009 Overweight and obesity: data and statistics. Center for Disease Control and Prevention. www.cdc.gov/obesity/data/trends.html
    • (2009) Overweight and Obesity: Data and Statistics
  • 2
    • 34247851021 scopus 로고    scopus 로고
    • The Epidemiology of Obesity
    • DOI 10.1053/j.gastro.2007.03.052, PII S0016508507005793
    • Ogden CL, Yanovski SZ, Carroll MD, Flegal KM 2007 The epidemiology of obesity. Gastroenterology 132:2087-2102 (Pubitemid 46693751)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2087-2102
    • Ogden, C.L.1    Yanovski, S.Z.2    Carroll, M.D.3    Flegal, K.M.4
  • 3
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • DOI 10.1002/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5
    • Merchenthaler I, Lane M, Shughrue P 1999 Distribution of pre-proglucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol 403:261-280 (Pubitemid 28566834)
    • (1999) Journal of Comparative Neurology , vol.403 , Issue.2 , pp. 261-280
    • Merchenthaler, I.1    Lane, M.2    Shughrue, P.3
  • 4
    • 0025343831 scopus 로고
    • Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas
    • Mojsov S, Kopczynski MG, Habener JF 1990 Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem 265:8001-8008
    • (1990) J Biol Chem , vol.265 , pp. 8001-8008
    • Mojsov, S.1    Kopczynski, M.G.2    Habener, J.F.3
  • 5
    • 77953724336 scopus 로고    scopus 로고
    • Role of the glucagon-like-peptide-1 receptor in the control of energy balance
    • Hayes MR, De Jonghe BC, Kanoski SE 2010 Role of the glucagon-like- peptide-1 receptor in the control of energy balance. Physiol Behav 100:503-510
    • (2010) Physiol Behav , vol.100 , pp. 503-510
    • Hayes, M.R.1    De Jonghe, B.C.2    Kanoski, S.E.3
  • 6
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • DOI 10.1152/physrev.00034.2006
    • Holst JJ 2007 The physiology of glucagon-like peptide 1. Physiol Rev 87:1409-1439 (Pubitemid 350041474)
    • (2007) Physiological Reviews , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 7
    • 17844399596 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors
    • DOI 10.1007/s00125-005-1705-7
    • Holst JJ, Deacon CF 2005 Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia 48:612-615 (Pubitemid 40591213)
    • (2005) Diabetologia , vol.48 , Issue.4 , pp. 612-615
    • Holst, J.J.1    Deacon, C.F.2
  • 11
    • 76249121426 scopus 로고    scopus 로고
    • Liraglutide for weight loss in obese people
    • author reply 552-553
    • Thum T, Anker SD 2010 Liraglutide for weight loss in obese people. Lancet 375:551-552; author reply 552-553
    • (2010) Lancet , vol.375 , pp. 551-552
    • Thum, T.1    Anker, S.D.2
  • 12
    • 18144381593 scopus 로고    scopus 로고
    • 3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway
    • DOI 10.1016/j.brainres.2005.03.011
    • Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JR, Ghatei MA, Bloom SR 2005 The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 1044:127-131 (Pubitemid 40616060)
    • (2005) Brain Research , vol.1044 , Issue.1 , pp. 127-131
    • Abbott, C.R.1    Monteiro, M.2    Small, C.J.3    Sajedi, A.4    Smith, K.L.5    Parkinson, J.R.C.6    Ghatei, M.A.7    Bloom, S.R.8
  • 13
    • 67649636449 scopus 로고    scopus 로고
    • Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms
    • Rüttimann EB, Arnold M, Hillebrand JJ, Geary N, Langhans W 2009 Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms. Endocrinology 150:1174-1181
    • (2009) Endocrinology , vol.150 , pp. 1174-1181
    • Rüttimann, E.B.1    Arnold, M.2    Hillebrand, J.J.3    Geary, N.4    Langhans, W.5
  • 14
    • 63849248275 scopus 로고    scopus 로고
    • Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety
    • Williams DL, Baskin DG, Schwartz MW 2009 Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 150:1680-1687
    • (2009) Endocrinology , vol.150 , pp. 1680-1687
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 16
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • DOI 10.1007/s00125-001-0719-z
    • Agerso H, Jensen LB, Elbrond B, Rolan P, Zdravkovic M 2002 The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 45:195-202 (Pubitemid 34208381)
    • (2002) Diabetologia , vol.45 , Issue.2 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3    Rolan, P.4    Zdravkovic, M.5
  • 17
    • 0037349072 scopus 로고    scopus 로고
    • Entry of exendin-4 into brain is rapid but may be limited at high doses
    • Kastin AJ, Akerstrom V 2003 Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord 27:313-318
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. 313-318
    • Kastin, A.J.1    Akerstrom, V.2
  • 19
    • 0028019633 scopus 로고
    • A method for selective section of vagal afferent or efferent axons in the rat
    • Norgren R, Smith GP 1994 A method for selective section of vagal afferent or efferent axons in the rat. Am J Physiol Regul Integr Comp Physiol 267:R1136-R1141
    • (1994) Am J Physiol Regul Integr Comp Physiol , vol.267
    • Norgren, R.1    Smith, G.P.2
  • 20
    • 0019794835 scopus 로고
    • Glucoreceptors controlling feeding and blood glucose: Location in the hindbrain
    • Ritter RC, Slusser PG, Stone S 1981 Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213:451-452
    • (1981) Science , vol.213 , pp. 451-452
    • Ritter, R.C.1    Slusser, P.G.2    Stone, S.3
  • 21
    • 33751120393 scopus 로고    scopus 로고
    • Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat
    • DOI 10.1523/JNEUROSCI.2606-06.2006
    • Arnold M, Mura A, Langhans W, Geary N 2006 Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci 26:11052-11060 (Pubitemid 44772195)
    • (2006) Journal of Neuroscience , vol.26 , Issue.43 , pp. 11052-11060
    • Arnold, M.1    Mura, A.2    Langhans, W.3    Geary, N.4
  • 25
    • 0028171996 scopus 로고
    • Exendin-4 and exendin-(9-39)NH2: Agonist and antagonist, respectively, at the rat parietal cell receptor for glucagon-like peptide-1-(7-36)NH2
    • Schepp W, Schmidtler J, Riedel T, Dehne K, Schusdziarra V, Holst JJ, Eng J, Raufman JP, Classen M 1994 Exendin-4 and exendin-(9-39)NH2: agonist and antagonist, respectively, at the rat parietal cell receptor for glucagon-like peptide-1-(7-36)NH2. Eur J Pharmacol 269:183-191
    • (1994) Eur J Pharmacol , vol.269 , pp. 183-191
    • Schepp, W.1    Schmidtler, J.2    Riedel, T.3    Dehne, K.4    Schusdziarra, V.5    Holst, J.J.6    Eng, J.7    Raufman, J.P.8    Classen, M.9
  • 26
    • 0000385121 scopus 로고    scopus 로고
    • Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans
    • Schirra J, Sturm K, Leicht P, Arnold R, Göke B, Katschinski M 1998 Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans. J Clin Invest 101:1421-1430
    • (1998) J Clin Invest , vol.101 , pp. 1421-1430
    • Schirra, J.1    Sturm, K.2    Leicht, P.3    Arnold, R.4    Göke, B.5    Katschinski, M.6
  • 27
    • 2142750158 scopus 로고    scopus 로고
    • Brain Uptake of the Glucagon-Like Peptide-1 Antagonist Exendin(9-39) after Intranasal Administration
    • DOI 10.1124/jpet.103.063222
    • Banks WA, During MJ, Niehoff ML 2004 Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration. J Pharmacol Exp Ther 309:469-475 (Pubitemid 38542596)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.309 , Issue.2 , pp. 469-475
    • Banks, W.A.1    During, M.J.2    Niehoff, M.L.3
  • 28
    • 77956893157 scopus 로고    scopus 로고
    • Liraglutide: The therapeutic promise from animal models
    • Knudsen LB 2010 Liraglutide: the therapeutic promise from animal models. Int J Clin Pract Suppl 64:4-11
    • (2010) Int J Clin Pract Suppl , vol.64 , pp. 4-11
    • Knudsen, L.B.1
  • 29
    • 47949104953 scopus 로고    scopus 로고
    • Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation
    • Hayes MR, Skibicka KP, Grill HJ 2008 Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Endocrinology 149:4059-4068
    • (2008) Endocrinology , vol.149 , pp. 4059-4068
    • Hayes, M.R.1    Skibicka, K.P.2    Grill, H.J.3
  • 31
    • 33847072735 scopus 로고    scopus 로고
    • Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not
    • Raun K, von Voss P, Gotfredsen CF, Golozoubova V, Rolin B, Knudsen LB 2007 Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not. Diabetes 56:8-15
    • (2007) Diabetes , vol.56 , pp. 8-15
    • Raun, K.1    Von Voss, P.2    Gotfredsen, C.F.3    Golozoubova, V.4    Rolin, B.5    Knudsen, L.B.6
  • 32
    • 34547951456 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human glucagon-like peptide-1 analog, minimizes food intake in severely obese minipigs
    • Raun K, von Voss P, Knudsen LB 2007 Liraglutide, a once-daily human glucagon-like peptide-1 analog, minimizes food intake in severely obese minipigs. Obesity (Silver Spring) 15:1710-1716 (Pubitemid 47264950)
    • (2007) Obesity , vol.15 , Issue.7 , pp. 1710-1716
    • Raun, K.1    Von Voss, P.2    Knudsen, L.B.3
  • 33
    • 34249869806 scopus 로고    scopus 로고
    • Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
    • DOI 10.2337/dc06-2593
    • Vilsboll T, Zdravkovic M, Le-Thi T, Krarup T, Schmitz O, Courrèges JP, Verhoeven R, Bugánová I, Madsbad S 2007 Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes. Diabetes Care 30:1608-1610 (Pubitemid 46871185)
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1608-1610
    • Vilsboll, T.1    Zdravkovic, M.2    Le-Thi, T.3    Krarup, T.4    Schmitz, O.5    Courreges, J.-P.6    Verhoeven, R.7    Buganova, I.8    Madsbad, S.9
  • 34
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • DOI 10.1111/j.1463-1326.2006.00602.x
    • Blonde L, Klein EJ, Han J, Zhang B, Mac SM, Poon TH, Taylor KL, Trautmann ME, Kim DD, Kendall DM 2006 Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab 8:436-447 (Pubitemid 44349236)
    • (2006) Diabetes, Obesity and Metabolism , vol.8 , Issue.4 , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3    Zhang, B.4    Mac, S.M.5    Poon, T.H.6    Taylor, K.L.7    Trautmann, M.E.8    Kim, D.D.9    Kendall, D.M.10
  • 35
    • 33845911799 scopus 로고    scopus 로고
    • Distributed neural control of energy balance: Contributions from hindbrain and hypothalamus
    • Silver Spring
    • Grill HJ 2006 Distributed neural control of energy balance: contributions from hindbrain and hypothalamus. Obesity (Silver Spring) 14(Suppl 5):216S-221S
    • (2006) Obesity , vol.14 , Issue.SUPPL. 5
    • Grill, H.J.1
  • 36
    • 66649088029 scopus 로고    scopus 로고
    • Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling
    • Hayes MR, Bradley L, Grill HJ 2009 Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling. Endocrinology 150:2654-2659
    • (2009) Endocrinology , vol.150 , pp. 2654-2659
    • Hayes, M.R.1    Bradley, L.2    Grill, H.J.3
  • 37
    • 0030819077 scopus 로고    scopus 로고
    • Decreased intake of a liquid diet in nonfood-deprived rats following intra-PVN injections of GLP-1 (7-36) amide
    • DOI 10.1016/S0091-3057(97)90017-4, PII S0091305797000178
    • McMahon LR, Wellman PJ 1997 Decreased intake of a liquid diet in nonfood-deprived rats following intra-PVN injections of GLP-1 (7-36) amide. Pharmacol Biochem Behav 58:673-677 (Pubitemid 27438122)
    • (1997) Pharmacology Biochemistry and Behavior , vol.58 , Issue.3 , pp. 673-677
    • McMahon, L.R.1    Wellman, P.J.2
  • 38
    • 0031891391 scopus 로고    scopus 로고
    • PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats
    • McMahon LR, Wellman PJ 1998 PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats. Am J Physiol Regul Integr Comp Physiol 274:R23-R29
    • (1998) Am J Physiol Regul Integr Comp Physiol , vol.274
    • McMahon, L.R.1    Wellman, P.J.2
  • 39
    • 0036896243 scopus 로고    scopus 로고
    • The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness
    • Kinzig KP, D'Alessio DA, Seeley RJ 2002 The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness. J Neurosci 22:10470-10476 (Pubitemid 35416883)
    • (2002) Journal of Neuroscience , vol.22 , Issue.23 , pp. 10470-10476
    • Kinzig, K.P.1    D'Alessio, D.A.2    Seeley, R.J.3
  • 40
    • 34447618969 scopus 로고    scopus 로고
    • Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK
    • DOI 10.1016/j.brainres.2007.06.016, PII S0006899307013698
    • Becskei C, Grabler V, Edwards GL, Riediger T, Lutz TA 2007 Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK. Brain Res 1162:76-84 (Pubitemid 47088378)
    • (2007) Brain Research , vol.1162 , Issue.1 , pp. 76-84
    • Becskei, C.1    Grabler, V.2    Edwards, G.L.3    Riediger, T.4    Lutz, T.A.5
  • 41
    • 33751255688 scopus 로고    scopus 로고
    • Chemical stimulation of visceral afferents activates medullary neurones projecting to the central amygdala and periaqueductal grey
    • DOI 10.1016/j.brainresbull.2006.07.016, PII S0361923006002437
    • Viltart O, Sartor DM, Verberne AJ 2006 Chemical stimulation of visceral afferents activates medullary neurones projecting to the central amygdala and periaqueductal grey. Brain Res Bull 71:51-59 (Pubitemid 44781151)
    • (2006) Brain Research Bulletin , vol.71 , Issue.1-3 , pp. 51-59
    • Viltart, O.1    Sartor, D.M.2    Verberne, A.J.M.3
  • 42
    • 33646550541 scopus 로고    scopus 로고
    • Gastric distension enhances CCK-induced Fos-like immunoreactivity in the dorsal hindbrain by activating 5-HT3 receptors
    • DOI 10.1016/j.brainres.2006.03.018, PII S0006899306007402
    • Hayes MR, Covasa M 2006 Gastric distension enhances CCK-induced Fos-like immunoreactivity in the dorsal hindbrain by activating 5-HT3 receptors. Brain Res 1088:120-130 (Pubitemid 43729418)
    • (2006) Brain Research , vol.1088 , Issue.1 , pp. 120-130
    • Hayes, M.R.1    Covasa, M.2
  • 43
    • 34247639607 scopus 로고    scopus 로고
    • Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei
    • DOI 10.1016/j.brainres.2007.02.043, PII S0006899307003423
    • Vrang N, Hansen M, Larsen PJ, Tang-Christensen M 2007 Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei. Brain Res 1149:118-126 (Pubitemid 46671416)
    • (2007) Brain Research , vol.1149 , Issue.1 , pp. 118-126
    • Vrang, N.1    Hansen, M.2    Larsen, P.J.3    Tang-Christensen, M.4
  • 48
    • 77949837737 scopus 로고    scopus 로고
    • Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the Glp-1 receptor agonist
    • Baraboi ED, Smith P, Ferguson AV, Richard D 2010 Lesions of area postrema and subfornical organ alter exendin-4-induced brain activation without preventing the hypophagic effect of the Glp-1 receptor agonist. Am J Physiol Regul Integr Comp Physiol 298:R1098-R1110
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298
    • Baraboi, E.D.1    Smith, P.2    Ferguson, A.V.3    Richard, D.4
  • 49
    • 0028867442 scopus 로고
    • Distribution of GLP-1 binding sites in the rat brain: Evidence that exendin-4 is a ligand of brain GLP-1 binding sites
    • Göke R, Larsen PJ, Mikkelsen JD, Sheikh SP 1995 Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites. Eur J Neurosci 7:2294-2300
    • (1995) Eur J Neurosci , vol.7 , pp. 2294-2300
    • Göke, R.1    Larsen, P.J.2    Mikkelsen, J.D.3    Sheikh, S.P.4
  • 50
    • 23844554610 scopus 로고    scopus 로고
    • 3-36 synergistically reduce food intake through different mechanisms in mice
    • DOI 10.1210/en.2005-0473
    • Talsania T, Anini Y, Siu S, Drucker DJ, Brubaker PL 2005 Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice. Endocrinology 146:3748-3756 (Pubitemid 41175742)
    • (2005) Endocrinology , vol.146 , Issue.9 , pp. 3748-3756
    • Talsania, T.1    Anini, Y.2    Siu, S.3    Drucker, D.J.4    Brubaker, P.L.5
  • 51
    • 78650677674 scopus 로고    scopus 로고
    • Effects of exendin-4 alone and with peptide YY(3-36) on food intake and body weight in diet-induced obese rats
    • Silver Spring
    • Reidelberger RD, Haver AC, Apenteng BA, Anders KL, Steenson SM 2011 Effects of exendin-4 alone and with peptide YY(3-36) on food intake and body weight in diet-induced obese rats. Obesity (Silver Spring) 19:121-127
    • (2011) Obesity , vol.19 , pp. 121-127
    • Reidelberger, R.D.1    Haver, A.C.2    Apenteng, B.A.3    Anders, K.L.4    Steenson, S.M.5
  • 52
    • 0023622052 scopus 로고
    • An investigation of tolerance to the actions of leptogenic and anorexigenic drugs in mice
    • DOI 10.1016/0024-3205(87)90534-0
    • Morley JE, Flood JF 1987 An investigation of tolerance to the actions of leptogenic and anorexigenic drugs in mice. Life Sci 41:2157-2165 (Pubitemid 18032328)
    • (1987) Life Sciences , vol.41 , Issue.18 , pp. 2157-2165
    • Morley, J.E.1    Flood, J.F.2


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