Cholecystokinin Knockout Mice Are Resistant to High-Fat Diet-Induced Obesity

Gastroenterology

Volumn 138, Issue 5, 2010, Pages 1997-2005

  Lo, Chun Min ^a,b   King, Alexandra ^a   Samuelson, Linda C ^c   Kindel, Tammy Lyn ^b   Rider, Therese ^b   Jandacek, Ronald J ^a,b   Raybould, Helen E ^d   Woods, Stephen C ^a,e   Tso, Patrick ^a,b  

^a UNIVERSITY OF CINCINNATI   (United States)

^b Genome Research Institute   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

CCK Receptor; Cholecystokinin; Fat Absorption; Indirect Calorimetry

Indexed keywords

CHOLECYSTOKININ; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; INSULIN; LEPTIN; LONG CHAIN FATTY ACID; SATURATED FATTY ACID; TRIACYLGLYCEROL LIPASE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CALORIMETER; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; GENE FUNCTION; HORMONE ACTION; HORMONE BLOOD LEVEL; KNOCKOUT MOUSE; LIPID ABSORPTION; LIPID DIET; LIPID METABOLISM; MALABSORPTION; METABOLIC RATE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; QUANTITATIVE STUDY; WEIGHT REDUCTION; WILD TYPE;

EID: 77951692010     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.01.044     Document Type: Article

References (42)

1. Woods S.C., Seeley R.J., Rushing P.A., et al. A controlled high-fat diet induces an obese syndrome in rats. J Nutr 133 (2003) 1081-1087
2. Woods S.C., and D'Alessio D.A. Central control of body weight and appetite. J Clin Endocrinol Metab 93 (2008) S37-S50
3. Walsh J.H. Gastrointesinal hormones. In: Johnson L.R., Christensen J., and Jackson M.J. (Eds). Physiology of the gastrointesinal tract. 2nd ed. (1986), Raven Press, New York 181-253
4. Muller K., and Hsiao S. Specificity of cholecystokinin satiety effect: reduction of food but not water intake. Pharmacol Biochem Behav 6 (1977) 643-646
5. Kraly F.S., Carty W.J., Resnick S., et al. Effect of cholecystokinin on meal size and intermeal interval in the sham-feeding rat. J Comp Physiol Psychol 92 (1978) 697-707
6. Crawley J.N., and Corwin R.L. Biological actions of cholecystokinin. Peptides 15 (1994) 731-755
7. Yox D.P., Brenner L., and Ritter R.C. CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients. Am J Physiol 262 (1992) R554-R561
8. Little T.J., Feltrin K.L., Horowitz M., et al. A high-fat diet raises fasting plasma CCK but does not affect upper gut motility, PYY, and ghrelin, or energy intake during CCK-8 infusion in lean men. Am J Physiol Regul Integr Comp Physiol 294 (2008) R45-R51
9. Schwartz G.J., Whitney A., Skoglund C., et al. Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors. Am J Physiol 277 (1999) R1144-R1151
10. Bi S., Chen J., Behles R.R., et al. Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors. Am J Physiol Regul Integr Comp Physiol 293 (2007) R55-R63
11. Lacourse K.A., Swanberg L.J., Gillespie P.J., et al. Pancreatic function in CCK-deficient mice: adaptation to dietary protein does not require CCK. Am J Physiol 276 (1999) G1302-G1309
12. Bi S., Scott K.A., Kopin A.S., et al. Differential roles for cholecystokinin a receptors in energy balance in rats and mice. Endocrinology 145 (2004) 3873-3880
13. Taicher G.Z., Tinsley F.C., Reiderman A., et al. Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis. Anal Bioanal Chem 377 (2003) 990-1002
14. Jandacek R.J., Heubi J.E., and Tso P. A novel, noninvasive method for the measurement of intestinal fat absorption. Gastroenterology 127 (2004) 139-144
15. Metcalfe L.D., Schmitz A.A., and Pelka J.R. Rapid preparation of fatty acid esters from lipids for gas chromatographic analysis. Anal Chem 38 (1966) 514-515
16. Huggins K.W., Camarota L.M., Howles P.N., et al. Pancreatic triglyceride lipase deficiency minimally affects dietary fat absorption but dramatically decreases dietary cholesterol absorption in mice. J Biol Chem 278 (2003) 42899-42905
17. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
18. Lo C.M., Samuelson L.C., Chambers J.B., et al. Characterization of mice lacking the gene for cholecystokinin. Am J Physiol Regul Integr Comp Physiol 294 (2008) R803-R810
19. Kopin A.S., Mathes W.F., McBride E.W., et al. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest 103 (1999) 383-391
20. Chen H., Kent S., and Morris M.J. Is the CCK2 receptor essential for normal regulation of body weight and adiposity?. Eur J Neurosci 24 (2006) 1427-1433
21. Herberg L., Doppen W., Major E., et al. Dietary-induced hypertrophic-hyperplastic obesity in mice. J Lipid Res 15 (1974) 580-585
22. Rebuffe-Scrive M., Surwit R., Feinglos M., et al. Regional fat distribution and metabolism in a new mouse model (C57BL/6J) of non-insulin-dependent diabetes mellitus. Metabolism 42 (1993) 1405-1409
23. Shillabeer G., and Lau D.C. Regulation of new fat cell formation in rats: the role of dietary fats. J Lipid Res 35 (1994) 592-600
24. Avram M.M., Avram A.S., and James W.D. Subcutaneous fat in normal and diseased states: 1. Introduction. J Am Acad Dermatol 53 (2005) 663-670
25. Surwit R.S., Feinglos M.N., Rodin J., et al. Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. Metabolism 44 (1995) 645-651
26. Maffei M., Halaas J., Ravussin E., et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1 (1995) 1155-1161
27. Attoub S., Levasseur S., Buyse M., et al. Physiological role of cholecystokinin B/gastrin receptor in leptin secretion. Endocrinology 140 (1999) 4406-4410
28. Aiken K.D., Kisslinger J.A., and Roth K.A. Immunohistochemical studies indicate multiple enteroendocrine cell differentiation pathways in the mouse proximal small intestine. Dev Dyn 201 (1994) 63-70
29. Woods S.C., West D.B., Stein L.J., et al. Peptides and the control of meal size. Diabetologia 20 Suppl (1981) 305-313
30. Miyawaki K., Yamada Y., Ban N., et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med 8 (2002) 738-742
31. Miyasaka K., Ichikawa M., Ohta M., et al. Energy metabolism and turnover are increased in mice lacking the cholecystokinin-B receptor. J Nutr 132 (2002) 739-741
32. Vasar E., Harro J., Lang A., et al. Differential involvement of CCK-A and CCK-B receptors in the regulation of locomotor activity in the mouse. Psychopharmacology (Berl) 105 (1991) 393-399
33. Weiland T.J., Voudouris N.J., and Kent S. The role of CCK2 receptors in energy homeostasis: insights from the CCK2 receptor-deficient mouse. Physiol Behav 82 (2004) 471-476
34. Mayes P. Digestion and absorption. In: Murray R.K., Mayes P.A., and Granner D.K. (Eds). Harper's biochemistry (1990), Appleton & Lange, Norwalk, Connecticut 580-590
35. Schmidt W.E., Creutzfeldt W., Schleser A., et al. Role of CCK in regulation of pancreaticobiliary functions and GI motility in humans: effects of loxiglumide. Am J Physiol 260 (1991) G197-G206
36. Rippe C., Berger K., Mei J., et al. Effect of long-term high-fat feeding on the expression of pancreatic lipases and adipose tissue uncoupling proteins in mice. Pancreas 26 (2003) e36-e42
37. Jones P.J., Pencharz P.B., and Clandinin M.T. Whole body oxidation of dietary fatty acids: implications for energy utilization. Am J Clin Nutr 42 (1985) 769-777
38. Birk R.Z., and Brannon P.M. Regulation of pancreatic lipase by dietary medium chain triglycerides in the weanling rat. Pediatr Res 55 (2004) 921-926
39. Pagliassotti M.J., Gayles E.C., and Hill J.O. Fat and energy balance. Ann N Y Acad Sci 827 (1997) 431-448
40. Funkat A., Massa C.M., Jovanovska V., et al. Metabolic adaptations of three inbred strains of mice (C57BL/6, DBA/2, and 129T2) in response to a high-fat diet. J Nutr 134 (2004) 3264-3269
41. Mead J.F., Slaton Jr. W.H., and Decker A.B. Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. J Biol Chem 218 (1956) 401-407
42. Avram A.S., Avram M.M., and James W.D. Subcutaneous fat in normal and diseased states: 2. Anatomy and physiology of white and brown adipose tissue. J Am Acad Dermatol 53 (2005) 671-683