5-HT system in the gut: Roles in the regulation of visceral sensitivity and motor functions

European Review for Medical and Pharmacological Sciences

Volumn 12, Issue SUPPL. 1, 2008, Pages 63-67

  Grundy, David ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

5 hydroxytryptaimine; Gastrointestinal tract; Irritable Bowel Syndrome; Spinal afferente; Vagal afferente

Indexed keywords

ALOSETRON; ANTINEOPLASTIC AGENT; AUTACOID; CISPLATIN; SEROTONIN; SEROTONIN 3 ANTAGONIST; SEROTONIN AGONIST; SEROTONIN RECEPTOR; TEGASEROD;

ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ARTICLE; CARDIOVASCULAR DISEASE; CHEMOTHERAPY INDUCED EMESIS; DEFECATION HABIT; DIGESTION; DRUG MECHANISM; ENTEROCHROMAFFIN CELL; GASTROINTESTINAL MOTILITY; HUMAN; INTESTINE ABSORPTION; INTESTINE FUNCTION; INTESTINE INNERVATION; INTESTINE TRANSIT TIME; IRRITABLE COLON; ISCHEMIC COLITIS; MAST CELL; MASTOCYTOSIS; MOTOR DYSFUNCTION; MYENTERIC PLEXUS; NAUSEA; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEROTONIN RELEASE; SEROTONIN UPTAKE; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; SOLID TUMOR; VOMITING;

ANIMALS; DIGESTIVE SYSTEM; ENTEROCHROMAFFIN CELLS; HUMANS; IRRITABLE BOWEL SYNDROME; MOTOR NEURONS; NEURONS, AFFERENT; RECEPTORS, SEROTONIN; SEROTONIN; VOMITING;

EID: 54749122804     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. BEYAK MJ, BULMER DC, KEATING C, RONG W, GRUNDY D. Extrinsic sensory afferent nerves innervating the gastrointestinal tract. In: Johnson LR, Ed, Physiology of the Gastrointestinal Tract, Elsevier Press, 2006.
2. DERKACH V, SURPRENANT A, NORTH RA. 5-Ht3 receptors are membrane ion channels. Nature 1989; 339: 706-709.
3. ROSENBERG M, PIE B, COOPER E. Developing neonatal rat sympathetic and sensory neurons differ in their regulation of 5-HT3 receptor expression. J Neurosci 1997; 17: 6629-6638.
4. HICKS GA, COLDWELL JR, SCHINDLER M, WARD PA, JENKINS D, LYNN PA, HUMPHREY PP, BLACKSHAW LA. Excitation of rat colonic afferent fibres by 5-HT(3) receptors. J Physiol 2002b; 544: 861-869.
5. RAYBOULD HE, GLATZLE J, ROBIN C, MEYER JH, PHAN T, WONG H, STERNINI C . Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying. Am J Physiol Gastrointest Liver Physiol 2003; 284: G367-G372.
6. PEETERS PJ, AERSSENS J, DE HOOGT R, STANISZ A, GOHLMANN HW, HILLSLEY K, MEULEMANS A, GRUNDY D, STEAD RH, COULIE B. Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity. Physiol Genomics 2006; 24: 252-263.
7. PETERS JA, MALONE HM, LAMBERT JJ. An electrophysiological investigation of the properties of 5-HT3 receptors of rabbit nodose ganglion neurones in culture. Br J Pharmacol 1993; 110: 665-676.
8. HILLSLEY K, KIRKUP AJ, GRUNDY D. Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum. J Physiol 1998; 506 (Pt 2): 551-561.
9. HILLSLEY K, GRUNDY D. Sensitivity to 5-hydroxytryptamine in different afferent subpopulations within mesenteric nerves supplying the rat jejunum. J Physiol 1998; 509(Pt 3): 717-727.
10. COLDWELL JR, PHILLIS BD, SUTHERLAND K, HOWARTH GS, BLACKSHAW LA. Increased responsiveness of rat colonic splanchnic afferents to 5-HT after inflammation and recovery. J Physiol 2007; 579: 203-213.
11. KOZLOWSKI CM, GREEN A, GRUNDY D, BOISSONADE FM, BOUNTRA C. The 5-HT(3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat. Gut 2000; 46: 474-480.
12. SUZUKI R, RYGH LJ, DICKENSON AH. Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci 2004; 25; 613-617.
13. ZEITZ KP, GUY N, MALMBERG AB, DIRAJLAL S, MARTIN J, SUN L, BONHAUS DW, STUCKY CL, JULIUS D, BASBAUM AI. The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci 2002; 22: 1010-1019.
14. RAYBOULD HE. Nutrient tasting and signaling mechanisms in the gut. I. Sensing of lipid by the intestinal mucosa. Am J Physiol 1999; 277: G751-G755.
15. BERTRAND PP, KUNZE WA, FURNESS JB, BORNSTEIN JC. The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors. Neuroscience 2000; 101: 459-469.
16. JIN JG, FOXX-ORENSTEIN AE, GRIDER JR. Propulsion in guinea pig colon induced by 5-hydroxytryptamine (HT) via 5-HT4 and 5-HT3 receptors. J Pharmacol Exp Ther 1999; 288: 93-97.
17. SJOLUND K, SANDEN G, HAKANSON R, SUNDLER F. Endocrine cells in human intestine: An immunocytochemical study. Gastroenterology 1983; 85; 1120-1130.
18. RACKE K, SCHWORER H. Regulation of serotonin release from the intestinal mucosa. Pharmacol Res 1991; 23: 13-25.
19. COATES MD, MAHONEY CR, LINDEN DR, SAMPSON JE, CHEN J, BLASZYK H, CROWELL MD, SHARKEY KA, GERSHON MD, MAWE GM, MOSE PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004; 126: 1657-1664.
20. LINDEN DR, CHEN JX, GERSHON MD, SHARKEY KA, MAWE GM. Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol 2003; 285: G207-G216.
21. DUNLOP SP, JENKINS D, SPILLER RC. Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome. Am J Gastroenterol 2003; 98: 1578-1583.
22. DUNLOP SP, COLEMAN NS, BLACKSHAW E, PERKINS AC, SINGH G, MARSDEN CA, SPILLER RC. Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome. Clin Gastroenterol Hepatol 2005; 3; 349-357.
23. BARBARA G, WANG B, STANGHELLINI V, DE GIORGIO R, CREMON C, DI NARDO G, TREVISANI M, CAMPI B, GEPPETTI P, TONINI M, BUNNETT NW, GRUNDY D, CORINALDESI R. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 2007; 132: 26-37.
24. BARBARA G, STANGHELLINI V, DE GIORGIO R, CREMON C, COTTRELL GS, SANTINI D, PASQUINELLI G, MORSELLI-LABATE AM, GRADY EF, BUNNETT NW, COLLINS SM, CORINALDESI R. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004; 126: 693-702.
25. CENAC N, ANDREWS CN, HOLZHAUSEN M, CHAPMAN K, COTTRELL G, ANDRADE-GORDON P, STEINHOFF M, BARBARA G, BECK P, BUNNETT NW, SHARKEY KA, FERRAZ JG, SHAFFER E, VERGNOLLE N. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 2007; 117: 636-647.
26. CAMILLERI M, CHEY WY, MAYER EA, NORTHCUTT AR, HEATH A, DUKES GE, MCSORLEY D, MANGEL AM. A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 2001; 161: 1733-1740.
27. VANNER S, MACNAUGHTON WK. Submucosal secretomotor and vasodilator reflexes. Neurogastroenterol Motil 2004; 16(Suppl 1): 39-43.
28. GRUNDY D, MCLEAN P, STEAD R. Impact of 5-HT3 receptor blockade on colonic haemodynamic responses to ischaemia and reperfusion in the rat. Neurogastroenterol Motil 2007; 19: 607-616.
29. NOVICK J, MINER P, KRAUSE R, GLEBAS K, BLIESATH H, LIGOZIO G, RUEGG P, LEFKOWITZ M. A randomized, double-blind, placebo-controlled trial of tegaserod in female patients suffering from irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2002; 16: 1877-1888.
30. GREENWOOD-VAN MEERVELD B, VENKOVA K, HICKS G, DENNIS E, CROWELL MD . Activation of peripheral 5-HT receptors attenuates colonic sensitivity to intraluminal distension. Neurogastroenterol Motil 2006; 18: 76-86.
31. CARDENAS LM, CARDENAS CG, SCROGGS RS. 5HT increases excitability of nociceptor-like rat dorsal root ganglion neurons via cAMP-coupled TTX-resistant Na(+) channels. J Neurophysiol 2001; 86: 241-248.
32. GERSHON MD, LIU MT. Serotonin and neuroprotection in functional bowel disorders. Neurogastroenterol Motil 2007; 19(Suppl 2): 19-24.
33. ANDREWS PL, DAVIS CJ, BINGHAM S, DAVIDSON HI, HAWTHORN J, MASKELL L . The abdominal visceral innervation and the emetic reflex: Pathways, pharmacology, and plasticity. Can J Physiol Pharmacol 1990; 68: 325-345.
34. HILLSLEY K, GRUNDY D. Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat. J Auton Nerv Syst 1999; 76: 93-98.
35. KING GL, RABIN BM, WEATHERSPOON JK. 5-HT3 receptor antagonists ameliorate emesis in the ferret evoked by neutron or proton radiation. Aviat Space Environ Med 1999; 70: 485-492.