Dose-dependent effects of cholecystokinin-8 on antropyloroduodenal motility, gastrointestinal hormones, appetite, and energy intake in healthy men

American Journal of Physiology - Endocrinology and Metabolism

Volumn 295, Issue 6, 2008, Pages

  Brennan, Ixchel M ^a,b   Little, Tanya J ^a   Feltrin, Kate L ^a   Smout, Andre J P M ^c   Wishart, Judith M ^a,b   Horowitz, Michael ^a,b   Feinle Bisset, Christine ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b NATIONAL HEALTH AND MEDICAL RESEARCH COUNCIL   (Australia)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Gastrointestinal peptides; Gut motility

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; GHRELIN; PEPTIDE YY;

ADULT; APPETITE; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; DUODENUM MOTILITY; HORMONAL REGULATION; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PYLORUS; SATIETY; STOMACH ANTRUM; STOMACH MOTILITY;

ADULT; APPETITE; CHOLECYSTOKININ; DOSE-RESPONSE RELATIONSHIP, DRUG; DUODENUM; ENERGY INTAKE; GASTROINTESTINAL HORMONES; GASTROINTESTINAL MOTILITY; HEALTH; HUMANS; INFUSIONS, INTRAVENOUS; MALE; PEPTIDE FRAGMENTS; PRESSURE; PYLORIC ANTRUM; YOUNG ADULT;

EID: 57349100497     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90791.2008     Document Type: Article

References (45)

1. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89: 1070-1077, 1985.
2. Ballinger A, McLoughlin L, Medbak S, Clark M. Cholecystokinin is a satiety hormone in humans at physiological post-prandial plasma concentrations. Clin Sci (Lond) 89: 375-381, 1995.
3. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349: 941-948, 2003.
4. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418: 650-654, 2002.
5. Beglinger C, Degen L, Matzinger D, D'Amato M, Drewe J. Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans. Am J Physiol Regul Integr Comp Physiol 280: R1149-R1154, 2001.
6. Bland JM, Altman DG. Calculating correlation coefficients with repeated observations: Part 1-Correlation within subjects. BMJ 3 10: 446, 1995.
7. Brennan IM, Feltrin KL, Horowitz M, Smout AJ, Meyer JH, Wishart J, Feinle-Bisset C. Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men. Am J Physiol Regul Integr Comp Physiol 288: R1477-R1485, 2005.
8. Brennan IM, Otto B, Feltrin KL, Meyer JH, Horowitz M, Feinle-Bisset C. Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men. Peptides 28: 607-611, 2007.
9. Degen L, Drewe J, Piccoli F, Grani K, Oesch S, Bunea R, D'Amato M, Beglinger C. Effect of CCK-1 receptor blockade on ghrelin and PYY secretion in men. Am J Physiol Regul Integr Comp Physiol 292: R1391-R1399, 2007.
10. Eysselein VE, Eberlein GA, Hesse WH, Schaeffer M, Grandt D, Williams R, Goebell H, Reeve JR Jr. Molecular variants of cholecystokinin after endogenous stimulation in humans: a time study. Am J Physiol Gastrointest Liver Physiol 258: G951-G957, 1990.
11. Feinle C, D'Amato M, Read NW. Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid. Gastroenterology 110: 1379-1385, 1996.
12. Feinle C, Grundy D, Otto B, Fried M. Relationship between increasing duodenal lipid doses, gastric perception, and plasma hormone levels in humans. Am J Physiol Regul Integr Comp Physiol 278: R1217-R1223, 2000.
13. Feinle C, O'Donovan DG, Doran S, Andrews JM, Wishart J, Chapman I, Horowitz M. Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans. Am J Physiol Gastrointest Liver Physiol 284: G798-G807, 2003.
14. Feltrin KL, Little TJ, Meyer JH, Horowitz M, Smout AJ, Wishart J, Pilichiewicz AN, Rades T, Chapman IM, Feinle-Bisset C. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. Am J Physiol Regul Integr Comp Physiol 287: R524-R533, 2004.
15. Fraser R, Fone D, Horowitz M, Dent J. Cholecystokinin octapeptide stimulates phasic and tonic pyloric motility in healthy humans. Gut 34: 33-37, 1993.
16. Fried M, Erlacher U, Schwizer W, Lochner C, Koerfer J, Beglinger C, Jansen JB, Lamers CB, Harder F, Bischof-Delaloye A, Stalder GA, Rovati L. Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide. Gastroenterology 101: 503-511, 1991.
17. Fried M, Schwizer W, Beglinger C, Keller U, Jansen JB, Lamers CB. Physiological role of cholecystokinin on postprandial insulin secretion and gastric meal emptying in man. Studies with the cholecystokinin receptor antagonist loxiglumide. Diabetologia 34: 721-726, 1991.
18. Grider JR, Makhlouf GM. Regional and cellular heterogeneity of cholecystokinin receptors mediating muscle contraction in the gut. Gastroenterology 92: 175-180, 1987.
19. Heddle R, Collins PJ, Dent J, Horowitz M, Read NW, Chatterton B, Houghton LA. Motor mechanisms associated with slowing of the gastric emptying of a solid meal by an intraduodenal lipid infusion. J Gastroenterol Hepatol 4: 437-447, 1989.
20. Heddle R, Dent J, Toouli J, Read NW. Topography and measurement of pyloric pressure waves and tone in humans. Am J Physiol Gastrointest Liver Physiol 255: G490-G497, 1988.
21. Herrmann C, Goke R, Richter G, Fehmann HC, Arnold R, Goke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion 56: 117-126, 1995.
22. Isenberg JI, Csendes A. Effect of octapeptide of cholecystokinin on canine pyloric pressure. Am J Physiol 222: 428-431, 1972.
23. Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP. C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr 34: 154-160, 1981.
24. Liddle RA, Goldfine ID, Rosen MS, Taplitz RA, Williams JA. Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction. J Clin Invest 75: 1144-1152, 1985.
25. Lieverse RJ, Jansen JB, Masclee AA, Lamers CB. Satiety effects of a physiological dose of cholecystokinin in humans. Gut 36: 176-179, 1995.
26. Lieverse RJ, Jansen JB, Masclee AA, Rovati LC, Lamers CB. Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide. Gut 35: 501-505, 1994.
27. Lin HC, Chey WY, Zhao X. Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK. Peptides 21: 1561-1563, 2000.
28. Lippl F, Kircher F, Erdmann J, Allescher HD, Schusdziarra V. Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regul Pept 119: 93-98, 2004.
29. MacIntosh CG, Morley JE, Wishart J, Morris H, Jansen JB, Horowitz M, Chapman IM. Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging. J Clin Endocrinol Metab 86: 5830-5837, 2001.
30. Matzinger D, Gutzwiller JP, Drewe J, Orban A, Engel R, D'Amato M, Rovati L, Beglinger C. Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans. Am J Physiol Regul Integr Comp Physiol 277: R1718-R1724, 1999.
31. Muurahainen N, Kissileff HR, Derogatis AJ, Pi-Sunyer FX. Effects of cholecystokinin-octapeptide (CCK-8) on food intake and gastric emptying in man. Physiol Behav 44: 645-649, 1988.
32. Naslund E, Bogefors J, Skogar S, Gryback P, Jacobsson H, Holst JJ, Hellstrom PM. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol Regul Integr Comp Physiol 277: R910-R916, 1999.
33. Parker B, Sturm K, MacIntosh CG, Feinle C, Horowitz M, Chapman IM. Relation between food intake and visual analogue scale ratings of appetite and other sensations in healthy older and young subjects. Eur J Clin Nutr 58: 212-218, 2004.
34. Parker BA, Doran S, Wishart J, Horowitz M, Chapman IM. Effects of small intestinal and gastric glucose administration on the suppression of plasma ghrelin concentrations in healthy older men and women. Clin Endocrinol (Oxf) 62: 539-546, 2005.
35. Pilichiewicz AN, Little TJ, Brennan IM, Meyer JH, Wishart JM, Otto B, Horowitz M, Feinle-Bisset C. Effects of load, and duration, of duodenal lipid on antropyloroduodenal motility, plasma CCK and PYY, and energy intake in healthy men. Am J Physiol Regul Integr Comp Physiol 290: R668-R677, 2006.
36. Rayner CK, Park HS, Doran SM, Chapman IM, Horowitz M. Effects of cholecystokinin on appetite and pyloric motility during physiological hyperglycemia. Am J Physiol Gastrointest Liver Physiol 278: G98-G104, 2000.
37. Rolls BJ, Kim-Harris S, Fischman MW, Foltin RW, Moran TH, Stoner SA. Satiety after preloads with different amounts of fat and carbohydrate: implications for obesity. Am J Clin Nutr 60: 476-487, 1994.
38. Samsom M, Roelofs JM, Akkermans LM, van Berge Henegouwen GP, Smout AJ. Proximal gastric motor activity in response to a liquid meal in type I diabetes mellitus with autonomic neuropathy. Dig Dis Sci 43: 491-496, 1998.
39. Santangelo A, Peracchi M, Conte D, Fraquelli M, Porrini M. Physical state of meal affects gastric emptying, cholecystokinin release and satiety. Br J Nutr 80: 521-527, 1998.
40. Schirra J, Sturm K, Leicht P, Arnold R, Goke B, Katschinski M. Exendin(9 -39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans. J Clin Invest 101: 1421-1430, 1998.
41. Shide DJ, Caballero B, Reidelberger R, Rolls BJ. Accurate energy compensation for intragastric and oral nutrients in lean males. Am J Clin Nutr 61: 754-764, 1995.
42. Stunkard AJ, Messick S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 29: 71-83, 1985.
43. Williams DL, Cummings DE, Grill HJ, Kaplan JM. Meal-related ghrelin suppression requires postgastric feedback. Endocrinology 144: 2765-2767, 2003.
44. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86: 5992-5995, 2001.
45. Xu X, Zhu H, Chen JD. Pyloric electrical stimulation reduces food intake by inhibiting gastric motility in dogs. Gastroenterology 128: 43-50, 2005.