Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

Nature

Volumn 425, Issue 6953, 2003, Pages 90-93

  Fu, Jin ^a   Gaetani, Silvana ^a   Oveisi, Fariba ^a   Lo Verme, Jesse ^a   Serrano, Antonia ^b   De Fonseca, Fernando Rodriguez ^b   Rosengarth, Anja ^a   Luecke, Hartmut ^a   Di Giacomo, Barbara ^c   Tarzia, Giorgio ^c   Piomelli, Daniele ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^c UNIVERSITY OF URBINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; ENZYMES; METABOLISM; PROTEINS;

AMIDES;

LIPIDS;

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; CAPSAICIN; CELL NUCLEUS RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; CIGLITAZONE; CLOFIBRATE; FENFLURAMINE; GW 7647; NITRIC OXIDE SYNTHASE; OLEYLETHANOLAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIRINIXIC ACID; UNCLASSIFIED DRUG;

BIOLOGY; LIPID;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; EATING DISORDER; ENZYME REPRESSION; FEEDING; FOOD INTAKE; HUMAN; HUMAN CELL; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; REGULATORY MECHANISM; SATIETY; SMALL INTESTINE; STIMULATION; TRANSCRIPTION INITIATION; WEIGHT GAIN; WILD TYPE;

ANIMALS; APPETITE DEPRESSANTS; BODY WEIGHT; CIRCADIAN RHYTHM; FEEDING BEHAVIOR; GENE DELETION; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; INTESTINES; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OLEIC ACID; OLEIC ACIDS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0041321275     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01921     Document Type: Article

References (30)

1. Rodríguez de Fonseca, F. et al. An anorexic lipid mediator regulated by feeding. Nature 414, 209-212 (2001).
2. Gaetani, S., Oveisi, F. & Piomelli, D. Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. Neuropsychopharmacology 28, 1311-1316 (2003).
3. Göttlicher, M., Widmark, E., Li, Q. & Gustafsson, J. A. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl Acad. Sci. USA 89,4653-4657 (1992).
4. Kliewer, S. A. et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc. Natl Acad. Sci. USA 94, 4318-4323 (1997).
5. Forman, B. M., Chen, I. & Evans, R. M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ Proc. Natl Acad. Sci. USA 94, 4312-4317 (1997).
6. Desvergne, B. & Wahli, W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20, 649-688 (1999).
7. Chawla, A., Repa, J. J., Evans, R. M. & Mangelsdorf, D. J. Nuclear receptors and lipid physiology: opening the X-files. Science 294, 1866-1870 (2001).
8. Berger, J. & Moller, D. E. The mechanisms of action of PPARs. Annu. Rev. Med. 53, 409-435 (2002).
9. Lazennec, G., Canaple, L., Saugy, D. & Wahli, W. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol. Endocrinol. 14, 1962-1975 (2000).
10. Devane, W. A. et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946-1949 (1992).
11. Willson, T. M., Brown, P. J., Sternbach, D. D. & Henke, B. R. The PPARs: from orphan receptors to drug discovery. J. Med. Chem. 43, 527-550 (2000).
12. Brown, P. J. et al. Chemical compounds as selective activators of PPAR-α. PCT Int. Appl. 32 (2000)
13. Lee, S. S. et al. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15, 3012-3022 (1995).
14. Butler, A. A. & Cone, R. D. Knockout models resulting in the development of obesity. Trends Genet. 17, S50-S54 (2001).
15. Oliver, W. R. Jr et al. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport. Proc. Natl Acad. Sci. USA 98, 5306-5311 (2001).
16. Chang, A. Y., Wyse, B. M., Gilchrist, B. J., Peterson, T. & Diani, A. R. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes 32, 830-838 (1983).
17. Martin, G., Schoonjans, K., Lefebvre, A. M., Staels, B. & Auwerx, J. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators. J. Biol. Chem. 272, 28210-28217 (1997).
18. Escher, P. et al. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology, 142, 4195-4202 (2001).
19. Motojima, K., Passilly, P., Peters, J. M., González, E. J. & Latruffe, N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue- and inducer-specific manner. J. Biol. Chem. 273, 16710-16714 (1998).
20. Colville-Nash, P. R., Qureshi, S. S. & Willoughby, D. A. Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonist: correlation of induction of heme oxygenase 1. J. Immunol. 161, 978-984 (1998).
21. Best, J. D. & Jenkins, A. J. Novel agents for managing dyslipidaemia. Expert Opin. Invest. Drugs 10, 1901-1911 (2001).
22. Cleary, M. P., Kasiske, B., O'Donnell, M. P. & Keane, W. F. Effect of long-term clofibric acid treatment on serum and tissue lipid and cholesterol levels in obese Zucker rats. Atherosclerosis 66, 107-112 (1987).
23. Chaput, E., Saladin, R., Silvestre, M. & Edgar, A. D. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem. Biophys. Res. Commun. 271, 445-450 (2000).
24. Akiyama, T. E. et al. Peroxisome proliferator-activated receptor-α regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines. J. Biol. Chem. 276, 39088-39093 (2001).
25. Sticker-krongrad, A., Beck, B. & Burlet, C. Nitric oxide mediates hyperphagia of obese Zucker rats: relation to specific changes in the microstructure of feeding behavior. Life Sci. 58, PL9-PL15 (1996).
26. Janero, D. R. Nutritional aspects of nitric oxide: human health implication and therapeutic opportunities. Nutrition 17, 896-903 (2001).
27. Chao, E. Y.-H. et al. Thiazoles and oxazole derivatives and their pharmaceutical use. PCT Int. Appl. 83 (2001).
28. Giuffrida, A., Rodriguez de Fonseca, F. & Piomelli, D. Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry. Anal. Biochem. 280, 87-93 (2000).
29. Schmittgen, T. D. et al. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal. Biochem. 285, 194-204 (2000).
30. Gregoire, F. M. et al. Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice. Am. J. Physiol. Endocrinol. Metab. 282, E703-E713 (2002).