Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants

Neuropharmacology

Volumn 35, Issue 12, 1996, Pages 1649-1660

  Stephan, Danielle ^a   Bon, Christelle ^a,b   Holzwarth, James A ^a   Galvan, Martin ^a   Pruss, Rebecca M ^a  

^a SANOFI   (France)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

calcium imaging; human chromosome 6; metabotropic glutamate receptor; Xenopus oocyte electrophysiology

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMIC ACID; MESSENGER RNA; METABOTROPIC RECEPTOR;

ANIMAL CELL; ARTICLE; BRAIN REGION; CALCIUM TRANSPORT; CHROMOSOME 6; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; INTRACELLULAR RECORDING; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RNA SPLICING; XENOPUS;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; CALCIUM; CELL LINE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; CLONING, MOLECULAR; CYCLOLEUCINE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; OOCYTES; OPEN READING FRAMES; RATS; RECEPTORS, AMPA; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC; TRANSFECTION; VARIATION (GENETICS); XENOPUS;

EID: 0030498294     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00108-6     Document Type: Article

References (44)

1. Aiba A., Chen C., Herrup K., Rosenmund C., Stevens C.F., Tonegawa S. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice. Cell. 79:1994;365-375.
2. Aiba A., Kano M., Chen C., Stanton M.E., Fox G.D., Herrup K., Zwingman T.A., Tonegawa S. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell. 79:1994;377-388.
3. Aramori I., Nakanishi S. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron. 8:1992;757-765.
4. Barish M.E. A transient calcium-dependent chloride current in the immature Xenopus oocyte. J. Physiol. 342:1983;309-325.
5. Blin N., Stafford D.W. A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res. 3:1976;2303-2308.
6. Colman A. (1984) Translation of eukaryotic messenger RNA in Xenopus oocytes. In: Transcription and Translation, a Practical Approach (Hames B.D. and Higgins J., Eds), pp. 271-302. IRL Press, Oxford.
7. Desai M.A., Burnett J.P., Mayne N.G., Schoepp D.D. Cloning and expression of a human metabotropic glutamate receptor 1α: enhanced coupling on co-transfection with a glutamate transporter. Molec. Pharmacol. 48:1995;648-657.
8. Flor P.J., Lindauer K., Püttner I., Rüegg D., Lukic S., Knöpfel T., Kuhn R. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2. Eur. J. Neurosci. 7:1995;622-629.
9. Flor P.J., Lukic S., Rüegg D., Leonhardt T., Knöpfel T., Kuhn R. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 4. Neuropharmacology. 34:1995;149-155.
10. Gomeza J., Joly C., Kuhn R., Knöpfel T., Bockaert J., Pin J.-P. The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins. J. Biol. Chem. 271:1996;2199-2205.
11. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:1985;3440-3450.
12. Hampson D.R., Theriault E., Huang X.-P., Kristensen P., Pickering D.S., Franck J.E., Mulvihill E.R. Characterization of two alternatively spliced forms of a metabotropic glutamate receptor in the central nervous system of the rat. Neuroscience. 60:1994;325-336.
13. Hayashi Y., Sekiyama N., Nakanishi S., Jane D.E., Sunter D.C., Birse E.F., Udvarhelyi P.M., Watkins J.C. Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes. J. Neurosci. 14:1994;3370-3377.
14. Houamed K.M., Kuijper J.L., Gilbert T.L., Haldeman B.A., O'Hara P.J., Mulvihill E.R., Almers W., Hagen F.S. Cloning, expression and gene structure of a G protein-coupled receptor from rat brain. Science (Washington, DC). 252:1991;1318-1321.
15. Joly C., Gomeza J., Brabet I., Curry K., Bockaert J., Pin J.-P. Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1. J. Neurosci. 15:1995;3970-3981.
16. Kingston A.E., Burnett J.P., Mayne N.G., Lodge D. Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1α and mGluR5a subtypes. Neuropharmacology. 34:1995;887-894.
17. Knöpfel T., Kuhn R., Allgeier H. Metabotropic glutamate receptors: novel targets for drug development. J. Med. Chem. 38:1995;1417-1426.
18. Knöpfel T., Leonardt L.T., Flor P.J., Kuhn R., Gasparini F. Pharmacological characterization of MCCG and MAP4 at the mGluR1b, mGluR2 and mGluR4a human metabotropic glutamate receptor subtypes. Neuropharmacology. 34:1995;1099-1102.
19. Kuramoto T., Maihara T., Masu M., Nakanishi S., Serikawa T. Gene mapping of NMDA receptors and metabotropic glutamate receptors in the rat (Rattus norvegicus). Genomics. 19:1994;358-361.
20. Laurie D.J., Boddeke H.W.G.M., Hiltscher R., Sommer B. HmGlur1d, a novel splice variant of the human type 1 metabotropic glutamate receptor. Eur. J. Pharmacol. 296:1996;R1-R3.
21. Lemaire P., Garett N., Gurdon J.B. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis. Cell. 81:1995;85-94.
22. Masu M., Tanabe Y., Tsuchida K., Sigemoto R., Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. Nature. 349:1991;760-765.
23. McDonald J.W., Fix A.S., Tizzano J.P., Schoepp D.D. Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist. J. Neurosci. 13:1993;4445-4455.
24. Minakami R., Katsuki F., Yamamoto T., Nakamura K., Sugiyama H. Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5. Biochem. Biophys. Res. Commun. 199:1994;1136-1143.
25. Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science (Washington, DC). 258:1992;597-603.
26. O'Hara P.J., Gilbert T.L., Haldeman B.A., Houamed K.M., Kuijper J.L., Hagen R.S., Almers W., Mulvihill E. Different sites of polyadenylation in mRNAs encoding a rat metabotropic glutamate receptor. J. DNA Sequenc. Mapp. 4:1993;53-57.
27. O'Hara P.J., Sheppard P.O., Thogersen H., Venezia D., Haldeman B.A., McGrane V., Houamed K.M., Thomsen C., Gilbert T.L., Mulvihill E.R. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron. 11:1993;41-52.
28. Pickering D.S., Thomsen C., Suzdak P.D., Fletcher E.J., Robitaille R., Salter M.W., MacDonald J.F., Huang X.-P., Hampson D.R. A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositide turnover. J. Neurochem. 61:1993;85-92.
29. Pin J.-P., Bockaert J. Get receptive to metabotropic glutamate receptors. Curr. Opin. Neurobiol. 5:1995;342-349.
30. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
31. Pin J.-P., Joly C., Heinemann S.F., Bockaert J. Domains involved in the specificity of G protein activation in phospholipase C coupled metabotropic glutamate receptors. EMBO J. 13:1994;342-348.
32. Pin J.-P., Waeber C., Prezeau L., Bockaert J., Heinemann S. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes. Proc. natn. Acad. Sci. U.S.A. 89:1992;10331-10335.
33. Ponce M.R., Micol J.L. PCR amplification of long DNA fragments. Nucleic Acids Res. 20:1992;623.
34. Sacaan A.I., Schoepp D.D. Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage. Neurosci. Lett. 138:1992;77-82.
35. Sambrook J., Fritsch E.F. and Maniatis T. (1989) Molecular Cloning. A Laboratory Manual, Second Edition, pp. 16.33-16.36. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
36. Scherer S.W., Duvoisin R.M., Kuhn R., Heng H.H.Q., Belloni E., Tsui L.C. Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8 to human chromosome 7q. Genomics. 31:1996;230-233.
37. Schoepp D.D., Conn P.J. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. Sci. 14:1993;13-20.
38. Scott D.M., Pateman J.A. The acidic amino acid transport system of the baby hamster kidney cell line BHK21-C13. Biochim. Biophys. Acta. 508:1978;379-388.
39. Seeburg P.H. The molecular biology of mammalian glutamate receptor channels. Trends Neurosci. 16:1993;359-365.
40. Shigemoto R., Nakanishi S., Mizuno N. Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: an in situ hybridization study in adult and developing rat. J. Comp. Neurol. 322:1992;121-135.
41. Takahashi K., Tsuchida K., Tanabe Y., Masu M., Nakanishi S. Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination. J. Biol. Chem. 268:1993;19341-19345.
42. Tanabe Y., Masu M., Ishii T., Shigemoto R., Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 8:1992;169-179.
43. Thomsen C., Hansen L., Suzdak P.D. L-Glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a. J. Neurochem. 63:1994;2038-2047.
44. Thomsen C., Mulvihill E.R., Haldeman B., Pickering D.S., Hampson D.R., Suzdak P.D. A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line. Brain Res. 619:1993;22-28.