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Volumn 104, Issue 7, 1999, Pages 975-982

Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; ARGININE; DEXTRO ARGININE; LEPTIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SEROTONIN; TRYPTOPHAN;

EID: 0032718692     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI5867     Document Type: Article
Times cited : (160)

References (56)
  • 1
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature. 372:425-432.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1
  • 2
    • 0030902584 scopus 로고    scopus 로고
    • Leptin expression and action: New experimental paradigms
    • Flier, J.S. 1997. Leptin expression and action: new experimental paradigms. Proc. Natl. Acad. Sci. USA. 94:4242-4245.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4242-4245
    • Flier, J.S.1
  • 3
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymounter, M.A., et al. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:540-543.
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1
  • 4
    • 0031438686 scopus 로고    scopus 로고
    • Leptin: Its role in obesity and beyond
    • Tritos, N.A., and Mantzoros, C.S. 1997. Leptin: its role in obesity and beyond. Diabetologia. 40:1371-1379.
    • (1997) Diabetologia , vol.40 , pp. 1371-1379
    • Tritos, N.A.1    Mantzoros, C.S.2
  • 5
    • 0032492453 scopus 로고    scopus 로고
    • Leptin
    • Auwerx, J., and Staels, B. 1998. Leptin. Lancet. 351:737-742.
    • (1998) Lancet , vol.351 , pp. 737-742
    • Auwerx, J.1    Staels, B.2
  • 6
    • 0029048408 scopus 로고
    • Recombinant mouse Ob protein; evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R., and Burn, P. 1995. Recombinant mouse Ob protein; evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:546-549.
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 7
    • 0029098589 scopus 로고
    • The role of neuropeptide Y in the antiobesity action of the obese gene product
    • Stephens, T.W., et al. 1995. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:530-532.
    • (1995) Nature , vol.377 , pp. 530-532
    • Stephens, T.W.1
  • 8
    • 0029776030 scopus 로고    scopus 로고
    • The full length leptin receptor has signalling capabilities of interleukin 6-type receptors
    • Baumann, H., et al. 1996. The full length leptin receptor has signalling capabilities of interleukin 6-type receptors. Proc. Natl. Acad. Sci. USA. 93:8374-8378.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8374-8378
    • Baumann, H.1
  • 9
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague, C.T., et al. 1997. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:903-908.
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1
  • 10
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, Ob-R
    • Tartaglia, L.A., et al. 1995. Identification and expression cloning of a leptin receptor, Ob-R. Cell. 83:1263-1271.
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1
  • 11
    • 0030039272 scopus 로고    scopus 로고
    • Abnormal splicing of the leptin receptor in diabetic mice
    • Lee, G.H., et al. 1996. Abnormal splicing of the leptin receptor in diabetic mice. Nature. 379:632-635.
    • (1996) Nature , vol.379 , pp. 632-635
    • Lee, G.H.1
  • 12
    • 13344259300 scopus 로고    scopus 로고
    • Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
    • Chen, H., et al. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell. 84:491-495.
    • (1996) Cell , vol.84 , pp. 491-495
    • Chen, H.1
  • 13
    • 13344280346 scopus 로고    scopus 로고
    • Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
    • Schwartz, M.W., et al. 1996. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes. 45:531-535.
    • (1996) Diabetes , vol.45 , pp. 531-535
    • Schwartz, M.W.1
  • 14
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erickson, J.C., Clegg, K.E., and Palmiter, R.D. 1996. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381:415-421.
    • (1996) Nature , vol.381 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 15
    • 0024296032 scopus 로고
    • Endothelium-derived relaxing factor release on activation of NMDA receptors suggests a role as intercellular messenger in the brain
    • Garthwaite, J., Charles, S.L., and Chess-Williams, R. 1988. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests a role as intercellular messenger in the brain. Nature. 336:385-388.
    • (1988) Nature , vol.336 , pp. 385-388
    • Garthwaite, J.1    Charles, S.L.2    Chess-Williams, R.3
  • 16
    • 0028917372 scopus 로고
    • Nitric oxide signaling in the central nervous system
    • Garthwaite, J., and Boulton, C.L. 1995. Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 57:683-706.
    • (1995) Annu. Rev. Physiol. , vol.57 , pp. 683-706
    • Garthwaite, J.1    Boulton, C.L.2
  • 17
    • 0026770529 scopus 로고
    • Evidence that nitric oxide modulates drinking behaviour
    • Calapai, G., et al. 1992. Evidence that nitric oxide modulates drinking behaviour. Neuropharmacology. 31:761-764.
    • (1992) Neuropharmacology , vol.31 , pp. 761-764
    • Calapai, G.1
  • 18
    • 0025776498 scopus 로고
    • Evidence that nitric oxide modulates food intake in mice
    • Morley, J.E., and Flood, J.F. 1991. Evidence that nitric oxide modulates food intake in mice. Life Sci. 49:707-711.
    • (1991) Life Sci. , vol.49 , pp. 707-711
    • Morley, J.E.1    Flood, J.F.2
  • 19
    • 0027339315 scopus 로고
    • G-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats
    • G-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats. Eur. J. Pharmacol. 230:125-128.
    • (1993) Eur. J. Pharmacol. , vol.230 , pp. 125-128
    • Squadrito, F.1
  • 21
    • 7844239801 scopus 로고    scopus 로고
    • Effects of intracerebroventricular leptin administration on food intake, body-weight gain and diencephalic nitric oxide synthase activity in the mouse
    • Calapai, G., et al. 1998. Effects of intracerebroventricular leptin administration on food intake, body-weight gain and diencephalic nitric oxide synthase activity in the mouse. Br. J. Pharmacol. 125:798-802.
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 798-802
    • Calapai, G.1
  • 22
    • 0021712027 scopus 로고
    • Serotonin and appetite
    • Blundell, J.E. 1984. Serotonin and appetite. Neuropharmacology. 23:1537-1551.
    • (1984) Neuropharmacology , vol.23 , pp. 1537-1551
    • Blundell, J.E.1
  • 23
    • 0025338577 scopus 로고
    • The role of 5-HT in eating disorders
    • Leibowitz, S.F. 1990. The role of 5-HT in eating disorders. Drugs. 39(Suppl. 3):33-48.
    • (1990) Drugs , vol.39 , Issue.SUPPL. 3 , pp. 33-48
    • Leibowitz, S.F.1
  • 24
    • 0029400285 scopus 로고
    • Biological actions of drugs affecting 5-HT and eating
    • Garattini, S. 1995. Biological actions of drugs affecting 5-HT and eating. Obes. Res. 3(Suppl. 4):463S-470S.
    • (1995) Obes. Res. , vol.3 , Issue.SUPPL. 4
    • Garattini, S.1
  • 26
    • 0023723068 scopus 로고
    • Hypothalamic serotonin: Pharmacological, biochemical, and behavioral analyses of its feeding-suppressive action
    • Leibowitz, S.F., Weiss, G.F., and Shor-Posner, G. 1988. Hypothalamic serotonin: pharmacological, biochemical, and behavioral analyses of its feeding-suppressive action. Clin. Neuropharmacol. 11(Suppl. 1):S51-S71.
    • (1988) Clin. Neuropharmacol. , vol.11 , Issue.SUPPL. 1
    • Leibowitz, S.F.1    Weiss, G.F.2    Shor-Posner, G.3
  • 27
    • 0028351077 scopus 로고
    • G-nitro-L-arginine, an inhibitor of nitric oxide synthase
    • G-nitro-L-arginine, an inhibitor of nitric oxide synthase. Eur. J. Pharmacol. 255:51-55.
    • (1994) Eur. J. Pharmacol. , vol.255 , pp. 51-55
    • Squadrito, F.1
  • 28
    • 85011486581 scopus 로고    scopus 로고
    • A leptin dose-response study in obese (ob/ob) and lean (+/?) mice
    • Harris, R.B., et al. 1998. A leptin dose-response study in obese (ob/ob) and lean (+/?) mice. Endocrinology. 139:8-19.
    • (1998) Endocrinology , vol.139 , pp. 8-19
    • Harris, R.B.1
  • 29
    • 0026467138 scopus 로고
    • Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L-calcium channel in DBA/2 mice
    • DeSarro, G., et al. 1992. Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L-calcium channel in DBA/2 mice. Gen. Pharmacol. 23:1205-1216.
    • (1992) Gen. Pharmacol. , vol.23 , pp. 1205-1216
    • DeSarro, G.1
  • 30
    • 0017184389 scopus 로고
    • A rapid method for quantitation of protein dye binding
    • Bradford, M.M. 1976. A rapid method for quantitation of protein dye binding. Anal. Biochem. 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 32
    • 0025740804 scopus 로고
    • Indolepyruvic acid, a tryptophan keto analogue, reduces food intake in obese Zucker rats
    • Squadrito, F., et al. 1991. Indolepyruvic acid, a tryptophan keto analogue, reduces food intake in obese Zucker rats. Neurosci. Res. Commun. 9:27-36.
    • (1991) Neurosci. Res. Commun. , vol.9 , pp. 27-36
    • Squadrito, F.1
  • 33
    • 0027471457 scopus 로고
    • Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro
    • Costa, A., Trainer, P., Besser, M., and Grossman, A. 1993. Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro. Brain Res. 605:187-192.
    • (1993) Brain Res. , vol.605 , pp. 187-192
    • Costa, A.1    Trainer, P.2    Besser, M.3    Grossman, A.4
  • 34
    • 0026603066 scopus 로고
    • The role of nitric oxide in hippocampal long-term potentiation
    • Haley, J.E., Wilcox, G.L., and Chapman, P.F. 1992. The role of nitric oxide in hippocampal long-term potentiation. Neuron. 8:211-216.
    • (1992) Neuron. , vol.8 , pp. 211-216
    • Haley, J.E.1    Wilcox, G.L.2    Chapman, P.F.3
  • 35
    • 0030575651 scopus 로고    scopus 로고
    • Nitric oxide and drinking behaviour
    • Calapai, G., and Caputi, A.P. 1996. Nitric oxide and drinking behaviour. Regul. Pept. 66:117-121.
    • (1996) Regul. Pept. , vol.66 , pp. 117-121
    • Calapai, G.1    Caputi, A.P.2
  • 36
    • 0029655548 scopus 로고    scopus 로고
    • Nitric oxide mediates hyperphagia of obese Zucker rats: Relation to specific changes in the microstructure of feeding behavior
    • Stricker-Krongrad, A., Beck, B., and Burlet, C. 1996. Nitric oxide mediates hyperphagia of obese Zucker rats: relation to specific changes in the microstructure of feeding behavior. Life Sci. 58:9-15.
    • (1996) Life Sci. , vol.58 , pp. 9-15
    • Stricker-Krongrad, A.1    Beck, B.2    Burlet, C.3
  • 38
    • 0028818035 scopus 로고
    • Nitric oxide synthase: Expression and expressional control of the three isoforms
    • Förstermann, U., and Kleinert, H. 1995. Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn Schmiedebergs Arch. Phamacol. 352:351-364.
    • (1995) Naunyn Schmiedebergs Arch. Phamacol. , vol.352 , pp. 351-364
    • Förstermann, U.1    Kleinert, H.2
  • 39
    • 0028987869 scopus 로고
    • Inhibition of constitutive and inducible nitric oxide synthase: Potential selective inhibition
    • Fukuto, J.M., and Chauduri, G. 1995. Inhibition of constitutive and inducible nitric oxide synthase: potential selective inhibition. Annu. Rev. Pharmacol. Toxicol. 35:165-194.
    • (1995) Annu. Rev. Pharmacol. Toxicol. , vol.35 , pp. 165-194
    • Fukuto, J.M.1    Chauduri, G.2
  • 40
    • 0025011298 scopus 로고
    • Localization of nitric oxide synthase indicating a neural role for nitric oxide
    • Bredt, D.S., Hwang, P.M., and Snyder, S.H. 1990. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 347:768-770.
    • (1990) Nature , vol.347 , pp. 768-770
    • Bredt, D.S.1    Hwang, P.M.2    Snyder, S.H.3
  • 41
    • 0025823405 scopus 로고
    • Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues
    • Dawson, T.M., Bredt, D.S., Fotuhi, M., Hwang, P.M., and Snyder, S.H. 1991. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc. Natl. Acad. Sci. USA. 88:7797-7801.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7797-7801
    • Dawson, T.M.1    Bredt, D.S.2    Fotuhi, M.3    Hwang, P.M.4    Snyder, S.H.5
  • 42
    • 0032533159 scopus 로고    scopus 로고
    • Argininc metabolism: Nitric oxide and beyond
    • Wu, G., and Morris, S.M. 1998. Argininc metabolism: nitric oxide and beyond. Biochem. J. 336:1-17.
    • (1998) Biochem. J. , vol.336 , pp. 1-17
    • Wu, G.1    Morris, S.M.2
  • 43
    • 0032577534 scopus 로고    scopus 로고
    • Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast
    • Thim, L., et al. 1998. Purification and characterisation of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast. FEBS Lett. 428:263-268.
    • (1998) FEBS Lett. , vol.428 , pp. 263-268
    • Thim, L.1
  • 44
    • 0032492893 scopus 로고    scopus 로고
    • Hypothalamic CART is a new anorectic peptide regulated by leptin
    • Kristensen, P., et al. 1998. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 393:72-76.
    • (1998) Nature , vol.393 , pp. 72-76
    • Kristensen, P.1
  • 45
    • 0031820785 scopus 로고    scopus 로고
    • CART peptides in the central control of feeding and interactions with neuropeptide Y
    • Lambert, P., et al. 1998. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse. 29:293-298.
    • (1998) Synapse , vol.29 , pp. 293-298
    • Lambert, P.1
  • 46
    • 0028328958 scopus 로고
    • Food deprivation increases brain nitric oxide synthase and depresses brain 5-HT levels in rats
    • Squadrito, F., et al. 1994. Food deprivation increases brain nitric oxide synthase and depresses brain 5-HT levels in rats. Neuropharmacology. 33:83-86.
    • (1994) Neuropharmacology , vol.33 , pp. 83-86
    • Squadrito, F.1
  • 48
    • 0026326384 scopus 로고
    • Obesity, a disorder of nutrient partitioning: The MONA LISA hypothesis
    • Bray, G.A. 1991. Obesity, a disorder of nutrient partitioning: the MONA LISA hypothesis. J. Nutr. 121:1146-1162.
    • (1991) J. Nutr. , vol.121 , pp. 1146-1162
    • Bray, G.A.1
  • 49
    • 0023258164 scopus 로고
    • Decreased brown adipose tissue thermogenic activity following a reduction in brain 5-HT by intraventricular p-chlorophenylalanine
    • Fuller, N.J., Stirling, D.M., Dunnett, S., Reynolds, B.P., and Ashwell, M. 1987. Decreased brown adipose tissue thermogenic activity following a reduction in brain 5-HT by intraventricular p-chlorophenylalanine. Biosci. Rep. 7:121-127.
    • (1987) Biosci. Rep. , vol.7 , pp. 121-127
    • Fuller, N.J.1    Stirling, D.M.2    Dunnett, S.3    Reynolds, B.P.4    Ashwell, M.5
  • 50
    • 0022475083 scopus 로고
    • Brain monoamines and peptides: Role in the control of eating behavior
    • Leibowitz, S. 1986. Brain monoamines and peptides: role in the control of eating behavior. Fed. Proc. 45:1396-1403.
    • (1986) Fed. Proc. , vol.45 , pp. 1396-1403
    • Leibowitz, S.1
  • 51
    • 0023613393 scopus 로고
    • Pharmacological treatments that affect CNS activity: Serotonin
    • Nathan, C., and Roland, Y. 1990. Pharmacological treatments that affect CNS activity: serotonin. Ann. NY Acad. Sci. 600:277-296.
    • (1990) Ann. NY Acad. Sci. , vol.600 , pp. 277-296
    • Nathan, C.1    Roland, Y.2
  • 52
    • 0027281675 scopus 로고
    • 5-HT manipulation and dietary choice: Variable carbohydrate (Polycose) suppression demonstrated only under specific experimental conditions
    • Berl.
    • Lawton, C.L., and Blundell, J.E. 1993. 5-HT manipulation and dietary choice: variable carbohydrate (Polycose) suppression demonstrated only under specific experimental conditions. Psychopharmacology (Berl.) 112:375-382.
    • (1993) Psychopharmacology , vol.112 , pp. 375-382
    • Lawton, C.L.1    Blundell, J.E.2
  • 53
    • 7144227374 scopus 로고    scopus 로고
    • Serotoninergic control of the organization of feeding and satiety
    • Simansky, K.J. 1996. Serotoninergic control of the organization of feeding and satiety. Behav. Brain Res. 73:37-42.
    • (1996) Behav. Brain Res. , vol.73 , pp. 37-42
    • Simansky, K.J.1
  • 54
    • 0024354674 scopus 로고
    • Effect of norepinephrine, 5-HT and tryptophan on the firing rate of sympathetic nerves
    • Sakaguchi, T., and Bray, G.A. 1989. Effect of norepinephrine, 5-HT and tryptophan on the firing rate of sympathetic nerves. Brain Res. 492:271-280.
    • (1989) Brain Res. , vol.492 , pp. 271-280
    • Sakaguchi, T.1    Bray, G.A.2
  • 55
    • 0022479910 scopus 로고
    • A comparison of biochemical indices 5-hydroxytryptaminergic neuronal activity following electrical stimulation of the dorsal raphe nucleus
    • Shannon, N.J., Gunnet, J.W., and Moore, K.E. 1986. A comparison of biochemical indices 5-hydroxytryptaminergic neuronal activity following electrical stimulation of the dorsal raphe nucleus. J. Neurochem. 47:958-965.
    • (1986) J. Neurochem. , vol.47 , pp. 958-965
    • Shannon, N.J.1    Gunnet, J.W.2    Moore, K.E.3
  • 56
    • 0033038418 scopus 로고    scopus 로고
    • Interacting appetite-regulating pathways in the hypothalamic regulation of body weight
    • Kalra, S.P., et al. 1999. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr. Rev. 20:68-100.
    • (1999) Endocr. Rev. , vol.20 , pp. 68-100
    • Kalra, S.P.1


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