Capsaicin-sensitive vagal fibres and 5-HT3-, gastrin releasing peptide- and cholecystokinin A-receptors are involved in distension-induced inhibition of gastric emptying in the rat

Regulatory Peptides

Volumn 83, Issue 2-3, 1999, Pages 81-86

  Bozkurt, Ayhan ^a   Oktar, Berna K ^a   Kurtel, Hizir ^a   Alican, Inci ^a   Coşkun, Tamer ^a   Yeǧen, Berrak Ç ^a  

^a MARMARA UNIVERSITY   (Turkey)

Author keywords

5 HT3; Capsaicin; CCK; Distension; GRP; Mechanoreceptor

Indexed keywords

CAPSAICIN; CHOLECYSTOKININ; GASTRIN; GASTRIN RELEASING PEPTIDE; SEROTONIN 3 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; MECHANORECEPTOR; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH DISTENSION; STOMACH EMPTYING; VAGUS NERVE STIMULATION;

ANIMALS; CAPSAICIN; GASTRIC EMPTYING; GRANISETRON; MALE; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CHOLECYSTOKININ A; RECEPTORS, BOMBESIN; RECEPTORS, CHOLECYSTOKININ; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN ANTAGONISTS; STOMACH; VAGUS NERVE;

FISTULA;

EID: 0032775616     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(99)00050-6     Document Type: Article

References (45)

1. Meyer J.H. Motility of the stomach and the gastroduodenal junction. Johnson L.R. Physiology of the gastrointestinal tract. (2nd ed) :1987;613-629 Raven, New York.
2. Forster E.R., Green T., Dockray G.J. Efferent pathways in the reflex control of gastric emptying in rats. Am. J. Physiol. 260:(Gastrointest. Liver Physiol. 23):1991;G499-G504.
3. Thompson D.G. Modulation of gastric perception and motility in man. Dig. Dis. Sci. 39:(Suppl. 12):1994.
4. Davison J.S., Clarke G.D. Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechanoreceptors. Am. J. Physiol. 255:(Gastrointest. Liver Physiol. 18):1988;G55-G61.
5. Iggo A. Tension receptors in the stomach and urinary bladder. J. Physiol. Lond. 128:1955;593-607.
6. Moran T.H., Norgren R., Crosby R.J., McHugh P.R. Central and peripheral transport of cholecystokinin binding sites occurs in afferent fibres. Brain Res. 526:1990;95-102.
7. Moran T.H., Smith G.P., Hostetler A.M., McHugh P.R. Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches. Brain Res. 415:1987;149-152.
8. Scarpignato C., Micali B., Vitulo B., Zimbaro G., Bertaccini G. The effect of bombesin on gastric emptying of solids in man. Peptides. 2:(Suppl. 2):1981;199-203.
9. Scarpignato C., Bertaccini G. Bombesin delays gastric emptying in the rat. Digestion. 21:1981;104-106.
10. Vagne M., Collinet M., Cuber J.C., Bernard C., Chayvialle J.A., McDonald T.J., Mutt V. Effects of porcine gastrin releasing peptide on gastric secretion and motility and the release of hormonal peptides in conscious cats. Peptides. 8:1987;423-430.
11. Walsh J.H., Maxwell V., Ferrari J., Varner A.A. Bombesin stimulates human gastric function by gastrin-dependent and independent mechanisms. Peptides. 2:(Suppl. 2):1981;193-198.
12. Yoshida-Yoneda E., O-Lee T.J., Vigna S.R., Tache Y. Peripheral bombesin induces gastric vagal afferent activation in rats. Am. J. Physiol. 276:1996;R1584-1593.
13. Grundy D., Blackshaw L.A., Hillsley K. Role of 5-hydroxytryptamine in gastrointestinal chemosensitivity. Dig Dis Sci. 39:(12 Suppl.):1994;44S-47S.
14. Andrews P.L.R., Bingham S., Davidson H.I.M. Vagotomy and 5-HT3 receptor antagonism modify the motility response to 5-HT in the gastric antrum of the anesthetized ferret (abstract). J Physiol Lond. 422:1990;93P.
15. Andrews P.L.R., Rapeport G.G., Sanger G.J. Neuropharmacology of emesis induced by anti-cancer therapy. Trends Pharmacol Sci. 9:1988;334-340.
16. Raybould H.E., Hölzer H.H. Duodenal acid-induced inhibition of gastric motility and emptying in rats. Am J Physiol. 265:(Gastrointest Liver Physiol. 28):1993;G540-G546.
17. Dimaline R., Carter N., Barnes S. Evidence for reflex adrenergic inhibition of acid secretion in conscious rats. Am J Physiol. 251:1986;G615-618.
18. Green T., Dimaline R., Peikin S., Dockray G.J. Action of cholecystokinin antagonist L364, 718 on gastric emptying in the rat. Am J Physiol. 255:1988;G685-689.
19. Debas H.T., Farooq O., Grossman M.I. Inhibition of gastric emptying is a physiological action of cholecystokinin. Gastroenterology. 68:1975;1211-1217.
20. Forster E.R., Green T., Elliot M., Dockray G.J. Gastric emptying in rats: role of afferent neurons and cholecystokinin. Am J Physiol. 258:1990;G552-G556.
21. Lewis L.D., Williams J.A. Regulation of cholecystokinin secretion by food, hormones, and neural pathways in the rat. Am J Physiol. 258:(Gastrointest Liver Physiol 21):1990;G512-G518.
22. Buck S.H., Burks T.F. The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev. 38:1986;179-250.
23. Lynn B. The immediate and long term effects of applying capsaicin to cutaneus nerves. Acta Physiol Hung. 69:1987;287-294.
24. Chey W.Y., Hitanant S., Hendricks J., Lorber S.H. effects of secretin and cholecystokinin on gastric emptying and gastric output in man. Gastroenterology. 58:1970;820-827.
25. Lotti V.J., Pendelton R.G., Goulg R.J., Hanson H.M., Chang R.S.L., Clineschmidt B.V. In vivo pharmacology of L364,718 a new potent nonpeptide peripheral cholecystokinin antagonist. J Pharmacol Exp Ther. 214:1987;103-109.
26. Mangel A.W., Koegel A. Effects of peptides on gastric emptying. Am J Physiol. 246:(Gastrointest. Liver Physiol. 9):1984;G342-G345.
27. Moran T.H., McHugh P.R. Cholecystokinin suppresses food intake by inhibiting gastric emptying. Am J Physiol. 11:(Regul Int Comp Physiol):1982;R491-R497.
28. Kleibeuker J.H., Beekhuis H.J., Jansen J.B.M.J., Piers D.A., Lamers C.B.H.W. Cholecystokinin is a physiological hormonal mediator of fat-induced inhibition of gastric emptying in man. Eur J Clin Invest. 18:1988;173-177.
29. Liddle R.A., Morite E.D., Conrad C.K., Williams J.A. Regulation of gastric emptying in humans by cholecystokinin. J Clin Invest. 117:1986;992-996.
30. Valenzuela J.E., Defilippi C. Inhibition of gastric emptying in humans by secretin, the octapeptide of cholecystokinin, and intraduodenal fat. Gastroenterology. 68:1975;1211-1217.
31. Shillabeer G., Davidson J.S. Proglumide, a cholecystokinin antagonist, increases gastric emptying in rats. Am J Physiol. 252:(Regul Integr Comp Physiol):1987;R353-R360.
32. Yamagishi T., Debas H.T. Cholecystokinin inhibits gastric emptying by acting on both proximal stomach and pylorus. Am J Physiol. 234:1978;E375-E378.
33. Dockray G.J. Mediation and modulation of gastric afferent functions by regulatory peptides. Tache Y., Wingate D. Brain-gut interactions. 1991;124-130 CRC, Boston, MA.
34. Raybould H.E. Vagal afferent modulation of gastric function by neuropeptides. Tache Y., Wingate D. Brain-gut interactions. 1991;134-144 CRC, Boston, MA.
35. Raybould H.E., Tache Y. CCK inhibits gastric motility and emptying via a capsaicin-sensitive pathway in rats. Am J Physiol. 255:(Gastrointest Liver Physiol. 18):1988;G242-G246.
36. Moran T.H., Crosby R.J., McHugh P.R. Effects of pylorectomy on cholecystokinin (CCK) induced inhibition of liquid gastric emptying. Am J Physiol. 261:1991;R531-535.
37. McCann M.J., Verbalis J.G., Stricker E.M. Capsaicin attenuates multiple responses to cholecystokinin in rats. J Auton Nerv Syst. 23:1988;265-272.
38. Moran T.H., Robinson P.H., Goldrich M.S., McHugh P.R. Two brain CCK receptors: implications for behavioral actions. Brain Res. 362:1985;175-179.
39. Smith G.T., Moran T.H., Coyle J.T., Kuhar M.J., O'Donohue T.L., McHugh P.R. Anatomic localization of cholecystokinin receptors to the pyloric sphincter. Am J Physiol. 246:(Regul. Integ. Comp. Physiol. 18):1984;R127-R130.
40. Grundy D., Bagaev V., Hillsley K. Inhibition of gastric mechanoreceptor discharge by cholecystokinin in the rat. Am J Physiol. 268:(Gastrointest Liver Physiol. 31):1995;G355-G360.
41. Schwartz G.J., McHugh P.R., Moran T.H. Pharmacological dissociation of responses to CCK and gastric loads in rat mechanosensitive vagal afferents. Am J Physiol. 267:(Regul Int Comp Physiol 36):1994;R303-R308.
42. Yegen B.Ç., Gürbüz V., Coşckun T., Bozkurt A., Kurtel H., Alican I., Dockray G.J. Inhibitory effects of gastrin releasing peptide on gastric emptying in rats. Regul Pept. 61:1996;175-180.
43. Schwartz G.J., Moran T.H., White W.O., Ladenheim E.E. Relationship between gastric motility and gastric vagal afferent responses to CCK and GRP in rats differ. Am J Physiol. 272:(Regul Int Comp Physiol 41):1997;R1726-R1733.
44. Ritter R.C., Ritter S., Ewart W.R., Wingate D.L. Capsaicin attenuates hindbrain neuron responses to circulating cholecystokinin. Am J Physiol. 257:(Regul Int Comp Physiol 26):1989;R1162-R1168.
45. Yoshida-Yoneda E., O-Lee T.J., Wei J.Y., Vigna S.R., Tache Y. Peripheral bombesin induces gastric vagal afferent activation in rats. Am J Physiol. 271:(Regul Int Comp Physiol 40):1996;R1584-R1593.