Differential body weight and feeding responses to high-fat diets in rats and mice lacking cholecystokinin 1 receptors

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 293, Issue 1, 2007, Pages

  Bi, Sheng ^a   Chen, Jie ^a,b   Behles, R Ryan ^a   Hyun, Jayson ^a   Kopin, Alan S ^c   Moran, Timothy H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TUFTS MEDICAL CENTER   (United States)

Author keywords

Dorsomedial hypothalamic nucleus; In situ hybridization; Neuropeptide Y; Proopiomelanocortin

Indexed keywords

CHOLECYSTOKININ A RECEPTOR; FAT; GLUCOSE; LEPTIN; MESSENGER RNA; NEUROPEPTIDE Y; NUCLEAR FACTOR Y;

ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; ENERGY BALANCE; FEEDING; FOOD INTAKE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; IN SITU HYBRIDIZATION; LIPID DIET; LONG EVANS RAT; MALE; MOUSE; NONHUMAN; OTSUKA LONG EVANS TOKUSHIMA FATTY RAT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; WILD TYPE;

ADIPOSE TISSUE; ADIPOSITY; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CORTICOTROPIN-RELEASING HORMONE; DIET; DIETARY FATS; EATING; ENERGY INTAKE; GENE EXPRESSION; HYPOTHALAMUS; IN SITU HYBRIDIZATION; LEPTIN; MALE; MICE; MICE, KNOCKOUT; NEUROPEPTIDE Y; PRO-OPIOMELANOCORTIN; RATS; RATS, INBRED OLETF; RECEPTOR, CHOLECYSTOKININ A; RNA PROBES;

EID: 34447617146     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00002.2007     Document Type: Article

References (34)

1. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250-252, 1996.
2. Antin J, Gibbs J, Holt J, Young RC, Smith GP. Cholecystokinin elicits the complete behavioral sequence of satiety in rats. J Comp Physiol Psychol 89: 784-790, 1975.
3. Beck B, Stricker-Krongrad A, Burlet A, Max JP, Musse N, Nicolas JP, Burlet C. Macronutrient type independently of energy intake modulates hypothalamic neuropeptide Y in Long-Evans rats. Brain Res Bull 34: 85-91, 1994.
4. Bi S, Ladenheim EE, Schwartz GJ, Moran TH. A role for NPY overexpression in the dorsomedial hypothalamus in hyperphagia and obesity of OLETF rats. Am J Physiol Regul Integr Comp Physiol 281: R254-R260, 2001.
5. Bi S, Moran TH. Actions of CCK in the controls of food intake and body weight: lessons from the CCK-A receptor deficient OLETF rat. Neuropeptides 36: 171-181, 2002.
6. Bi S, Robinson BM, Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am J Physiol Regul Integr Comp Physiol 285: R1030-R1036, 2003.
7. Bi S, Scott KA, Kopin AS, Moran TH. Differential roles for cholecystokinin a receptors in energy balance in rats and mice. Endocrinology 145: 3873-3880, 2004.
8. Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S. Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci USA 101: 4695-4700, 2004.
9. Clegg DJ, Benoit SC, Air EL, Jackman A, Tso P, D'Alessio D, Woods SC, Seeley RJ. Increased dietary fat attenuates the anorexic effects of intracerebroventricular injections of MTII. Endocrinology 144: 2941-2946, 2003.
10. Covasa M, Ritter RC. Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors. Peptides 22: 1339-1348, 2001.
11. Dourish CT, Ruckert AC, Tattersall FD, Iversen SD. Evidence that decreased feeding induced by systemic injection of cholecystokinin is mediated by CCK-A receptors. Eur J Pharmacol 173: 233-234, 1989.
12. Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 23: 775-786, 1999.
13. Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA 95: 741-746, 1998.
14. Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395: 535-547, 1998.
15. Guan XM, Yu H, Trumbauer M, Frazier E, Van der Ploeg LH, Chen H. Induction of neuropeptide Y expression in dorsomedial hypothalamus of diet-induced obese mice. Neuroreport 9: 3415-3419, 1998.
16. Hansen MJ, Jovanovska V, Morris MJ. Adaptive responses in hypothalamic neuropeptide Y in the face of prolonged high-fat feeding in the rat. J Neurochem 88: 909-916, 2004.
17. Kim EM, Welch CC, Grace MK, Billington CJ, Levine AS. Effects of palatability-induced hyperphagia and food restriction on mRNA levels of neuropeptide-Y in the arcuate nucleus. Brain Res 806: 117-121, 1998.
18. Kinzig KP, Scott KA, Hyun J, Bi S, Moran TH. Altered hypothalamic signaling and responses to food deprivation in rats fed a low-carbohydrate diet. Obes Res 13: 1672-1682, 2005.
19. Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F, Bonner-Weir S, Kanarek R, Beinborn M. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest 103: 383-391, 1999.
20. Lin S, Storlien LH, Huang XF. Leptin receptor, NPY, POMC mRNA expression in the diet-induced obese mouse brain. Brain Res 875: 89-95, 2000.
21. Melville LD, Smith GP, Gibbs J. Devazepide antagonizes the inhibitory effect of cholecystokinin on intake in sham-feeding rats. Pharmacol Biochem Behav 43: 975-977, 1992.
22. Moran TH, Ameglio PJ, Schwartz GJ, McHugh PR. Blockade of type A, not type B, CCK receptors attenuates satiety actions of exogenous and endogenous CCK. Am J Physiol Regul Integr Comp Physiol 262: R46-R50, 1992.
23. Moran TH, Katz LF, Plata-Salaman CR, Schwartz GJ. Disordered food intake and obesity in rats lacking cholecystokinin A receptors. Am J Physiol Regul Integr Comp Physiol 274: R618-R625, 1998.
24. Paxinos G, Franklin KBJ. The Mouse Brain in Stereotaxic Coordinates (2nd ed.). San Diego, CA: Elsevier Academic, 2001.
25. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates (5th ed.). San Diego, CA: Elsevier Academic, 2005.
26. Reidelberger RD, O'Rourke MF. Potent cholecystokinin antagonist L364718 stimulates food intake in rats. Am J Physiol Regul Integr Comp Physiol 257: R1512-R1518, 1989.
27. Reidelberger RD, Varga G, Solomon TE. Effects of selective cholecystokinin antagonists L364,718 and L365,260 on food intake in rats. Peptides 12: 1215-1221, 1991.
28. Schwartz GJ, Whitney A, Skoglund C, Castonguay TW, Moran TH. Decreased responsiveness to dietary fat in Otsuka Long-Evans Tokushima fatty rats lacking CCK-A receptors. Am J Physiol Regul Integr Comp Physiol 277: R1144-R1151, 1999.
29. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 404: 661-671, 2000.
30. Smith GP, Gibbs J. Satiating effect of cholecystokinin. Ann NY Acad Sci 713: 236-241, 1994.
31. Takiguchi S, Takata Y, Funakoshi A, Miyasaka K, Kataoka K, Fujimura Y, Goto T, Kono A. Disrupted cholecystokinin type-A receptor (CCKAR) gene in OLETF rats. Gene 197: 169-175, 1997.
32. Williams G, Shellard L, Lewis DE, McKibbin PE, McCarthy HD, Koeslag DG, Russell JC. Hypothalamic neuropeptide Y disturbances in the obese (cp/cp) JCR:LA corpulent rat. Peptides 13: 537-540, 1992.
33. Yox DP, Brenner L, Ritter RC. CCK-receptor antagonists attenuate suppression of sham feeding by intestinal nutrients. Am J Physiol Regul Integr Comp Physiol 262: R554-R561, 1992.
34. Ziotopoulou M, Mantzoros CS, Hileman SM, Flier JS. Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice. Am J Physiol Endocrinol Metab 279: E838-E845, 2000.