-
2
-
-
70349492117
-
Hyaluronic acid complexed to biodegradable poly L-arginine for targeted delivery of siRNAs
-
Kim E. J., Shim G., Kim K., Kwon I. C., Oh Y. K., Shim C. K. 2009. Hyaluronic acid complexed to biodegradable poly L-arginine for targeted delivery of siRNAs. J. Gene Med. 11, 791-803.
-
(2009)
J. Gene Med.
, vol.11
, pp. 791-803
-
-
Kim, E.J.1
Shim, G.2
Kim, K.3
Kwon, I.C.4
Oh, Y.K.5
Shim, C.K.6
-
3
-
-
1242316928
-
Biodistribution of phosphodiester and phosphorothioate siRNA
-
Braasch D. A., Paroo Z., Constantinescu A., Ren G., Oz O. K., Mason R. P., Corey D. R. 2004. Biodistribution of phosphodiester and phosphorothioate siRNA. Bioorg. Med. Chem. Lett. 14, 1139-1143.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 1139-1143
-
-
Braasch, D.A.1
Paroo, Z.2
Constantinescu, A.3
Ren, G.4
Oz, O.K.5
Mason, R.P.6
Corey, D.R.7
-
4
-
-
11344257391
-
RNA interference using boranophosphate siRNAs: Structure-activity relationships
-
Hall A. H., Wan J., Shaughnessy E. E., Ramsay Sh. B., Alexander K. A. 2004. RNA interference using boranophosphate siRNAs: Structure-activity relationships. Nucleic Acids Res. 32, 5991-6000.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 5991-6000
-
-
Hall, A.H.1
Wan, J.2
Shaughnessy, E.E.3
Ramsay, S.B.4
Alexander, K.A.5
-
5
-
-
0041331496
-
siRNA function in RNAi: A chemical modification analysis
-
Chiu Y. L., Rana T. M. 2003. siRNA function in RNAi: A chemical modification analysis. RNA. 9, 1034-1048.
-
(2003)
RNA.
, vol.9
, pp. 1034-1048
-
-
Chiu, Y.L.1
Rana, T.M.2
-
6
-
-
1942533474
-
In vivo activity of nuclease-resistant siRNAs
-
Layzer J. M., McCaffrey A. P., Tanner A. K., Huang Z., Kay M. A., Sullenger B. A. 2004. In vivo activity of nuclease-resistant siRNAs. RNA. 10, 766-771.
-
(2004)
RNA.
, vol.10
, pp. 766-771
-
-
Layzer, J.M.1
McCaffrey, A.P.2
Tanner, A.K.3
Huang, Z.4
Kay, M.A.5
Sullenger, B.A.6
-
7
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek J., Akinc A., Bramlage B., Charisse K., Constien R., Donoghue M., Elbashir S., Geick A., Hadwiger P., Harborth J., John M., Kesavan V., Lavine G., Pandey R. K., Racie T., Rajeev K. G., Röhl I., Toudjarska I., Wang G., Wuschko S., Bumcrot D., Koteliansky V., Limmer S., Manoharan M., Vornlocher H. P. 2004. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 432, 173-178.
-
(2004)
Nature.
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
Akinc, A.2
Bramlage, B.3
Charisse, K.4
Constien, R.5
Donoghue, M.6
Elbashir, S.7
Geick, A.8
Hadwiger, P.9
Harborth, J.10
John, M.11
Kesavan, V.12
Lavine, G.13
Pandey, R.K.14
Racie, T.15
Rajeev, K.G.16
Röhl, I.17
Toudjarska, I.18
Wang, G.19
Wuschko, S.20
Bumcrot, D.21
Koteliansky, V.22
Limmer, S.23
Manoharan, M.24
Vornlocher, H.P.25
more..
-
8
-
-
34047190259
-
Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting
-
de Paula D., Bentley M. V., Mahato R. I. 2007. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA. 13, 431-456.
-
(2007)
RNA.
, vol.13
, pp. 431-456
-
-
de Paula, D.1
Bentley, M.V.2
Mahato, R.I.3
-
9
-
-
57349134691
-
Chemical modification of siRNAs for in vivo use
-
Behlke M. A. 2008. Chemical modification of siRNAs for in vivo use. Oligonucleotides. 18, 305-319.
-
(2008)
Oligonucleotides.
, vol.18
, pp. 305-319
-
-
Behlke, M.A.1
-
10
-
-
33746931297
-
Ligand-targeted delivery of therapeutic siRNA
-
Ikeda Y., Taira K. 2006. Ligand-targeted delivery of therapeutic siRNA. Pharm. Res. 23, 1631-1640.
-
(2006)
Pharm. Res.
, vol.23
, pp. 1631-1640
-
-
Ikeda, Y.1
Taira, K.2
-
11
-
-
33751099034
-
RNAi therapeutics: A potential new class of pharmaceutical drugs
-
Bumcrot D., Manoharan M., Koteliansky V., Sah D. W. 2006. RNAi therapeutics: A potential new class of pharmaceutical drugs. Nature Chem. Biol. 2, 711-719.
-
(2006)
Nature Chem. Biol.
, vol.2
, pp. 711-719
-
-
Bumcrot, D.1
Manoharan, M.2
Koteliansky, V.3
Sah, D.W.4
-
12
-
-
0037440005
-
Tolerance for mutations and chemical modifications in a siRNA
-
Amarzguioui M., Holen T., Babaie E., Prydz H. 2003. Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res. 31, 589-595.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 589-595
-
-
Amarzguioui, M.1
Holen, T.2
Babaie, E.3
Prydz, H.4
-
13
-
-
67650657743
-
Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators
-
Shaw B. R., Moussa L., Sharaf M., Cheek M., Dobrikov M. Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators. 2008. Nucleic Acids Symp. Ser. (Oxford). 52, 655-656.
-
(2008)
Nucleic Acids Symp. Ser. (Oxford)
, vol.52
, pp. 655-656
-
-
Shaw, B.R.1
Moussa, L.2
Sharaf, M.3
Cheek, M.4
Dobrikov, M.5
-
14
-
-
0038606999
-
Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
-
Czauderna F., Fechtner M., Dames S., Aygun H., Klippel A., Pronk G. J., Giese K., Kaufmann J. 2003. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res. 31, 2705-2716.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2705-2716
-
-
Czauderna, F.1
Fechtner, M.2
Dames, S.3
Aygun, H.4
Klippel, A.5
Pronk, G.J.6
Giese, K.7
Kaufmann, J.8
-
15
-
-
21244497878
-
Positional effect of chemical modifications on short interference RNA activity in mammalian cells
-
Prakash T. P., Allerson C. R., Dande P., Vickers T. A., Sioufi N., Jarres R., Baher B. F., Swayze E. E., Griffey R. H., Bhar B. 2005. Positional effect of chemical modifications on short interference RNA activity in mammalian cells. J. Med. Chem. 48, 4247-4253.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 4247-4253
-
-
Prakash, T.P.1
Allerson, C.R.2
Dande, P.3
Vickers, T.A.4
Sioufi, N.5
Jarres, R.6
Baher, B.F.7
Swayze, E.E.8
Griffey, R.H.9
Bhar, B.10
-
16
-
-
32944454941
-
Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo
-
Judge A. D., Bola G., Lee A. C., MacLachlan I. 2006. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. Mol. Ther. 13, 494-505.
-
(2006)
Mol. Ther.
, vol.13
, pp. 494-505
-
-
Judge, A.D.1
Bola, G.2
Lee, A.C.3
MacLachlan, I.4
-
17
-
-
13744250159
-
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
-
Elmen J., Thonberg H., Ljungberg K., Frieden M., Westergaard M., Xu Y., Wahren B., Liang Z., Orum H., Koch T., Wahlestedt C. 2005. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Res. 33, 439-447.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 439-447
-
-
Elmen, J.1
Thonberg, H.2
Ljungberg, K.3
Frieden, M.4
Westergaard, M.5
Xu, Y.6
Wahren, B.7
Liang, Z.8
Orum, H.9
Koch, T.10
Wahlestedt, C.11
-
18
-
-
77952329345
-
Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo
-
Laursen M. M., Pakula M. B., Gao S., Fluiter K., Mook O. R., Baas F., Langklaer N., Wengel S. L., Wengel J., Kjems J., Bramsen J. B. 2010. Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo. Mol. Biosyst. 6, 862-870.
-
(2010)
Mol. Biosyst.
, vol.6
, pp. 862-870
-
-
Laursen, M.M.1
Pakula, M.B.2
Gao, S.3
Fluiter, K.4
Mook, O.R.5
Baas, F.6
Langklaer, N.7
Wengel, S.L.8
Wengel, J.9
Kjems, J.10
Bramsen, J.B.11
-
19
-
-
0032560835
-
Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides
-
Obika S., Nanbu D., Hari Y., Andoh J., Morio K., Doi T., Imanishi T. 1998. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O, 4′-C-methyleneribonucleosides. Tetrahedron Lett. 39, 5401-5404.
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 5401-5404
-
-
Obika, S.1
Nanbu, D.2
Hari, Y.3
Andoh, J.4
Morio, K.5
Doi, T.6
Imanishi, T.7
-
20
-
-
0032473890
-
LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine, and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
-
Koshkin A. A., Singh S. K., Nielsen P., Rajwanshi V. K., Kumar R., Meldgaard M., Olsen C. E., Wengel J. 1998. LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine, and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition. Tetrahedron. 54, 3607-3630.
-
(1998)
Tetrahedron.
, vol.54
, pp. 3607-3630
-
-
Koshkin, A.A.1
Singh, S.K.2
Nielsen, P.3
Rajwanshi, V.K.4
Kumar, R.5
Meldgaard, M.6
Olsen, C.E.7
Wengel, J.8
-
21
-
-
0343065617
-
LNA (locked nucleic acids): Synthesis and high-affinity nucleic acid recognition
-
Singh S. K., Nielsen P., Koshkin A. A., Wengel J. 1998. LNA (locked nucleic acids): Synthesis and high-affinity nucleic acid recognition. J. Chem. Commun. 4, 455-456.
-
(1998)
J. Chem. Commun.
, vol.4
, pp. 455-456
-
-
Singh, S.K.1
Nielsen, P.2
Koshkin, A.A.3
Wengel, J.4
-
22
-
-
64549083734
-
The therapeutic potential of LNA-modified siRNAs: Reduction of off-target effects by chemical modification of the siRNA sequence
-
Fluiter K., Mook O. R., Baas F. 2009. The therapeutic potential of LNA-modified siRNAs: Reduction of off-target effects by chemical modification of the siRNA sequence. Methods Mol. Biol. 487, 189-203.
-
(2009)
Methods Mol. Biol.
, vol.487
, pp. 189-203
-
-
Fluiter, K.1
Mook, O.R.2
Baas, F.3
-
23
-
-
34147180058
-
Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo
-
Mook O. R., Baas F., de Wissel M. B., Fluiter K. 2007. Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo. Mol. Cancer Ther. 6, 833-843.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 833-843
-
-
Mook, O.R.1
Baas, F.2
de Wissel, M.B.3
Fluiter, K.4
-
24
-
-
84872756998
-
-
UsiRNA Technology. http://www. marinabio. com/usinra-technology.
-
UsiRNA Technology
-
-
-
25
-
-
34648834877
-
Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity
-
Moschos S. A, Jones S. W., Perry M. M., Williams A. E., Erjefalt J. S., Turner J. J., Barnes P. J., Sproat B. S., Gait M. J., Lindsay M. A. 2007. Lung delivery studies using siRNA conjugated to TAT(48-60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity. Bioconjug. Chem. 18, 1450-1459.
-
(2007)
Bioconjug. Chem.
, vol.18
, pp. 1450-1459
-
-
Moschos, S.A.1
Jones, S.W.2
Perry, M.M.3
Williams, A.E.4
Erjefalt, J.S.5
Turner, J.J.6
Barnes, P.J.7
Sproat, B.S.8
Gait, M.J.9
Lindsay, M.A.10
-
26
-
-
0842346326
-
Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells
-
Muratovska A., Eccles M. R. 2004. Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Lett. 558, 63-68.
-
(2004)
FEBS Lett.
, vol.558
, pp. 63-68
-
-
Muratovska, A.1
Eccles, M.R.2
-
27
-
-
0036804013
-
Arginine-rich peptides: Potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms
-
Futaki S. 2002. Arginine-rich peptides: Potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms. Int. J. Pharm. 245, 1-7.
-
(2002)
Int. J. Pharm.
, vol.245
, pp. 1-7
-
-
Futaki, S.1
-
28
-
-
0035937124
-
Arginine-rich peptides: An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery
-
Futaki S., Suzuki T., Ohashi W., Yagami T., Tanaka S., Ueda K., Sugiura Y. 2001. Arginine-rich peptides: An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J. Biol. Chem. 276, 5836-5840.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5836-5840
-
-
Futaki, S.1
Suzuki, T.2
Ohashi, W.3
Yagami, T.4
Tanaka, S.5
Ueda, K.6
Sugiura, Y.7
-
29
-
-
28844454642
-
Arginine-rich cell penetrating peptides: From endosomal uptake to nuclear delivery
-
Melikov K., Chernomordik L. V. 2005. Arginine-rich cell penetrating peptides: From endosomal uptake to nuclear delivery. Cell. Mol. Life Sci. 62, 2739-2749.
-
(2005)
Cell. Mol. Life Sci.
, vol.62
, pp. 2739-2749
-
-
Melikov, K.1
Chernomordik, L.V.2
-
30
-
-
0029982569
-
Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
-
Derossi D., Calvet S., Trembleau A., Brunissen A., Chassaing G., Prochiantz A. 1996. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J. Biol. Chem. 271, 18188-18193.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18188-18193
-
-
Derossi, D.1
Calvet, S.2
Trembleau, A.3
Brunissen, A.4
Chassaing, G.5
Prochiantz, A.6
-
31
-
-
2642680830
-
Cell penetration by transportan
-
Pooga M., Hallbrink M., Zorko M., Langel U. 1998. Cell penetration by transportan. FASEB J. 12, 67-77.
-
(1998)
FASEB J.
, vol.12
, pp. 67-77
-
-
Pooga, M.1
Hallbrink, M.2
Zorko, M.3
Langel, U.4
-
32
-
-
42949116303
-
Enhanced cell penetration of acid-degradable particles functionalized with cell-penetrating peptides
-
Cohen J. L., Almutairi A., Cohen J. A., Bernstein M., Brody S. L., Schuster D. P., Fréchet J. M. 2008. Enhanced cell penetration of acid-degradable particles functionalized with cell-penetrating peptides. Bioconjug. Chem. 19, 876-881.
-
(2008)
Bioconjug. Chem.
, vol.19
, pp. 876-881
-
-
Cohen, J.L.1
Almutairi, A.2
Cohen, J.A.3
Bernstein, M.4
Brody, S.L.5
Schuster, D.P.6
Fréchet, J.M.7
-
33
-
-
23944483437
-
Cell-penetrating peptides: Tools for intracellular delivery of therapeutics
-
Deshayes S., Morris M. C., Divita G., Heitz F. 2005. Cell-penetrating peptides: Tools for intracellular delivery of therapeutics. Cell. Mol. Life Sci. 62, 1839-1849.
-
(2005)
Cell. Mol. Life Sci.
, vol.62
, pp. 1839-1849
-
-
Deshayes, S.1
Morris, M.C.2
Divita, G.3
Heitz, F.4
-
34
-
-
0035210533
-
Stearylated arginine-rich peptides: A new class of transfection systems
-
Futaki S., Ohashi W., Suzuki T., Niwa M., Tanaka S., Ueda K., Harashima H., Sugiura Y. 2001. Stearylated arginine-rich peptides: A new class of transfection systems. Bioconjug. Chem. 12, 1005-1011.
-
(2001)
Bioconjug. Chem.
, vol.12
, pp. 1005-1011
-
-
Futaki, S.1
Ohashi, W.2
Suzuki, T.3
Niwa, M.4
Tanaka, S.5
Ueda, K.6
Harashima, H.7
Sugiura, Y.8
-
35
-
-
0041816277
-
Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans
-
Console S., Marty C., Garcia-Echeverria C., Schwendener R., Ballmer-Hofer K. 2003. Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans. J. Biol. Chem. 278, 35109-35114.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35109-35114
-
-
Console, S.1
Marty, C.2
Garcia-Echeverria, C.3
Schwendener, R.4
Ballmer-Hofer, K.5
-
36
-
-
23044477438
-
Mechanism of penetration of Antp(43-58) into membrane bilayers
-
Zhang W., Smith S. O. 2005. Mechanism of penetration of Antp(43-58) into membrane bilayers. Biochemistry. 44, 10110-10118.
-
(2005)
Biochemistry.
, vol.44
, pp. 10110-10118
-
-
Zhang, W.1
Smith, S.O.2
-
37
-
-
34548183102
-
Arginine-rich peptides and their internalization mechanisms
-
Futaki S., Nakase I., Tadokoro A., Takeuchi T., Jones A. T. 2007. Arginine-rich peptides and their internalization mechanisms. Biochem. Soc. Trans. 35, 784-787.
-
(2007)
Biochem. Soc. Trans.
, vol.35
, pp. 784-787
-
-
Futaki, S.1
Nakase, I.2
Tadokoro, A.3
Takeuchi, T.4
Jones, A.T.5
-
38
-
-
10344221003
-
Cellular uptake of arginine-rich peptides: Roles for macropinocytosis and actin rearrangement
-
Nakase I., Niwa M., Takeuchi T., Sonomura K., Kawabata N., Koike Y., Takehashi M., Tanaka S., Ueda K., Simpson J. C., Jones A. T., Sugiura Y., Futaki S. 2004. Cellular uptake of arginine-rich peptides: Roles for macropinocytosis and actin rearrangement. Mol. Ther. 10, 1011-1022.
-
(2004)
Mol. Ther.
, vol.10
, pp. 1011-1022
-
-
Nakase, I.1
Niwa, M.2
Takeuchi, T.3
Sonomura, K.4
Kawabata, N.5
Koike, Y.6
Takehashi, M.7
Tanaka, S.8
Ueda, K.9
Simpson, J.C.10
Jones, A.T.11
Sugiura, Y.12
Futaki, S.13
-
39
-
-
33846223900
-
Interaction of argininerich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis
-
Nakase I., Tadokoro A., Kawabata N., Takeuchi T., Katoh H., Hiramoto K., Negishi M., Nomizu M., Sugiura Y., Futaki S. 2007. Interaction of argininerich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis. Biochemistry. 46, 492-501.
-
(2007)
Biochemistry.
, vol.46
, pp. 492-501
-
-
Nakase, I.1
Tadokoro, A.2
Kawabata, N.3
Takeuchi, T.4
Katoh, H.5
Hiramoto, K.6
Negishi, M.7
Nomizu, M.8
Sugiura, Y.9
Futaki, S.10
-
41
-
-
67149093390
-
Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein
-
Eguchi A., Meade B. R., Chang Y. C., Fredrickson C. T., Willert K., Puri N., Dowdy S. F. 2009. Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nature Biotechnol. 27, 567-571.
-
(2009)
Nature Biotechnol.
, vol.27
, pp. 567-571
-
-
Eguchi, A.1
Meade, B.R.2
Chang, Y.C.3
Fredrickson, C.T.4
Willert, K.5
Puri, N.6
Dowdy, S.F.7
-
42
-
-
33746863376
-
Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma
-
Kim W. J., Christensen L. V., Jo S., Yockman J. W., Jeong J. H., Kim Y. H., Kim S. W. 2006. Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma. Mol. Ther. 14, 343-350.
-
(2006)
Mol. Ther.
, vol.14
, pp. 343-350
-
-
Kim, W.J.1
Christensen, L.V.2
Jo, S.3
Yockman, J.W.4
Jeong, J.H.5
Kim, Y.H.6
Kim, S.W.7
-
43
-
-
34248656980
-
Gene manipulation through the use of small interfering RNA (siRNA): From in vitro to in vivo applications
-
Kumar L. D., Clarke A. R. 2007. Gene manipulation through the use of small interfering RNA (siRNA): From in vitro to in vivo applications. Adv. Drug Deliv. Rev. 59, 87-100.
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 87-100
-
-
Kumar, L.D.1
Clarke, A.R.2
-
44
-
-
13644254495
-
Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells
-
Oishi M., Nagasaki Y., Itaka K., Nishiyama N., Kataoka K. 2005. Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J. Am. Chem. Soc. 127, 1624-1625.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 1624-1625
-
-
Oishi, M.1
Nagasaki, Y.2
Itaka, K.3
Nishiyama, N.4
Kataoka, K.5
-
45
-
-
34548735210
-
Dynamic Polyconjugates for targeted in vivo delivery of siRNA to hepatocytes
-
Rozema D. B., Lewis D. L., Wakefield D. H., Wong S. C., Klein J. J., Roesch P. L., Bertin S. L., Reppen T. W., Chu Q., Blokhin A. V., Hagstrom J. E., Wolff J. A. 2007. Dynamic Polyconjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc. Natl. Acad. Sci. U. S. A. 104, 12982-12987.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 12982-12987
-
-
Rozema, D.B.1
Lewis, D.L.2
Wakefield, D.H.3
Wong, S.C.4
Klein, J.J.5
Roesch, P.L.6
Bertin, S.L.7
Reppen, T.W.8
Chu, Q.9
Blokhin, A.V.10
Hagstrom, J.E.11
Wolff, J.A.12
-
46
-
-
35148815670
-
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
-
Wolfrum C., Shi S., Jayaprakash K. N., Jayaraman M., Wang G., Pandey R. K., Rajeev K. G., Nakayama T., Charrise K., Ndungo E. M., Zimmermann T., Koteliansky V., Manoharan M., Stoffel M. 2007. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nature Biotechnol. 25, 1149-1157.
-
(2007)
Nature Biotechnol.
, vol.25
, pp. 1149-1157
-
-
Wolfrum, C.1
Shi, S.2
Jayaprakash, K.N.3
Jayaraman, M.4
Wang, G.5
Pandey, R.K.6
Rajeev, K.G.7
Nakayama, T.8
Charrise, K.9
Ndungo, E.M.10
Zimmermann, T.11
Koteliansky, V.12
Manoharan, M.13
Stoffel, M.14
-
47
-
-
41149179660
-
Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol
-
Nishina K., Unno T., Uno Y., Kubodera T., Kanouchi T., Miz U. S. Awa H., Yokota T. 2008. Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol. Mol. Ther. 16, 734-740.
-
(2008)
Mol. Ther.
, vol.16
, pp. 734-740
-
-
Nishina, K.1
Unno, T.2
Uno, Y.3
Kubodera, T.4
Kanouchi, T.5
Miz, U.S.6
Awa, H.7
Yokota, T.8
-
49
-
-
48949100324
-
Thousands of proteins affected by miRNAs
-
Check Hayen E. 2008. Thousands of proteins affected by miRNAs. Nature. 454, 562.
-
(2008)
Nature.
, vol.454
, pp. 562
-
-
Check Hayen, E.1
-
50
-
-
33745200043
-
A novel siRNA validation system for functional screening and identification of effective RNAi probes in mammalian cells
-
Hung C. F., Lu K. C., Cheng T. L., Wu R. H., Huang L. Y., Teng C. F., Chanq W. T. 2006. A novel siRNA validation system for functional screening and identification of effective RNAi probes in mammalian cells. Biochem. Biophys. Res. Commun. 346, 707-720.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.346
, pp. 707-720
-
-
Hung, C.F.1
Lu, K.C.2
Cheng, T.L.3
Wu, R.H.4
Huang, L.Y.5
Teng, C.F.6
Chanq, W.T.7
-
51
-
-
43849106645
-
siRNAs with high specificity to the target: A systematic design by CRM algorithm
-
Alsheddi T., Vasin L., Meduri R., Randhawa M., Glazko G., Baranova A. 2008. siRNAs with high specificity to the target: A systematic design by CRM algorithm. Mol. Biol. (Moscow). 42, 163-171.
-
(2008)
Mol. Biol. (Moscow).
, vol.42
, pp. 163-171
-
-
Alsheddi, T.1
Vasin, L.2
Meduri, R.3
Randhawa, M.4
Glazko, G.5
Baranova, A.6
-
52
-
-
63849266266
-
Design and validation of siRNAs and shRNAs
-
Tilesi F., Fradiani P., Socci V., Willems D., Ascenzioni F. 2009. Design and validation of siRNAs and shRNAs. Curr. Opin. Mol. Ther. 11, 156-164.
-
(2009)
Curr. Opin. Mol. Ther.
, vol.11
, pp. 156-164
-
-
Tilesi, F.1
Fradiani, P.2
Socci, V.3
Willems, D.4
Ascenzioni, F.5
-
53
-
-
79957449345
-
An efficient algorithm for systematic analysis of nucleotide strings suitable for siRNA design
-
Baranova A., Bode J., Manyam G., Emelianenko M. 2011. An efficient algorithm for systematic analysis of nucleotide strings suitable for siRNA design. BMC Res. Notes. 27, 168.
-
(2011)
BMC Res. Notes.
, vol.27
, pp. 168
-
-
Baranova, A.1
Bode, J.2
Manyam, G.3
Emelianenko, M.4
-
54
-
-
33646188259
-
3' UTR seed matches, but not overall identity, are associated with RNAi off-targets
-
Birmingham A., Anderson E. M., Reynolds A., Ilsley-Tyree D., Leake D., Fedorov Y., Baskerville S., Maksimova E., Robinson K., Karpilow J., Marshall W. S., Khvorova A. 2006. 3' UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nature Methods. 3, 199-204.
-
(2006)
Nature Methods.
, vol.3
, pp. 199-204
-
-
Birmingham, A.1
Anderson, E.M.2
Reynolds, A.3
Ilsley-Tyree, D.4
Leake, D.5
Fedorov, Y.6
Baskerville, S.7
Maksimova, E.8
Robinson, K.9
Karpilow, J.10
Marshall, W.S.11
Khvorova, A.12
-
55
-
-
34548850318
-
hClp1: A novel kinase revitalizes RNA metabolism
-
Weitzer S., Martinez J. 2007. hClp1: A novel kinase revitalizes RNA metabolism. Cell Cycle. 6, 2133-2137.
-
(2007)
Cell Cycle.
, vol.6
, pp. 2133-2137
-
-
Weitzer, S.1
Martinez, J.2
-
56
-
-
38649099969
-
Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity
-
Chen P. Y., Weinmann L., Gaidatzis D., Pei Y., Zavolan M., Tuschl T., Meister G. 2008. Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA. 14, 263-274.
-
(2008)
RNA.
, vol.14
, pp. 263-274
-
-
Chen, P.Y.1
Weinmann, L.2
Gaidatzis, D.3
Pei, Y.4
Zavolan, M.5
Tuschl, T.6
Meister, G.7
-
58
-
-
49549116014
-
Silencing HIV-1 in vivo
-
Kirchhoff F. 2008. Silencing HIV-1 in vivo. Cell. 134, 566-568.
-
(2008)
Cell.
, vol.134
, pp. 566-568
-
-
Kirchhoff, F.1
-
59
-
-
84930541492
-
Advances in systemic siRNA delivery
-
Leng Q., Woodle M. C., Lu P. Y., Mixson A. J. 2009. Advances in systemic siRNA delivery. Drugs Future. 34, 721.
-
(2009)
Drugs Future.
, vol.34
, pp. 721
-
-
Leng, Q.1
Woodle, M.C.2
Lu, P.Y.3
Mixson, A.J.4
-
60
-
-
33847099637
-
Lipid-based nanoparticles for nucleic acid delivery
-
Li W., Szoka Jr. F. C. 2007. Lipid-based nanoparticles for nucleic acid delivery. Pharm. Res. 24, 438-449.
-
(2007)
Pharm. Res.
, vol.24
, pp. 438-449
-
-
Li, W.1
Szoka Jr., F.C.2
-
61
-
-
67249122712
-
Biological barriers to therapy with antisense and siRNA oligonucleotides
-
Juliano R., Bauman J., Kang H., Ming X. 2009. Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol. Pharm. 6, 686-695.
-
(2009)
Mol. Pharm.
, vol.6
, pp. 686-695
-
-
Juliano, R.1
Bauman, J.2
Kang, H.3
Ming, X.4
-
62
-
-
0001200347
-
In vivo behavior of liposomes: Interactions with the mononuclear phagocyte system and implications for drug targeting
-
R. L. Juliano (Ed.), Berlin: Springer
-
Scherphof G. L. 1991. In vivo behavior of liposomes: Interactions with the mononuclear phagocyte system and implications for drug targeting. In: Handbook of Experimental Pharmacology. Ed. Juliano R. L. Berlin: Springer, vol. 100, pp. 285-300.
-
(1991)
Handbook of Experimental Pharmacology
, pp. 285-300
-
-
Scherphof, G.L.1
-
63
-
-
78449309070
-
Efficient and targeted delivery of siRNA in vivo
-
Shim M. S., Kwon Y. J. 2010. Efficient and targeted delivery of siRNA in vivo. FEBS J. 277, 4814-4827.
-
(2010)
FEBS J.
, vol.277
, pp. 4814-4827
-
-
Shim, M.S.1
Kwon, Y.J.2
-
64
-
-
0141790758
-
Drug delivery and transport to solid tumors
-
Jang S. H., Wientjes M. G., Lu D., Au J. L. 2003. Drug delivery and transport to solid tumors. Pharm. Res. 20, 1337-13350.
-
(2003)
Pharm. Res.
, vol.20
, pp. 1337-13350
-
-
Jang, S.H.1
Wientjes, M.G.2
Lu, D.3
Au, J.L.4
-
65
-
-
33646564091
-
Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo
-
Cho-Rock J., Yoo J., Jang Y. J., Kim S., Chu I.-S., Yeom Y. I., Choi J. Y., Im D.-S. 2006. Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo. Hepatology. 43, 1042-1052.
-
(2006)
Hepatology.
, vol.43
, pp. 1042-1052
-
-
Cho-Rock, J.1
Yoo, J.2
Jang, Y.J.3
Kim, S.4
Chu, I.-S.5
Yeom, Y.I.6
Choi, J.Y.7
Im, D.-S.8
-
66
-
-
47249138782
-
Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
-
Juliano R., Alam M. R., Dixit V., Kang H. 2008. Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides. Nucleic Acids Res. 36, 4158-4171.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 4158-4171
-
-
Juliano, R.1
Alam, M.R.2
Dixit, V.3
Kang, H.4
-
67
-
-
33644593889
-
Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery
-
Khalil I. A., Kogure K., Akita H., Harashima H. 2006. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol. Rev. 58, 32-45.
-
(2006)
Pharmacol. Rev.
, vol.58
, pp. 32-45
-
-
Khalil, I.A.1
Kogure, K.2
Akita, H.3
Harashima, H.4
-
68
-
-
1642575957
-
Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
-
Rejman J., Oberle V., Zuhorn I. S., Hoekstra D. 2004. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 377, 159-169.
-
(2004)
Biochem. J.
, vol.377
, pp. 159-169
-
-
Rejman, J.1
Oberle, V.2
Zuhorn, I.S.3
Hoekstra, D.4
-
69
-
-
6344291687
-
Lipidic carriers of siRNA: Differences in the formulation, cellular uptake, and delivery with plasmid DNA
-
Spagnou S., Miller A. D., Keller M. 2004. Lipidic carriers of siRNA: Differences in the formulation, cellular uptake, and delivery with plasmid DNA. Biochemistry. 43, 13348-13356.
-
(2004)
Biochemistry.
, vol.43
, pp. 13348-13356
-
-
Spagnou, S.1
Miller, A.D.2
Keller, M.3
-
70
-
-
65349088500
-
Systemic therapeutic gene delivery for cancer: crafting Paris' arrow
-
Tong A. W., Jay C. M., Senzer N., Maples P. B., Nemunaitis J. 2009. Systemic therapeutic gene delivery for cancer: crafting Paris' arrow. Curr. Gene Ther. 9, 45-60.
-
(2009)
Curr. Gene Ther.
, vol.9
, pp. 45-60
-
-
Tong, A.W.1
Jay, C.M.2
Senzer, N.3
Maples, P.B.4
Nemunaitis, J.5
-
71
-
-
0032536438
-
Effect of serum components on the physicochemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells
-
Zelphati O., Uyechi L. S., Barron L. G., Szoka Jr. F. C. 1998. Effect of serum components on the physicochemical properties of cationic lipid/oligonucleotide complexes and on their interactions with cells. Biochim. Biophys. Acta. 1390, 119-133.
-
(1998)
Biochim. Biophys. Acta.
, vol.1390
, pp. 119-133
-
-
Zelphati, O.1
Uyechi, L.S.2
Barron, L.G.3
Szoka Jr., F.C.4
-
72
-
-
0030866645
-
In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
-
Li S., Huang L. 1997. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther. 4, 891-900.
-
(1997)
Gene Ther.
, vol.4
, pp. 891-900
-
-
Li, S.1
Huang, L.2
-
73
-
-
0030813879
-
Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration
-
Liu F., Qi H., Huang L., Liu D. 1997. Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration. Gene Ther. 4, 517-523.
-
(1997)
Gene Ther.
, vol.4
, pp. 517-523
-
-
Liu, F.1
Qi, H.2
Huang, L.3
Liu, D.4
-
74
-
-
0029971068
-
Influence of dose on liposome clearance: Critical role of blood proteins
-
Oja C. D., Semple S. C., Chonn A., Cullis P. 1996. Influence of dose on liposome clearance: Critical role of blood proteins. Biochim. Biophys. Acta. 1281, 31-37.
-
(1996)
Biochim. Biophys. Acta.
, vol.1281
, pp. 31-37
-
-
Oja, C.D.1
Semple, S.C.2
Chonn, A.3
Cullis, P.4
-
75
-
-
0029988431
-
Influence of cholesterol on the association of plasma proteins with liposomes
-
Semple S. C., Chonn A., Cullis P. 1996. Influence of cholesterol on the association of plasma proteins with liposomes. Biochemistry. 35, 2521-2525.
-
(1996)
Biochemistry.
, vol.35
, pp. 2521-2525
-
-
Semple, S.C.1
Chonn, A.2
Cullis, P.3
-
76
-
-
77953683945
-
Non-viral nanosystems for systemic siRNA delivery
-
David S., Pitard B., Benoît J. P., Passirani C. 2010. Non-viral nanosystems for systemic siRNA delivery. Pharmacol. Res. 62, 100-114.
-
(2010)
Pharmacol. Res.
, vol.62
, pp. 100-114
-
-
David, S.1
Pitard, B.2
Benoît, J.P.3
Passirani, C.4
-
77
-
-
0037088992
-
Targeting tumors with nonviral gene delivery systems
-
Ogris M., Wagner E. 2002. Targeting tumors with nonviral gene delivery systems. Drug Discov. Today. 7, 479-485.
-
(2002)
Drug Discov. Today.
, vol.7
, pp. 479-485
-
-
Ogris, M.1
Wagner, E.2
-
78
-
-
23444444512
-
Biodegradable long-circulating polymeric nanospheres
-
Gref R., Minamitake Y., Peracchia M. T., Trubetskoy V., Torchilin V., Langer R. 1994. Biodegradable long-circulating polymeric nanospheres. Science. 263, 1600-1603.
-
(1994)
Science.
, vol.263
, pp. 1600-1603
-
-
Gref, R.1
Minamitake, Y.2
Peracchia, M.T.3
Trubetskoy, V.4
Torchilin, V.5
Langer, R.6
-
79
-
-
26944452043
-
PEGylation, successful approach to drug delivery
-
Veronses F. M., Pasut G. 2005. PEGylation, successful approach to drug delivery. Drug Discovery Today. 10, 1451-1458.
-
(2005)
Drug Discovery Today.
, vol.10
, pp. 1451-1458
-
-
Veronses, F.M.1
Pasut, G.2
-
80
-
-
77953553846
-
Therapeutic targeting in the silent era: advances in non-viral siRNA delivery
-
Guo J., Fisher K. A., Darcy R., Cryan J. F., O'Driscoll C. 2010. Therapeutic targeting in the silent era: advances in non-viral siRNA delivery. Mol. Biosys. 6, 1143-1161.
-
(2010)
Mol. Biosys.
, vol.6
, pp. 1143-1161
-
-
Guo, J.1
Fisher, K.A.2
Darcy, R.3
Cryan, J.F.4
O'Driscoll, C.5
-
81
-
-
40849138014
-
Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes
-
Ishida T., Kiwada H. 2008. Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes. Int. J. Pharm. 354, 56-62.
-
(2008)
Int. J. Pharm.
, vol.354
, pp. 56-62
-
-
Ishida, T.1
Kiwada, H.2
-
82
-
-
70349492117
-
Hyaluronic acid complexed to biodegradable poly L-arginine for targeted delivery of siRNAs
-
Kim E. J., Shim G., Kim K., Kwon I. C., Oh Y. K., Shim C. K. 2009. Hyaluronic acid complexed to biodegradable poly L-arginine for targeted delivery of siRNAs. J. Gene Med. 11, 791-803.
-
(2009)
J. Gene Med.
, vol.11
, pp. 791-803
-
-
Kim, E.J.1
Shim, G.2
Kim, K.3
Kwon, I.C.4
Oh, Y.K.5
Shim, C.K.6
-
83
-
-
77950786710
-
Nanoparticle-based delivery system for application of siRNA in vivo
-
Wang Y., Li Z., Han Y., Liang L. H., Ji A. 2010. Nanoparticle-based delivery system for application of siRNA in vivo. Curr. Drug Metab. 11, 182-196.
-
(2010)
Curr. Drug Metab.
, vol.11
, pp. 182-196
-
-
Wang, Y.1
Li, Z.2
Han, Y.3
Liang, L.H.4
Ji, A.5
-
84
-
-
67249100358
-
Target-specific intracellular delivery of siRNA/PEIHA complex by receptor mediated endocytosis
-
Jiang G., Park K., Kim J., Kim K. S., Hahn S. K. 2009. Target-specific intracellular delivery of siRNA/PEIHA complex by receptor mediated endocytosis. Mol. Pharm. 6, 727-737.
-
(2009)
Mol. Pharm.
, vol.6
, pp. 727-737
-
-
Jiang, G.1
Park, K.2
Kim, J.3
Kim, K.S.4
Hahn, S.K.5
-
85
-
-
60749099046
-
Polymer nanocarriers for the delivery of small fragments of nucleic acids: Oligonucleotides and siRNA
-
de Martimprey H., Vauthier C., Malvy C., Couvreur P. 2009. Polymer nanocarriers for the delivery of small fragments of nucleic acids: Oligonucleotides and siRNA. Eur. J. Pharm. Biopharm. 71, 490-504.
-
(2009)
Eur. J. Pharm. Biopharm.
, vol.71
, pp. 490-504
-
-
de Martimprey, H.1
Vauthier, C.2
Malvy, C.3
Couvreur, P.4
-
86
-
-
0033084717
-
Polycation-based DNA complexes for tumor-targeted gene delivery in vivo
-
Kircheis R., Schuller S., Brunner S., Ogris M., Heider K. H., Zauner W., Wagner E. J. 1999. Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. Gene Med. 1, 111-120.
-
(1999)
Gene Med.
, vol.1
, pp. 111-120
-
-
Kircheis, R.1
Schuller, S.2
Brunner, S.3
Ogris, M.4
Heider, K.H.5
Zauner, W.6
Wagner, E.J.7
-
87
-
-
0011797006
-
Sterically stabilized BGTC-based lipoplexes: Structural features and gene transfection into the mouse airways in vivo
-
Pitard B., Oudrhiri N., Lambert O., Vivien E., Masson C., Wetzer B., Hauchecorne M., Scherman D., Rigaud J. L., Vigneron J. P., Lehn J. M., Lehn P. 2001. Sterically stabilized BGTC-based lipoplexes: Structural features and gene transfection into the mouse airways in vivo. Gene Med. 3, 478-487.
-
(2001)
Gene Med.
, vol.3
, pp. 478-487
-
-
Pitard, B.1
Oudrhiri, N.2
Lambert, O.3
Vivien, E.4
Masson, C.5
Wetzer, B.6
Hauchecorne, M.7
Scherman, D.8
Rigaud, J.L.9
Vigneron, J.P.10
Lehn, J.M.11
Lehn, P.12
-
88
-
-
22144447455
-
Design and development of polymers for gene delivery
-
Pack D. W., Hoffman A. S., Pun S., Stayton P. S. 2005. Design and development of polymers for gene delivery. Nature Rev. Drug Discovery. 4, 581-593.
-
(2005)
Nature Rev. Drug Discovery.
, vol.4
, pp. 581-593
-
-
Pack, D.W.1
Hoffman, A.S.2
Pun, S.3
Stayton, P.S.4
-
89
-
-
33748054817
-
RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system
-
Howard K. A., Rahbek U. L., Liu X., Damgaard C. K., Glud S. Z., Andersen M. O., Hovgaard M. B., Schmitz A., Nyengaard J. R., Besenbacher F., Kjems J. 2006. RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. Mol. Ther. 14, 476-484.
-
(2006)
Mol. Ther.
, vol.14
, pp. 476-484
-
-
Howard, K.A.1
Rahbek, U.L.2
Liu, X.3
Damgaard, C.K.4
Glud, S.Z.5
Andersen, M.O.6
Hovgaard, M.B.7
Schmitz, A.8
Nyengaard, J.R.9
Besenbacher, F.10
Kjems, J.11
-
90
-
-
1642291631
-
Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis
-
Zhang X., Shan P., Jiang D., Noble P. W., Abraham N. G., Kappas A., Lee P. J. 2004. Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J. Biol. Chem. 279, 10677-10684.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10677-10684
-
-
Zhang, X.1
Shan, P.2
Jiang, D.3
Noble, P.W.4
Abraham, N.G.5
Kappas, A.6
Lee, P.J.7
-
91
-
-
13444262170
-
Inhibition of respiratory viruses by nasally administered siRNA
-
Bitko V., Musiyenko A., Shulyayeva O., Barik S. 2005. Inhibition of respiratory viruses by nasally administered siRNA. Nature Med. 11, 50-55.
-
(2005)
Nature Med.
, vol.11
, pp. 50-55
-
-
Bitko, V.1
Musiyenko, A.2
Shulyayeva, O.3
Barik, S.4
-
92
-
-
78149445102
-
In vivo electroporation of the central nervous system: a non-viral approach for targeted gene delivery
-
de Vry J., Martínez-Martínez P., Losen M., Temel Y., Steckler T., Steinbusch H. W., de Baets M. H., Prickaerts J. 2010. In vivo electroporation of the central nervous system: a non-viral approach for targeted gene delivery. Prog. Neurobiol. 92, 227-44.
-
(2010)
Prog. Neurobiol.
, vol.92
, pp. 227-244
-
-
de Vry, J.1
Martínez-Martínez, P.2
Losen, M.3
Temel, Y.4
Steckler, T.5
Steinbusch, H.W.6
de Baets, M.H.7
Prickaerts, J.8
-
93
-
-
0037038758
-
Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake
-
Makimura H., Mizuno T. M., Mastaitis J. W., Agami R., Mobbs C. V. 2002. Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci. 3, 18.
-
(2002)
BMC Neurosci.
, vol.3
, pp. 18
-
-
Makimura, H.1
Mizuno, T.M.2
Mastaitis, J.W.3
Agami, R.4
Mobbs, C.V.5
-
94
-
-
10344228801
-
Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference
-
Thakker D. R., Natt F., Hüsken D., Maier R., Müller M., van der Putten H., Hoyer D., Cryan J. F. 2004. Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference. Proc. Natl. Acad. Sci. U. S. A. 101, 17270-17275.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 17270-17275
-
-
Thakker, D.R.1
Natt, F.2
Hüsken, D.3
Maier, R.4
Müller, M.5
van der Putten, H.6
Hoyer, D.7
Cryan, J.F.8
-
95
-
-
23744502650
-
siRNA-mediated knock-down of the serotonin transporter in the adult mouse brain
-
Thakker D. R., Hüsken D., van der Putten H., Maier R., Hoyer D., Cryan J. F. 2005. siRNA-mediated knock-down of the serotonin transporter in the adult mouse brain. Mol. Psychiatry. 10, 782-789, 714.
-
(2005)
Mol. Psychiatry.
, vol.10
, pp. 782-789
-
-
Thakker, D.R.1
Hüsken, D.2
van der Putten, H.3
Maier, R.4
Hoyer, D.5
Cryan, J.F.6
-
96
-
-
10344261343
-
siRNA relieves chronic neuropathic pain
-
Dorn G., Patel S., Wotherspoon G., Hemmings-Mieszczak M., Barclay J., Natt F. J., Martin P., Bevan, S., Fox A., Ganju P., Wishart W., Hall J. 2004. siRNA relieves chronic neuropathic pain. Nucleic Acids Res. 32, e49.
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Dorn, G.1
Patel, S.2
Wotherspoon, G.3
Hemmings-Mieszczak, M.4
Barclay, J.5
Natt, F.J.6
Martin, P.7
Bevan, S.8
Fox, A.9
Ganju, P.10
Wishart, W.11
Hall, J.12
-
97
-
-
34547119296
-
Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema
-
Emerson M. V., Lauer A. K. 2007. Emerging therapies for the treatment of neovascular age-related macular degeneration and diabetic macular edema. BioDrugs. 21, 245-257.
-
(2007)
BioDrugs.
, vol.21
, pp. 245-257
-
-
Emerson, M.V.1
Lauer, A.K.2
-
98
-
-
2942620143
-
Protection against lethal influenza virus challenge by RNA interference in vivo
-
Tompkins S. M., Lo C. Y., Tumpey T. M., Epstein S. L. 2004. Protection against lethal influenza virus challenge by RNA interference in vivo. Proc. Natl. Acad. Sci. U. S. A. 101, 8682-8686.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 8682-8686
-
-
Tompkins, S.M.1
Lo, C.Y.2
Tumpey, T.M.3
Epstein, S.L.4
-
99
-
-
9644252866
-
Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference
-
Chae S. S., Paik J. H., Furneaux H., Hla T. 2004. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J. Clin. Invest. 114, 1082-1089.
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 1082-1089
-
-
Chae, S.S.1
Paik, J.H.2
Furneaux, H.3
Hla, T.4
-
100
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song E., Zhu P., Lee S. K., Chowdhury D., Kussman S., Dykxhoorn D. M., Feng Y., Palliser D., Weiner D. B., Shankar P., Marasco W. A., Lieberman J. 2005. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nature Biotechnol. 23, 709-717.
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.K.3
Chowdhury, D.4
Kussman, S.5
Dykxhoorn, D.M.6
Feng, Y.7
Palliser, D.8
Weiner, D.B.9
Shankar, P.10
Marasco, W.A.11
Lieberman, J.12
-
101
-
-
72949119713
-
Lipidic systems for in vivo siRNA delivery
-
Wu S. Y., McMillan N. A. 2009. Lipidic systems for in vivo siRNA delivery. AAPS J. 11, 639-652.
-
(2009)
AAPS J.
, vol.11
, pp. 639-652
-
-
Wu, S.Y.1
McMillan, N.A.2
-
102
-
-
30144434185
-
An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
-
Palliser D., Chowdhury D., Wang Q. Y., Lee S. J., Bronson R. T., Knipe D. M., Lieberman J. 2006. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature. 439, 89-94.
-
(2006)
Nature.
, vol.439
, pp. 89-94
-
-
Palliser, D.1
Chowdhury, D.2
Wang, Q.Y.3
Lee, S.J.4
Bronson, R.T.5
Knipe, D.M.6
Lieberman, J.7
-
103
-
-
77951702180
-
Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease
-
Azuma M., Ritprajak P., Hashiguchi M. 2010. Topical application of siRNA targeting cutaneous dendritic cells in allergic skin disease. Methods Mol. Biol. 623, 373-381.
-
(2010)
Methods Mol. Biol.
, vol.623
, pp. 373-381
-
-
Azuma, M.1
Ritprajak, P.2
Hashiguchi, M.3
-
104
-
-
69249215187
-
Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse
-
Takanashi M., Oikawa K., Sudo K., Tanaka M., Fujita K., Ishikawa A., Nakae S., Kaspar R. L., Matsuzaki M., Kudo M., Kuroda M. 2009. Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse. Gene Ther. 16, 982-989.
-
(2009)
Gene Ther.
, vol.16
, pp. 982-989
-
-
Takanashi, M.1
Oikawa, K.2
Sudo, K.3
Tanaka, M.4
Fujita, K.5
Ishikawa, A.6
Nakae, S.7
Kaspar, R.L.8
Matsuzaki, M.9
Kudo, M.10
Kuroda, M.11
-
105
-
-
77956621869
-
Advances in synthetic siRNA delivery
-
Manjunath N., Dykxhoorn D. M. 2010. Advances in synthetic siRNA delivery. Discov. Med. 9, 418-430.
-
(2010)
Discov. Med.
, vol.9
, pp. 418-430
-
-
Manjunath, N.1
Dykxhoorn, D.M.2
-
106
-
-
34248228071
-
Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system
-
Pirollo K. F., Rait A., Zhou Q., Hwang S. H., Dagata J. A., Zon G., Hogrefe R. I., Palchik G., Chang E. H. 2007. Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system. Cancer Res. 67, 2938-2943.
-
(2007)
Cancer Res.
, vol.67
, pp. 2938-2943
-
-
Pirollo, K.F.1
Rait, A.2
Zhou, Q.3
Hwang, S.H.4
Dagata, J.A.5
Zon, G.6
Hogrefe, R.I.7
Palchik, G.8
Chang, E.H.9
-
107
-
-
34247255870
-
Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1
-
Peer D., Zhu P., Carman C. V., Lieberman J., Shimaoka M. 2007. Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc. Natl. Acad. Sci. U. S. A. 104, 4095-4100.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 4095-4100
-
-
Peer, D.1
Zhu, P.2
Carman, C.V.3
Lieberman, J.4
Shimaoka, M.5
-
108
-
-
33845654382
-
Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice
-
Sato A., Takagi M., Shimamoto A., Kawakami S., Hashida M. 2007. Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice. Biomaterials. 28, 1434-1442.
-
(2007)
Biomaterials.
, vol.28
, pp. 1434-1442
-
-
Sato, A.1
Takagi, M.2
Shimamoto, A.3
Kawakami, S.4
Hashida, M.5
-
109
-
-
25444482607
-
Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma
-
Hu-Lieskovan S., Heidel J. D., Bartlett D. W., Davis M. E., Triche T. J. 2005. Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res. 65, 8984-8992.
-
(2005)
Cancer Res.
, vol.65
, pp. 8984-8992
-
-
Hu-Lieskovan, S.1
Heidel, J.D.2
Bartlett, D.W.3
Davis, M.E.4
Triche, T.J.5
-
110
-
-
14544298301
-
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
-
Schiffelers R. M., Ansari A., Xu J., Zhou Q., Tang Q., Storm G., Molema G., Lu P. Y., Scaria P. V., Woodle M. C. 2004. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res. 32, e149.
-
(2004)
Nucleic Acids Res.
, vol.32
-
-
Schiffelers, R.M.1
Ansari, A.2
Xu, J.3
Zhou, Q.4
Tang, Q.5
Storm, G.6
Molema, G.7
Lu, P.Y.8
Scaria, P.V.9
Woodle, M.C.10
-
111
-
-
0034993240
-
The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting
-
Maeda H. 2001. The enhanced permeability and retention (EPR) effect in tumor vasculature: The key role of tumor-selective macromolecular drug targeting. Adv. Enzyme Regul. 41, 189-207.
-
(2001)
Adv. Enzyme Regul.
, vol.41
, pp. 189-207
-
-
Maeda, H.1
-
112
-
-
77953457158
-
Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting
-
Greish K. 2010. Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. Methods Mol. Biol. 624, 25-37.
-
(2010)
Methods Mol. Biol.
, vol.624
, pp. 25-37
-
-
Greish, K.1
-
113
-
-
77954362096
-
Aptamer-targeted cell-specific RNA interference
-
Zhou J., Rossi J. J. 2010. Aptamer-targeted cell-specific RNA interference. Silence. 1, 4.
-
(2010)
Silence.
, vol.1
, pp. 4
-
-
Zhou, J.1
Rossi, J.J.2
-
114
-
-
0028869690
-
Diversity of oligonucleotide functions
-
Gold L., Polisky B., Uhlenbeck O., Yarus M. 1995. Diversity of oligonucleotide functions. Annu. Rev. Biochem. 64, 763-797.
-
(1995)
Annu. Rev. Biochem.
, vol.64
, pp. 763-797
-
-
Gold, L.1
Polisky, B.2
Uhlenbeck, O.3
Yarus, M.4
-
115
-
-
70249110439
-
Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
-
Dassie J. P., Liu X. Y., Thomas G. S., Whitaker R. M., Thiel K. W., Stockdale K. R., Meyerholz D. K., McCaffrey A. P., McNamara J. O., Giangrande P. H. 2009. Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nature Biotechnol. 27, 839-849.
-
(2009)
Nature Biotechnol.
, vol.27
, pp. 839-849
-
-
Dassie, J.P.1
Liu, X.Y.2
Thomas, G.S.3
Whitaker, R.M.4
Thiel, K.W.5
Stockdale, K.R.6
Meyerholz, D.K.7
McCaffrey, A.P.8
McNamara, J.O.9
Giangrande, P.H.10
-
116
-
-
33747031960
-
Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
-
McNamara J. O., Andrechek E. R., Wang Y., Viles K. D., Rempel R. E., Gilboa E., Sullenger B. A., Giangrande P. H. 2006. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nature Biotechnol. 24, 1005-1015.
-
(2006)
Nature Biotechnol.
, vol.24
, pp. 1005-1015
-
-
McNamara, J.O.1
Andrechek, E.R.2
Wang, Y.3
Viles, K.D.4
Rempel, R.E.5
Gilboa, E.6
Sullenger, B.A.7
Giangrande, P.H.8
-
117
-
-
38849166053
-
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target
-
Peer D., Park E. J., Morishita Y., Carman C. V., Shimaoka M. 2008. Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science. 319, 627-630.
-
(2008)
Science.
, vol.319
, pp. 627-630
-
-
Peer, D.1
Park, E.J.2
Morishita, Y.3
Carman, C.V.4
Shimaoka, M.5
-
118
-
-
2542561420
-
Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer
-
Zhang Y., Zhang Y. F., Bryant J., Charles A., Boado R. J., Pardridge W. M. 2004. Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin. Cancer Res. 10, 3667-3677.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 3667-3677
-
-
Zhang, Y.1
Zhang, Y.F.2
Bryant, J.3
Charles, A.4
Boado, R.J.5
Pardridge, W.M.6
-
119
-
-
35748948383
-
Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome
-
Watanabe T., Umehara T., Yasui F., Nakagawa S., Yano J., Ohgi T., Sonoke S., Satoh K., Inoue K., Yoshiba M., Kohara M. 2007. Liver target delivery of small interfering RNA to the HCV gene by lactosylated cationic liposome. J. Hepatol. 47, 744-750.
-
(2007)
J. Hepatol.
, vol.47
, pp. 744-750
-
-
Watanabe, T.1
Umehara, T.2
Yasui, F.3
Nakagawa, S.4
Yano, J.5
Ohgi, T.6
Sonoke, S.7
Satoh, K.8
Inoue, K.9
Yoshiba, M.10
Kohara, M.11
-
120
-
-
67249131198
-
Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells
-
Chen Y., Sen J., Bathula S. R., Yang Q., Fittipaldi R., Huang L. 2009. Novel cationic lipid that delivers siRNA and enhances therapeutic effect in lung cancer cells. Mol. Pharm. 6, 696-705.
-
(2009)
Mol. Pharm.
, vol.6
, pp. 696-705
-
-
Chen, Y.1
Sen, J.2
Bathula, S.R.3
Yang, Q.4
Fittipaldi, R.5
Huang, L.6
-
121
-
-
0025934603
-
Interaction of positively-charged liposomes with blood: implications for their application in vivo
-
Senior J. H., Trimble K. R., Maskiewicz R. 1991. Interaction of positively-charged liposomes with blood: implications for their application in vivo. Biochim. Biophys. Acta. 1070, 173-179.
-
(1991)
Biochim. Biophys. Acta.
, vol.1070
, pp. 173-179
-
-
Senior, J.H.1
Trimble, K.R.2
Maskiewicz, R.3
-
122
-
-
17844401203
-
Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid
-
Sakurai F., Nishioka T., Saito H., Baba T., Okuda A., Matsumoto O., Taga T., Yamashita F., Takakura Y., Hashida M. 2001. Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid. Gene Ther. 8, 677-686.
-
(2001)
Gene Ther.
, vol.8
, pp. 677-686
-
-
Sakurai, F.1
Nishioka, T.2
Saito, H.3
Baba, T.4
Okuda, A.5
Matsumoto, O.6
Taga, T.7
Yamashita, F.8
Takakura, Y.9
Hashida, M.10
-
123
-
-
1542404783
-
Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice
-
Oyewumi M. O., Yokel R. A., Jay M., Coakley T., Mumper R. J. 2004. Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice. J. Control Release. 95, 613-626.
-
(2004)
J. Control Release.
, vol.95
, pp. 613-626
-
-
Oyewumi, M.O.1
Yokel, R.A.2
Jay, M.3
Coakley, T.4
Mumper, R.J.5
-
124
-
-
0032990267
-
Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution, and ability to complex and protect DNA
-
Richardson S. C., Kolbe H. V., Duncan R. 1999. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution, and ability to complex and protect DNA. Int. J. Pharm. 178, 231-243.
-
(1999)
Int. J. Pharm.
, vol.178
, pp. 231-243
-
-
Richardson, S.C.1
Kolbe, H.V.2
Duncan, R.3
-
125
-
-
34248672837
-
Toxicogenomics of nonviral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity
-
Akhtar S., Benter I. 2007. Toxicogenomics of nonviral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. Adv. Drug Deliv. Rev. 59, 164-182.
-
(2007)
Adv. Drug Deliv. Rev.
, vol.59
, pp. 164-182
-
-
Akhtar, S.1
Benter, I.2
-
126
-
-
34248213490
-
Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity
-
Hollins A. J., Omidi Y., Benter I. F., Akhtar S. 2007. Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity. J. Drug Target. 15, 83-88.
-
(2007)
J. Drug Target.
, vol.15
, pp. 83-88
-
-
Hollins, A.J.1
Omidi, Y.2
Benter, I.F.3
Akhtar, S.4
-
127
-
-
30644478022
-
Polypropylenimine dendrimer-induced gene expression changes: The effect of complexation with DNA, dendrimer generation and cell type
-
Omidi Y., Hollins A. J., Drayton R. M., Akhtar S. 2005. Polypropylenimine dendrimer-induced gene expression changes: The effect of complexation with DNA, dendrimer generation and cell type. J. Drug Target. 13, 431-443.
-
(2005)
J. Drug Target.
, vol.13
, pp. 431-443
-
-
Omidi, Y.1
Hollins, A.J.2
Drayton, R.M.3
Akhtar, S.4
-
128
-
-
0347756922
-
Toxicogenomics of nonviral vectors for gene therapy: A microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells
-
Omidi Y., Hollins A. J., Benboubetra M., Drayton R., Benter I. F., Akhtar S. 2003. Toxicogenomics of nonviral vectors for gene therapy: A microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells. J. Drug Target. 6, 311-323.
-
(2003)
J. Drug Target.
, vol.6
, pp. 311-323
-
-
Omidi, Y.1
Hollins, A.J.2
Benboubetra, M.3
Drayton, R.4
Benter, I.F.5
Akhtar, S.6
-
129
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir S. M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411, 494-498.
-
(2001)
Nature.
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
130
-
-
20144389695
-
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
Hornung V., Guenthner-Biller M., Bourquin C., Ablasser A., Schlee M., Uematsu S., Noronha A., Manoharan M., Akira S., de Fougerolles A., Endres S., Hartmann G. 2005. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nature Med. 11, 263-270.
-
(2005)
Nature Med.
, vol.11
, pp. 263-270
-
-
Hornung, V.1
Guenthner-Biller, M.2
Bourquin, C.3
Ablasser, A.4
Schlee, M.5
Uematsu, S.6
Noronha, A.7
Manoharan, M.8
Akira, S.9
de Fougerolles, A.10
Endres, S.11
Hartmann, G.12
-
131
-
-
0344926320
-
Cationic liposome-mediated delivery of siRNAs in adult mice
-
Sioud M., Sørensen D. R. 2003. Cationic liposome-mediated delivery of siRNAs in adult mice. Biochem. Biophys. Res. Commun. 312, 1220-1225.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.312
, pp. 1220-1225
-
-
Sioud, M.1
Sørensen, D.R.2
-
132
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge A. D., Sood V., Shaw J. R., Fang D., McClintock K., MacLachlan I. 2005. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nature Biotechnol. 23, 457-462.
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
Sood, V.2
Shaw, J.R.3
Fang, D.4
McClintock, K.5
MacLachlan, I.6
-
133
-
-
2442705429
-
Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3
-
Kariko K., Bhuyan P., Capodici J., Weissman D. 2004. Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3. J. Immunol. 172, 6545-6549.
-
(2004)
J. Immunol.
, vol.172
, pp. 6545-6549
-
-
Kariko, K.1
Bhuyan, P.2
Capodici, J.3
Weissman, D.4
-
134
-
-
27944459341
-
Activation of the mammalian immune system by siRNAs
-
Marques J. T., Williams B. R. G. 2005. Activation of the mammalian immune system by siRNAs. Nature Biotechnol. 23, 1399-1405.
-
(2005)
Nature Biotechnol.
, vol.23
, pp. 1399-1405
-
-
Marques, J.T.1
Williams, B.R.G.2
-
136
-
-
16244362066
-
Cationic lipids enhance siRNA-mediated interferon response in mice
-
Ma Z., Li J., He F., Wilson A., Pitt B., Li S. 2005. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem. Biophys. Res. Commun. 330, 755-759.
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.330
, pp. 755-759
-
-
Ma, Z.1
Li, J.2
He, F.3
Wilson, A.4
Pitt, B.5
Li, S.6
-
137
-
-
2942530436
-
Inhibition of influenza virus production in virus-infected mice by RNA interference
-
Ge Q., Filip L., Bai A., Nguyen T., Eisen H. N., Chen J. 2004. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc. Natl. Acad. Sci. U. S. A. 101, 8676-8681.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 8676-8681
-
-
Ge, Q.1
Filip, L.2
Bai, A.3
Nguyen, T.4
Eisen, H.N.5
Chen, J.6
-
138
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek J., Akinc A., Bramlage B., Charisse K., Constien R., Donoghue M., Elbashir S., Geick A., Hadwiger P., Harborth J., John M., Kesavan V., Lavine G., Pandey R. K., Racie T., Rajeev K. G., Röhl I., Toudjarska I., Wang G., Wuschko S., Bumcrot D., Koteliansky V., Limmer S., Manoharan M., Vornlocher H. P. 2004. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature. 432, 173-178.
-
(2004)
Nature.
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
Akinc, A.2
Bramlage, B.3
Charisse, K.4
Constien, R.5
Donoghue, M.6
Elbashir, S.7
Geick, A.8
Hadwiger, P.9
Harborth, J.10
John, M.11
Kesavan, V.12
Lavine, G.13
Pandey, R.K.14
Racie, T.15
Rajeev, K.G.16
Röhl, I.17
Toudjarska, I.18
Wang, G.19
Wuschko, S.20
Bumcrot, D.21
Koteliansky, V.22
Limmer, S.23
Manoharan, M.24
Vornlocher, H.P.25
more..
-
139
-
-
33646185371
-
RNAi-mediated gene silencing in non-human primates
-
Zimmermann T. S., Lee A. C., Akinc A., Bramlage B., Bumcrot D., Fedoruk, M. N., Harborth J., Heyes J. A., Jeffs L. B., John M., Judge A. D., Lam K., McClintock K., Nechev L. V., Palmer L. R., Racie T., Röhl I., Seiffert S., Shanmugam S., Sood V., Soutschek J., Toudjarska I., Wheat A. J., Yaworski E., Zedalis W., Koteliansky V., Manoharan M., Vornlocher H. P., MacLachlan I. 2006. RNAi-mediated gene silencing in non-human primates. Nature. 441, 111-114.
-
(2006)
Nature.
, vol.441
, pp. 111-114
-
-
Zimmermann, T.S.1
Lee, A.C.2
Akinc, A.3
Bramlage, B.4
Bumcrot, D.5
Fedoruk, M.N.6
Harborth, J.7
Heyes, J.A.8
Jeffs, L.B.9
John, M.10
Judge, A.D.11
Lam, K.12
McClintock, K.13
Nechev, L.V.14
Palmer, L.R.15
Racie, T.16
Röhl, I.17
Seiffert, S.18
Shanmugam, S.19
Sood, V.20
Soutschek, J.21
Toudjarska, I.22
Wheat, A.J.23
Yaworski, E.24
Zedalis, W.25
Koteliansky, V.26
Manoharan, M.27
Vornlocher, H.P.28
MacLachlan, I.29
more..
-
140
-
-
77950518550
-
Rational design of immunostimulatory siRNAs
-
Gantier M. P., Tong S., Behlke M. A., Irving A. T., Lappas M., Nilsson U. W., Latz E., McMillan N. A., Williams B. R. 2010. Rational design of immunostimulatory siRNAs. Mol. Ther. 18, 785-795.
-
(2010)
Mol. Ther.
, vol.18
, pp. 785-795
-
-
Gantier, M.P.1
Tong, S.2
Behlke, M.A.3
Irving, A.T.4
Lappas, M.5
Nilsson, U.W.6
Latz, E.7
McMillan, N.A.8
Williams, B.R.9
-
141
-
-
33845298010
-
Design of bifunctional siRNAs: Combining immunostimulation and gene-silencing in one single siRNA molecule
-
Furset G., Sioud M. 2007. Design of bifunctional siRNAs: Combining immunostimulation and gene-silencing in one single siRNA molecule. Biochem. Biophys. Res. Commun. 352, 642-649.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.352
, pp. 642-649
-
-
Furset, G.1
Sioud, M.2
-
142
-
-
55549114663
-
5′-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
-
Poeck H., Besch R., Maihoefer C., Renn M., Tormo D., Morskaya S. S., Kirschnek S., Gaffal E., Landsberg J., Hellmuth J., Schmidt A., Anz D., Bscheider M., Schwerd T., Berking C., Bourquin C., Kalinke U., Kremmer E., Kato H., Akira S., Meyers R., Häcker G., Neuenhahn M., Busch D., Ruland J., Rothenfusser S., Prinz M., Hornung V., Endres S., Tüting T., Hartmann G. 2008. 5′-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nature Med. 14, 1256-1263.
-
(2008)
Nature Med.
, vol.14
, pp. 1256-1263
-
-
Poeck, H.1
Besch, R.2
Maihoefer, C.3
Renn, M.4
Tormo, D.5
Morskaya, S.S.6
Kirschnek, S.7
Gaffal, E.8
Landsberg, J.9
Hellmuth, J.10
Schmidt, A.11
Anz, D.12
Bscheider, M.13
Schwerd, T.14
Berking, C.15
Bourquin, C.16
Kalinke, U.17
Kremmer, E.18
Kato, H.19
Akira, S.20
Meyers, R.21
Häcker, G.22
Neuenhahn, M.23
Busch, D.24
Ruland, J.25
Rothenfusser, S.26
Prinz, M.27
Hornung, V.28
Endres, S.29
Tüting, T.30
Hartmann, G.31
more..
-
143
-
-
28844508593
-
Translocation of positively charged copoly(Lys/Tyr) across phospholipid membranes
-
Liu S., Shibata A., Ueno S., Huang Y., Wang Y., Li Y. 2006. Translocation of positively charged copoly(Lys/Tyr) across phospholipid membranes. Biochem. Biophys. Res. Commun. 339, 761-768.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.339
, pp. 761-768
-
-
Liu, S.1
Shibata, A.2
Ueno, S.3
Huang, Y.4
Wang, Y.5
Li, Y.6
-
144
-
-
33847789142
-
Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
-
Cedervall T., Lynch I., Lindman S., Berggard T., Thulin E., Nilsson H., Dawson K. A., Linse S. 2007. Understanding the nanoparticle-protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles. Proc. Natl. Acad. Sci. U. S. A. 104, 2050-2055.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 2050-2055
-
-
Cedervall, T.1
Lynch, I.2
Lindman, S.3
Berggard, T.4
Thulin, E.5
Nilsson, H.6
Dawson, K.A.7
Linse, S.8
|