Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity

Journal of Drug Targeting

Volumn 15, Issue 1, 2007, Pages 83-88

  Hollins, Andrew J ^a   Omidi, Yadollah ^a   Benter, Ibrahim F ^a,b   Akhtar, Saghir ^a,b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b KUWAIT UNIVERSITY   (Kuwait)

Author keywords

Dendrimer; Drug delivery systems; Epidermal growth factor receptor; Gene expression; Microarray; SiRNAs

Indexed keywords

DENDRIMER; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; POLYAMIDOAMINE; SMALL INTERFERING RNA; BIOMATERIAL; PAMAM STARBURST; POLYAMINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; DRUG UPTAKE; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; TOXICOGENETICS; DNA MICROARRAY; ELECTROCHEMISTRY; ELECTROPHORESIS; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

BIOCOMPATIBLE MATERIALS; BLOTTING, WESTERN; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; ELECTROCHEMISTRY; ELECTROPHORESIS; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYAMINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TOXICOGENETICS; TRANSFECTION;

EID: 34248213490     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860601151860     Document Type: Article

References (16)

1. Beale, G., Hollins, AJ, Benboubetra, M., Sohail, M., Fox, SP, Benter, I. and Akhtar, S. (2003) Gene silencing nucleic acids design by scanning arrays: Anti-EGFR activity of siRNA, ribozyme and DNA enzymes targeting a single hybridization-accessible region using the same delivery system. J Drug Target, 117, pp. 449-456.
2. Fedorov, Y., King, A., Anderson, E., Karpilow, J., Ilsley, D., Marshall, W. and Khvorova, A. (2005) Different delivery methods-different expression profiles. Nat Methods, 2, p. 241.
3. Gilmore, IR, Fox, SP, Hollins, AJ, Sohail, M. and Akhtar, S. (2004) The design and exogenous delivery of siRNA for post-transcriptional gene silencing. J Drug Target, 12:6, pp. 315-340.
4. Gilmore, IR, Fox, SP, Hollins, AJ and Akhtar, S. (2006) Delivery strategies for siRNA-mediated gene silencing. Curr Drug Deliv, 3:2, pp. 147-155.
5. Hollins, AJ, Benboubetra, M., Omidi, Y., Zinselmeyer, BH, Schatzlein, AG, Uchegbu, I. and Akhtar, S. (2004) Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor. Pharm Res, 21:30, pp. 458-466.
6. Jackson, AL, Bartz, SR, Schelter, J., Kobayashi, SV, Burchard, J., Mao, M., Cavet, G. and Linsley, PS (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol, 21, pp. 635-637.
7. Lin, X., Ruan, X., Anderson, MG, McDowell, JA, Kroeger, PE, Fesik, SW and Shen, Y. (2005) siRNA-mediated off-target gene silencing triggered by a 7 nt complementation. Nucleic Acids Res, 33:14, pp. 4527-4535.
8. Manoharan, M. (2004) RNA interference and chemically modified small interfering RNAs. Curr Opin Chem Biol, 8, pp. 570-579.
9. McManus, MT and Sharp, PA (2002) Gene silencing in mammals by small interfering RNAs. Nat Rev Genet, 3, pp. 737-747.
10. Mittal, V. (2004) Improving the efficiency of RNA interference in mammals. Nat Rev Genet, 5, pp. 355-365.
11. Omidi, Y., Hollins, AJ, Benboubetra, M., Drayton, R. and Akhtar, S. (2003) Toxicogenomics of non-viral vectors for gene therapy: A microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells. J Drug Target, 11:6, pp. 1-13.
12. Omidi, Y., Hollins, AJ, Drayton, RM and Akhtar, S. (2005) Polypropylenimine dendrimer-induced gene expression changes: The effect of complexation with DNA, dendrimer generation and cell type. J Drug Target, 13:7, pp. 431-443.
13. Saxena, S., Jonsson, ZO and Dutta, A. (2003) Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J Biol Chem, 278, pp. 44312-44319.
14. Scacheri, PC, Rozenblatt-Rosen, O., Caplen, NJ, Wolfsberg, TG, Umayam, L., Lee, JC, Hughes, CM, Shanmugam, KS, Bhattacharjee, A., Meyerson, M. and Collins, FS (2004) Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells. Proc Natl Acad Sci USA, 101, pp. 1892-1897.
15. Semizarov, D., Kroeger, P. and Fesik, S. (2004) siRNA-mediated gene silencing: A global genome view. Nucleic Acids Res, 32, pp. 3836-3845.
16. Sledz, CA, Holko, M., de Veer, MJ, Silverman, RH and Williams, BR (2003) Activation of the interferon system by short-interfering RNAs. Nat Cell Biol, 5, pp. 834-839.