Factors controlling the efficiency of cationic lipidmediated transfection in vivo via intravenous administration

Gene Therapy

Volumn 4, Issue 6, 1997, Pages 517-523

  Liu, F ^a   Qi, H ^a   Huang, L ^b   Liu, D ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cationic liposomes; Gene therapy; Gene transfer; Transfection

Indexed keywords

BETA GALACTOSIDASE; CATION; COMPLEMENTARY DNA; IODINE 125; LIPID; LUCIFERASE; PLASMID DNA; POLYSORBATE 80; TRIMETHYLAMMONIUM SALT DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; HEART; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SOUTHERN BLOTTING; SPLEEN; TISSUE DISTRIBUTION; TRANSGENE;

ANIMALIA;

EID: 0030813879     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300424     Document Type: Article

References (25)

1. Felgner PL et al. Lipofectin: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 1987; 84: 7413-7417.
2. Felgner JL et al. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J Biol Chem 1994, 269: 2550-2561.
3. Gao X, Huang L. A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem Biophys Res Comm 1991; 179: 280-285.
4. Hawley NP, Ciccarone V, Gebeyehu G, Jessee J. Lipofectamine reagent: a new, higher efficiency polycationic liposome transfection reagent. Focus 1993; 15: 73-79.
5. Behr JP, Demeneix B, Loeffler JP, Mutul JP. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc Natl Acad Sci USA 1989; 86: 6982-6986.
6. Solodin I et al. A novel series of amphiphilic imidazolinium compounds for in vitro and in vivo gene delivery. Biochemistry 1995; 34: 13537-13544.
7. Leventis R, Silvius JR. Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles. Biochim Biophys Acta 1990; 1023: 124-132.
8. Lee ER et al. Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung. Hum Gene Ther 1996; 7: 1701-1717.
9. Malone RW, Felgner PL, Verma IM. Cationic liposome-mediated RNA transfection. Proc Natl Acad Sci USA 1989; 86: 6077-6081.
10. Walker C et al. Cationic lipids direct a viral glycoprotein into the class I major histocompatibility complex antigen-presentation pathway. Proc Natl Acad Sci USA 1992; 89: 7915-7918.
11. Gao X, Huang L. Cytoplasmic expression of a reporter gene by co-delivery of T7 RNA polymerase and T7 promoter sequence with cationic liposomes. Nucleic Acids Res 1993; 21: 2867-2872.
12. Gao X, Huang L. Cationic liposome-mediated gene transfer. Gene Therapy 1996; 2: 710-722.
13. Nabel GJ et al Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci USA 1993; 90: 11307-11311.
14. Nabel GL et al. Immunotherapy for cancer by direct gene transfer into tumors. Hum Gem Ther 1994; 5: 57-77.
15. Sorscher EJ et al. Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway. Hum Gene Ther 1994; 5: 1259-1277.
16. Caplen NJ et al. Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nature Med 1995; 1: 39-46.
17. Liu F, Yang JP, Huang L, Liu D. New cationic lipid formulations for gene transfer. Pharm Res 1996; 13: 1642-1646.
18. Liu F, Yang JP, Huang L, Liu D. Effect of non-ionic surfactants on the formation of DNA-emulsion complexes and emulsion-mediated gene transfer. Pharm Res 1996; 13: 1856-1860.
19. Zhu N, Liggitt D, Liu Y, Debs R. Systemic gene expression after intravenous DNA delivery into adult mice. Science 1993; 261: 209-211.
20. Thierry AR et al. Systemic gene therapy: biodistribution and long-term expression of a transgene in mice. Proc Natl Acad Sci USA 1995; 92: 9742-9746.
21. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual, Vol. 1. Cold Spring Harbor Laboratory Press: New York, 1989, pp 21-24.
22. Wolf P. The radioiodination of RNA and DNA to high specific activities. Meth Cell Biol 1976; 13: 121-152.
23. Wu MS et al. Modified in vivo behavior of liposomes containing synthetic glycolipids. Biochim Biophys Acta 1981; 674: 19-26.
24. 1-containing liposomes. Biochim Biophys Acta 1992; 1104: 95-101.
25. Wolff JA, Malone RW, Williams P. Direct gene transfer into mouse muscle in vivo Science 1990; 247: 1456-1468.