Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 10, 2007, Pages 4095-4100

  Peer, Dan ^a   Zhu, Pengcheng ^a   Carman, Christopher V ^a   Lieberman, Judy ^a   Shimaoka, Motomu ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Affinity up regulation; AL 57 and TS1 22; Antiinflammation; Cell adhesion molecule; Drug delivery

Indexed keywords

HYBRID PROTEIN; INTERFERON; LIPID; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PROTAMINE; SMALL INTERFERING RNA; CELL NUCLEUS ANTIGEN; CHEMOKINE RECEPTOR CCR5; DNA BINDING PROTEIN; KU ANTIGEN;

ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL STRAIN K 562; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; GENE FUNCTION; GENE REPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE ACTIVATION; LYMPHOCYTE ACTIVATION; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA INTERFERENCE; SCID MOUSE; VALIDATION PROCESS; ANIMAL; BIOSYNTHESIS; CELL ADHESION; CHEMISTRY; DOSE RESPONSE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; T LYMPHOCYTE;

MUS;

ANIMALS; ANTIGENS, NUCLEAR; CELL ADHESION; CELL PROLIFERATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE SILENCING; HUMANS; K562 CELLS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; MICE, SCID; RECEPTORS, CCR5; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; T-LYMPHOCYTES;

EID: 34247255870     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0608491104     Document Type: Article

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