-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70 (Pubitemid 30046295)
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
4043181214
-
Cancer genes and the pathways they control
-
DOI 10.1038/nm1087
-
Vogelstein B, Kinzler KW (2004) Cancer genes and the pathways they control. Nat Med 10:789-799 (Pubitemid 39070849)
-
(2004)
Nature Medicine
, vol.10
, Issue.8
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
3
-
-
0033604499
-
Active site-directed protein regulation
-
Kobe B, Kemp BE (1999) Active site-directed protein regulation. Nature 402:373-376 (Pubitemid 129544817)
-
(1999)
Nature
, vol.402
, Issue.6760
, pp. 373-376
-
-
Kobe, B.1
Kemp, B.E.2
-
5
-
-
0032875697
-
Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
-
DOI 10.1038/13690
-
Gygi SP, Rist B, Gerber SA et al (1999) Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol 17:994-999 (Pubitemid 29474856)
-
(1999)
Nature Biotechnology
, vol.17
, Issue.10
, pp. 994-999
-
-
Gygi, S.P.1
Rist, B.2
Gerber, S.A.3
Turecek, F.4
Gelb, M.H.5
Aebersold, R.6
-
6
-
-
0035106351
-
Large-scale analysis of the yeast proteome by multidimensional protein identification technology
-
DOI 10.1038/85686
-
Washburn MP, Wolters D, Yates JR 3rd (2001) Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat Biotechnol 19:242-247 (Pubitemid 32220565)
-
(2001)
Nature Biotechnology
, vol.19
, Issue.3
, pp. 242-247
-
-
Washburn, M.P.1
Wolters, D.2
Yates, J.R.3
-
8
-
-
0036691946
-
Roles for the two-hybrid system in exploration of the yeast protein interactome
-
Ito T, Ota K, Kubota H et al (2002) Roles for the two-hybrid system in exploration of the yeast protein interactome. Mol Cell Proteomics 1:561-566
-
(2002)
Mol Cell Proteomics
, vol.1
, pp. 561-566
-
-
Ito, T.1
Ota, K.2
Kubota, H.3
-
9
-
-
0036898579
-
Protein microarrays and proteomics
-
MacBeath G (2002) Protein microarrays and proteomics. Nat Genet 32(Suppl):526-532 (Pubitemid 35435157)
-
(2002)
Nature Genetics
, vol.32
, Issue.SUPPL. DEC. 5
, pp. 526-532
-
-
MacBeath, G.1
-
10
-
-
33748595526
-
Mechanism-based profiling of enzyme families
-
DOI 10.1021/cr050288g
-
Evans MJ, Cravatt BF (2006) Mechanism-based profiling of enzyme families. Chem Rev 106:3279-3301 (Pubitemid 44376936)
-
(2006)
Chemical Reviews
, vol.106
, Issue.8
, pp. 3279-3301
-
-
Evans, M.J.1
Cravatt, B.F.2
-
11
-
-
78650363876
-
Activity-based probes: Discovering new biology and new drug targets
-
Heal WP, Dang TH, Tate EW (2011) Activity-based probes: discovering new biology and new drug targets. Chem Soc Rev 40:246-257
-
(2011)
Chem Soc Rev
, vol.40
, pp. 246-257
-
-
Heal, W.P.1
Dang, T.H.2
Tate, E.W.3
-
12
-
-
50649112213
-
Activity-based protein profiling: From enzyme chemistry to proteomic chemistry
-
Cravatt BF, Wright AT, Kozarich JW (2008) Activity-based protein profiling: from enzyme chemistry to proteomic chemistry. Annu Rev Biochem 77:383-414
-
(2008)
Annu Rev Biochem
, vol.77
, pp. 383-414
-
-
Cravatt, B.F.1
Wright, A.T.2
Kozarich, J.W.3
-
13
-
-
77950493758
-
Natural products and their biological targets: Proteomic and metabolomic labeling strategies
-
Bottcher T, Pitscheider M, Sieber SA (2010) Natural products and their biological targets: proteomic and metabolomic labeling strategies. Angew Chem Int Ed Engl 49:2680-2698
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, pp. 2680-2698
-
-
Bottcher, T.1
Pitscheider, M.2
Sieber, S.A.3
-
14
-
-
35848965006
-
Activity-based protein profiling for the functional annotation of enzymes
-
DOI 10.1038/nmeth1092, PII NMETH1092
-
Barglow KT, Cravatt BF (2007) Activity-based protein profiling for the functional annotation of enzymes. Nat Methods 4:822-827 (Pubitemid 350055579)
-
(2007)
Nature Methods
, vol.4
, Issue.10
, pp. 822-827
-
-
Barglow, K.T.1
Cravatt, B.F.2
-
15
-
-
31844449784
-
Cytosolic and nuclear protein targets of thiol-reactive electrophiles
-
DOI 10.1021/tx050312l
-
Dennehy MK, Richards KA, Wernke GR et al (2006) Cytosolic and nuclear protein targets of thiol-reactive electrophiles. Chem Res Toxicol 19:20-29 (Pubitemid 43185458)
-
(2006)
Chemical Research in Toxicology
, vol.19
, Issue.1
, pp. 20-29
-
-
Dennehy, M.K.1
Richards, K.A.M.2
Wernke, G.R.3
Shyr, Y.4
Liebler, D.C.5
-
16
-
-
0033005165
-
Probing the reactivity of nucleophile residues in human 2,3-diphosphoglycerate/deoxy-hemoglobin complex by aspecific chemical modifications
-
DOI 10.1016/S0014-5793(99)00601-8, PII S0014579399006018
-
Scaloni A, Ferranti P, De Simone G et al (1999) Probing the reactivity of nucleophile residues in human 2,3-diphosphoglycerate/deoxy-hemoglobin complex by aspecific chemical modifications. FEBS Lett 452:190-194 (Pubitemid 29301742)
-
(1999)
FEBS Letters
, vol.452
, Issue.3
, pp. 190-194
-
-
Scaloni, A.1
Ferranti, P.2
De Simone, G.3
Mamone, G.4
Sannolo, N.5
Malorni, A.6
-
17
-
-
0025753921
-
Identification of epoxide-and quinone-derived bromobenzene adducts to protein sulfur nucleophiles
-
Slaughter DE, Hanzlik RP (1991) Identification of epoxide-and quinone-derived bromobenzene adducts to protein sulfur nucleophiles. Chem Res Toxicol 4:349-359
-
(1991)
Chem Res Toxicol
, vol.4
, pp. 349-359
-
-
Slaughter, D.E.1
Hanzlik, R.P.2
-
18
-
-
0017355595
-
Mechanism-based irreversible enzyme inhibitors
-
Rando RR (1977) Mechanism-based irreversible enzyme inhibitors. Methods Enzymol 46:28-41
-
(1977)
Methods Enzymol
, vol.46
, pp. 28-41
-
-
Rando, R.R.1
-
20
-
-
67649863774
-
Cinnamic aldehyde derived probes for the active site labeling of pathogenesis associated enzymes
-
Pitscheider M, Sieber SA (2009) Cinnamic aldehyde derived probes for the active site labeling of pathogenesis associated enzymes. Chem Commun 2009:3741-3743
-
(2009)
Chem Commun
, vol.2009
, pp. 3741-3743
-
-
Pitscheider, M.1
Sieber, S.A.2
-
21
-
-
45549108466
-
Disparate proteome reactivity profiles of carbon electrophiles
-
DOI 10.1038/nchembio.91, PII NCHEMBIO91
-
Weerapana E, Simon GM, Cravatt BF (2008) Disparate proteome reactivity profiles of carbon electrophiles. Nat Chem Biol 4:405-407 (Pubitemid 351860548)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.7
, pp. 405-407
-
-
Weerapana, E.1
Simon, G.M.2
Cravatt, B.F.3
-
22
-
-
27144510184
-
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling
-
DOI 10.1038/nbt1149, PII N1149
-
Evans MJ, Saghatelian A, Sorensen EJ et al (2005) Target discovery in small-molecule cellbased screens by in situ proteome reactivity profiling. Nat Biotechnol 23:1303-1307 (Pubitemid 41486859)
-
(2005)
Nature Biotechnology
, vol.23
, Issue.10
, pp. 1303-1307
-
-
Evans, M.J.1
Saghatelian, A.2
Sorensen, E.J.3
Cravatt, B.F.4
-
23
-
-
33747190864
-
Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics
-
DOI 10.1586/14789450.3.4.399
-
Robinette D, Neamati N, Tomer KB et al (2006) Photoaffinity labeling combined with mass spectrometric approaches as a tool for structural proteomics. Expert Rev Proteomics 3:399-408 (Pubitemid 44231983)
-
(2006)
Expert Review of Proteomics
, vol.3
, Issue.4
, pp. 399-408
-
-
Robinette, D.1
Neamati, N.2
Tomer, K.B.3
Borchers, C.H.4
-
24
-
-
43949112287
-
Photocrosslinkers illuminate interactions in living cells
-
DOI 10.1039/b803218a
-
Tanaka Y, Bond MR, Kohler JJ (2008) Photocrosslinkers illuminate interactions in living cells. Mol Biosyst 4:473-480 (Pubitemid 351706286)
-
(2008)
Molecular BioSystems
, vol.4
, Issue.6
, pp. 473-480
-
-
Tanaka, Y.1
Bond, M.R.2
Kohler, J.J.3
-
25
-
-
77953631827
-
A medicinal chemist's guide to molecular interactions
-
Bissantz C, Kuhn B, Stahl M (2010) A medicinal chemist's guide to molecular interactions. J Med Chem 53:5061-5084
-
(2010)
J Med Chem
, vol.53
, pp. 5061-5084
-
-
Bissantz, C.1
Kuhn, B.2
Stahl, M.3
-
26
-
-
0037099395
-
A stepwise huisgen cycloaddition process: Copper(I)-catalyzed regioselective 'ligation' of azides and terminal alkynes
-
DOI 10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4
-
Rostovtsev VV, Green LG, Fokin VV et al (2002) A stepwise Huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Angew Chem Int Ed Engl 41:2596-2599 (Pubitemid 34803480)
-
(2002)
Angewandte Chemie - International Edition
, vol.41
, Issue.14
, pp. 2596-2599
-
-
Rostovtsev, V.V.1
Green, L.G.2
Fokin, V.V.3
Sharpless, K.B.4
-
27
-
-
51049094897
-
Cu-catalyzed azide-alkyne cycloaddition
-
Meldal M, Tornoe CW (2008) Cu-catalyzed azide-alkyne cycloaddition. Chem Rev 108:2952-3015
-
(2008)
Chem Rev
, vol.108
, pp. 2952-3015
-
-
Meldal, M.1
Tornoe, C.W.2
-
28
-
-
0037462106
-
Activity-based protein profiling in vivo using a copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition
-
DOI 10.1021/ja034490h
-
Speers AE, Adam GC, Cravatt BF (2003) Activity-based protein profiling in vivo using a copper(I)-catalyzed azide-alkyne [3+2] cycloaddition. J Am Chem Soc 125:4686-4687 (Pubitemid 36505343)
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.16
, pp. 4686-4687
-
-
Speers, A.E.1
Adam, G.C.2
Cravatt, B.F.3
-
29
-
-
0034677879
-
Cell surface engineering by a modified Staudinger reaction
-
DOI 10.1126/science.287.5460.2007
-
Saxon E, Bertozzi CR (2000) Cell surface engineering by a modified Staudinger reaction. Science 287:2007-2010 (Pubitemid 30158675)
-
(2000)
Science
, vol.287
, Issue.5460
, pp. 2007-2010
-
-
Saxon, E.1
Bertozzi, C.R.2
-
30
-
-
4344639697
-
The Staudinger ligation - A gift to chemical biology
-
DOI 10.1002/anie.200401744
-
Kohn M, Breinbauer R (2004) The Staudinger ligation-a gift to chemical biology. Angew Chem Int Ed Engl 43:3106-3116 (Pubitemid 39257599)
-
(2004)
Angewandte Chemie - International Edition
, vol.43
, Issue.24
, pp. 3106-3116
-
-
Kohn, M.1
Breinbauer, R.2
-
31
-
-
9344227358
-
A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems
-
DOI 10.1021/ja044996f
-
Agard NJ, Prescher JA, Bertozzi CR (2004) A strain-promoted [3+2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems. J Am Chem Soc 126:15046-15047 (Pubitemid 39557262)
-
(2004)
Journal of the American Chemical Society
, vol.126
, Issue.46
, pp. 15046-15047
-
-
Agard, N.J.1
Prescher, J.A.2
Bertozzi, C.R.3
-
32
-
-
79751523257
-
Live-cell imaging of cellular proteins by a strainpromoted azide-alkyne cycloaddition
-
Beatty KE, Fisk JD, Smart BP et al (2010) Live-cell imaging of cellular proteins by a strainpromoted azide-alkyne cycloaddition. Chembiochem 11:2092-2095
-
(2010)
Chembiochem
, vol.11
, pp. 2092-2095
-
-
Beatty, K.E.1
Fisk, J.D.2
Smart, B.P.3
-
33
-
-
50249085119
-
Second-generation difluorinated cyclooctynes for copper-free click chemistry
-
Codelli JA, Baskin JM, Agard NJ et al (2008) Second-generation difluorinated cyclooctynes for copper-free click chemistry. J Am Chem Soc 130:11486-11493
-
(2008)
J Am Chem Soc
, vol.130
, pp. 11486-11493
-
-
Codelli, J.A.1
Baskin, J.M.2
Agard, N.J.3
-
34
-
-
68049115757
-
Covalent inhibition of bacterial quorum sensing
-
Amara N, Mashiach R, Amar D et al (2009) Covalent inhibition of bacterial quorum sensing. J Am Chem Soc 131:10610-10619
-
(2009)
J Am Chem Soc
, vol.131
, pp. 10610-10619
-
-
Amara, N.1
Mashiach, R.2
Amar, D.3
-
35
-
-
46049095914
-
Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases
-
DOI 10.1021/ja711125p
-
Liu S, Zhou B, Yang H et al (2008) Aryl vinyl sulfonates and sulfones as active site-directed and mechanism-based probes for protein tyrosine phosphatases. J Am Chem Soc 130:8251-8260 (Pubitemid 351898544)
-
(2008)
Journal of the American Chemical Society
, vol.130
, Issue.26
, pp. 8251-8260
-
-
Liu, S.1
Zhou, B.2
Yang, H.3
He, Y.4
Jiang, Z.-X.5
Kumar, S.6
Wu, L.7
Zhang, Z.-Y.8
-
36
-
-
0036022519
-
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype
-
DOI 10.1038/nbt714
-
Adam GC, Sorensen EJ, Cravatt BF (2002) Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype. Nat Biotechnol 20:805-809 (Pubitemid 34836757)
-
(2002)
Nature Biotechnology
, vol.20
, Issue.8
, pp. 805-809
-
-
Adam, G.C.1
Sorensen, E.J.2
Cravatt, B.F.3
-
37
-
-
0035469599
-
Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes
-
DOI 10.1002/1615-9861(200109)1:9<1067::AID-PROT1067>3.0.CO;2-4
-
Patricelli MP, Giang DK, Stamp LM et al (2001) Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes. Proteomics 1:1067-1071 (Pubitemid 33696471)
-
(2001)
Proteomics
, vol.1
, Issue.9
, pp. 1067-1071
-
-
Patricelli, M.P.1
Giang, D.K.2
Stamp, L.M.3
Burbaum, J.J.4
-
39
-
-
0035799319
-
Profiling serine hydrolase activities in complex proteomes
-
DOI 10.1021/bi002579j
-
Kidd D, Liu Y, Cravatt BF (2001) Profiling serine hydrolase activities in complex proteomes. Biochemistry 40:4005-4015 (Pubitemid 32280438)
-
(2001)
Biochemistry
, vol.40
, Issue.13
, pp. 4005-4015
-
-
Kidd, D.1
Liu, Y.2
Cravatt, B.F.3
-
40
-
-
0034066471
-
Membrane proteins and proteomics: Un amour impossible?
-
DOI 10.1002/(SICI)1522-2683(20000401)21:6<1054::AID-ELPS1054>3.0. CO;2-8
-
Santoni V, Molloy M, Rabilloud T (2000) Membrane proteins and proteomics: un amour impossible? Electrophoresis 21:1054-1070 (Pubitemid 30230772)
-
(2000)
Electrophoresis
, vol.21
, Issue.6
, pp. 1054-1070
-
-
Santoni, V.1
Molloy, M.2
Rabilloud, T.3
-
41
-
-
0034056940
-
The dynamic range of protein expression: A challenge for proteomic research
-
DOI 10.1002/(SICI)1522-2683(20000401)21:6<1104::AID-ELPS1104>3.0. CO;2-C
-
Corthals GL, Wasinger VC, Hochstrasser DF et al (2000) The dynamic range of protein expression: a challenge for proteomic research. Electrophoresis 21:1104-1115 (Pubitemid 30230776)
-
(2000)
Electrophoresis
, vol.21
, Issue.6
, pp. 1104-1115
-
-
Corthals, C.L.1
Wasinger, V.C.2
Hochstrasser, D.F.3
Sanchez, J.-C.4
-
42
-
-
77952571663
-
Showdomycin as a versatile chemical tool for the detection of pathogenesis-associated enzymes in bacteria
-
Bottcher T, Sieber SA (2010) Showdomycin as a versatile chemical tool for the detection of pathogenesis-associated enzymes in bacteria. J Am Chem Soc 132:6964-6972
-
(2010)
J Am Chem Soc
, vol.132
, pp. 6964-6972
-
-
Bottcher, T.1
Sieber, S.A.2
-
43
-
-
77950511344
-
Activity-based probes that target functional subclasses of phospholipases in proteomes
-
Tully SE, Cravatt BF (2010) Activity-based probes that target functional subclasses of phospholipases in proteomes. J Am Chem Soc 132:3264-3265
-
(2010)
J Am Chem Soc
, vol.132
, pp. 3264-3265
-
-
Tully, S.E.1
Cravatt, B.F.2
-
44
-
-
24044520992
-
A streamlined platform for high-content functional proteomics of primary human specimens
-
DOI 10.1038/nmeth778
-
Jessani N, Niessen S, Wei BQ et al (2005) A streamlined platform for high-content functional proteomics of primary human specimens. Nat Methods 2:691-697 (Pubitemid 41223096)
-
(2005)
Nature Methods
, vol.2
, Issue.9
, pp. 691-697
-
-
Jessani, N.1
Niessen, S.2
Wei, B.Q.3
Nicolau, M.4
Humphrey, M.5
Ji, Y.6
Han, W.7
Noh, D.-Y.8
Yates III, J.R.9
Jeffrey, S.S.10
Cravatt, B.F.11
-
45
-
-
3242731195
-
A model for random sampling and estimation of relative protein abundance in shotgun proteomics
-
DOI 10.1021/ac0498563
-
Liu H, Sadygov RG, Yates JR 3rd (2004) A model for random sampling and estimation of relative protein abundance in shotgun proteomics. Anal Chem 76:4193-4201 (Pubitemid 38943698)
-
(2004)
Analytical Chemistry
, vol.76
, Issue.14
, pp. 4193-4201
-
-
Liu, H.1
Sadygov, R.G.2
Yates III, J.R.3
-
46
-
-
27644543078
-
Comparison of label-free methods for quantifying human proteins by shotgun proteomics
-
DOI 10.1074/mcp.M500084-MCP200
-
Old WM, Meyer-Arendt K, Aveline-Wolf L et al (2005) Comparison of label-free methods for quantifying human proteins by shotgun proteomics. Mol Cell Proteomics 4:1487-1502 (Pubitemid 41555475)
-
(2005)
Molecular and Cellular Proteomics
, vol.4
, Issue.10
, pp. 1487-1502
-
-
Old, W.M.1
Meyer-Arendt, K.2
Aveline-Wolf, L.3
Pierce, K.G.4
Mendoza, A.5
Sevinsky, J.R.6
Resing, K.A.7
Ahn, N.G.8
-
47
-
-
1042288188
-
Mapping enzyme active sites in complex proteomes
-
DOI 10.1021/ja038441g
-
Adam GC, Burbaum J, Kozarich JW et al (2004) Mapping enzyme active sites in complex proteomes. J Am Chem Soc 126:1363-1368 (Pubitemid 38200806)
-
(2004)
Journal of the American Chemical Society
, vol.126
, Issue.5
, pp. 1363-1368
-
-
Adam, G.C.1
Burbaum, J.2
Kozarich, J.W.3
Patricelli, M.P.4
Cravatt, B.F.5
-
48
-
-
17044407508
-
High-resolution functional proteomics by activesite peptide profiling
-
Okerberg ES, Wu J, Zhang B et al (2005) High-resolution functional proteomics by activesite peptide profiling. Proc Natl Acad Sci USA 102:4996-5001
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 4996-5001
-
-
Okerberg, E.S.1
Wu, J.2
Zhang, B.3
-
49
-
-
22244445882
-
A tandem orthogonal proteolysis strategy for high-content chemical proteomics
-
DOI 10.1021/ja0532842
-
Speers AE, Cravatt BF (2005) A tandem orthogonal proteolysis strategy for high-content chemical proteomics. J Am Chem Soc 127:10018-10019 (Pubitemid 40995443)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.28
, pp. 10018-10019
-
-
Speers, A.E.1
Cravatt, B.F.2
-
51
-
-
0035072645
-
Protein microarrays: Prospects and problems
-
DOI 10.1016/S1074-5521(00)90067-X, PII S1074552100000673
-
Kodadek T (2001) Protein microarrays: prospects and problems. Chem Biol 8:105-115 (Pubitemid 32296105)
-
(2001)
Chemistry and Biology
, vol.8
, Issue.2
, pp. 105-115
-
-
Kodadek, T.1
-
55
-
-
0031470482
-
Proteases and protease inhibitors in tumor progression
-
DeClerck YA, Imren S, Montgomery AM et al (1997) Proteases and protease inhibitors in tumor progression. Adv Exp Med Biol 425:89-97 (Pubitemid 128701763)
-
(1997)
Advances in Experimental Medicine and Biology
, vol.425
, pp. 89-97
-
-
DeClerck, Y.A.1
Imren, S.2
Montgomery, A.M.P.3
Mueller, B.M.4
Reisfeld, R.A.5
Laug, W.E.6
-
56
-
-
17144404555
-
Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders
-
DOI 10.1042/CS20040302
-
Gorrell MD (2005) Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clin Sci (Lond) 108:277-292 (Pubitemid 40516992)
-
(2005)
Clinical Science
, vol.108
, Issue.4
, pp. 277-292
-
-
Gorrell, M.D.1
-
58
-
-
0036882396
-
Irreversible inhibitors of serine, cysteine, and threonine proteases
-
Powers JC, Asgian JL, Ekici OD et al (2002) Irreversible inhibitors of serine, cysteine, and threonine proteases. Chem Rev 102:4639-4750
-
(2002)
Chem Rev
, vol.102
, pp. 4639-4750
-
-
Powers, J.C.1
Asgian, J.L.2
Ekici, O.D.3
-
59
-
-
0019307238
-
Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate
-
DOI 10.1021/bi00547a018
-
Bouma BN, Miles LA, Beretta G et al (1980) Human plasma prekallikrein. Studies of its activation by activated factor XII and of its inactivation by diisopropyl phosphofluoridate. Biochemistry 19:1151-1160 (Pubitemid 10033197)
-
(1980)
Biochemistry
, vol.19
, Issue.6
, pp. 1151-1160
-
-
Bouma, B.N.1
Miles, L.A.2
Beretta, G.3
Griffin, J.H.4
-
60
-
-
4644279779
-
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo
-
DOI 10.1073/pnas.0404727101
-
Jessani N, Humphrey M, McDonald WH et al (2004) Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo. Proc Natl Acad Sci USA 101:13756-13761 (Pubitemid 39298480)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.38
, pp. 13756-13761
-
-
Jessani, N.1
Humphrey, M.2
McDonald, W.H.3
Niessen, S.4
Masuda, K.5
Gangadharant, B.6
Yates III, J.R.7
Mueller, B.M.8
Cravatt, B.F.9
-
61
-
-
0036678119
-
Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness
-
Jessani N, Liu Y, Humphrey M et al (2002) Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc Natl Acad Sci USA 99:10335-10340
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10335-10340
-
-
Jessani, N.1
Liu, Y.2
Humphrey, M.3
-
62
-
-
19544385609
-
Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells
-
DOI 10.1016/j.chembiol.2005.03.006, PII S107455210500102X
-
Mahrus S, Craik CS (2005) Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells. Chem Biol 12:567-577 (Pubitemid 40727931)
-
(2005)
Chemistry and Biology
, vol.12
, Issue.5
, pp. 567-577
-
-
Mahrus, S.1
Craik, C.S.2
-
63
-
-
0029809357
-
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
-
Gelb BD, Shi GP, Chapman HA et al (1996) Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273:1236-1238
-
(1996)
Science
, vol.273
, pp. 1236-1238
-
-
Gelb, B.D.1
Shi, G.P.2
Chapman, H.A.3
-
64
-
-
19944431196
-
Cathepsin B and tumor proteolysis: Contribution of the tumor microenvironment
-
DOI 10.1016/j.semcancer.2004.08.001, PII S1044579X04000689, Microenvironmental Regulation of Tumor Development
-
Sloane BF, Yan S, Podgorski I et al (2005) Cathepsin B and tumor proteolysis: contribution of the tumor microenvironment. Semin Cancer Biol 15:149-157 (Pubitemid 40126246)
-
(2005)
Seminars in Cancer Biology
, vol.15
, Issue.2
, pp. 149-157
-
-
Sloane, B.F.1
Yan, S.2
Podgorski, I.3
Linebaugh, B.E.4
Cher, M.L.5
Mai, J.6
Cavallo-Medved, D.7
Sameni, M.8
Dosescu, J.9
Moin, K.10
-
65
-
-
0031884265
-
Cathepsin B and human tumor progression
-
Yan S, Sameni M, Sloane BF (1998) Cathepsin B and human tumor progression. Biol Chem 379:113-123 (Pubitemid 28075970)
-
(1998)
Biological Chemistry
, vol.379
, Issue.2
, pp. 113-123
-
-
Yan, S.1
Sameni, M.2
Sloane, B.F.3
-
66
-
-
0034666133
-
Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum
-
Shenai BR, Sijwali PS, Singh A et al (2000) Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. J Biol Chem 275:29000-29010
-
(2000)
J Biol Chem
, vol.275
, pp. 29000-29010
-
-
Shenai, B.R.1
Sijwali, P.S.2
Singh, A.3
-
67
-
-
0030949751
-
Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis
-
DOI 10.1002/art.1780400316
-
Iwata Y, Mort JS, Tateishi H et al (1997) Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis. Arthritis Rheum 40:499-509 (Pubitemid 27123666)
-
(1997)
Arthritis and Rheumatism
, vol.40
, Issue.3
, pp. 499-509
-
-
Iwata, Y.1
Mort, J.S.2
Tateishi, H.3
Lee, E.R.4
-
68
-
-
0019948262
-
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins, B, H and L
-
Barrett AJ, Kembhavi AA, Brown MA et al (1982) L-trans-Epoxysuccinyl- leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J 201:189-198 (Pubitemid 12038477)
-
(1982)
Biochemical Journal
, vol.201
, Issue.1
, pp. 189-198
-
-
Barrett, A.J.1
Kembhavi, A.A.2
Brown, M.A.3
-
69
-
-
0019720180
-
E-64 [L-trans-epoxysuccinyl-leucyl-amido(4-guanidino)butane] and related epoxides as inhibitors of cysteine proteinases
-
Barrett AJ, Kembhavi AA, Hanada K (1981) E-64 [L-trans-epoxysuccinyl- leucyl-amido(4-guanidino)butane] and related epoxides as inhibitors of cysteine proteinases. Acta Biol Med Ger 40:1513-1517 (Pubitemid 12022366)
-
(1981)
Acta Biologica et Medica Germanica
, vol.40
, Issue.10-11
, pp. 1513-1517
-
-
Barrett, A.J.1
Kembhavi, A.A.2
Hanada, K.3
-
70
-
-
0029099619
-
Vinyl sulfones as mechanism-based cysteine protease inhibitors
-
Palmer JT, Rasnick D, Klaus JL et al (1995) Vinyl sulfones as mechanism-based cysteine protease inhibitors. J Med Chem 38:3193-3196
-
(1995)
J Med Chem
, vol.38
, pp. 3193-3196
-
-
Palmer, J.T.1
Rasnick, D.2
Klaus, J.L.3
-
71
-
-
0028672775
-
Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases
-
Shaw E (1994) Peptidyl diazomethanes as inhibitors of cysteine and serine proteinases. Methods Enzymol 244:649-656
-
(1994)
Methods Enzymol
, vol.244
, pp. 649-656
-
-
Shaw, E.1
-
72
-
-
0022881510
-
Peptidyl fluoromethyl ketones as thiol protease inhibitors
-
Shaw E, Angliker H, Rauber P et al (1986) Peptidyl fluoromethyl ketones as thiol protease inhibitors. Biomed Biochim Acta 45:1397-1403 (Pubitemid 17018569)
-
(1986)
Biomedica Biochimica Acta
, vol.45
, Issue.11-12
, pp. 1397-1403
-
-
Shaw, E.1
Angliker, H.2
Rauber, P.3
-
73
-
-
0027052740
-
Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibited of cysteine proteinases
-
Pliura DH, Bonaventura BJ, Smith RA et al (1992) Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases. Biochem J 288(Pt 3):759-762 (Pubitemid 23031752)
-
(1992)
Biochemical Journal
, vol.288
, Issue.3
, pp. 759-762
-
-
Pliura, D.H.1
Bonaventura, B.J.2
Smith, R.A.3
Coles, P.J.4
Krantz, A.5
-
74
-
-
33846167705
-
Activity based probes for proteases: Applications to biomarker discovery, molecular imaging and drug screening
-
DOI 10.2174/138161207779313623
-
Fonovic M, Bogyo M (2007) Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening. Curr Pharm Des 13:253-261 (Pubitemid 46085277)
-
(2007)
Current Pharmaceutical Design
, vol.13
, Issue.3
, pp. 253-261
-
-
Fonovic, M.1
Bogyo, M.2
-
75
-
-
0033036804
-
A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones
-
DOI 10.1016/S0968-0896(99)00009-7, PII S0968089699000097
-
Brady KD, Giegel DA, Grinnell C et al (1999) A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones. Bioorg Med Chem 7:621-631 (Pubitemid 29150305)
-
(1999)
Bioorganic and Medicinal Chemistry
, vol.7
, Issue.4
, pp. 621-631
-
-
Brady, K.D.1
Giegel, D.A.2
Grinnell, C.3
Lunney, E.4
Talanian, R.V.5
Wong, W.6
Walker, N.7
-
76
-
-
0034732951
-
Inactivation of cysteine proteases by (acyloxy)methyl ketones using S'- P' interactions
-
DOI 10.1021/bi0002378
-
Dai Y, Hedstrom L, Abeles RH (2000) Inactivation of cysteine proteases by (acyloxy)methyl ketones using S0-P0 interactions. Biochemistry 39:6498-6502 (Pubitemid 30347156)
-
(2000)
Biochemistry
, vol.39
, Issue.21
, pp. 6498-6502
-
-
Dai, Y.1
Hedstrom, L.2
Abeles, R.H.3
-
77
-
-
29444460784
-
Activity-based probes that target diverse cysteine protease families
-
Kato D, Boatright KM, Berger AB et al (2005) Activity-based probes that target diverse cysteine protease families. Nat Chem Biol 1:33-38
-
(2005)
Nat Chem Biol
, vol.1
, pp. 33-38
-
-
Kato, D.1
Boatright, K.M.2
Berger, A.B.3
-
78
-
-
33748502826
-
The catalytic mechanisms of binuclear metallohydrolases
-
DOI 10.1021/cr050318f
-
Mitic N, Smith SJ, Neves A et al (2006) The catalytic mechanisms of binuclear metallohydrolases. Chem Rev 106:3338-3363 (Pubitemid 44376939)
-
(2006)
Chemical Reviews
, vol.106
, Issue.8
, pp. 3338-3363
-
-
Mitic, N.1
Smith, S.J.2
Neves, A.3
Guddat, L.W.4
Gahan, L.R.5
Schenk, G.6
-
79
-
-
0001651169
-
Design and therapeutic application of matrix metalloproteinase inhibitors
-
Whittaker M, Floyd CD, Brown P et al (1999) Design and therapeutic application of matrix metalloproteinase inhibitors. Chem Rev 99:2735-2776
-
(1999)
Chem Rev
, vol.99
, pp. 2735-2776
-
-
Whittaker, M.1
Floyd, C.D.2
Brown, P.3
-
80
-
-
0035030734
-
The design, structure, and therapeutic application of matrix metalloproteinase inhibitors
-
Skiles JW, Gonnella NC, Jeng AY (2001) The design, structure, and therapeutic application of matrix metalloproteinase inhibitors. Curr Med Chem 8:425-474 (Pubitemid 32409788)
-
(2001)
Current Medicinal Chemistry
, vol.8
, Issue.4
, pp. 425-474
-
-
Skilest, J.W.1
Gonnella, N.C.2
Jeng, A.Y.3
-
81
-
-
0036262945
-
The search for α-secretase and its potential as a therapeutic approach to Alzheimer's disease
-
Hooper NM, Turner AJ (2002) The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease. Curr Med Chem 9:1107-1119 (Pubitemid 34568187)
-
(2002)
Current Medicinal Chemistry
, vol.9
, Issue.11
, pp. 1107-1119
-
-
Hooper, N.M.1
Turner, A.J.2
-
82
-
-
0037052641
-
Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets
-
DOI 10.1002/ijc.10329
-
Vihinen P, Kahari VM (2002) Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets. Int J Cancer 99:157-166 (Pubitemid 34309470)
-
(2002)
International Journal of Cancer
, vol.99
, Issue.2
, pp. 157-166
-
-
Vihinen, P.1
Kahari, V.-M.2
-
84
-
-
33646462162
-
Proteomic profiling of metalloprotease activities with cocktails of active-site probes
-
Sieber SA, Niessen S, Hoover HS et al (2006) Proteomic profiling of metalloprotease activities with cocktails of active-site probes. Nat Chem Biol 2:274-281
-
(2006)
Nat Chem Biol
, vol.2
, pp. 274-281
-
-
Sieber, S.A.1
Niessen, S.2
Hoover, H.S.3
-
85
-
-
3042831921
-
Activity-based probes for the proteomic profiling of metalloproteases
-
DOI 10.1073/pnas.0402784101
-
Saghatelian A, Jessani N, Joseph A et al (2004) Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci USA 101:10000-10005 (Pubitemid 38891185)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.27
, pp. 10000-10005
-
-
Saghatelian, A.1
Jessani, N.2
Joseph, A.3
Humphrey, M.4
Cravatt, B.F.5
-
86
-
-
7744233875
-
Developing photoactive affinity probes for proteomic profiling: Hydroxamate-based probes for metalloproteases
-
DOI 10.1021/ja047044i
-
Chan EW, Chattopadhaya S, Panicker RC et al (2004) Developing photoactive affinity probes for proteomic profiling: hydroxamate-based probes for metalloproteases. J Am Chem Soc 126:14435-14446 (Pubitemid 39463627)
-
(2004)
Journal of the American Chemical Society
, vol.126
, Issue.44
, pp. 14435-14446
-
-
Chan, E.W.S.1
Chattopadhaya, S.2
Panicker, R.C.3
Huang, X.4
Yao, S.Q.5
-
87
-
-
30344477367
-
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
-
DOI 10.1038/nrc1779
-
Minucci S, Pelicci PG (2006) Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer 6:38-51 (Pubitemid 43054973)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.1
, pp. 38-51
-
-
Minucci, S.1
Pelicci, P.G.2
-
88
-
-
33748451151
-
Anticancer activities of histone deacetylase inhibitors
-
DOI 10.1038/nrd2133, PII NRD2133
-
Bolden JE, Peart MJ, Johnstone RW (2006) Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 5:769-784 (Pubitemid 44348499)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.9
, pp. 769-784
-
-
Bolden, J.E.1
Peart, M.J.2
Johnstone, R.W.3
-
89
-
-
33846122993
-
Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug
-
DOI 10.1038/nbt1272, PII NBT1272
-
Marks PA, Breslow R (2007) Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol 25:84-90 (Pubitemid 46087907)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.1
, pp. 84-90
-
-
Marks, P.A.1
Breslow, R.2
-
91
-
-
84857780152
-
Photoaffinity labeling in activity-based protein profiling
-
Springer, Berlin, Heidelberg. doi: 10.1007/128-2011-XXX
-
Overkleeft HS et al. (2012) Photoaffinity labeling in activity-based protein profiling. Topics in Current Chemistry. Springer, Berlin, Heidelberg. doi: 10.1007/128-2011-XXX
-
(2012)
Topics in Current Chemistry
-
-
Overkleeft, H.S.1
-
92
-
-
0037032835
-
The protein kinase complement of the human genome
-
DOI 10.1126/science.1075762
-
Manning G, Whyte DB, Martinez R et al (2002) The protein kinase complement of the human genome. Science 298:1912-1934 (Pubitemid 35425239)
-
(2002)
Science
, vol.298
, Issue.5600
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
93
-
-
34347394374
-
Using chemical genetics and ATP analogues to dissect protein kinase function
-
DOI 10.1021/cb700027u
-
Elphick LM, Lee SE, Gouverneur V et al (2007) Using chemical genetics and ATP analogs to dissect protein kinase function. ACS Chem Biol 2:299-314 (Pubitemid 350001578)
-
(2007)
ACS Chemical Biology
, vol.2
, Issue.5
, pp. 299-314
-
-
Elphick, L.M.1
Lee, S.E.2
Gouverneur, V.3
Mann, D.J.4
-
94
-
-
22044442973
-
Tyrosine kinases as targets for cancer therapy
-
DOI 10.1056/NEJMra044389
-
Krause DS, Van Etten RA (2005) Tyrosine kinases as targets for cancer therapy. N Engl J Med 353:172-187 (Pubitemid 41058349)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 172-187
-
-
Krause, D.S.1
Van Etten, R.A.2
-
95
-
-
15044338824
-
Phosphoinositide 3-kinase in disease: Timing, location, and scaffolding
-
DOI 10.1016/j.ceb.2005.02.011, Cell Regulation
-
Wymann MP, Marone R (2005) Phosphoinositide 3-kinase in disease: timing, location, and scaffolding. Curr Opin Cell Biol 17:141-149 (Pubitemid 40380937)
-
(2005)
Current Opinion in Cell Biology
, vol.17
, Issue.2
, pp. 141-149
-
-
Wymann, M.P.1
Marone, R.2
-
96
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design from structure
-
DOI 10.1126/science.1095920
-
Noble ME, Endicott JA, Johnson LN (2004) Protein kinase inhibitors: insights into drug design from structure. Science 303:1800-1805 (Pubitemid 38374863)
-
(2004)
Science
, vol.303
, Issue.5665
, pp. 1800-1805
-
-
Noble, M.E.M.1
Endicott, J.A.2
Johnson, L.N.3
-
97
-
-
38049155899
-
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
-
Fedorov O, Marsden B, Pogacic V et al (2007) A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci USA 104:20523-20528
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20523-20528
-
-
Fedorov, O.1
Marsden, B.2
Pogacic, V.3
-
98
-
-
34247350792
-
Insights for the development of specific kinase inhibitors by targeted structural genomics
-
DOI 10.1016/j.drudis.2007.03.006, PII S1359644607001250
-
Fedorov O, Sundstrom M, Marsden B et al (2007) Insights for the development of specific kinase inhibitors by targeted structural genomics. Drug Discov Today 12:365-372 (Pubitemid 46636375)
-
(2007)
Drug Discovery Today
, vol.12
, Issue.9-10
, pp. 365-372
-
-
Fedorov, O.1
Sundstrom, M.2
Marsden, B.3
Knapp, S.4
-
99
-
-
0029020282
-
Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
-
Hanks SK, Hunter T (1995) Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J 9:576-596
-
(1995)
FASEB J
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
100
-
-
0027408171
-
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor
-
Zheng J, Knighton DR, ten Eyck LF et al (1993) Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry 32:2154-2161 (Pubitemid 23094874)
-
(1993)
Biochemistry
, vol.32
, Issue.9
, pp. 2154-2161
-
-
Zheng, J.1
Knighton, D.R.2
Ten Eyck, L.F.3
Karlsson, R.4
Xuong, N.-H.5
Taylor, S.S.6
Sowadski, J.M.7
-
101
-
-
33846248354
-
Functional interrogation of the kinome using nucleotide acyl phosphates
-
DOI 10.1021/bi062142x
-
Patricelli MP, Szardenings AK, Liyanage M et al (2007) Functional interrogation of the kinome using nucleotide acyl phosphates. Biochemistry 46:350-358 (Pubitemid 46105428)
-
(2007)
Biochemistry
, vol.46
, Issue.2
, pp. 350-358
-
-
Patricelli, M.P.1
Szardenings, A.K.2
Liyanage, M.3
Nomanbhoy, T.K.4
Wu, M.5
Weissig, H.6
Aban, A.7
Chun, D.8
Tanner, S.9
Kozarich, J.W.10
-
102
-
-
0027432424
-
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
-
Arcaro A, Wymann MP (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 296(Pt 2):297-301 (Pubitemid 23350826)
-
(1993)
Biochemical Journal
, vol.296
, Issue.2
, pp. 297-301
-
-
Arcaro, A.1
Wymann, M.P.2
-
103
-
-
0027374488
-
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
-
Yano H, Nakanishi S, Kimura K et al (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 268:25846-25856 (Pubitemid 23358203)
-
(1993)
Journal of Biological Chemistry
, vol.268
, Issue.34
, pp. 25846-25856
-
-
Yano, H.1
Nakanishi, S.2
Kimura, K.3
Hanai, N.4
Saitoh, Y.5
Fukui, Y.6
Nonomura, Y.7
Matsuda, Y.8
-
104
-
-
84857702948
-
Activity based protein profiling for natural product target discovery
-
Springer, Berlin, Heidelberg. doi: 10.1007/128-2011-XXX
-
Breinbauer R et al. (2012) Activity Based Protein Profiling for Natural Product Target Discovery. Topics in Current Chemistry. Springer, Berlin, Heidelberg. doi: 10.1007/128-2011-XXX
-
(2012)
Topics in Current Chemistry
-
-
Breinbauer, R.1
-
105
-
-
0030806027
-
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A
-
DOI 10.1021/jm960873x
-
Gupta V, Ogawa AK, Du X et al (1997) A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A. J Med Chem 40:3199-3206 (Pubitemid 27413744)
-
(1997)
Journal of Medicinal Chemistry
, vol.40
, Issue.20
, pp. 3199-3206
-
-
Gupta, V.1
Ogawa, A.K.2
Du, X.3
Houk, K.N.4
Armstrong, R.W.5
-
106
-
-
0036617994
-
Relationship between microcystin in drinking water and colorectal cancer
-
Zhou L, Yu H, Chen K (2002) Relationship between microcystin in drinking water and colorectal cancer. Biomed Environ Sci 15:166-171
-
(2002)
Biomed Environ Sci
, vol.15
, pp. 166-171
-
-
Zhou, L.1
Yu, H.2
Chen, K.3
-
107
-
-
0029094754
-
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
-
Goldberg J, Huang HB, Kwon YG et al (1995) Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature 376:745-753
-
(1995)
Nature
, vol.376
, pp. 745-753
-
-
Goldberg, J.1
Huang, H.B.2
Kwon, Y.G.3
-
108
-
-
3242759075
-
Design and synthesis of AX7574: A microcystin-derived, fluorescent probe for serine/threonine phosphatases
-
DOI 10.1021/bc0499580
-
Shreder KR, Liu Y, Nomanhboy T et al (2004) Design and synthesis of AX7574: a microcystin-derived, fluorescent probe for serine/threonine phosphatases. Bioconjug Chem 15:790-798 (Pubitemid 38981953)
-
(2004)
Bioconjugate Chemistry
, vol.15
, Issue.4
, pp. 790-798
-
-
Shreder, K.R.1
Liu, Y.2
Nomanhboy, T.3
Fuller, S.R.4
Wong, M.S.5
Gai, W.Z.6
Wu, J.7
Leventhal, P.S.8
Lill, J.R.9
Corral, S.10
-
109
-
-
0036391485
-
Design and synthesis of class-selective activity probes for protein tyrosine phosphatases
-
Lo LC, Pang TL, Kuo CH et al (2002) Design and synthesis of class-selective activity probes for protein tyrosine phosphatases. J Proteome Res 1:35-40
-
(2002)
J Proteome Res
, vol.1
, pp. 35-40
-
-
Lo, L.C.1
Pang, T.L.2
Kuo, C.H.3
-
110
-
-
2542529285
-
Activity-based probes for protein tyrosine phosphatases
-
DOI 10.1073/pnas.0402323101
-
Kumar S, Zhou B, Liang F et al (2004) Activity-based probes for protein tyrosine phosphatases. Proc Natl Acad Sci USA 101:7943-7948 (Pubitemid 38698033)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.21
, pp. 7943-7948
-
-
Kumar, S.1
Zhou, B.2
Liang, F.3
Wang, W.-Q.4
Huang, Z.5
Zhang, Z.-Y.6
-
111
-
-
0033963529
-
Glycosidase mechanisms: Anatomy of a finely tuned catalyst
-
Zechel DL, Withers SG (2000) Glycosidase mechanisms: anatomy of a finely tuned catalyst. Acc Chem Res 33:11-18
-
(2000)
Acc Chem Res
, vol.33
, pp. 11-18
-
-
Zechel, D.L.1
Withers, S.G.2
-
112
-
-
0037126198
-
Design and synthesis of activity probes for glycosidases
-
Tsai CS, Li YK, Lo LC (2002) Design and synthesis of activity probes for glycosidases. Org Lett 4:3607-3610
-
(2002)
Org Lett
, vol.4
, pp. 3607-3610
-
-
Tsai, C.S.1
Li, Y.K.2
Lo, L.C.3
-
113
-
-
0036403587
-
Trapping covalent intermediates on beta-glycosidases
-
Wicki J, Rose DR, Withers SG (2002) Trapping covalent intermediates on beta-glycosidases. Methods Enzymol 354:84-105
-
(2002)
Methods Enzymol
, vol.354
, pp. 84-105
-
-
Wicki, J.1
Rose, D.R.2
Withers, S.G.3
-
114
-
-
7244251649
-
A strategy for functional proteomic analysis of glycosidase activity from cell lysates
-
DOI 10.1002/anie.200454235
-
Vocadlo DJ, Bertozzi CR (2004) A strategy for functional proteomic analysis of glycosidase activity from cell lysates. Angew Chem Int Ed Engl 43:5338-5342 (Pubitemid 39433912)
-
(2004)
Angewandte Chemie - International Edition
, vol.43
, Issue.40
, pp. 5338-5342
-
-
Vocadlo, D.J.1
Bertozzi, C.R.2
-
115
-
-
0041422487
-
A chemical approach for identifying O-GlcNAc-modified proteins in cells
-
DOI 10.1073/pnas.1632821100
-
Vocadlo DJ, Hang HC, Kim EJ et al (2003) A chemical approach for identifying O-GlcNAcmodified proteins in cells. Proc Natl Acad Sci USA 100:9116-9121 (Pubitemid 37033892)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.16
, pp. 9116-9121
-
-
Vocadlo, D.J.1
Hang, H.C.2
Kim, E.-J.3
Hanover, J.A.4
Bertozzi, C.R.5
-
118
-
-
33846635481
-
Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes
-
DOI 10.1016/j.cmet.2006.12.009, PII S1550413106004244
-
Hughes AL, Powell DW, Bard M et al (2007) Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Cell Metab 5:143-149 (Pubitemid 46172917)
-
(2007)
Cell Metabolism
, vol.5
, Issue.2
, pp. 143-149
-
-
Hughes, A.L.1
Powell, D.W.2
Bard, M.3
Eckstein, J.4
Barbuch, R.5
Link, A.J.6
Espenshade, P.J.7
-
119
-
-
18744393086
-
Regulation of cytochrome P450 by posttranslational modification
-
DOI 10.1081/DMR-200046136
-
Aguiar M, Masse R, Gibbs BF (2005) Regulation of cytochrome P450 by posttranslational modification. Drug Metab Rev 37:379-404 (Pubitemid 40677509)
-
(2005)
Drug Metabolism Reviews
, vol.37
, Issue.2
, pp. 379-404
-
-
Aguiar, M.1
Masse, R.2
Gibbs, B.F.3
-
120
-
-
34548628220
-
Chemical proteomic probes for profiling cytochrome P450 activities and drug interactions in vivo
-
DOI 10.1016/j.chembiol.2007.08.008, PII S1074552107002876
-
Wright AT, Cravatt BF (2007) Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo. Chem Biol 14:1043-1051 (Pubitemid 47404904)
-
(2007)
Chemistry and Biology
, vol.14
, Issue.9
, pp. 1043-1051
-
-
Wright, A.T.1
Cravatt, B.F.2
-
121
-
-
68049107457
-
A suite of activity-based probes for human cytochrome P450 enzymes
-
Wright AT, Song JD, Cravatt BF (2009) A suite of activity-based probes for human cytochrome P450 enzymes. J Am Chem Soc 131:10692-10700
-
(2009)
J Am Chem Soc
, vol.131
, pp. 10692-10700
-
-
Wright, A.T.1
Song, J.D.2
Cravatt, B.F.3
-
122
-
-
70149086262
-
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential
-
Jones JE, Causey CP, Knuckley B et al (2009) Protein arginine deiminase 4 (PAD4): current understanding and future therapeutic potential. Curr Opin Drug Discov Devel 12:616-627
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 616-627
-
-
Jones, J.E.1
Causey, C.P.2
Knuckley, B.3
-
123
-
-
2942555614
-
Citrullinated proteins: Sparks that may ignite the fire in rheumatoid arthritis
-
Vossenaar ER, van Venrooij WJ (2004) Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis. Arthritis Res Ther 6:107-111 (Pubitemid 38735665)
-
(2004)
Arthritis Research and Therapy
, vol.6
, Issue.3
, pp. 107-111
-
-
Vossenaar, E.R.1
Van Venrooij, W.J.2
-
124
-
-
33749359452
-
Inhibitors and inactivators of protein arginine deiminase 4: Functional and structural characterization
-
DOI 10.1021/bi061180d
-
Luo Y, Arita K, Bhatia M et al (2006) Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry 45:11727-11736 (Pubitemid 44497800)
-
(2006)
Biochemistry
, vol.45
, Issue.39
, pp. 11727-11736
-
-
Luo, Y.1
Arita, K.2
Bhatia, M.3
Knuckley, B.4
Lee, Y.-H.5
Stallcup, M.R.6
Sato, M.7
Thompson, P.R.8
-
125
-
-
31944448153
-
A fluoroacetamidine-based inactivator of protein arginine deiminase 4: Design, synthesis, and in vitro and in vivo evaluation
-
DOI 10.1021/ja0576233
-
Luo Y, Knuckley B, Lee YH et al (2006) A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation. J Am Chem Soc 128:1092-1093 (Pubitemid 43190618)
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.4
, pp. 1092-1093
-
-
Luo, Y.1
Knuckley, B.2
Lee, Y.-H.3
Stallcup, M.R.4
Thompson, P.R.5
-
126
-
-
27144463085
-
Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: Dimethylargininase and peptidylarginine deiminase
-
DOI 10.1021/bi051341y
-
Stone EM, Schaller TH, Bianchi H et al (2005) Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase. Biochemistry 44:13744-13752 (Pubitemid 41507455)
-
(2005)
Biochemistry
, vol.44
, Issue.42
, pp. 13744-13752
-
-
Stone, E.M.1
Schaller, T.H.2
Bianchi, H.3
Person, M.D.4
Fast, W.5
-
127
-
-
79955874694
-
Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4
-
Slack JL, Causey CP, Luo Y et al (2011) Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4. ACS Chem Biol 6:466-476
-
(2011)
ACS Chem Biol
, vol.6
, pp. 466-476
-
-
Slack, J.L.1
Causey, C.P.2
Luo, Y.3
-
128
-
-
33751010478
-
Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): Synthesis and in vitro evaluation of a fluorescently labeled probe
-
DOI 10.1021/ja0656907
-
Luo Y, Knuckley B, Bhatia M et al (2006) Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe. J Am Chem Soc 128:14468-14469 (Pubitemid 44749840)
-
(2006)
Journal of the American Chemical Society
, vol.128
, Issue.45
, pp. 14468-14469
-
-
Luo, Y.1
Knuckley, B.2
Bhatia, M.3
Pellechia, P.J.4
Thompson, P.R.5
-
130
-
-
0031010398
-
Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors
-
Bogyo M, McMaster JS, Gaczynska M et al (1997) Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. Proc Natl Acad Sci USA 94:6629-6634
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 6629-6634
-
-
Bogyo, M.1
McMaster, J.S.2
Gaczynska, M.3
-
132
-
-
27944431658
-
Bortezomib, a novel proteasome inhibitor, in the treatment of hematologic malignancies
-
DOI 10.1016/j.ctrv.2005.10.001, PII S0305737205001994
-
Jackson G, Einsele H, Moreau P et al (2005) Bortezomib, a novel proteasome inhibitor, in the treatment of hematologic malignancies. Cancer Treat Rev 31:591-602 (Pubitemid 41662886)
-
(2005)
Cancer Treatment Reviews
, vol.31
, Issue.8
, pp. 591-602
-
-
Jackson, G.1
Einsele, H.2
Moreau, P.3
San Miguel, J.4
-
134
-
-
0033564512
-
Eponemycin exerts its antitumor effect through the inhibition of proteasome function
-
Meng L, Kwok BH, Sin N et al (1999) Eponemycin exerts its antitumor effect through the inhibition of proteasome function. Cancer Res 59:2798-2801 (Pubitemid 29283111)
-
(1999)
Cancer Research
, vol.59
, Issue.12
, pp. 2798-2801
-
-
Meng, L.1
Kwok, B.H.B.2
Sin, N.3
Crews, C.M.4
-
135
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
-
DOI 10.1016/j.ccr.2005.10.013, PII S153561080500334X
-
Chauhan D, Catley L, Li G et al (2005) A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell 8:407-419 (Pubitemid 41579835)
-
(2005)
Cancer Cell
, vol.8
, Issue.5
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
Podar, K.4
Hideshima, T.5
Velankar, M.6
Mitsiades, C.7
Mitsiades, N.8
Yasui, H.9
Letai, A.10
Ovaa, H.11
Berkers, C.12
Nicholson, B.13
Chao, T.-H.14
Neuteboom, S.T.C.15
Richardson, P.16
Palladino, M.A.17
Anderson, K.C.18
-
136
-
-
0032488846
-
The proteasome: Paradigm of a selfcompartmentalizing protease
-
Baumeister W, Walz J, Zuhl F et al (1998) The proteasome: paradigm of a selfcompartmentalizing protease. Cell 92:367-380
-
(1998)
Cell
, vol.92
, pp. 367-380
-
-
Baumeister, W.1
Walz, J.2
Zuhl, F.3
-
137
-
-
33750989899
-
A Fluorescent Broad-Spectrum Proteasome Inhibitor for Labeling Proteasomes In Vitro and In Vivo
-
DOI 10.1016/j.chembiol.2006.09.013, PII S1074552106003462
-
Verdoes M, Florea BI, Menendez-Benito V et al (2006) A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. Chem Biol 13:1217-1226 (Pubitemid 44750733)
-
(2006)
Chemistry and Biology
, vol.13
, Issue.11
, pp. 1217-1226
-
-
Verdoes, M.1
Florea, B.I.2
Menendez-Benito, V.3
Maynard, C.J.4
Witte, M.D.5
Van Der Linden, W.A.6
Van Den Nieuwendijk, A.M.C.H.7
Hofmann, T.8
Berkers, C.R.9
Van Leeuwen, F.W.B.10
Groothuis, T.A.11
Leeuwenburgh, M.A.12
Ovaa, H.13
Neefjes, J.J.14
Filippov, D.V.15
Van Der Marel, G.A.16
Dantuma, N.P.17
Overkleeft, H.S.18
-
138
-
-
77953194791
-
A panel of subunit-selective activity-based proteasome probes
-
Verdoes M, Willems LI, van der Linden WA et al (2010) A panel of subunit-selective activity-based proteasome probes. Org Biomol Chem 8:2719-2727
-
(2010)
Org Biomol Chem
, vol.8
, pp. 2719-2727
-
-
Verdoes, M.1
Willems, L.I.2
Van Der Linden, W.A.3
-
139
-
-
78649347332
-
Probing the proteasome cavity in three steps: Bio-orthogonal photo-reactive suicide substrates
-
Geurink PP, Florea BI, Van der Marel GA et al (2010) Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates. Chem Commun (Camb) 46:9052-9054
-
(2010)
Chem Commun (Camb)
, vol.46
, pp. 9052-9054
-
-
Geurink, P.P.1
Florea, B.I.2
Van Der Marel, G.A.3
-
140
-
-
55949109901
-
Cancer treatment of the future: Inhibitors of histone methyltransferases
-
Spannhoff A, Sippl W, Jung M (2009) Cancer treatment of the future: inhibitors of histone methyltransferases. Int J Biochem Cell Biol 41:4-11
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 4-11
-
-
Spannhoff, A.1
Sippl, W.2
Jung, M.3
-
141
-
-
34447312020
-
ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease
-
DOI 10.1073/pnas.0606373103
-
Ryu H, Lee J, Hagerty SW et al (2006) ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Proc Natl Acad Sci USA 103:19176-19181 (Pubitemid 350002846)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.50
, pp. 19176-19181
-
-
Ryu, H.1
Lee, J.2
Hagerty, S.W.3
Byoung, Y.S.4
McAlpin, S.E.5
Cormier, K.A.6
Smith, K.M.7
Ferrante, R.J.8
-
142
-
-
76049084596
-
Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma
-
Berdasco M, Ropero S, Setien F et al (2009) Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci USA 106:21830-21835
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 21830-21835
-
-
Berdasco, M.1
Ropero, S.2
Setien, F.3
-
143
-
-
18544384537
-
Haploinsufficiency of NSD1 causes Sotos syndrome
-
Kurotaki N, Imaizumi K, Harada N et al (2002) Haploinsufficiency of NSD1 causes Sotos syndrome. Nat Genet 30:365-366
-
(2002)
Nat Genet
, vol.30
, pp. 365-366
-
-
Kurotaki, N.1
Imaizumi, K.2
Harada, N.3
-
144
-
-
33847076849
-
Chromatin modifications and their function
-
DOI 10.1016/j.cell.2007.02.005, PII S0092867407001845
-
Kouzarides T (2007) Chromatin modifications and their function. Cell 128:693-705 (Pubitemid 46273577)
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 693-705
-
-
Kouzarides, T.1
-
145
-
-
59349115177
-
Chemical mechanisms of histone lysine and arginine modifications
-
Smith BC, Denu JM (2009) Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta 1789:45-57
-
(2009)
Biochim Biophys Acta
, vol.1789
, pp. 45-57
-
-
Smith, B.C.1
Denu, J.M.2
-
146
-
-
51949111451
-
Chemical probes for histone-modifying enzymes
-
Cole PA (2008) Chemical probes for histone-modifying enzymes. Nat Chem Biol 4:590-597
-
(2008)
Nat Chem Biol
, vol.4
, pp. 590-597
-
-
Cole, P.A.1
-
147
-
-
9244247669
-
Regulation of p53 activity through lysine methylation
-
DOI 10.1038/nature03117
-
Chuikov S, Kurash JK, Wilson JR et al (2004) Regulation of p53 activity through lysine methylation. Nature 432:353-360 (Pubitemid 39551664)
-
(2004)
Nature
, vol.432
, Issue.7015
, pp. 353-360
-
-
Chuikov, S.1
Kurash, J.K.2
Wilson, J.R.3
Xiao, B.4
Justin, N.5
Ivanov, G.S.6
McKinney, K.7
Tempst, P.8
Prives, C.9
Gamblin, S.J.10
Barlev, N.A.11
Reinberg, D.12
-
148
-
-
33845204856
-
Repression of p53 activity by Smyd2-mediated methylation
-
DOI 10.1038/nature05287, PII NATURE05287
-
Huang J, Perez-Burgos L, Placek BJ et al (2006) Repression of p53 activity by Smyd2-mediated methylation. Nature 444:629-632 (Pubitemid 44864441)
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 629-632
-
-
Huang, J.1
Perez-Burgos, L.2
Placek, B.J.3
Sengupta, R.4
Richter, M.5
Dorsey, J.A.6
Kubicek, S.7
Opravil, S.8
Jenuwein, T.9
Berger, S.L.10
-
149
-
-
42949142112
-
Regulation of Estrogen Receptor α by the SET7 Lysine Methyltransferase
-
DOI 10.1016/j.molcel.2008.03.022, PII S1097276508002888
-
Subramanian K, Jia D, Kapoor-Vazirani P et al (2008) Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol Cell 30:336-347 (Pubitemid 351615317)
-
(2008)
Molecular Cell
, vol.30
, Issue.3
, pp. 336-347
-
-
Subramanian, K.1
Jia, D.2
Kapoor-Vazirani, P.3
Powell, D.R.4
Collins, R.E.5
Sharma, D.6
Peng, J.7
Cheng, X.8
Vertino, P.M.9
-
150
-
-
77954265666
-
Negative regulation of hypoxic responses via induced Reptin methylation
-
Lee JS, Kim Y, Kim IS et al (2010) Negative regulation of hypoxic responses via induced Reptin methylation. Mol Cell 39:71-85
-
(2010)
Mol Cell
, vol.39
, pp. 71-85
-
-
Lee, J.S.1
Kim, Y.2
Kim, I.S.3
-
151
-
-
78751622160
-
A chemical method for labeling lysine methyltransferase substrates
-
Binda O, Boyce M, Rush JS et al (2011) A chemical method for labeling lysine methyltransferase substrates. Chembiochem 12:330-334
-
(2011)
Chembiochem
, vol.12
, pp. 330-334
-
-
Binda, O.1
Boyce, M.2
Rush, J.S.3
-
152
-
-
79960496067
-
Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling
-
Islam K, Zheng W, Yu H et al (2011) Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling. ACS Chem Biol 6(7):679-684
-
(2011)
ACS Chem Biol
, vol.6
, Issue.7
, pp. 679-684
-
-
Islam, K.1
Zheng, W.2
Yu, H.3
-
153
-
-
77954851029
-
Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling
-
Peters W, Willnow S, Duisken M et al (2010) Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling. Angew Chem Int Ed Engl 49:5170-5173
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, pp. 5170-5173
-
-
Peters, W.1
Willnow, S.2
Duisken, M.3
-
154
-
-
35548934558
-
MLL translocations, histone modifications and leukaemia stem-cell development
-
DOI 10.1038/nrc2253, PII NRC2253
-
Krivtsov AV, Armstrong SA (2007) MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 7:823-833 (Pubitemid 350006257)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.11
, pp. 823-833
-
-
Krivtsov, A.V.1
Armstrong, S.A.2
-
155
-
-
0035816682
-
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
-
Tachibana M, Sugimoto K, Fukushima T et al (2001) Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J Biol Chem 276:25309-25317
-
(2001)
J Biol Chem
, vol.276
, pp. 25309-25317
-
-
Tachibana, M.1
Sugimoto, K.2
Fukushima, T.3
-
156
-
-
43749093216
-
Protein lysine methyltransferase G9a acts on non-histone targets
-
DOI 10.1038/nchembio.88, PII NCHEMBIO88
-
Rathert P, Dhayalan A, Murakami M et al (2008) Protein lysine methyltransferase G9a acts on non-histone targets. Nat Chem Biol 4:344-346 (Pubitemid 351693993)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.6
, pp. 344-346
-
-
Rathert, P.1
Dhayalan, A.2
Murakami, M.3
Zhang, X.4
Tamas, R.5
Jurkowska, R.6
Komatsu, Y.7
Shinkai, Y.8
Cheng, X.9
Jeltsch, A.10
-
157
-
-
33846038833
-
5-Aza-2′-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation
-
DOI 10.1038/sj.onc.1209763, PII 1209763
-
Wozniak RJ, Klimecki WT, Lau SS et al (2007) 5-Aza-20-deoxycytidine- mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation. Oncogene 26:77-90 (Pubitemid 46067333)
-
(2007)
Oncogene
, vol.26
, Issue.1
, pp. 77-90
-
-
Wozniak, R.J.1
Klimecki, W.T.2
Lau, S.S.3
Feinstein, Y.4
Futscher, B.W.5
-
158
-
-
79957762180
-
Labeling substrates of protein arginine methyltransferase with engineered enzymes and matched S-adenosyl-L-methionine analogues
-
Wang R, Zheng W, Yu H et al (2011) Labeling substrates of protein arginine methyltransferase with engineered enzymes and matched S-adenosyl-L-methionine analogues. J Am Chem Soc 133:7648-7651
-
(2011)
J Am Chem Soc
, vol.133
, pp. 7648-7651
-
-
Wang, R.1
Zheng, W.2
Yu, H.3
-
160
-
-
0032008085
-
Engineering Src family protein kinases with unnatural nucleotide specificity
-
Liu Y, Shah K, Yang F et al (1998) Engineering Src family protein kinases with unnatural nucleotide specificity. Chem Biol 5:91-101 (Pubitemid 28199138)
-
(1998)
Chemistry and Biology
, vol.5
, Issue.2
, pp. 91-101
-
-
Liu, Y.1
Shah, K.2
Yang, F.3
Witucki, L.4
Shokat, K.M.5
-
161
-
-
0034699382
-
A chemical switch for inhibitor-sensitive alleles of any protein kinase
-
Bishop AC, Ubersax JA, Petsch DT et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407:395-401
-
(2000)
Nature
, vol.407
, pp. 395-401
-
-
Bishop, A.C.1
Ubersax, J.A.2
Petsch, D.T.3
-
162
-
-
0035113229
-
Profiling the specific reactivity of the proteome with non-directed activity-based probes
-
DOI 10.1016/S1074-5521(00)90060-7, PII S1074552100000600
-
Adam GC, Cravatt BF, Sorensen EJ (2001) Profiling the specific reactivity of the proteome with non-directed activity-based probes. Chem Biol 8:81-95 (Pubitemid 32165814)
-
(2001)
Chemistry and Biology
, vol.8
, Issue.1
, pp. 81-95
-
-
Adam, G.C.1
Cravatt, B.F.2
Sorensen, E.J.3
-
163
-
-
8844268481
-
Discovering disease-associated enzymes by proteome reactivity profiling
-
DOI 10.1016/j.chembiol.2004.08.023, PII S1074552104002686
-
Barglow KT, Cravatt BF (2004) Discovering disease-associated enzymes by proteome reactivity profiling. Chem Biol 11:1523-1531 (Pubitemid 39527279)
-
(2004)
Chemistry and Biology
, vol.11
, Issue.11
, pp. 1523-1531
-
-
Barglow, K.T.1
Cravatt, B.F.2
-
164
-
-
33751248759
-
Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes
-
DOI 10.1002/anie.200603187
-
Barglow KT, Cravatt BF (2006) Substrate mimicry in an activity-based probe that targets the nitrilase family of enzymes. Angew Chem Int Ed Engl 45:7408-7411 (Pubitemid 44786970)
-
(2006)
Angewandte Chemie - International Edition
, vol.45
, Issue.44
, pp. 7408-7411
-
-
Barglow, K.T.1
Cravatt, B.F.2
-
165
-
-
33745631769
-
2, a necessary evil for cell signaling
-
DOI 10.1126/science.1130481
-
Rhee SG (2006) Cell signaling. H2O2, a necessary evil for cell signaling. Science 312:1882-1883 (Pubitemid 43993698)
-
(2006)
Science
, vol.312
, Issue.5782
, pp. 1882-1883
-
-
Rhee, S.G.1
-
166
-
-
33748466565
-
Specificity in reactive oxidant signaling: Think globally, act locally
-
Terada LS (2006) Specificity in reactive oxidant signaling: think globally, act locally. J Cell Biol 174:615-623
-
(2006)
J Cell Biol
, vol.174
, pp. 615-623
-
-
Terada, L.S.1
-
167
-
-
34648813720
-
ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis
-
DOI 10.1038/nrm2256, PII NRM2256
-
D'Autreaux B, Toledano MB (2007) ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 8:813-824 (Pubitemid 47462134)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.10
, pp. 813-824
-
-
D'Autreaux, B.1
Toledano, M.B.2
-
168
-
-
40849097418
-
Discovering mechanisms of signaling-mediated cysteine oxidation
-
Poole LB, Nelson KJ (2008) Discovering mechanisms of signaling-mediated cysteine oxidation. Curr Opin Chem Biol 12:18-24
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 18-24
-
-
Poole, L.B.1
Nelson, K.J.2
-
169
-
-
57549095616
-
Expanding the functional diversity of proteins through cysteine oxidation
-
Reddie KG, Carroll KS (2008) Expanding the functional diversity of proteins through cysteine oxidation. Curr Opin Chem Biol 12:746-754
-
(2008)
Curr Opin Chem Biol
, vol.12
, pp. 746-754
-
-
Reddie, K.G.1
Carroll, K.S.2
-
170
-
-
0016256290
-
The inactivation of the acyl phosphatase activity catalyzed by the sulfenic acid form of glyceraldehyde 3-phosphate dehydrogenase by dimedone and olefins
-
Benitez LV, Allison WS (1974) The inactivation of the acyl phosphatase activity catalyzed by the sulfenic acid form of glyceraldehyde 3-phosphate dehydrogenase by dimedone and olefins. J Biol Chem 249:6234-6243
-
(1974)
J Biol Chem
, vol.249
, pp. 6234-6243
-
-
Benitez, L.V.1
Allison, W.S.2
-
172
-
-
70349284540
-
Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells
-
Leonard SE, Reddie KG, Carroll KS (2009) Mining the thiol proteome for sulfenic acid modifications reveals new targets for oxidation in cells. ACS Chem Biol 4:783-799
-
(2009)
ACS Chem Biol
, vol.4
, pp. 783-799
-
-
Leonard, S.E.1
Reddie, K.G.2
Carroll, K.S.3
-
173
-
-
18044378410
-
Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling
-
DOI 10.1002/anie.200463098
-
Jessani N, Young JA, Diaz SL et al (2005) Class assignment of sequence-unrelated members of enzyme superfamilies by activity-based protein profiling. Angew Chem Int Ed Engl 44:2400-2403 (Pubitemid 40600225)
-
(2005)
Angewandte Chemie - International Edition
, vol.44
, Issue.16
, pp. 2400-2403
-
-
Jessani, N.1
Young, J.A.2
Diaz, S.L.3
Patricelli, M.P.4
Varki, A.5
Cravatt, B.F.6
-
174
-
-
0024807408
-
O-Acetylation and de-O-acetylation of sialic acids. Sialic acid esterases of diverse evolutionary origins have serine active sites and essential arginine residues
-
Hayes BK, Varki A (1989) O-acetylation and de-O-acetylation of sialic acids. Sialic acid esterases of diverse evolutionary origins have serine active sites and essential arginine residues. J Biol Chem 264:19443-19448 (Pubitemid 19285856)
-
(1989)
Journal of Biological Chemistry
, vol.264
, Issue.32
, pp. 19443-19448
-
-
Hayes, B.K.1
Varki, A.2
-
175
-
-
0034621824
-
Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
-
DOI 10.1038/35015085
-
Li YM, Xu M, Lai MT et al (2000) Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405:689-694 (Pubitemid 30428655)
-
(2000)
Nature
, vol.405
, Issue.6787
, pp. 689-694
-
-
Li, Y.-M.1
Xu, M.2
Lai, M.-T.3
Huang, Q.4
Castro, J.L.5
DiMuzlo-Mower, J.6
Harrison, T.7
Lellis, C.8
Nadin, A.9
Neduvelli, J.G.10
Register, R.B.11
Sardana, M.K.12
Shearman, M.S.13
Smith, A.L.14
Shi, X.-P.15
Yin, K.-C.16
Shafer, J.A.17
Gardell, S.J.18
-
176
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg O (1956) On respiratory impairment in cancer cells. Science 124:269-270
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
177
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
DOI 10.1038/nature06667, PII NATURE06667
-
Christofk HR, Vander Heiden MG, Wu N et al (2008) Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452:181-186 (Pubitemid 351380242)
-
(2008)
Nature
, vol.452
, Issue.7184
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
178
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S et al (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:739-744
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
179
-
-
34748912615
-
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
-
DOI 10.1038/nrc2222, PII NRC2222
-
Menendez JA, Lupu R (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7:763-777 (Pubitemid 47469806)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.10
, pp. 763-777
-
-
Menendez, J.A.1
Lupu, R.2
-
180
-
-
33749017931
-
Cysteine cathepsins: Multifunctional enzymes in cancer
-
DOI 10.1038/nrc1949, PII NRC1949
-
Mohamed MM, Sloane BF (2006) Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 6:764-775 (Pubitemid 44450465)
-
(2006)
Nature Reviews Cancer
, vol.6
, Issue.10
, pp. 764-775
-
-
Mohamed, M.M.1
Sloane, B.F.2
-
181
-
-
0033532205
-
Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion
-
Ramos-DeSimone N, Hahn-Dantona E, Sipley J et al (1999) Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem 274:13066-13076
-
(1999)
J Biol Chem
, vol.274
, pp. 13066-13076
-
-
Ramos-Desimone, N.1
Hahn-Dantona, E.2
Sipley, J.3
-
182
-
-
25444510617
-
Breast cancer cell lines grown in vivo: What goes in isn't always the same as what comes out
-
Jessani N, Niessen S, Mueller BM et al (2005) Breast cancer cell lines grown in vivo: what goes in isn't always the same as what comes out. Cell Cycle 4:253-255 (Pubitemid 41365329)
-
(2005)
Cell Cycle
, vol.4
, Issue.2
, pp. 253-255
-
-
Jessani, N.1
Niessen, S.2
Mueller, B.M.3
Cravatt, B.F.4
-
183
-
-
2342603891
-
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
-
DOI 10.1016/S1535-6108(04)00111-4, PII S1535610804001114
-
Joyce JA, Baruch A, Chehade K et al (2004) Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5:443-453 (Pubitemid 38610246)
-
(2004)
Cancer Cell
, vol.5
, Issue.5
, pp. 443-453
-
-
Joyce, J.A.1
Baruch, A.2
Chehade, K.3
Meyer-Morse, N.4
Giraudo, E.5
Tsai, F.-Y.6
Greenbaum, D.C.7
Hager, J.H.8
Bogyo, M.9
Hanahan, D.10
-
184
-
-
47749093130
-
The bacteria fight back
-
Taubes G (2008) The bacteria fight back. Science 321:356-361
-
(2008)
Science
, vol.321
, pp. 356-361
-
-
Taubes, G.1
-
185
-
-
84857768953
-
On the applications of activity-based protein profiling to microbial pathogenesis
-
Springer, Berlin, Heidelberg. doi: 10.1007/128-2011-299
-
Heal WP, Tate EW (2012) On the Applications of Activity-Based Protein Profiling to Microbial Pathogenesis. Topics in Current Chemistry. Springer, Berlin, Heidelberg. doi: 10.1007/128-2011-299
-
(2012)
Topics in Current Chemistry
-
-
Heal, W.P.1
Tate, E.W.2
-
186
-
-
34548666006
-
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes
-
DOI 10.1038/nchembio.2007.26, PII NCHEMBIO200726
-
Blum G, von Degenfeld G, Merchant MJ et al (2007) Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nat Chem Biol 3:668-677 (Pubitemid 47417706)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.10
, pp. 668-677
-
-
Blum, G.1
Von Degenfeld, G.2
Merchant, M.J.3
Blau, H.M.4
Bogyo, M.5
-
187
-
-
10044296973
-
Cysteine cathepsins in human cancer
-
DOI 10.1515/BC.2004.132
-
Jedeszko C, Sloane BF (2004) Cysteine cathepsins in human cancer. Biol Chem 385:1017-1027 (Pubitemid 39600309)
-
(2004)
Biological Chemistry
, vol.385
, Issue.11
, pp. 1017-1027
-
-
Jedeszko, C.1
Sloane, B.F.2
-
188
-
-
0034802806
-
Prognostic impact of proteolytic factors (urokinase-type plasminogen activator, plasminogen activator inhibitor 1, and Cathepsins B, D, and L) in primary breast cancer reflects effects of adjuvant systemic therapy
-
Harbeck N, Alt U, Berger U et al (2001) Prognostic impact of proteolytic factors (urokinasetype plasminogen activator, plasminogen activator inhibitor 1, and cathepsins B, D, and L) in primary breast cancer reflects effects of adjuvant systemic therapy. Clin Cancer Res 7:2757-2764 (Pubitemid 32911381)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.9
, pp. 2757-2764
-
-
Harbeck, N.1
Alt, U.2
Berger, U.3
Kruger, A.4
Thomssen, C.5
Janicke, F.6
Hofler, H.7
Kates, R.E.8
Schmitt, M.9
-
189
-
-
0031887693
-
Prognostic significance of cathepsins B and L in primary human breast cancer
-
Foekens JA, Kos J, Peters HA et al (1998) Prognostic significance of cathepsins B and L in primary human breast cancer. J Clin Oncol 16:1013-1021 (Pubitemid 28108735)
-
(1998)
Journal of Clinical Oncology
, vol.16
, Issue.3
, pp. 1013-1021
-
-
Foekens, J.A.1
Kos, J.2
Peters, H.A.3
Krasovec, M.4
Look, M.P.5
Cimerman, N.6
Meijer-van Gelder, M.E.7
Henzen-Logmans, S.C.8
Van Putten, W.L.J.9
Klijn, J.G.M.10
-
190
-
-
79955902283
-
Live cell labeling of native intracellular bacterial receptors using aniline-catalyzed oxime ligation
-
Rayo J, Amara N, Krief P et al (2011) Live cell labeling of native intracellular bacterial receptors using aniline-catalyzed oxime ligation. J Am Chem Soc 133(19):7469-7475
-
(2011)
J Am Chem Soc
, vol.133
, Issue.19
, pp. 7469-7475
-
-
Rayo, J.1
Amara, N.2
Krief, P.3
-
191
-
-
84857702948
-
Activity-based protein profiling for natural product target discovery
-
Springer, Berlin, Heidelberg. doi: 10.1007/128-2011-289
-
Krysiak J, Breinbauer R (2012) Activity-based protein profiling for natural product target discovery. Topics in Current Chemistry. Springer, Berlin, Heidelberg. doi: 10.1007/128-2011-289
-
(2012)
Topics in Current Chemistry
-
-
Krysiak, J.1
Breinbauer, R.2
-
192
-
-
0032560621
-
Ionization-reactivity relationships for cysteine thiols in polypeptides
-
DOI 10.1021/bi973101r
-
Bulaj G, Kortemme T, Goldenberg DP (1998) Ionization-reactivity relationships for cysteine thiols in polypeptides. Biochemistry 37:8965-8972 (Pubitemid 28299665)
-
(1998)
Biochemistry
, vol.37
, Issue.25
, pp. 8965-8972
-
-
Bulaj, G.1
Kortemme, T.2
Goldenberg, D.P.3
-
193
-
-
0024499102
-
Cysteine 288: An essential hyperreactive thiol of cytosolic phosphoenolpyruvate carboxykinase (GTP)
-
Lewis CT, Seyer JM, Carlson GM (1989) Cysteine 288: an essential hyperreactive thiol of cytosolic phosphoenolpyruvate carboxykinase (GTP). J Biol Chem 264:27-33 (Pubitemid 19027570)
-
(1989)
Journal of Biological Chemistry
, vol.264
, Issue.1
, pp. 27-33
-
-
Lewis, C.T.1
Seyer, J.M.2
Carlson, G.M.3
-
194
-
-
0017018406
-
The intrinsic pKa-values of functional groups in enzymes: Improper deductions from the pH-dependence of steady-state parameters
-
Knowles JR (1976) The intrinsic pKa-values of functional groups in enzymes: improper deductions from the pH-dependence of steady-state parameters. CRC Crit Rev Biochem 4:165-173
-
(1976)
CRC Crit Rev Biochem
, vol.4
, pp. 165-173
-
-
Knowles, J.R.1
-
195
-
-
78650078496
-
Quantitative reactivity profiling predicts functional cysteines in proteomes
-
Weerapana E, Wang C, Simon GM et al (2010) Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature 468:790-795
-
(2010)
Nature
, vol.468
, pp. 790-795
-
-
Weerapana, E.1
Wang, C.2
Simon, G.M.3
|