Plasminogen activators and angiogenesis

Current Topics in Microbiology and Immunology

Volumn 213 I, Issue , 1996, Pages 33-50

  Mignatti, P ^a   Rifkin, D B ^b,c  

^a UNIVERSITY OF PAVIA   (Italy)

^b Kaplan Cancer Center   (United States)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PLASMINOGEN ACTIVATOR; UROKINASE;

ANGIOGENESIS; CELL MIGRATION; ENDOTHELIUM; HUMAN; METASTASIS; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; REVIEW;

EID: 0029991534     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-61107-0_3     Document Type: Review

References (134)

1. Alessandri G, Rajn K, Gullino PM (1983) Mobilization of capillary endothelium in vitro induced by effectors of angiogenesis in vivo. Cancer Res 43: 1790-1797
2. Andrade-Gordon P, Strickland S (1986) Interaction of heparin with plasminogen activators and plasminogen: effects on the activation of plasminogen Biochemistry 25: 4033-4040
3. Anichini E, Fibbi G, Pucci M, Caldini R, Chevanne M, Del Rosso M (1994) Production of second messengers following chemotactic and mitogenic urokinase-receptor interaction in human fibroblasts and mouse fibroblasts transfected with human urokinase receptor. Exp Cell Res 213. 438-448
4. Appella E, Robinson EA, Ullrich SJ, Stoppelli MP, Corti A, Cassani G, Blasi F (1987) The receptor-binding sequence of urokinase. A biological function for the growth factor module of proteases. J Biol Chem 262: 4437-4440
5. Astedt B, Lecander I, Brodin T, Ludblad A, Low K (1985) Purification of a specific placental plasminogen activator inhibitor by monoclonal antibody and its complex formation with plasminogen activator. Thromb Haemost 53: 122-125
6. Ausprunk DH, Folkman J (1977) Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis Microvasc Res 14: 53-65
7. Bacharach E, Itin A, Keshet E (1992) In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis Proc Natl Acad Sci USA 89: 10686-10690
8. Baker JB, Low DA, Simmer RL, Cunningham DD (1980) Protease-nexin: a cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell 21: 37-45
9. Bamathan ES, Kuo A, Kariko K, Rosenfeld L, Murray SC, Behrendt N, Rønne E, Weiner D, Henkin J, Cines DB (1990a) Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA. Blood 76. 1795-1806
10. Barnathan ES, Kuo A, Rosenfeld L, Kariko K, Leski M, Robbiati F, Nolli ML, Henkin J, Cines DB (1990b) Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells. J Biol Chem 265: 2865-2872
11. Bashkin P, Doctrow S, Klagsbrun M, Svahn CM, Folkman J, Vlodavski I (1989) Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules. Biochemistry 28: 1737-1743
12. Basilico C, Moscatelli D (1992) The FGF family of growth factors and oncogenes. Adv Cancer Res 59: 115-165
13. Behrendt N, Rønne E, Ploug M, Petri T, Løber D, Nielsen LS, Schleuning WD, Blasi F, Appella E, Danø K (1990) The human receptor for urokinase plasminogen activator. NH2-terminal sequence and glycosylation variants. J Biol Chem 265: 6453-6460
14. Bikfalvi A, Klein S, Pintucci G, Quarto N, Mignatti P, Rifkin DB (1995) Differential modulation of cell phenotype by different molecular weight forms of basic fibroblast growth factor, possible intracellular signaling by the high molecular weight forms. J Cell Biol 129: 233-243
15. Blei F, Wilson EL, Mignatti P, Rifkin DB (1993) Mechanism of action of angiostatic steroids, suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis. J Cell Physiol 155: 568-578
16. Bowersox JC, Sorgente N (1982) Chemotaxis of aortic endothelial cells in response to fibronectin. Cancer Res 42 2547-2551
17. Busso N, Masur SK, Lazega D, Waxman S, Ossowski L (1994) Induction of cell migration by prourokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells. J Cell Biol 126: 259-270
18. Bussolino F, Di Renzo MF, Ziche M, Bocchietto E, Olivero M, Naldini L, Gaudino G, Tamagnone L, Coffer A, Comoglio PM (1992) Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 119: 629-641
19. Bykowska K, Levin EG, Rijken DC, Loskutoff DJ, Collen D (1982) Characterization of a plasminogen activator secreted by cultured bovine aortic endothelial cells. Biochim Biophys Acta 703: 113-115
20. Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, DeVos R, van den Oord JJ, Collen D, Mulligan RC (1994) Physiological consequences of loss of plasminogen activator gene function in mice. Nature 386: 419-425
21. Cesarman GM, Guevara CA, Hajjar KA (1994) An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation. J Biol Chem 269: 21198-21203
22. Chapman HA, Stone OL Jr (1984) Cooperation between plasmin and elastase in elastin degradation by intact murine macrophages. Biochem J 222: 721-728
23. Cubellis MV, Wun TC, Blasi F (1990) Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1 EMBO J 9 1079-1085
24. Del Rosso M, Fibbi G, Dini G, Grappone C, Pucci M, Caldini R, Magnelli L, Fimiani M, Lotti T, Panconesi E (1990) Role of specific membrane receptors in urokinase-dependent migration of human keratinocytes J Invest Dermatol 94: 310-316
25. Del Rosso M, Anichini E, Pedersen N, Blasi F, Fibbi G, Pucci M, Ruggiero M (1993) Urokinase-urokinase receptor interaction: non-mitogenic signal transduction in human epidermal cells. Biochem Biophys Res Commun 190: 347-352
26. DiMario J, Buffinger N, Yamada S, Strohman RC (1989) Fibroblast growth factor in the extracellular matrix of dystrophic (mdx) mouse muscle. Science 244 688-690
27. Dubois-Stringfellow N, Jonczyk A, Bautch VL (1994) Perturbations in the fibrinolytic pathway abolish cyst formation but not capillary-like organization of cultured murine endothelial cells. Blood 83. 3206-3217
28. Eaton DL, Scott RW, Baker JB (1984) Purification of human fibroblast urokinase proenzyme and analysis of its regulation by proteases and protease nexin. J Biol Chem 259: 6241-6247
29. Ellis V, Behrendt N, Danø K (1991) Plasminogen activation by receptor-bound urokinase A kinetic study with both cell-associated and isolated receptor. J Biol Chem 266: 12752-12758
30. Felez J, Chanquia CJ, Fabregas P, PPlow EF, Miles LA (1993) Competition between plasminogen and tissue plasminogen activator for cellular binding sites Blood 82: 2433-2441
31. Ferrara N, Houck KA, Jakeman LB, Winer J, Leung DW (1991) The vascular endothelial cell growth factor family of polypeptides. J Cell Biochem 47: 211-218
32. Fibbi G, Ziche M, Morbidelli L, Magnelli L, Del Rosso M (1988) Interaction of urokinase with specific receptors stimulates mobilization of bovine adrenal capillary endothelial cells. Exp Cell Res 179. 385-395 [published erratum in Exp Cell Res 186:196]
33. Fidler IJ, Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis (comment). Cell 79: 185-188
34. Flaumenhaft R, Moscatelli D, Rifkin DB (1990) Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor J Cell Biol 111: 1651-1659
35. Flaumenhaft R, Abe M, Mignatti P, Rifkin DB (1992) Basic fibroblast growth factor-induced activation of latent transforming growth factor β in endothelial cells: regulation of plasminogen activator activity J Cell Biol 118: 901-909
36. Folkman J (1986) How is blood vessel growth regulated in normal and neoplastic tissue? G.H A Clowes Memorial Award Lecture Cancer Res 46 467-473
37. Folkman J (1990) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4-6 (editorial)
38. Folkman J, Watson K, Ingber D, Hanahan D (1989) Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 339: 58-61
39. Grant DS, Kleinman HK, Goldberg ID, Bhargava MM, Nickoloff BJ, Kinsella JL, Polverini P, Rosen EM (1993) Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci USA 90: 1937-1941
40. Gross JL, Moscatelli D, Rifkin DB (1983) Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro. Proc Natl Acad Sci USA 80 2623-2627
41. Hajjar KA (1991) The endothelial cell tissue plasminogen activator receptor. Specific interaction with plasminogen. J Biol Chem 266: 21962-21970
42. Hajjar KA (1993) Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J Clin Invest 91: 2873-2879
43. Hajjar KA, Hamel NM (1990) Identification and characterization of human endothelial cell membrane binding sites for tissue plasminogen activator and urokinase. J Biol Chem 265: 2908-2916
44. Hajjar KA, Harpel PC, Jaffe EA, Nachman RL (1986) Binding of plasminogen to cultured human endothelial cells. J Biol Chem 261: 11656-11662
45. Hajjar KA, Jacovina AT, Chacko J (1994) An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II J Biol Chem 269: 21191-21197
46. Hébert CA, Baker JB (1988) Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton colocalization of cell surface urokinase with vinculin. J Cell Biol 106: 1241-1248
47. Heeb MJ, Espana F, Geiger M, Collen D, Stump DC, Griffin JH (1987) Immunological identity of heparin-dependent plasma and urinary protein C inhibitor and plasminogen activator inhibitor-3 J Biol Chem 262. 15813-15816
48. Heimark RL, Twardzik DR, Schwartz SM (1986) Inhibition of endothelial cell regeneration by type-beta transforming growih factor from platelets. Science 233: 1078-1080
49. Hekman CM, Loskutoff DJ (1985) Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J Biol Chem 260: 11581-11587
50. Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N (1992) Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267: 26031-26037
51. Kanalas JJ, Makker SP (1991) Identification of the rat Heymann nephritis autoantigen (gp330) as a receptor site for plasminogen J Biol Chem 266: 10825-10829
52. Kawano T, Morimoto K, Uemura Y (1970) Partial purification and properties of urokinase inhibitor from human placenta. J Biochem 67: 333-342
53. Kleiner DE, Stetler-Stevenson WG (1993) Structural biochemistry and activation of matrix metalloproteinases. Curr Opin Cell Biol 5. 891-897
54. Kristensen P, Larsson LI, Nielsen LS, Grøndahl-Hansen J, Andreasen PA, Danø K (1984) Human endothelial cells contain one type of plasminogen activator. FEBS Lett 168 33-37
55. Kruithof EKO, Vassalli JD, Schleuning W-D, Mattaliano RJ, Bachman F (1986) Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937 J Biol Chem 261: 11207-11213
56. Laterra J, Indurti RR, Goldstein GW (1994) Regulation of in vitro glia-induced microvessel morphogenesis by urokinase J Cell Physiol 158: 317-324
57. Laug WE, Tokes ZA, Benedict WF, Sorgente N (1980) Anchorage independent growth and plasminogen activator production by bovine endothelial cells. J Cell Biol 84 281-293
58. Lee SW, Ellis V, Dichek DA (1994) Characterization of plasminogen activation by glycosylphosphatidylinositol-anchored urokinase. J Biol Chem 269: 2411-2418
59. Levin EG, Loskutoff DJ (1982) Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators. J Cell Biol 94: 631-636
60. Loskutoff DJ, Edgington TS (1977) Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci USA 74. 3903-3907
61. Lyons RM, Keski Oja J, Moses HL (1988) Proteolytic activation of latent transforming growth factor-β from fibroblast conditioned medium. J Cell Biol 106: 1659-1665
62. Lyons RM, Gentry LE, Purchio AF, Moses HL (1990) Mechanism of activation of latent recombinant transforming growth factor β-1 by plasmin. J Cell Biol 110. 1361-1367
63. Maciag T (1984) Angiogenesis. Angiogenesis: the phenomenon. In: Spaet TH (ed) Thrombosis and haemostasis. Grune and Stratton, New York, pp 167-182
64. Mandriota S, Seghezzi G, Vassalli JD, Ferrara N, Wasi S, Mazzieri R, Mignatti P, Pepper MS (1995) Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem (in press)
65. Matrisian LM (1990) Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 6: 121-125
66. Mignatti P, Rifkin DB (1993) Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 73: 161-195
67. Mignatti P, Robbins E, Rifkin DB (1986) Tumor invasion through the human amniotic membrane: requirement for a proteinase cascade. Cell 47: 487-498
68. Mignatti P, Tsuboi R, Robbins E, Rifkin DB (1989) In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases. J Cell Biol 108: 671-682
69. Mignatti P, Mazzieri R, Rifkin DB (1991a) Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor J Cell Biol 113 1193-1201
70. Mignatti P, Morimoto T, Rifkin DB (1991b) Basic fibroblast growth factor released by single, isolated cells stimulates their migration in an autocrine manner. Proc Natl Acad Sci USA 88: 11007-11011
71. Mignatti P, Morimoto T, Rifkin DB (1992) Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex. J Cell Physiol 151: 81-93
72. Miles LA, Plow EF (1985) Binding and activation of plasminogen on the platelet surface. J Biol Chem 260. 4303-4311
73. Miles LA, Dahlberg CM, Plescia J, Felez J, Kato K, Plow EF (1991) Role of cell-surface lysines in plasminogen binding to cells: Identification of alpha-enolase as a candidate plasminogen receptor. Biochemistry 30: 1682-1691
74. Miyazono K, Hellman U, Westedt C, Heldin CH (1988) Latent high molecular weight complex of transforming growth factor β1. J Biol Chem 263. 6407-6415
75. Mizuno K, Nakamura T (1993) Molecular characteristics of HGF and the gene, and its biochemical aspects. EXS 65: 1-29
76. Møller LB, Pöllanen J, Rønne E, Pedersen N, Blasi F (1993) N-linked glycosylation of the ligand-binding domain of the human urokinase receptor contributes to the affinity for its ligand J Biol Chem 268, 11152-11159
77. Montesano R, Orci L (1985) Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell 42: 469-477
78. Montesano R, Vassalli JD, Baird A, Guillemin R, Orci L (1986) Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci USA 83: 7297-7301
79. Montesano R, Pepper MS, Vassalli JD, Orci L (1987) Phorbol ester induces cultured endothelial cells to invade a fibrin matrix in the presence of fibrinolytic inhibitors J Cell Physiol 132: 509-516
80. Montesano R, Pepper MS, Belin D, Vassalli JD, Orci L (1988) Induction of angiogenesis in vitro by vanadate, an inhibitor of phosphotyrosine phosphatases. J Cell Physiol 134: 460-466
81. Montesano R, Pepper MS, Möhle-Steinlein U, Risau W, Wagner EF, Orci L (1990) Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 62: 435-445
82. Morton PA, Owensby DA, Wun TC, Billadello J, Schwartz AL (1990) Identification of determinants involved in binding of tissue-type plasminogen activator-plasminogen activator inhibitor type 1 complexes to HepG2 cells. J Biol Chem 265: 14093-14099
83. Moscatelli D, Rifkin DB (1988) Membrane and matrix localization of proteinase: a common theme in tumor cell invasion and angiogenesis Biochim Biophys Acta 948: 67-85
84. Moscatelli D, Jaffe E, Rifkin DB (1980) Tetradecanoyl phorbol acetate stimulates latent collagenase production by cultured human endothelial cells. Cell 20. 343-51
85. Moscatelli D, Presta M, Joseph-Silverstein J, Rifkin DB (1986a) Both normal and tumor cells produce basic fibroblast growth factor. J Cell Physiol 129: 273-276
86. Moscatelli D, Presta M, Rifkin DB (1986b) Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis and migration. Proc Natl Acad Sci USA 83 2091-2095
87. Moser TL, Enghild JJ, Pizzo SV, Stack MS (1993) The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. J Biol Chem 268. 18917-18923
88. Muller G, Behrens J, Nussbaumer U, Bohlen P, Birchmeyer W (1987) Inhibitory action of transforming growth factor β on endothelial cells. Proc Natl Acad Sci USA 84: 5600-5604
89. Murphy G, Allan JA, Willenbrock F, Cockett MI, O'Connell JP, Docherty AJP (1992) The C-terminal domain in collagenase and stromelysin specificity. J Biol Chem 267: 9612-9618
90. Naldini L, Tamagnone L, Vigna E, Sachs M, Hartmann G, Birchmeier W, Daikuhara Y, Tsubouchi H, Blasi F, Comoglio PM (1992) Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor EMBO J 11 4825-4833
91. O'Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH, Folkman J (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79: 315-328
92. Odekon LE, Sato Y, Rifkin DB (1992) Urokinase-type plasminogen activator mediates basic fibroblast growth factor-induced bovine endothelial cell migration independent of its proteolytic activity. J Cell Physiol 150 258-263
93. Odekon LE, Blasi F, Rifkin DB (1994) Requirement for receptor-bound urokinase in plasmin-dependent cellular conversion of latent TGF-beta to TGF-beta. J Cell Physiol 158. 398-407
94. Pepper MS, Vassalli JD, Montesano R, Orci L (1987) Urokinase-type plasminogen activator is induced in migrating capillary endothelial cells. J Cell Biol 105: 2535-2541
95. Pepper MS, Belin D, Montesano R, Orci L, Vassalli JD (1990) Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro J Cell Biol 111 743-755
96. Pepper MS, Ferrara N, Orci L, Montesano R (1991) Vascular endothelial cell growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem Biophys Res Commun 181: 902-906
97. Pepper MS, Ferrara N, Orci L, Montesano R (1992a) Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro. Biochem Biophys Res Commun 189. 824-831
98. Pepper MS, Sappino AP, Montesano R, Orci L, Vassalli JD (1992b) Plasminogen activator inhibitor-1 is induced in migrating endothelial cells. J Cell Physiol 153: 129-139
99. Pepper MS, Sappino AP, Stocklin R, Montesano R, Orci L, Vassalli JD (1993) Upregulation of urokinase receptor expression on migrating endothelial cells. J Cell Biol 122: 673-684
100. Peverali FA, Mandriota S, Ciana P, Marelli R, Quax P, Rifkin DB, Della Valle G, Mignatti P (1994) Tumor cells secrete an angsogenic factor that stimulates basic fibroblast growth factor and urokinase expression in vascular endothelial cells. J Cell Physiol 161: 1-14
101. Philips M, Juul AG, Thorsen S (1984) Human endothelial cells produce a plasminogen activator inhibitor and a tissue plasminogen activator-inhibitor complex Biochim Biophys Acta 802: 99-110
102. Ploug M, Rønne E, Behrendt N, Jensen AL, Blasi F, Danø K (1991) Cellular receptor for urokinase plasminogen activator Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol J Biol Chem 266. 1926-1933
103. Plow EF, Miles LA (1990) Plasminogen receptors in the mediation of pericellular proteolysis. Cell Differ Dev 32: 293-298
104. Plow EF, Freaney DE, Plescia J, Miles LA (1986) The plasminogen system and cell surfaces, evidence for plasminogen and urokinase receptors on the same cell type J Cell Biol 103: 2411-2420
105. Pollack R, Rifkin DB (1975) Actin-containing cables within anchorage-dependent rat embryo cells are dissociated by plasmin and trypsin. Cell 6. 495-506
106. Pöllanen J, Hedman K, Nielsen LN, Danø K, Vaheri A (1988) Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts. J Cell Biol 106: 87-95
107. Ramakrishnan V, Sinicropi DV, Dere R, Darbonne WC, Bechtol KB, Baker JB (1990) Interaction of wild-type and catalytically inactive mutant forms of tissue-type plasminogen activator with human umbilical vein endothelial cell monalayers. J Biol Chem 265: 2755-2762
108. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, Fauci AS (1986) Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 83: 4167-4171
109. Rogelj S, Klagsbrun M, Atzmon R, Kurokawa M, Haimovitz A, Fuks Z, Vlodavski I (1989) Basic fibroblast growth factor is an extracellular matrix component required for supporting the proliferation of vascular endothelial cells and the diffferentiation of PC12 cells. J Cell Biol 109: 823-831
110. Roldan AL, Cubellis MV, Masucci MT, Behrendt N, Lund LR, Danø K, Appella E, Blasi F (1990) Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis EMBO J 9: 467-474
111. Russell ME, Quertermous T, Declerck PJ, Collen D, Haber E, Homcy CJ (1990) Binding of tissue-type plasminogen activator with human endothelial cell monolayers Characterization of the high affinity interaction with plasminogen activator inhibitor-1 J Biol Chem 265: 2569-2575
112. Saksela O, Rrfkin DB (1988) Cell-associated plasminogen activation: regulation and physiological functions. Annu Rev Cell Biol 4: 93-126
113. Saksela O, Rifkin DB (1990) Release of basic fibrobtast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity. J Cell Biol 110. 767-775
114. Saksela O, Moscatelli D, Rifkin DB (1987) The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells. J Cell Biol 105 957-963
115. Saksela O, Moscatelli D, Sommer A, Rifkin DB (1988) Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. J Cell Biol 107: 743-751
116. Sato Y, Rifkin DB (1988) Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J Cell Biol 107: 1199-1205
117. Sato Y, Rifkin DB (1989) Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor β-1-like molecule by plasmin J Cell Biol 109: 309-315
118. Sato Y, Tsuboi R, Lyons RM, Moses HL, Rifkin DB (1990) Characterization of the activation of latent TGFβ by co-cultures of endothelial cells and pericytes or smooth muscle cells, a self-regulating system. J Cell Biol 111 757-763
119. Schulze-Osthoff K, Risau W, Vollmer E, Sorg C (1990) In situ detection of basic fibroblast growth factor by highly specific antibodies Am J Pathol 137: 85-92
120. Shih GC, Hajjar KA (1993) Plasminogen and plasminogen activator assembly on the human endothelial cell Proc Soc Exp Biol Med 202 258-64
121. Stack MS, Pizzo SV (1993) Modulation of tissue plasminogen activator-catalyzed plasminogen activation by synthetic peptides derived from the amino-terminal heparin binding domain of fibronectin. J Biol Chem 268 18924-18928
122. Thompson EA, Nelles L, Collen D (1991) Effect of retinoic acid on the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in human endothelial cells Eur J Biochem 201 627-632
123. Tsuboi R, Sato Y, Rifkin DB (1990) Correlation of cell migration, cell invasion, receptor number, proteinase production, and basic fibroblast growth factor levels in endothelial cells. J Cell Biol 110: 511-517
124. van Hinsbergh VW, van den Berg EA, Fiers W, Dooijewaard G (1990) Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells. Blood 75: 1991-1998
125. Vassalli J-D, Baccino D, Belin D (1985) A cellular binding site for the M. 55,000 form of the human plasminogen activator, urokinase J Cell Biol 100: 86-92
126. Vlodavsky I, Fuks Z, Bar-Ner M, Ariav Y, Schirrmacher V (1983) Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis Cancer Res 43 2704-2711
127. Vlodavsky I, Korner G, Ishai-Michaeli R, Bashkin P, Bar-Shavit R, Fuks Z (1990) Extracellular matrix-resident growth factors and enzymes: possible involvement in tumor metastasis and angiogenesis. Cancer Metastasis Rev 9: 203-226
128. Weidner N, Semple JP, Welch WR, Folkman J (1991) Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N Engl J Med 324: 1-8
129. Werb Z, Mainardi C, Vater CA, Harris ED (1977) Endogenous activation of latent collagenase by rheumatoid synovial cells. Evidence for a role of plasminogen activator. N Engl J Med 296: 1017-1023
130. Werb Z, Banda MJ, Jones PA (1980) Degradation of connective tissue matrices by macrophages. I Proteolysis of elastin, glycoproteins and collagen by proteinases isolated from macrophages. J Exp Med 152: 1340-1357
131. Wittwer AJ, Sanzo MA (1990) Effect of peptides on the inactivation of tissue plasminogen activator by plasminogen activator inhibitor-1 and on the binding of tissue plasminogen activator to endothelial cells. Thromb Haemost 64: 270-275
132. Wolff JE, Guerin C, Laterra J, Bressler J, Indurti RR, Brem H, Goldstein GW (1993) Dexamethasone reduces vascular density and plasminogen activator activity in 9L rat brain tumors. Brain Res 604: 79-85
133. Yang EY, Moses HL (1990) Transforming growth factor β1-induced changes in cell migration, proliferation, and angiogenesis in the chick chorioallantoic membrane. J Cell Biol 111: 731-741
134. Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM (1991) Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 64. 841-848