A chemical switch for inhibitor-sensitive alleles of any protein kinase

Nature

Volumn 407, Issue 6802, 2000, Pages 395-401

  Bishop, Anthony C ^a   Ubersax, Jeffrey A ^b   Pøtsch, Dejah T ^c   Matheos, Dina P ^a   Gray, Nathanael S ^d   Blethrow, Justin ^b   Shimizu, Eiji ^a   Tsien, Joe Z ^a   Schultz, Peter G ^d   Rose, Mark D ^a   Wood, John L ^c   Morgan, David O ^b   Shokat, Kevan M ^a,b  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c YALE UNIVERSITY   (United States)

^d GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KINASE INHIBITOR;

ALLELE; ARTICLE; CELL MEMBRANE PERMEABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; MITOSIS; MULTIGENE FAMILY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALLELES; AMINO ACID SEQUENCE; CARBAZOLES; CDC28 PROTEIN KINASE; CELL CYCLE; ENZYME INHIBITORS; FUNGAL PROTEINS; GENE EXPRESSION; HUMAN; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC;

EID: 0034699382     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35030148     Document Type: Article

References (30)

1. Gray, N. S. et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitions. Science 281, 533-538 (1998).
2. Bishop, A. C. et al. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 121, 627-631 (1999).
3. Reed, S. I. The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95, 561-577 (1980).
4. Liu, Y., Shah, K., Yang, F., Witucki, L. & Shokat, K. M. Engineering Src family protein kinases with unnatural nucleotide specificity. Chem. Biol. 5, 91-101 (1998).
5. Hanke, J. H. et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. J. Biol. Chem. 271, 695-701 (1996).
6. Brown, M. T. & Cooper, J. A. Regulation, substrates and functions of src. Biochim. Biophys. Acta 1287, 121-149 (1996).
7. Resh, M. D. Fyn, a Src family tyrosine kinase. Int. J. Biochem. Cell Biol. 30, 1159-1162 (1998).
8. Laneuville, P. Abl tyrosine protein kinase. Semin. Immunol. 7, 255-266 (1995).
9. Kelly, P. T. Calmodulin-dependent protein kinase II. Multifunctional roles in neuronal differentiation and synaptic plasticity. Mol. Neurobiol. 5, 153-177 (1991).
10. Morgan, D. O. Principles of CDK regulation. Nature 374, 131-134 (1995).
11. Lawrie, A. M. et al. Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2. Nature Struct. Biol. 4, 796-801 (1997).
12. Wood, J. L., Stoltz, B. M., Dietrich, H. J., Pflum, D. A. & Petsch, D. T. Design and implementation of an efficient synthetic approach to furanosylated indolocarbazoles: total synthesis of (+)- and (-)-K252a. J. Am. Chem. Soc. 119, 9641-9651 (1997).
13. Liu, Y. et al. Structural basis for selective inhibition of Src family kinases by PPI. Chem. Biol. 6, 671-678 (1999).
14. Hunter, T. & Plowman, G. D. The protein kinases of budding yeast: six score and more. Trends Biochem. Sci. 22, 18-22 (1997).
15. Fujimura, H. A. Yeast homolog of mammalian mitogen-activated protein kinase, Fus3/Dac2 kinase, is required both for cell fusion and for G1 arrest of the cell cycle and morphological changes by the cdc37 mutation. J. Cell. Sci. 107, 2617-2622 (1994).
16. Doi, S. & Yoshimura, M. Temperature-sensitive loss of sexual agglutinability in Saccharomyces cerevisiae. Arch. Microbiol. 114, 287-288 (1977).
17. Mendenhall, M. D. & Hodge, A. E. Regulation of Cdc28 cyclin-dependent protein kinase activity during the cell cycle of the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 62, 1191-1243 (1998).
18. King, R. W., Jackson, P. K. & Kirschner, M. W. Mitosis in transition. Cell 79, 563-571 (1994).
19. Surana, U. et al. The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65, 145-161 (1991).
20. Bourne, Y. et al. Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell 84, 863-874 (1996).
21. Wodicka, L., Dong, H., Mittmann, M., Ho, M. H. & Lockhart, D. J. Genome-wide expression monitoring in Saccharomyces cerevisiae. Nature Biotechnol. 15, 1359-1367 (1997).
22. Espinoza, F. H., Ogas, J., Herskowitz, J. & Morgan, D. O. Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. Science 266, 1388-1391 (1994).
23. Spellman, P. T. et al. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell 9, 3273-3297 (1998).
24. Fitch, I. et al. Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell 3, 805-818 (1992).
25. Stern, B. & Nurse, P. A quantitative model for the cdc2 control of S phase and mitosis in fission yeast. Trends Genet. 12, 345-350 (1996).
26. Farrell, A. & Morgan, D. O. Cdc37 promotes the stability of protein kinases Cdc28 and Cak1. Mol. Cell. Biol. 20, 749-754 (2000).
27. Sherman, F., Fink, G. & Lawrence, C. Methods in Yeast Genetics (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, 1974).
28. Sikorski, R. S. & Hieter, P. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27 (1989).
29. Schindler, T. et al. Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol. Cell 3, 639-648 (1999).
30. Biggins, S. et al. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev. 13, 532-544 (1999).