A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 4, 1999, Pages 621-631

  Brady, Kenneth D ^a   Giegel, David A ^b   Grinnell, Christine ^a   Lunney, Elizabeth ^b   Talanian, Robert V ^a   Wong, Winnie ^a   Walker, Nigel ^c  

^a BASF Bioresearch Corporation   (United States)

^b PFIZER INC   (United States)

^c BASF SE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; KETONE DERIVATIVE;

CATALYSIS; CONFERENCE PAPER; DRUG DESIGN; DRUG STRUCTURE; ENZYME INACTIVATION; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CASPASE 1; CRYSTALLOGRAPHY, X-RAY; INHIBITORY CONCENTRATION 50; KETONES; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; PYRIDINES; TIME FACTORS;

EID: 0033036804     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00009-7     Document Type: Conference Paper

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