Using chemical genetics and ATP analogues to dissect protein kinase function

ACS Chemical Biology

Volumn 2, Issue 5, 2007, Pages 299-314

  Elphick, Lucy M ^a   Lee, Sarah E ^b   Gouverneur, Véronique ^b   Mann, David J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE; RIBAVIRIN; ADENOSINE TRIPHOSPHATE; DRUG DERIVATIVE;

ANTIBODY SPECIFICITY; BINDING AFFINITY; BINDING SITE; CATALYSIS; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL LYSATE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; GENETIC CODE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HYDROPHOBICITY; MOLECULAR GENETICS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEOMICS; REGULATORY MECHANISM; REVIEW; SENSITIVITY AND SPECIFICITY; WILD TYPE; ANIMAL; CHEMISTRY; COMBINATORIAL CHEMISTRY; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ENGINEERING; SYNTHESIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN KINASES; SUBSTRATE SPECIFICITY;

EID: 34347394374     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700027u     Document Type: Review

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110. Bishop, A. C., Kung, C.-Y., Shah, K., Witucki, L., Shokat, K. M., and Liu, Y. (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach, J. Am. Chem. Soc. 121, 627-631.
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112. Papa, F. R., Zhang, C., Shokat, K., and Walter, P. (2003) Bypassing a kinase activity with an ATP-competitive drug, Science 302, 1533-1537.
113. Weiss, E. L., Bishop, A. C., Shokat, K. M., and Drubin, D. G. (2000) Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p, Nat. Cell Biol. 2, 677-685.
114. Wang, H., Shimizu, E., Tang, Y. P., Cho, M., Kyin, M., Zuo, W., Robinson, D. A., Alaimo, P. J., Zhang, C., Morimoto, H., Zhuo, M., Feng, R., Shokat, K. M., and Tsien, J. Z. (2003) Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain, Proc. Natl. Acad. Sci. U.S.A. 100, 4287-4292.
115. Benjamin, K. R., Zhang, C., Shokat, K. M., and Herskowitz, I. (2003) Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2, Genes Devel. 17, 1524-1539.
116. Fan, Q. W., Zhang, C., Shokat, K. M., and Weiss, W. A. (2002) Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling, Curr. Biol. 12, 1386-1394.
117. Abeliovich, H., Zhang, C., Dunn, W. A., Jr., Shokat, K. M., and Klionsky, D. J. (2003) Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy, Mol. Biol. Cell. 14, 477-490.
118. Carroll, A. S., Bishop, A. C., DeRisi, J. L., Shokat, K. M., and O'Shea, E. K. (2001) Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response, Proc. Natl. Acad. Sci. U.S.A. 98, 12578-12583.
119. Cohen, M. S., Zhang, C., Shokat, K. M., and Taunton, J. (2005) Structural bioinformatics-based design of selective, irreversible kinase inhibitors, Science 308, 1318-1321.
120. Lascu, I., and Gonin, P. (2000) The catalytic mechanism of nucleoside diphosphate kinases, J. Bioenerg. Biomembr. 32, 237-246.