메뉴 건너뛰기




Volumn 22, Issue 2, 2012, Pages 151-174

Cancer Stem Cells as a Predictive Factor in Radiotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALDEHYDE DEHYDROGENASE; CD133 ANTIGEN; CD147 ANTIGEN; CD24 ANTIGEN; CD44V ANTIGEN; CD44V6 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; HERMES ANTIGEN; STROMAL CELL DERIVED FACTOR 1;

EID: 84857611290     PISSN: 10534296     EISSN: 15329461     Source Type: Journal    
DOI: 10.1016/j.semradonc.2011.12.003     Document Type: Review
Times cited : (82)

References (309)
  • 1
    • 0001515617 scopus 로고
    • Erfahrungen über die Verträglichkeitsgrenze für Röntgenstrahlen und deren Nutzanwendung zur Verhütung von Schäden
    • Holthusen H. Erfahrungen über die Verträglichkeitsgrenze für Röntgenstrahlen und deren Nutzanwendung zur Verhütung von Schäden. Strahlentherapie 1936, 57:254-269.
    • (1936) Strahlentherapie , vol.57 , pp. 254-269
    • Holthusen, H.1
  • 2
    • 0024535580 scopus 로고
    • The proportion of stem cells in murine tumors
    • Hill R.P., Milas L. The proportion of stem cells in murine tumors. Int J Radiat Oncol Biol Phys 1989, 16:513-518.
    • (1989) Int J Radiat Oncol Biol Phys , vol.16 , pp. 513-518
    • Hill, R.P.1    Milas, L.2
  • 3
    • 79960317000 scopus 로고    scopus 로고
    • Ablation of breast cancer stem cells with radiation
    • Zielske S.P., Spalding A.C., Wicha M.S., et al. Ablation of breast cancer stem cells with radiation. Transl Oncol 2011, 4:227-233.
    • (2011) Transl Oncol , vol.4 , pp. 227-233
    • Zielske, S.P.1    Spalding, A.C.2    Wicha, M.S.3
  • 4
  • 5
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh S.K., Hawkins C., Clarke I.D., et al. Identification of human brain tumour initiating cells. Nature 2004, 432:396-401.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 6
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S., Wu Q., McLendon R.E., et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006, 444:756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    McLendon, R.E.3
  • 7
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • Prince M.E., Sivanandan R., Kaczorowski A., et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A 2007, 104:973-978.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 973-978
    • Prince, M.E.1    Sivanandan, R.2    Kaczorowski, A.3
  • 8
    • 36849078711 scopus 로고    scopus 로고
    • Let-7 regulates self renewal and tumorigenicity of breast cancer cells
    • Yu F., Yao H., Zhu P., et al. Let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007, 131:1109-1123.
    • (2007) Cell , vol.131 , pp. 1109-1123
    • Yu, F.1    Yao, H.2    Zhu, P.3
  • 9
    • 0037388204 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic breast cancer cells
    • Al-Hajj M., Wicha M.S., Benito-Hernandez A., et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003, 100:3983-3988.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 3983-3988
    • Al-Hajj, M.1    Wicha, M.S.2    Benito-Hernandez, A.3
  • 10
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier C., Hur M.H., Charafe-Jauffret E., et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 2007, 1:555-567.
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1    Hur, M.H.2    Charafe-Jauffret, E.3
  • 11
    • 39449088496 scopus 로고    scopus 로고
    • Identification and expansion of the tumorigenic lung cancer stem cell population
    • Eramo A., Lotti F., Sette G., et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 2008, 15:504-514.
    • (2008) Cell Death Differ , vol.15 , pp. 504-514
    • Eramo, A.1    Lotti, F.2    Sette, G.3
  • 12
    • 65349130616 scopus 로고    scopus 로고
    • Isolation and identification of cancer stem-like cells in esophageal carcinoma cell lines
    • Huang D., Gao Q., Guo L., et al. Isolation and identification of cancer stem-like cells in esophageal carcinoma cell lines. Stem Cells Dev 2009, 18:465-473.
    • (2009) Stem Cells Dev , vol.18 , pp. 465-473
    • Huang, D.1    Gao, Q.2    Guo, L.3
  • 13
    • 79959590586 scopus 로고    scopus 로고
    • Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44
    • Zhao J.S., Li W.J., Ge D., et al. Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44. PLoS One 2011, 6:e21419.
    • (2011) PLoS One , vol.6
    • Zhao, J.S.1    Li, W.J.2    Ge, D.3
  • 14
    • 38549139140 scopus 로고    scopus 로고
    • + cancer stem cells in human liver cancer
    • + cancer stem cells in human liver cancer. Cancer Cell 2008, 13:153-166.
    • (2008) Cancer Cell , vol.13 , pp. 153-166
    • Yang, Z.F.1    Ho, D.W.2    Ng, M.N.3
  • 15
    • 34548455927 scopus 로고    scopus 로고
    • Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    • Hermann P.C., Huber S.L., Herrler T., et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007, 1:313-323.
    • (2007) Cell Stem Cell , vol.1 , pp. 313-323
    • Hermann, P.C.1    Huber, S.L.2    Herrler, T.3
  • 16
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C., Heidt D.G., Dalerba P., et al. Identification of pancreatic cancer stem cells. Cancer Res 2007, 67:1030-1037.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 17
    • 48249150771 scopus 로고    scopus 로고
    • Bladder cancer initiating cells (BCICs) are among EMA-CD44v6+ subset: Novel methods for isolating undetermined cancer stem (initiating) cells
    • Yang Y.M., Chang J.W. Bladder cancer initiating cells (BCICs) are among EMA-CD44v6+ subset: Novel methods for isolating undetermined cancer stem (initiating) cells. Cancer Invest 2008, 26:725-733.
    • (2008) Cancer Invest , vol.26 , pp. 725-733
    • Yang, Y.M.1    Chang, J.W.2
  • 18
    • 70449366086 scopus 로고    scopus 로고
    • Identification and characterization of cancer stem-like cells from primary carcinoma of the cervix uteri
    • Feng D., Peng C., Li C., et al. Identification and characterization of cancer stem-like cells from primary carcinoma of the cervix uteri. Oncol Rep 2009, 22:1129-1134.
    • (2009) Oncol Rep , vol.22 , pp. 1129-1134
    • Feng, D.1    Peng, C.2    Li, C.3
  • 19
    • 80051565199 scopus 로고    scopus 로고
    • The expression of ALDH1 in cervical carcinoma
    • Yao T., Chen Q., Lin Z., et al. The expression of ALDH1 in cervical carcinoma. Med Sci Monit 2011, 17:HY21-HY26.
    • (2011) Med Sci Monit , vol.17
    • Yao, T.1    Chen, Q.2    Lin, Z.3
  • 20
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien C.A., Pollett A., Gallinger S., et al. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3
  • 21
    • 33846095137 scopus 로고    scopus 로고
    • Identification and expansion of human colon-cancer-initiating cells
    • Ricci-Vitiani L., Lombardi D.G., Pilozzi E., et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445:111-115.
    • (2007) Nature , vol.445 , pp. 111-115
    • Ricci-Vitiani, L.1    Lombardi, D.G.2    Pilozzi, E.3
  • 22
    • 34547193404 scopus 로고    scopus 로고
    • Phenotypic characterization of human colorectal cancer stem cells
    • Dalerba P., Dylla S.J., Park I.K., et al. Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A 2007, 104:10158-10163.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10158-10163
    • Dalerba, P.1    Dylla, S.J.2    Park, I.K.3
  • 23
    • 28244472369 scopus 로고    scopus 로고
    • Prospective identification of tumorigenic prostate cancer stem cells
    • Collins A.T., Berry P.A., Hyde C., et al. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005, 65:10946-10951.
    • (2005) Cancer Res , vol.65 , pp. 10946-10951
    • Collins, A.T.1    Berry, P.A.2    Hyde, C.3
  • 24
    • 38349165576 scopus 로고    scopus 로고
    • Identification of cells initiating human melanomas
    • Schatton T., Murphy G.F., Frank N.Y., et al. Identification of cells initiating human melanomas. Nature 2008, 451:345-349.
    • (2008) Nature , vol.451 , pp. 345-349
    • Schatton, T.1    Murphy, G.F.2    Frank, N.Y.3
  • 25
    • 79957850890 scopus 로고    scopus 로고
    • CD133 negative cancer stem cells in glioblastoma
    • Beier C.P., Beier D. CD133 negative cancer stem cells in glioblastoma. Front Biosci (Elite Ed) 2011, 3:701-710.
    • (2011) Front Biosci (Elite Ed) , vol.3 , pp. 701-710
    • Beier, C.P.1    Beier, D.2
  • 26
    • 78649900502 scopus 로고    scopus 로고
    • Insight into the complex regulation of CD133 in glioma
    • Campos B., Herold-Mende C.C. Insight into the complex regulation of CD133 in glioma. Int J Cancer 2011, 128:501-510.
    • (2011) Int J Cancer , vol.128 , pp. 501-510
    • Campos, B.1    Herold-Mende, C.C.2
  • 27
    • 0025778099 scopus 로고
    • Rationale for different chemotherapeutic and radiation therapy strategies in cancer management
    • Looney W.B., Hopkins H.A. Rationale for different chemotherapeutic and radiation therapy strategies in cancer management. Cancer 1991, 67:1471-1483.
    • (1991) Cancer , vol.67 , pp. 1471-1483
    • Looney, W.B.1    Hopkins, H.A.2
  • 28
    • 45849089879 scopus 로고    scopus 로고
    • Exploring the role of cancer stem cells in radioresistance
    • Baumann M., Krause M., Hill R. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer 2008, 8:545-554.
    • (2008) Nat Rev Cancer , vol.8 , pp. 545-554
    • Baumann, M.1    Krause, M.2    Hill, R.3
  • 29
    • 79960352442 scopus 로고    scopus 로고
    • Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression
    • Gurtner K., Deuse Y., Bütof R., et al. Diverse effects of combined radiotherapy and EGFR inhibition with antibodies or TK inhibitors on local tumour control and correlation with EGFR gene expression. Radiother Oncol 2011, 99:323-330.
    • (2011) Radiother Oncol , vol.99 , pp. 323-330
    • Gurtner, K.1    Deuse, Y.2    Bütof, R.3
  • 30
    • 0142209198 scopus 로고    scopus 로고
    • Selective inhibition of the epidermal growth factor tyrosine kinase by BIBX1382BS improves growth delay but not local control after fractionated irradiation in human FaDu squamous cell carcinoma in nude mice
    • Baumann M., Krause M., Zips D., et al. Selective inhibition of the epidermal growth factor tyrosine kinase by BIBX1382BS improves growth delay but not local control after fractionated irradiation in human FaDu squamous cell carcinoma in nude mice. Int J Radiat Biol 2003, 79:547-559.
    • (2003) Int J Radiat Biol , vol.79 , pp. 547-559
    • Baumann, M.1    Krause, M.2    Zips, D.3
  • 31
    • 3242686127 scopus 로고    scopus 로고
    • Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma
    • Krause M., Hessel F., Zips D., et al. Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma. Radiother Oncol 2004, 72:95-101.
    • (2004) Radiother Oncol , vol.72 , pp. 95-101
    • Krause, M.1    Hessel, F.2    Zips, D.3
  • 32
    • 13844266132 scopus 로고    scopus 로고
    • Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice
    • Zips D., Hessel F., Krause M., et al. Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice. Int J Radiat Oncol Biol Phys 2005, 61:908-914.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 908-914
    • Zips, D.1    Hessel, F.2    Krause, M.3
  • 33
    • 33846262588 scopus 로고    scopus 로고
    • Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: Possible role for thrombosis
    • Weppler S.A., Krause M., Zyromska A., et al. Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: Possible role for thrombosis. Radiother Oncol 2007, 82:96-104.
    • (2007) Radiother Oncol , vol.82 , pp. 96-104
    • Weppler, S.A.1    Krause, M.2    Zyromska, A.3
  • 34
    • 70249111874 scopus 로고    scopus 로고
    • Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas
    • Zips D., Le K., Yaromina A., et al. Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas. Radiother Oncol 2009, 92:405-410.
    • (2009) Radiother Oncol , vol.92 , pp. 405-410
    • Zips, D.1    Le, K.2    Yaromina, A.3
  • 35
    • 0024820825 scopus 로고
    • Lethal mutations, the survival curve shoulder and split-dose recovery
    • Seymour C.B., Mothersill C. Lethal mutations, the survival curve shoulder and split-dose recovery. Int J Radiat Biol 1989, 56:999-1010.
    • (1989) Int J Radiat Biol , vol.56 , pp. 999-1010
    • Seymour, C.B.1    Mothersill, C.2
  • 36
  • 37
    • 0001294133 scopus 로고
    • Relation between division delay and damage expressed in later generations
    • Trott K.R. Relation between division delay and damage expressed in later generations. Curr Top Radiat Res Q 1972, 7:336-337.
    • (1972) Curr Top Radiat Res Q , vol.7 , pp. 336-337
    • Trott, K.R.1
  • 38
    • 0032939119 scopus 로고    scopus 로고
    • Comparison between the clonogenic, MTT, and SRB assays for determining radiosensitivity in a panel of human bladder cancer cell lines and a ureteral cell line
    • Banasiak D., Barnetson A.R., Odell R.A., et al. Comparison between the clonogenic, MTT, and SRB assays for determining radiosensitivity in a panel of human bladder cancer cell lines and a ureteral cell line. Radiat Oncol Investig 1999, 7:77-85.
    • (1999) Radiat Oncol Investig , vol.7 , pp. 77-85
    • Banasiak, D.1    Barnetson, A.R.2    Odell, R.A.3
  • 39
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells-Perspectives on current status and future directions: AACR workshop on cancer stem cells
    • Clarke M.F., Dick J.E., Dirks P.B., et al. Cancer stem cells-Perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res 2006, 66:9339-9344.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 40
    • 59049105873 scopus 로고    scopus 로고
    • Die hard: Are cancer stem cells the Bruce Willises of tumor biology?
    • Fαbiαn A., Barok M., Vereb G., et al. Die hard: Are cancer stem cells the Bruce Willises of tumor biology?. Cytometry A 2009, 75:67-74.
    • (2009) Cytometry A , vol.75 , pp. 67-74
    • Fαbiαn, A.1    Barok, M.2    Vereb, G.3
  • 41
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: Mirage or reality?
    • Gupta P.B., Chaffer C.L., Weinberg R.A. Cancer stem cells: Mirage or reality?. Nat Med 2009, 15:1010-1012.
    • (2009) Nat Med , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 42
    • 77953810074 scopus 로고    scopus 로고
    • Cancer stem cells at the crossroads of current cancer therapy failures-Radiation oncology perspective
    • Koch U., Krause M., Baumann M. Cancer stem cells at the crossroads of current cancer therapy failures-Radiation oncology perspective. Semin Cancer Biol 2010, 20:116-124.
    • (2010) Semin Cancer Biol , vol.20 , pp. 116-124
    • Koch, U.1    Krause, M.2    Baumann, M.3
  • 43
    • 77649208749 scopus 로고    scopus 로고
    • Cancer stem cells: A reality, a myth, a fuzzy concept or a misnomer?. An analysis
    • Maenhaut C., Dumont J.E., Roger P.P., et al. Cancer stem cells: A reality, a myth, a fuzzy concept or a misnomer?. An analysis. Carcinogenesis 2010, 31:149-158.
    • (2010) Carcinogenesis , vol.31 , pp. 149-158
    • Maenhaut, C.1    Dumont, J.E.2    Roger, P.P.3
  • 44
    • 79951674942 scopus 로고    scopus 로고
    • The cancer stem cell hypothesis: Failures and pitfalls
    • discussion 545
    • Rahman M., Deleyrolle L., Vedam-Mai V., et al. The cancer stem cell hypothesis: Failures and pitfalls. Neurosurgery 2011, 68:531-545. discussion 545.
    • (2011) Neurosurgery , vol.68 , pp. 531-545
    • Rahman, M.1    Deleyrolle, L.2    Vedam-Mai, V.3
  • 45
    • 77956503422 scopus 로고    scopus 로고
    • Cancer stem cells: A stride towards cancer cure?
    • Sengupta A., Cancelas J.A. Cancer stem cells: A stride towards cancer cure?. J Cell Physiol 2010, 225:7-14.
    • (2010) J Cell Physiol , vol.225 , pp. 7-14
    • Sengupta, A.1    Cancelas, J.A.2
  • 46
    • 65349131893 scopus 로고    scopus 로고
    • Cancer stem cells: A guide for skeptics
    • Tomasson M.H. Cancer stem cells: A guide for skeptics. J Cell Biochem 2009, 106:745-749.
    • (2009) J Cell Biochem , vol.106 , pp. 745-749
    • Tomasson, M.H.1
  • 47
    • 77955512077 scopus 로고    scopus 로고
    • Understanding the cancer stem cell
    • Bomken S., Fiser K., Heidenreich O., et al. Understanding the cancer stem cell. Br J Cancer 2010, 103:439-445.
    • (2010) Br J Cancer , vol.103 , pp. 439-445
    • Bomken, S.1    Fiser, K.2    Heidenreich, O.3
  • 48
    • 1842611103 scopus 로고    scopus 로고
    • Relationships between stem cells and cancer stem cells
    • Crowe D.L., Parsa B., Sinha U.K. Relationships between stem cells and cancer stem cells. Histol Histopathol 2004, 19:505-509.
    • (2004) Histol Histopathol , vol.19 , pp. 505-509
    • Crowe, D.L.1    Parsa, B.2    Sinha, U.K.3
  • 50
    • 33644560281 scopus 로고    scopus 로고
    • Cancer stem cells: An old idea-A paradigm shift
    • discussion 1895-1896
    • Wicha M.S., Liu S., Dontu G. Cancer stem cells: An old idea-A paradigm shift. Cancer Res 2006, 66:1883-1890. discussion 1895-1896.
    • (2006) Cancer Res , vol.66 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3
  • 51
    • 75749090819 scopus 로고    scopus 로고
    • Cell-fusion-mediated somatic-cell reprogramming: A mechanism for tissue regeneration
    • Lluis F., Cosma M.P. Cell-fusion-mediated somatic-cell reprogramming: A mechanism for tissue regeneration. J Cell Physiol 2010, 223:6-13.
    • (2010) J Cell Physiol , vol.223 , pp. 6-13
    • Lluis, F.1    Cosma, M.P.2
  • 52
    • 69249222535 scopus 로고    scopus 로고
    • Recurrence cancer stem cells-Made by cell fusion?
    • Dittmar T., Nagler C., Schwitalla S., et al. Recurrence cancer stem cells-Made by cell fusion?. Med Hypotheses 2009, 73:542-547.
    • (2009) Med Hypotheses , vol.73 , pp. 542-547
    • Dittmar, T.1    Nagler, C.2    Schwitalla, S.3
  • 53
    • 72249120354 scopus 로고    scopus 로고
    • Cell fusion as a hidden force in tumor progression
    • Lu X., Kang Y. Cell fusion as a hidden force in tumor progression. Cancer Res 2009, 69:8536-8539.
    • (2009) Cancer Res , vol.69 , pp. 8536-8539
    • Lu, X.1    Kang, Y.2
  • 54
    • 79960896892 scopus 로고    scopus 로고
    • Cell fusion hypothesis of the cancer stem cell
    • Lu X., Kang Y. Cell fusion hypothesis of the cancer stem cell. Adv Exp Med Biol 2011, 714:129-140.
    • (2011) Adv Exp Med Biol , vol.714 , pp. 129-140
    • Lu, X.1    Kang, Y.2
  • 55
    • 79960900961 scopus 로고    scopus 로고
    • Cell fusion, drug resistance and recurrence CSCs
    • Nagler C., Zänker K.S., Dittmar T. Cell fusion, drug resistance and recurrence CSCs. Adv Exp Med Biol 2011, 714:173-182.
    • (2011) Adv Exp Med Biol , vol.714 , pp. 173-182
    • Nagler, C.1    Zänker, K.S.2    Dittmar, T.3
  • 56
    • 0141842674 scopus 로고    scopus 로고
    • Identification of a cancer stem cell in human brain tumors
    • Singh S.K., Clarke I.D., Terasaki M., et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003, 63:5821-5828.
    • (2003) Cancer Res , vol.63 , pp. 5821-5828
    • Singh, S.K.1    Clarke, I.D.2    Terasaki, M.3
  • 57
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions
    • Visvader J.E., Lindeman G.J. Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat Rev Cancer 2008, 8:755-768.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 58
    • 35649019863 scopus 로고    scopus 로고
    • Precancerous stem cells have the potential for both benign and malignant differentiation
    • Chen L., Shen R., Ye Y., et al. Precancerous stem cells have the potential for both benign and malignant differentiation. PLoS One 2007, 2:e293.
    • (2007) PLoS One , vol.2
    • Chen, L.1    Shen, R.2    Ye, Y.3
  • 59
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: The next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 60
    • 77954983149 scopus 로고    scopus 로고
    • Tumor-initiating and -propagating cells: Cells that we would like to identify and control
    • Tysnes B.B. Tumor-initiating and -propagating cells: Cells that we would like to identify and control. Neoplasia 2010, 12:506-515.
    • (2010) Neoplasia , vol.12 , pp. 506-515
    • Tysnes, B.B.1
  • 61
    • 57349143739 scopus 로고    scopus 로고
    • Efficient tumour formation by single human melanoma cells
    • Quintana E., Shackleton M., Sabel M.S., et al. Efficient tumour formation by single human melanoma cells. Nature 2008, 456:593-598.
    • (2008) Nature , vol.456 , pp. 593-598
    • Quintana, E.1    Shackleton, M.2    Sabel, M.S.3
  • 62
    • 77956318306 scopus 로고    scopus 로고
    • Progress in understanding melanoma propagation
    • Shackleton M., Quintana E. Progress in understanding melanoma propagation. Mol Oncol 2010, 4:451-457.
    • (2010) Mol Oncol , vol.4 , pp. 451-457
    • Shackleton, M.1    Quintana, E.2
  • 63
    • 0023686464 scopus 로고
    • Quantitative transplantation assays of spontaneous tumors of the C3H mouse as allografts in athymic NCr/Sed-nu/nu nude mice and isografts in C3Hf/Sed mice
    • Suit H.D., Sedlacek R.S., Zietman A. Quantitative transplantation assays of spontaneous tumors of the C3H mouse as allografts in athymic NCr/Sed-nu/nu nude mice and isografts in C3Hf/Sed mice. Cancer Res 1988, 48:4525-4528.
    • (1988) Cancer Res , vol.48 , pp. 4525-4528
    • Suit, H.D.1    Sedlacek, R.S.2    Zietman, A.3
  • 64
    • 0023709399 scopus 로고
    • Quantitative studies on the transplantability of murine and human tumors into the brain and subcutaneous tissues of NCr/Sed nude mice
    • Zietman A.L., Suit H.D., Ramsay J.R., et al. Quantitative studies on the transplantability of murine and human tumors into the brain and subcutaneous tissues of NCr/Sed nude mice. Cancer Res 1988, 48:6510-6516.
    • (1988) Cancer Res , vol.48 , pp. 6510-6516
    • Zietman, A.L.1    Suit, H.D.2    Ramsay, J.R.3
  • 65
    • 0027363079 scopus 로고
    • Quantitative comparison between the transplantability of human and murine tumors into the subcutaneous tissue of NCr/Sed-nu/nu nude and severe combined immunodeficient mice
    • Taghian A., Budach W., Zietman A., et al. Quantitative comparison between the transplantability of human and murine tumors into the subcutaneous tissue of NCr/Sed-nu/nu nude and severe combined immunodeficient mice. Cancer Res 1993, 53:5012-5017.
    • (1993) Cancer Res , vol.53 , pp. 5012-5017
    • Taghian, A.1    Budach, W.2    Zietman, A.3
  • 66
    • 0027517781 scopus 로고
    • Quantitative comparison between the transplantability of human and murine tumors into the brain of NCr/Sed-nu/nu nude and severe combined immunodeficient mice
    • Taghian A., Budach W., Zietman A., et al. Quantitative comparison between the transplantability of human and murine tumors into the brain of NCr/Sed-nu/nu nude and severe combined immunodeficient mice. Cancer Res 1993, 53:5018-5021.
    • (1993) Cancer Res , vol.53 , pp. 5018-5021
    • Taghian, A.1    Budach, W.2    Zietman, A.3
  • 67
    • 13344287069 scopus 로고    scopus 로고
    • The effect of whole-body irradiation of nude mice on the tumor transplantability and control probability of a human soft tissue sarcoma xenograft
    • Huang P., Taghian A., Allam A., et al. The effect of whole-body irradiation of nude mice on the tumor transplantability and control probability of a human soft tissue sarcoma xenograft. Radiat Res 1996, 145:337-342.
    • (1996) Radiat Res , vol.145 , pp. 337-342
    • Huang, P.1    Taghian, A.2    Allam, A.3
  • 68
    • 78049478203 scopus 로고    scopus 로고
    • CD44: A cancer stem cell-related biomarker with predictive potential for radiotherapy
    • Baumann M., Krause M. CD44: A cancer stem cell-related biomarker with predictive potential for radiotherapy. Clin Cancer Res 2010, 16:5091-5093.
    • (2010) Clin Cancer Res , vol.16 , pp. 5091-5093
    • Baumann, M.1    Krause, M.2
  • 69
    • 77955268969 scopus 로고    scopus 로고
    • New models for cancer research: Human cancer stem cell xenografts
    • Baiocchi M., Biffoni M., Ricci-Vitiani L., et al. New models for cancer research: Human cancer stem cell xenografts. Curr Opin Pharmacol 2010, 10:380-384.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 380-384
    • Baiocchi, M.1    Biffoni, M.2    Ricci-Vitiani, L.3
  • 70
    • 78650035864 scopus 로고    scopus 로고
    • Cancer stem cells: Problems for therapy?
    • Alison M.R., Lim S.M., Nicholson L.J. Cancer stem cells: Problems for therapy?. J Pathol 2011, 223:147-161.
    • (2011) J Pathol , vol.223 , pp. 147-161
    • Alison, M.R.1    Lim, S.M.2    Nicholson, L.J.3
  • 71
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • Somervaille T.C., Cleary M.L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 2006, 10:257-268.
    • (2006) Cancer Cell , vol.10 , pp. 257-268
    • Somervaille, T.C.1    Cleary, M.L.2
  • 72
    • 77953507641 scopus 로고    scopus 로고
    • Biologic and experimental variation of measured cancer stem cells
    • Heuser M., Humphries R.K. Biologic and experimental variation of measured cancer stem cells. Cell Cycle 2010, 9:909-912.
    • (2010) Cell Cycle , vol.9 , pp. 909-912
    • Heuser, M.1    Humphries, R.K.2
  • 73
    • 49649085001 scopus 로고    scopus 로고
    • Identification of tumor-initiating cells in a p53-null mouse model of breast cancer
    • Zhang M., Behbod F., Atkinson R.L., et al. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res 2008, 68:4674-4682.
    • (2008) Cancer Res , vol.68 , pp. 4674-4682
    • Zhang, M.1    Behbod, F.2    Atkinson, R.L.3
  • 74
    • 40949116308 scopus 로고    scopus 로고
    • Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors
    • Cho R.W., Wang X., Diehn M., et al. Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells 2008, 26:364-371.
    • (2008) Stem Cells , vol.26 , pp. 364-371
    • Cho, R.W.1    Wang, X.2    Diehn, M.3
  • 75
    • 58649111264 scopus 로고    scopus 로고
    • Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma
    • Read T.A., Fogarty M.P., Markant S.L., et al. Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma. Cancer Cell 2009, 15:135-147.
    • (2009) Cancer Cell , vol.15 , pp. 135-147
    • Read, T.A.1    Fogarty, M.P.2    Markant, S.L.3
  • 76
    • 75349108271 scopus 로고    scopus 로고
    • Notch promotes radioresistance of glioma stem cells
    • Wang J., Wakeman T.P., Lathia J.D., et al. Notch promotes radioresistance of glioma stem cells. Stem Cells 2010, 28:17-28.
    • (2010) Stem Cells , vol.28 , pp. 17-28
    • Wang, J.1    Wakeman, T.P.2    Lathia, J.D.3
  • 77
    • 79955679188 scopus 로고    scopus 로고
    • Eyes wide open: A critical review of sphere-formation as an assay for stem cells
    • Pastrana E., Silva-Vargas V., Doetsch F. Eyes wide open: A critical review of sphere-formation as an assay for stem cells. Cell Stem Cell 2011, 8:486-498.
    • (2011) Cell Stem Cell , vol.8 , pp. 486-498
    • Pastrana, E.1    Silva-Vargas, V.2    Doetsch, F.3
  • 78
    • 4944250781 scopus 로고    scopus 로고
    • Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma
    • Galli R., Binda E., Orfanelli U., et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004, 64:7011-7021.
    • (2004) Cancer Res , vol.64 , pp. 7011-7021
    • Galli, R.1    Binda, E.2    Orfanelli, U.3
  • 79
    • 11244293572 scopus 로고    scopus 로고
    • Isolation of cancer stem cells from adult glioblastoma multiforme
    • Yuan X., Curtin J., Xiong Y., et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 2004, 23:9392-9400.
    • (2004) Oncogene , vol.23 , pp. 9392-9400
    • Yuan, X.1    Curtin, J.2    Xiong, Y.3
  • 80
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R., Weinberg R.A. The basics of epithelial-mesenchymal transition. J Clin Invest 2009, 119:1420-1428.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 81
    • 65749087298 scopus 로고    scopus 로고
    • Neurosphere formation is an independent predictor of clinical outcome in malignant glioma
    • Laks D.R., Masterman-Smith M., Visnyei K., et al. Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem Cells 2009, 27:980-987.
    • (2009) Stem Cells , vol.27 , pp. 980-987
    • Laks, D.R.1    Masterman-Smith, M.2    Visnyei, K.3
  • 82
    • 38349075007 scopus 로고    scopus 로고
    • CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    • Wang J., Sakariassen P.Ø., Tsinkalovsky O., et al. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer 2008, 122:761-768.
    • (2008) Int J Cancer , vol.122 , pp. 761-768
    • Wang, J.1    Sakariassen, P.Ø.2    Tsinkalovsky, O.3
  • 83
    • 42949149114 scopus 로고    scopus 로고
    • Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria
    • Günther H.S., Schmidt N.O., Phillips H.S., et al. Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria. Oncogene 2008, 27:2897-2909.
    • (2008) Oncogene , vol.27 , pp. 2897-2909
    • Günther, H.S.1    Schmidt, N.O.2    Phillips, H.S.3
  • 84
    • 37049033079 scopus 로고    scopus 로고
    • Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell
    • Hansford L.M., McKee A.E., Zhang L., et al. Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res 2007, 67:11234-11243.
    • (2007) Cancer Res , vol.67 , pp. 11234-11243
    • Hansford, L.M.1    McKee, A.E.2    Zhang, L.3
  • 85
    • 33748051406 scopus 로고    scopus 로고
    • Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
    • Bao S., Wu Q., Sathornsumetee S., et al. Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 2006, 66:7843-7848.
    • (2006) Cancer Res , vol.66 , pp. 7843-7848
    • Bao, S.1    Wu, Q.2    Sathornsumetee, S.3
  • 86
    • 33845785589 scopus 로고    scopus 로고
    • Differentiation profile of brain tumor stem cells: A comparative study with neural stem cells
    • Zhang Q.B., Ji X.Y., Huang Q., et al. Differentiation profile of brain tumor stem cells: A comparative study with neural stem cells. Cell Res 2006, 16:909-915.
    • (2006) Cell Res , vol.16 , pp. 909-915
    • Zhang, Q.B.1    Ji, X.Y.2    Huang, Q.3
  • 87
    • 77957010441 scopus 로고    scopus 로고
    • Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer
    • Stratford A.L., Reipas K., Maxwell C., et al. Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer. Expert Rev Mol Med 2010, 12:e22.
    • (2010) Expert Rev Mol Med , vol.12
    • Stratford, A.L.1    Reipas, K.2    Maxwell, C.3
  • 88
    • 48949119465 scopus 로고    scopus 로고
    • Cancer stem cell heterogeneity in hereditary breast cancer
    • Wicha M.S. Cancer stem cell heterogeneity in hereditary breast cancer. Breast Cancer Res 2008, 10:105.
    • (2008) Breast Cancer Res , vol.10 , pp. 105
    • Wicha, M.S.1
  • 89
    • 55749106963 scopus 로고    scopus 로고
    • Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells
    • Grimshaw M.J., Cooper L., Papazisis K., et al. Mammosphere culture of metastatic breast cancer cells enriches for tumorigenic breast cancer cells. Breast Cancer Res 2008, 10:R52.
    • (2008) Breast Cancer Res , vol.10
    • Grimshaw, M.J.1    Cooper, L.2    Papazisis, K.3
  • 90
    • 21344454219 scopus 로고    scopus 로고
    • Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties
    • Ponti D., Costa A., Zaffaroni N., et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005, 65:5506-5511.
    • (2005) Cancer Res , vol.65 , pp. 5506-5511
    • Ponti, D.1    Costa, A.2    Zaffaroni, N.3
  • 91
    • 76149121161 scopus 로고    scopus 로고
    • O'Brien CA: Colon cancer stem cells
    • 7:3.1.1-3.1.12.
    • Kreso A, O'Brien CA: Colon cancer stem cells. Curr Protoc Stem Cell 7:3.1.1-3.1.12., 2008.
    • (2008) Curr Protoc Stem Cell
    • Kreso, A.1
  • 92
    • 51649111430 scopus 로고    scopus 로고
    • Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
    • Vermeulen L., Todaro M., de Sousa Mello F., et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci U S A 2008, 105:13427-13432.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 13427-13432
    • Vermeulen, L.1    Todaro, M.2    de Sousa Mello, F.3
  • 93
    • 77951639324 scopus 로고    scopus 로고
    • Colon cancer stem cells: Promise of targeted therapy
    • Todaro M., Francipane M.G., Medema J.P., et al. Colon cancer stem cells: Promise of targeted therapy. Gastroenterology 2010, 138:2151-2162.
    • (2010) Gastroenterology , vol.138 , pp. 2151-2162
    • Todaro, M.1    Francipane, M.G.2    Medema, J.P.3
  • 94
    • 58149269566 scopus 로고    scopus 로고
    • CD44 is of functional importance for colorectal cancer stem cells
    • Du L., Wang H., He L., et al. CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 2008, 14:6751-6760.
    • (2008) Clin Cancer Res , vol.14 , pp. 6751-6760
    • Du, L.1    Wang, H.2    He, L.3
  • 95
    • 79956100438 scopus 로고    scopus 로고
    • Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population
    • Luk S.U., Lee T.K., Liu J., et al. Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population. PLoS One 2011, 6:e19804.
    • (2011) PLoS One , vol.6
    • Luk, S.U.1    Lee, T.K.2    Liu, J.3
  • 96
    • 65349160330 scopus 로고    scopus 로고
    • Isolation of stem/progenitor cells from normal lung tissue of adult humans
    • Tesei A., Zoli W., Arienti C., et al. Isolation of stem/progenitor cells from normal lung tissue of adult humans. Cell Prolif 2009, 42:298-308.
    • (2009) Cell Prolif , vol.42 , pp. 298-308
    • Tesei, A.1    Zoli, W.2    Arienti, C.3
  • 97
    • 79551686424 scopus 로고    scopus 로고
    • Cancer stem cell traits in squamospheres derived from primary head and neck squamous cell carcinomas
    • Lim Y.C., Oh S.Y., Cha Y.Y., et al. Cancer stem cell traits in squamospheres derived from primary head and neck squamous cell carcinomas. Oral Oncol 2011, 47:83-91.
    • (2011) Oral Oncol , vol.47 , pp. 83-91
    • Lim, Y.C.1    Oh, S.Y.2    Cha, Y.Y.3
  • 98
    • 77953578576 scopus 로고    scopus 로고
    • The in vitro spheroid melanoma cell culture assay: Cues on tumor initiation?
    • Schatton T., Frank M.H. The in vitro spheroid melanoma cell culture assay: Cues on tumor initiation?. J Invest Dermatol 2011, 130:1769-1771.
    • (2011) J Invest Dermatol , vol.130 , pp. 1769-1771
    • Schatton, T.1    Frank, M.H.2
  • 99
    • 77955158299 scopus 로고    scopus 로고
    • The utility and limitations of neurosphere assay, CD133 immunophenotyping and side population assay in glioma stem cell research
    • Wan F., Zhang S., Xie R., et al. The utility and limitations of neurosphere assay, CD133 immunophenotyping and side population assay in glioma stem cell research. Brain Pathol 2010, 20:877-889.
    • (2010) Brain Pathol , vol.20 , pp. 877-889
    • Wan, F.1    Zhang, S.2    Xie, R.3
  • 100
    • 66049085403 scopus 로고    scopus 로고
    • Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens
    • Pollard S.M., Yoshikawa K., Clarke I.D., et al. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 2009, 4:568-580.
    • (2009) Cell Stem Cell , vol.4 , pp. 568-580
    • Pollard, S.M.1    Yoshikawa, K.2    Clarke, I.D.3
  • 101
    • 66049112359 scopus 로고    scopus 로고
    • Glioma stem cells: Better flat than round
    • Woolard K., Fine H.A. Glioma stem cells: Better flat than round. Cell Stem Cell 2009, 4:466-467.
    • (2009) Cell Stem Cell , vol.4 , pp. 466-467
    • Woolard, K.1    Fine, H.A.2
  • 102
    • 0344420263 scopus 로고    scopus 로고
    • Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR
    • Pandita A., Aldape K.D., Zadeh G., et al. Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR. Genes Chromosomes Cancer 2004, 39:29-36.
    • (2004) Genes Chromosomes Cancer , vol.39 , pp. 29-36
    • Pandita, A.1    Aldape, K.D.2    Zadeh, G.3
  • 103
    • 41149163821 scopus 로고    scopus 로고
    • The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids
    • De Witt Hamer P.C., Van Tilborg A.A., Eijk P.P., et al. The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids. Oncogene 2008, 27:2091-2096.
    • (2008) Oncogene , vol.27 , pp. 2091-2096
    • De Witt Hamer, P.C.1    Van Tilborg, A.A.2    Eijk, P.P.3
  • 105
    • 33646231995 scopus 로고    scopus 로고
    • Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies
    • Sasai K., Romer J.T., Lee Y., et al. Shh pathway activity is down-regulated in cultured medulloblastoma cells: Implications for preclinical studies. Cancer Res 2006, 66:4215-4222.
    • (2006) Cancer Res , vol.66 , pp. 4215-4222
    • Sasai, K.1    Romer, J.T.2    Lee, Y.3
  • 106
    • 33846414709 scopus 로고    scopus 로고
    • Establishment of human colon cancer cell lines from fresh tumors versus xenografts: Comparison of success rate and cell line features
    • Dangles-Marie V., Pocard M., Richon S., et al. Establishment of human colon cancer cell lines from fresh tumors versus xenografts: Comparison of success rate and cell line features. Cancer Res 2007, 67:398-407.
    • (2007) Cancer Res , vol.67 , pp. 398-407
    • Dangles-Marie, V.1    Pocard, M.2    Richon, S.3
  • 107
    • 65949099336 scopus 로고    scopus 로고
    • A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro
    • Daniel V.C., Marchionni L., Hierman J.S., et al. A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res 2009, 69:3364-3373.
    • (2009) Cancer Res , vol.69 , pp. 3364-3373
    • Daniel, V.C.1    Marchionni, L.2    Hierman, J.S.3
  • 108
    • 58749103524 scopus 로고    scopus 로고
    • From human to mouse and back: "Tumorgraft" models surge in popularity
    • Garber K. From human to mouse and back: "Tumorgraft" models surge in popularity. J Natl Cancer Inst 2009, 101:6-8.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 6-8
    • Garber, K.1
  • 109
    • 34249332411 scopus 로고    scopus 로고
    • CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
    • Beier D., Hau P., Proescholdt M., et al. CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 2007, 67:4010-4015.
    • (2007) Cancer Res , vol.67 , pp. 4010-4015
    • Beier, D.1    Hau, P.2    Proescholdt, M.3
  • 110
    • 70449721415 scopus 로고    scopus 로고
    • Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers
    • Al-Assar O., Muschel R.J., Mantoni T.S., et al. Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers. Int J Radiat Oncol Biol Phys 2009, 75:1216-1225.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , pp. 1216-1225
    • Al-Assar, O.1    Muschel, R.J.2    Mantoni, T.S.3
  • 111
    • 77649257052 scopus 로고    scopus 로고
    • Cancer stem cells from colorectal cancer-derived cell lines
    • Yeung T.M., Gandhi S.C., Wilding J.L., et al. Cancer stem cells from colorectal cancer-derived cell lines. Proc Natl Acad Sci U S A 2010, 107:3722-3727.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3722-3727
    • Yeung, T.M.1    Gandhi, S.C.2    Wilding, J.L.3
  • 112
    • 77949285132 scopus 로고    scopus 로고
    • CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell line HCT-116
    • Dittfeld C., Dietrich A., Peickert S., et al. CD133 expression is not selective for tumor-initiating or radioresistant cell populations in the CRC cell line HCT-116. Radiother Oncol 2010, 94:375-383.
    • (2010) Radiother Oncol , vol.94 , pp. 375-383
    • Dittfeld, C.1    Dietrich, A.2    Peickert, S.3
  • 113
    • 60649100252 scopus 로고    scopus 로고
    • Cancer stem cells and tumor response to therapy: Current problems and future prospects
    • Milas L., Hittelman W.N. Cancer stem cells and tumor response to therapy: Current problems and future prospects. Semin Radiat Oncol 2009, 19:96-105.
    • (2009) Semin Radiat Oncol , vol.19 , pp. 96-105
    • Milas, L.1    Hittelman, W.N.2
  • 114
    • 77953916745 scopus 로고    scopus 로고
    • Multicellular tumor spheroids: An underestimated tool is catching up again
    • Hirschhaeuser F., Menne H., Dittfeld C., et al. Multicellular tumor spheroids: An underestimated tool is catching up again. J Biotechnol 2010, 148:3-15.
    • (2010) J Biotechnol , vol.148 , pp. 3-15
    • Hirschhaeuser, F.1    Menne, H.2    Dittfeld, C.3
  • 115
    • 40549084643 scopus 로고    scopus 로고
    • IL-4-mediated drug resistance in colon cancer stem cells
    • Todaro M., Perez Alea M., Scopelliti A., et al. IL-4-mediated drug resistance in colon cancer stem cells. Cell Cycle 2008, 7:309-313.
    • (2008) Cell Cycle , vol.7 , pp. 309-313
    • Todaro, M.1    Perez Alea, M.2    Scopelliti, A.3
  • 116
    • 79957467315 scopus 로고    scopus 로고
    • Molecular identification and targeting of colorectal cancer stem cells
    • Kemper K., Grandela C., Medema J.P. Molecular identification and targeting of colorectal cancer stem cells. Oncotarget 2010, 1:387-395.
    • (2010) Oncotarget , vol.1 , pp. 387-395
    • Kemper, K.1    Grandela, C.2    Medema, J.P.3
  • 117
    • 79953042645 scopus 로고    scopus 로고
    • CD44: Can a cancer-initiating cell profit from an abundantly expressed molecule?
    • Zöller M. CD44: Can a cancer-initiating cell profit from an abundantly expressed molecule?. Nat Rev Cancer 2011, 11:254-267.
    • (2011) Nat Rev Cancer , vol.11 , pp. 254-267
    • Zöller, M.1
  • 118
    • 77954922985 scopus 로고    scopus 로고
    • Stem cells in cancer: Instigators and propagators?
    • Alison M.R., Islam S., Wright N.A. Stem cells in cancer: Instigators and propagators?. J Cell Sci 2010, 123:2357-2368.
    • (2010) J Cell Sci , vol.123 , pp. 2357-2368
    • Alison, M.R.1    Islam, S.2    Wright, N.A.3
  • 120
    • 70349100257 scopus 로고    scopus 로고
    • CD133 as a marker for cancer stem cells: Progresses and concerns
    • Wu Y., Wu P.Y. CD133 as a marker for cancer stem cells: Progresses and concerns. Stem Cells Dev 2009, 18:1127-1134.
    • (2009) Stem Cells Dev , vol.18 , pp. 1127-1134
    • Wu, Y.1    Wu, P.Y.2
  • 121
    • 45749125992 scopus 로고    scopus 로고
    • Is CD133 a marker of metastatic colon cancer stem cells?
    • LaBarge M.A., Bissell M.J. Is CD133 a marker of metastatic colon cancer stem cells?. J Clin Invest 2008, 118:2021-2024.
    • (2008) J Clin Invest , vol.118 , pp. 2021-2024
    • LaBarge, M.A.1    Bissell, M.J.2
  • 122
    • 77958537327 scopus 로고    scopus 로고
    • Isolation and propagation of a human CD133(-) colon tumor-derived cell line with tumorigenic and angiogenic properties
    • Navarro-Alvarez N., Kondo E., Kawamoto H., et al. Isolation and propagation of a human CD133(-) colon tumor-derived cell line with tumorigenic and angiogenic properties. Cell Transplant 2010, 19:865-877.
    • (2010) Cell Transplant , vol.19 , pp. 865-877
    • Navarro-Alvarez, N.1    Kondo, E.2    Kawamoto, H.3
  • 123
    • 33847649534 scopus 로고    scopus 로고
    • Tumour-initiating cells vs. cancer "stem" cells and CD133: What's in the name?
    • Neuzil J., Stantic M., Zobalova R., et al. Tumour-initiating cells vs. cancer "stem" cells and CD133: What's in the name?. Biochem Biophys Res Commun 2007, 355:855-859.
    • (2007) Biochem Biophys Res Commun , vol.355 , pp. 855-859
    • Neuzil, J.1    Stantic, M.2    Zobalova, R.3
  • 125
    • 76549120193 scopus 로고    scopus 로고
    • The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation
    • Kemper K., Sprick M.R., de Bree M., et al. The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res 2010, 70:719-729.
    • (2010) Cancer Res , vol.70 , pp. 719-729
    • Kemper, K.1    Sprick, M.R.2    de Bree, M.3
  • 126
    • 64849096118 scopus 로고    scopus 로고
    • The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif
    • Taïeb N., Maresca M., Guo X.J., et al. The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif. Cancer Lett 2009, 278:164-173.
    • (2009) Cancer Lett , vol.278 , pp. 164-173
    • Taïeb, N.1    Maresca, M.2    Guo, X.J.3
  • 127
    • 53849134099 scopus 로고    scopus 로고
    • CD133 expression is an independent prognostic marker for low survival in colorectal cancer
    • Horst D., Kriegl L., Engel J., et al. CD133 expression is an independent prognostic marker for low survival in colorectal cancer. Br J Cancer 2008, 99:1285-1289.
    • (2008) Br J Cancer , vol.99 , pp. 1285-1289
    • Horst, D.1    Kriegl, L.2    Engel, J.3
  • 128
    • 72249120793 scopus 로고    scopus 로고
    • The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer
    • Horst D., Scheel S.K., Liebmann S., et al. The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer. J Pathol 2009, 219:427-434.
    • (2009) J Pathol , vol.219 , pp. 427-434
    • Horst, D.1    Scheel, S.K.2    Liebmann, S.3
  • 129
    • 78149310691 scopus 로고    scopus 로고
    • Frequency and pattern of expression of the stem cell marker CD133 have strong prognostic effect on the surgical outcome of colorectal cancer patients
    • Takahashi S., Kamiyama T., Tomaru U., et al. Frequency and pattern of expression of the stem cell marker CD133 have strong prognostic effect on the surgical outcome of colorectal cancer patients. Oncol Rep 2010, 24:1201-1212.
    • (2010) Oncol Rep , vol.24 , pp. 1201-1212
    • Takahashi, S.1    Kamiyama, T.2    Tomaru, U.3
  • 130
    • 77954350454 scopus 로고    scopus 로고
    • Immunohistochemical features of CD133 expression: Association with resistance to chemoradiotherapy in rectal cancer
    • Saigusa S., Tanaka K., Toiyama Y., et al. Immunohistochemical features of CD133 expression: Association with resistance to chemoradiotherapy in rectal cancer. Oncol Rep 2010, 24:345-350.
    • (2010) Oncol Rep , vol.24 , pp. 345-350
    • Saigusa, S.1    Tanaka, K.2    Toiyama, Y.3
  • 131
    • 70350383057 scopus 로고    scopus 로고
    • Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer
    • Yasuda H., Tanaka K., Saigusa S., et al. Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer. Oncol Rep 2009, 22:709-717.
    • (2009) Oncol Rep , vol.22 , pp. 709-717
    • Yasuda, H.1    Tanaka, K.2    Saigusa, S.3
  • 132
    • 79955674615 scopus 로고    scopus 로고
    • Clinical significance of CD133 and hypoxia inducible factor-1alpha gene expression in rectal cancer after preoperative chemoradiotherapy
    • Saigusa S., Tanaka K., Toiyama Y., et al. Clinical significance of CD133 and hypoxia inducible factor-1alpha gene expression in rectal cancer after preoperative chemoradiotherapy. Clin Oncol (R Coll Radiol) 2011, 23:323-332.
    • (2011) Clin Oncol (R Coll Radiol) , vol.23 , pp. 323-332
    • Saigusa, S.1    Tanaka, K.2    Toiyama, Y.3
  • 133
    • 49149110192 scopus 로고    scopus 로고
    • The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: From research to therapy
    • Sagiv E., Arber N. The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: From research to therapy. Expert Rev Gastroenterol Hepatol 2008, 2:125-133.
    • (2008) Expert Rev Gastroenterol Hepatol , vol.2 , pp. 125-133
    • Sagiv, E.1    Arber, N.2
  • 134
    • 13544263786 scopus 로고    scopus 로고
    • Tumour biological aspects of CD24, a mucin-like adhesion molecule
    • Kristiansen G., Sammar M., Altevogt P. Tumour biological aspects of CD24, a mucin-like adhesion molecule. J Mol Histol 2004, 35:255-262.
    • (2004) J Mol Histol , vol.35 , pp. 255-262
    • Kristiansen, G.1    Sammar, M.2    Altevogt, P.3
  • 135
    • 32244439441 scopus 로고    scopus 로고
    • CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells
    • Schabath H., Runz S., Joumaa S., et al. CD24 affects CXCR4 function in pre-B lymphocytes and breast carcinoma cells. J Cell Sci 2006, 119:314-325.
    • (2006) J Cell Sci , vol.119 , pp. 314-325
    • Schabath, H.1    Runz, S.2    Joumaa, S.3
  • 136
    • 33746490800 scopus 로고    scopus 로고
    • CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis
    • Sagiv E., Memeo L., Karin A., et al. CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis. Gastroenterology 2006, 131:630-639.
    • (2006) Gastroenterology , vol.131 , pp. 630-639
    • Sagiv, E.1    Memeo, L.2    Karin, A.3
  • 137
    • 42349101138 scopus 로고    scopus 로고
    • Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA
    • Sagiv E., Starr A., Rozovski U., et al. Targeting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or small interfering RNA. Cancer Res 2008, 68:2803-2812.
    • (2008) Cancer Res , vol.68 , pp. 2803-2812
    • Sagiv, E.1    Starr, A.2    Rozovski, U.3
  • 138
    • 77956245743 scopus 로고    scopus 로고
    • Integrin alpha 6 regulates glioblastoma stem cells
    • Lathia J.D., Gallagher J., Heddleston J.M., et al. Integrin alpha 6 regulates glioblastoma stem cells. Cell Stem Cell 2010, 6:421-432.
    • (2010) Cell Stem Cell , vol.6 , pp. 421-432
    • Lathia, J.D.1    Gallagher, J.2    Heddleston, J.M.3
  • 139
    • 72249113369 scopus 로고    scopus 로고
    • Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model
    • Mulholland D.J., Xin L., Morim A., et al. Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer Res 2009, 69:8555-8562.
    • (2009) Cancer Res , vol.69 , pp. 8555-8562
    • Mulholland, D.J.1    Xin, L.2    Morim, A.3
  • 140
    • 78449305061 scopus 로고    scopus 로고
    • Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells
    • Jo M., Eastman B.M., Webb D.L., et al. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res 2010, 70:8948-8958.
    • (2010) Cancer Res , vol.70 , pp. 8948-8958
    • Jo, M.1    Eastman, B.M.2    Webb, D.L.3
  • 141
    • 71849103142 scopus 로고    scopus 로고
    • Functional blocking of specific integrins inhibit colonic cancer migration
    • Robertson J.H., Yang S.Y., Winslet M.C., et al. Functional blocking of specific integrins inhibit colonic cancer migration. Clin Exp Metastasis 2009, 26:769-780.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 769-780
    • Robertson, J.H.1    Yang, S.Y.2    Winslet, M.C.3
  • 142
    • 36849052354 scopus 로고    scopus 로고
    • Alpha6 integrin cleavage: Sensitizing human prostate cancer to ionizing radiation
    • Pawar S.C., Dougherty S., Pennington M.E., et al. alpha6 integrin cleavage: Sensitizing human prostate cancer to ionizing radiation. Int J Radiat Biol 2007, 83:761-767.
    • (2007) Int J Radiat Biol , vol.83 , pp. 761-767
    • Pawar, S.C.1    Dougherty, S.2    Pennington, M.E.3
  • 143
    • 36849053853 scopus 로고    scopus 로고
    • Beta1 integrin as a molecular therapeutic target
    • Cordes N., Park C.C. beta1 integrin as a molecular therapeutic target. Int J Radiat Biol 2007, 83:753-760.
    • (2007) Int J Radiat Biol , vol.83 , pp. 753-760
    • Cordes, N.1    Park, C.C.2
  • 144
    • 57749179067 scopus 로고    scopus 로고
    • Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: A risk factor for colon cancer
    • Patel B.B., Yu Y., Du J., et al. Age-related increase in colorectal cancer stem cells in macroscopically normal mucosa of patients with adenomas: A risk factor for colon cancer. Biochem Biophys Res Commun 2009, 378:344-347.
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 344-347
    • Patel, B.B.1    Yu, Y.2    Du, J.3
  • 145
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: Models and concepts
    • Dalerba P., Cho R.W., Clarke M.F. Cancer stem cells: Models and concepts. Annu Review Med 2007, 58:267-284.
    • (2007) Annu Review Med , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 146
    • 8444241199 scopus 로고    scopus 로고
    • ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival
    • Weichert W., Knösel T., Bellach J., et al. ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival. J Clin Pathol 2004, 57:1160-1164.
    • (2004) J Clin Pathol , vol.57 , pp. 1160-1164
    • Weichert, W.1    Knösel, T.2    Bellach, J.3
  • 147
    • 77955051047 scopus 로고    scopus 로고
    • Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer
    • Lugli A., Iezzi G., Hostettler I., et al. Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer. Br J Cancer 2010, 103:382-390.
    • (2010) Br J Cancer , vol.103 , pp. 382-390
    • Lugli, A.1    Iezzi, G.2    Hostettler, I.3
  • 148
    • 78049452311 scopus 로고    scopus 로고
    • CD44 expression predicts local recurrence after radiotherapy in larynx cancer
    • de Jong M.C., Pramana J., van der Wal J.E., et al. CD44 expression predicts local recurrence after radiotherapy in larynx cancer. Clin Cancer Res 2010, 16:5329-5338.
    • (2010) Clin Cancer Res , vol.16 , pp. 5329-5338
    • de Jong, M.C.1    Pramana, J.2    van der Wal, J.E.3
  • 149
    • 0028316803 scopus 로고
    • Multivariate determinants of radiocurability. I: Prediction of single fraction tumor control doses
    • Gerweck L.E., Zaidi S.T., Zietman A. Multivariate determinants of radiocurability. I: Prediction of single fraction tumor control doses. Int J Radiat Oncol Biol Phys 1994, 29:57-66.
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 57-66
    • Gerweck, L.E.1    Zaidi, S.T.2    Zietman, A.3
  • 150
    • 67651159117 scopus 로고    scopus 로고
    • Cancer cells in transit: The vascular interactions of tumor cells
    • Konstantopoulos K., Thomas S.N. Cancer cells in transit: The vascular interactions of tumor cells. Annu Rev Biomed Eng 2009, 11:177-202.
    • (2009) Annu Rev Biomed Eng , vol.11 , pp. 177-202
    • Konstantopoulos, K.1    Thomas, S.N.2
  • 151
    • 70149123439 scopus 로고    scopus 로고
    • CD44v6 dependence of premetastatic niche preparation by exosomes
    • Jung T., Castellana D., Klingbeil P., et al. CD44v6 dependence of premetastatic niche preparation by exosomes. Neoplasia 2009, 11:1093-1105.
    • (2009) Neoplasia , vol.11 , pp. 1093-1105
    • Jung, T.1    Castellana, D.2    Klingbeil, P.3
  • 152
    • 76249122104 scopus 로고    scopus 로고
    • Characterization of the expression of variant and standard CD44 in prostate cancer cells: Identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface
    • Desai B., Ma T., Zhu J., et al. Characterization of the expression of variant and standard CD44 in prostate cancer cells: Identification of the possible molecular mechanism of CD44/MMP9 complex formation on the cell surface. J Cell Biochem 2009, 108:272-284.
    • (2009) J Cell Biochem , vol.108 , pp. 272-284
    • Desai, B.1    Ma, T.2    Zhu, J.3
  • 153
    • 0031776902 scopus 로고    scopus 로고
    • CD44V6 expression in human colorectal carcinoma
    • Coppola D., Hyacinthe M., Fu L., et al. CD44V6 expression in human colorectal carcinoma. Hum Pathol 1998, 29:627-635.
    • (1998) Hum Pathol , vol.29 , pp. 627-635
    • Coppola, D.1    Hyacinthe, M.2    Fu, L.3
  • 154
    • 0032168184 scopus 로고    scopus 로고
    • Decreased expression of CD44 splicing variants in advanced colorectal carcinomas
    • Weg-Remers S., Anders M., von Lampe B., et al. Decreased expression of CD44 splicing variants in advanced colorectal carcinomas. Eur J Cancer 1998, 34:1607-1611.
    • (1998) Eur J Cancer , vol.34 , pp. 1607-1611
    • Weg-Remers, S.1    Anders, M.2    von Lampe, B.3
  • 155
    • 0028131614 scopus 로고
    • Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins
    • Mulder J.W., Kruyt P.M., Sewnath M., et al. Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins. Lancet 1994, 344:1470-1472.
    • (1994) Lancet , vol.344 , pp. 1470-1472
    • Mulder, J.W.1    Kruyt, P.M.2    Sewnath, M.3
  • 156
    • 6844259864 scopus 로고    scopus 로고
    • CD44 splice variants as prognostic markers in colorectal cancer
    • Wielenga V.J., van der Voort R., Mulder J.W., et al. CD44 splice variants as prognostic markers in colorectal cancer. Scand J Gastroenterol 1998, 33:82-87.
    • (1998) Scand J Gastroenterol , vol.33 , pp. 82-87
    • Wielenga, V.J.1    van der Voort, R.2    Mulder, J.W.3
  • 157
    • 0036361763 scopus 로고    scopus 로고
    • CD44v6 is not relevant in colorectal tumour progression
    • Morrin M., Delaney P.V. CD44v6 is not relevant in colorectal tumour progression. Int J Colorectal Dis 2002, 17:30-36.
    • (2002) Int J Colorectal Dis , vol.17 , pp. 30-36
    • Morrin, M.1    Delaney, P.V.2
  • 158
    • 34250711189 scopus 로고    scopus 로고
    • A multivariate analysis of adhesion molecules expression in assessment of colorectal cancer
    • Ngan C.Y., Yamamoto H., Seshimo I., et al. A multivariate analysis of adhesion molecules expression in assessment of colorectal cancer. J Surg Oncol 2007, 95:652-662.
    • (2007) J Surg Oncol , vol.95 , pp. 652-662
    • Ngan, C.Y.1    Yamamoto, H.2    Seshimo, I.3
  • 159
    • 67650138937 scopus 로고    scopus 로고
    • Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma
    • Choi D., Lee H.W., Hur K.Y., et al. Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma. World J Gastroenterol 2009, 15:2258-2264.
    • (2009) World J Gastroenterol , vol.15 , pp. 2258-2264
    • Choi, D.1    Lee, H.W.2    Hur, K.Y.3
  • 160
    • 63849268405 scopus 로고    scopus 로고
    • Expression of standard CD44 in human colorectal carcinoma: Association with prognosis
    • Huh J.W., Kim H.R., Kim Y.J., et al. Expression of standard CD44 in human colorectal carcinoma: Association with prognosis. Pathol Int 2009, 59:241-246.
    • (2009) Pathol Int , vol.59 , pp. 241-246
    • Huh, J.W.1    Kim, H.R.2    Kim, Y.J.3
  • 162
    • 0037227965 scopus 로고    scopus 로고
    • CD44: From adhesion molecules to signalling regulators
    • Ponta H., Sherman L., Herrlich P.A. CD44: From adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 2003, 4:33-45.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 33-45
    • Ponta, H.1    Sherman, L.2    Herrlich, P.A.3
  • 163
    • 44749091840 scopus 로고    scopus 로고
    • Involvement of CD44, a molecule with a thousand faces, in cancer dissemination
    • Naor D., Wallach-Dayan S.B., Zahalka M.A., et al. Involvement of CD44, a molecule with a thousand faces, in cancer dissemination. Semin Cancer Biol 2008, 18:260-267.
    • (2008) Semin Cancer Biol , vol.18 , pp. 260-267
    • Naor, D.1    Wallach-Dayan, S.B.2    Zahalka, M.A.3
  • 164
    • 73349134974 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interactions in cancer: Paradoxes and possibilities
    • Toole B.P. Hyaluronan-CD44 interactions in cancer: Paradoxes and possibilities. Clin Cancer Res 2009, 15:7462-7468.
    • (2009) Clin Cancer Res , vol.15 , pp. 7462-7468
    • Toole, B.P.1
  • 165
    • 33846702026 scopus 로고    scopus 로고
    • Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
    • Morrison H., Sperka T., Manent J., et al. Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res 2007, 67:520-527.
    • (2007) Cancer Res , vol.67 , pp. 520-527
    • Morrison, H.1    Sperka, T.2    Manent, J.3
  • 166
    • 53049084660 scopus 로고    scopus 로고
    • CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2
    • Kim Y., Lee Y.S., Choe J., et al. CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. J Biol Chem 2008, 283:22513-22528.
    • (2008) J Biol Chem , vol.283 , pp. 22513-22528
    • Kim, Y.1    Lee, Y.S.2    Choe, J.3
  • 167
    • 33746142421 scopus 로고    scopus 로고
    • Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer
    • Wang S.J., Bourguignon L.Y. Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer. Arch Otolaryngol Head Neck Surg 2006, 132:771-778.
    • (2006) Arch Otolaryngol Head Neck Surg , vol.132 , pp. 771-778
    • Wang, S.J.1    Bourguignon, L.Y.2
  • 168
    • 34250345258 scopus 로고    scopus 로고
    • EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms
    • Baumann M., Krause M., Dikomey E., et al. EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms. Radiother Oncol 2007, 83:238-248.
    • (2007) Radiother Oncol , vol.83 , pp. 238-248
    • Baumann, M.1    Krause, M.2    Dikomey, E.3
  • 169
    • 46149112989 scopus 로고    scopus 로고
    • Hyaluronan, CD44 and Emmprin: Partners in cancer cell chemoresistance
    • Toole B.P., Slomiany M.G. Hyaluronan, CD44 and Emmprin: Partners in cancer cell chemoresistance. Drug Resist Updat 2008, 11:110-121.
    • (2008) Drug Resist Updat , vol.11 , pp. 110-121
    • Toole, B.P.1    Slomiany, M.G.2
  • 170
    • 0034795256 scopus 로고    scopus 로고
    • The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype
    • Zhou S., Schuetz J.D., Bunting K.D., et al. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 2001, 7:1028-1034.
    • (2001) Nat Med , vol.7 , pp. 1028-1034
    • Zhou, S.1    Schuetz, J.D.2    Bunting, K.D.3
  • 171
    • 0029958876 scopus 로고    scopus 로고
    • Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo
    • Goodell M.A., Brose K., Paradis G., et al. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J Exp Med 1996, 183:1797-1806.
    • (1996) J Exp Med , vol.183 , pp. 1797-1806
    • Goodell, M.A.1    Brose, K.2    Paradis, G.3
  • 172
    • 0031435428 scopus 로고    scopus 로고
    • Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species
    • Goodell M.A., Rosenzweig M., Kim H., et al. Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med 1997, 3:1337-1345.
    • (1997) Nat Med , vol.3 , pp. 1337-1345
    • Goodell, M.A.1    Rosenzweig, M.2    Kim, H.3
  • 173
    • 1642474273 scopus 로고    scopus 로고
    • Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line
    • Kondo T., Setoguchi T., Taga T. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci U S A 2004, 101:781-786.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 781-786
    • Kondo, T.1    Setoguchi, T.2    Taga, T.3
  • 174
    • 57749091753 scopus 로고    scopus 로고
    • Cancer stem cells are enriched in the side population cells in a mouse model of glioma
    • Harris M.A., Yang H., Low B.E., et al. Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res 2008, 68:10051-10059.
    • (2008) Cancer Res , vol.68 , pp. 10051-10059
    • Harris, M.A.1    Yang, H.2    Low, B.E.3
  • 175
    • 48349133869 scopus 로고    scopus 로고
    • Side population cells in human cancers
    • Wu C., Alman B.A. Side population cells in human cancers. Cancer Lett 2008, 268:1-9.
    • (2008) Cancer Lett , vol.268 , pp. 1-9
    • Wu, C.1    Alman, B.A.2
  • 176
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau A.M., Hambardzumyan D., Ozawa T., et al. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 2009, 4:226-235.
    • (2009) Cell Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3
  • 177
    • 70349296853 scopus 로고    scopus 로고
    • The ABCG2 resistance network of glioblastoma
    • Bleau A.M., Huse J.T., Holland E.C. The ABCG2 resistance network of glioblastoma. Cell Cycle 2009, 8:2936-2944.
    • (2009) Cell Cycle , vol.8 , pp. 2936-2944
    • Bleau, A.M.1    Huse, J.T.2    Holland, E.C.3
  • 178
    • 38549180030 scopus 로고    scopus 로고
    • Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade
    • Loebinger M.R., Giangreco A., Groot K.R., et al. Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade. Br J Cancer 2008, 98:380-387.
    • (2008) Br J Cancer , vol.98 , pp. 380-387
    • Loebinger, M.R.1    Giangreco, A.2    Groot, K.R.3
  • 179
    • 79955063673 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interactions as potential targets for cancer therapy
    • Misra S., Heldin P., Hascall V.C., et al. Hyaluronan-CD44 interactions as potential targets for cancer therapy. FEBS J 2011, 278:1429-1443.
    • (2011) FEBS J , vol.278 , pp. 1429-1443
    • Misra, S.1    Heldin, P.2    Hascall, V.C.3
  • 180
    • 79957920505 scopus 로고    scopus 로고
    • Transport processes of radiopharmaceuticals and -modulators
    • Efferth T., Langguth P. Transport processes of radiopharmaceuticals and -modulators. Radiol Oncol 2011, 6:59.
    • (2011) Radiol Oncol , vol.6 , pp. 59
    • Efferth, T.1    Langguth, P.2
  • 181
    • 60549091044 scopus 로고    scopus 로고
    • Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells
    • Slomiany M.G., Grass G.D., Robertson A.D., et al. Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer Res 2009, 69:1293-1301.
    • (2009) Cancer Res , vol.69 , pp. 1293-1301
    • Slomiany, M.G.1    Grass, G.D.2    Robertson, A.D.3
  • 182
    • 70449507021 scopus 로고    scopus 로고
    • The anti-oxidant capacity of tumour glycolysis
    • Sattler U.G., Mueller-Klieser W. The anti-oxidant capacity of tumour glycolysis. Int J Radiat Biol 2009, 85:963-971.
    • (2009) Int J Radiat Biol , vol.85 , pp. 963-971
    • Sattler, U.G.1    Mueller-Klieser, W.2
  • 183
    • 3142588858 scopus 로고    scopus 로고
    • Lactate: Mirror and motor of tumor malignancy
    • Walenta S., Mueller-Klieser W.F. Lactate: Mirror and motor of tumor malignancy. Semin Radiat Oncol 2004, 14:267-274.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 267-274
    • Walenta, S.1    Mueller-Klieser, W.F.2
  • 184
    • 0034663601 scopus 로고    scopus 로고
    • The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells
    • Dimmer K.S., Friedrich B., Lang F., et al. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem J 2000, 350:219-227.
    • (2000) Biochem J , vol.350 , pp. 219-227
    • Dimmer, K.S.1    Friedrich, B.2    Lang, F.3
  • 185
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux P., Végran F., Schroeder T., et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 2008, 118:3930-3942.
    • (2008) J Clin Invest , vol.118 , pp. 3930-3942
    • Sonveaux, P.1    Végran, F.2    Schroeder, T.3
  • 186
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • Ullah M.S., Davies A.J., Halestrap A.P. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J Biol Chem 2006, 281:9030-9037.
    • (2006) J Biol Chem , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 187
    • 33750716354 scopus 로고    scopus 로고
    • Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice
    • Quennet V., Yaromina A., Zips D., et al. Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. Radiother Oncol 2006, 81:130-135.
    • (2006) Radiother Oncol , vol.81 , pp. 130-135
    • Quennet, V.1    Yaromina, A.2    Zips, D.3
  • 188
    • 74549186565 scopus 로고    scopus 로고
    • Glycolytic metabolism and tumour response to fractionated irradiation
    • Sattler U.G., Meyer S.S., Quennet V., et al. Glycolytic metabolism and tumour response to fractionated irradiation. Radiother Oncol 2010, 94:102-109.
    • (2010) Radiother Oncol , vol.94 , pp. 102-109
    • Sattler, U.G.1    Meyer, S.S.2    Quennet, V.3
  • 189
    • 70449509857 scopus 로고    scopus 로고
    • Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts
    • Yaromina A., Quennet V., Zips D., et al. Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts. Int J Radiat Biol 2009, 85:972-980.
    • (2009) Int J Radiat Biol , vol.85 , pp. 972-980
    • Yaromina, A.1    Quennet, V.2    Zips, D.3
  • 190
    • 79954423356 scopus 로고    scopus 로고
    • Acidic stress promotes a glioma stem cell phenotype
    • Hjelmeland A.B., Wu Q., Heddleston J.M., et al. Acidic stress promotes a glioma stem cell phenotype. Cell Death Differ 2011, 18:829-840.
    • (2011) Cell Death Differ , vol.18 , pp. 829-840
    • Hjelmeland, A.B.1    Wu, Q.2    Heddleston, J.M.3
  • 191
    • 0035479076 scopus 로고    scopus 로고
    • Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer
    • Brizel D.M., Schroeder T., Scher R.L., et al. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys 2001, 51:349-353.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , pp. 349-353
    • Brizel, D.M.1    Schroeder, T.2    Scher, R.L.3
  • 192
    • 0042660824 scopus 로고    scopus 로고
    • Metabolic classification of human rectal adenocarcinomas: A novel guideline for clinical oncologists?
    • Walenta S., Chau T.V., Schroeder T., et al. Metabolic classification of human rectal adenocarcinomas: A novel guideline for clinical oncologists?. J Cancer Res Clin Oncol 2003, 129:321-326.
    • (2003) J Cancer Res Clin Oncol , vol.129 , pp. 321-326
    • Walenta, S.1    Chau, T.V.2    Schroeder, T.3
  • 193
    • 0034083386 scopus 로고    scopus 로고
    • Metabolic imaging in multicellular spheroids of oncogene-transfected fibroblasts
    • Walenta S., Doetsch J., Mueller-Klieser W., et al. Metabolic imaging in multicellular spheroids of oncogene-transfected fibroblasts. J Histochem Cytochem 2000, 48:509-522.
    • (2000) J Histochem Cytochem , vol.48 , pp. 509-522
    • Walenta, S.1    Doetsch, J.2    Mueller-Klieser, W.3
  • 194
    • 68949092126 scopus 로고    scopus 로고
    • Lactate promotes glioma migration by TGF-beta2 dependent regulation of matrix metalloproteinase-2
    • Baumann F., Leukel P., Doerfelt A., et al. Lactate promotes glioma migration by TGF-beta2 dependent regulation of matrix metalloproteinase-2. Neuro Oncol 2009, 11:368-380.
    • (2009) Neuro Oncol , vol.11 , pp. 368-380
    • Baumann, F.1    Leukel, P.2    Doerfelt, A.3
  • 195
    • 79960029992 scopus 로고    scopus 로고
    • Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
    • Goetze K., Walenta S., Ksiazkiewicz M., et al. Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol 2011, 39:453-463.
    • (2011) Int J Oncol , vol.39 , pp. 453-463
    • Goetze, K.1    Walenta, S.2    Ksiazkiewicz, M.3
  • 196
    • 79955025420 scopus 로고    scopus 로고
    • The role of human aldehyde dehydrogenase in normal and cancer stem cells
    • Ma I., Allan A.L. The role of human aldehyde dehydrogenase in normal and cancer stem cells. Stem Cell Res 2011, 7:292-306.
    • (2011) Stem Cell Res , vol.7 , pp. 292-306
    • Ma, I.1    Allan, A.L.2
  • 197
    • 80054038990 scopus 로고    scopus 로고
    • Update on the aldehyde dehydrogenase gene (ALDH) superfamily
    • Jackson B., Brocker C., Thompson D.C., et al. Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Hum Genomics 2011, 5:283-303.
    • (2011) Hum Genomics , vol.5 , pp. 283-303
    • Jackson, B.1    Brocker, C.2    Thompson, D.C.3
  • 198
    • 0033529756 scopus 로고    scopus 로고
    • Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity
    • Storms R.W., Trujillo A.P., Springer J.B., et al. Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity. Proc Natl Acad Sci U S A 1999, 96:9118-9123.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 9118-9123
    • Storms, R.W.1    Trujillo, A.P.2    Springer, J.B.3
  • 199
    • 78349289554 scopus 로고    scopus 로고
    • Finding cancer stem cells: Are aldehyde dehydrogenases fit for purpose?
    • Alison M.R., Guppy N.J., Lim S.M., et al. Finding cancer stem cells: Are aldehyde dehydrogenases fit for purpose?. J Pathol 2010, 222:335-344.
    • (2010) J Pathol , vol.222 , pp. 335-344
    • Alison, M.R.1    Guppy, N.J.2    Lim, S.M.3
  • 200
    • 60149101077 scopus 로고    scopus 로고
    • ALDH1 as a functional marker of cancer stem and progenitor cells
    • Douville J., Beaulieu R., Balicki D. ALDH1 as a functional marker of cancer stem and progenitor cells. Stem Cells Dev 2009, 18:17-25.
    • (2009) Stem Cells Dev , vol.18 , pp. 17-25
    • Douville, J.1    Beaulieu, R.2    Balicki, D.3
  • 201
    • 84861075268 scopus 로고    scopus 로고
    • Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDH(hi)CD44 (+) human breast cancer cells
    • (in press)
    • Croker AK, Allan AL: Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDH(hi)CD44 (+) human breast cancer cells. Breast Cancer Res Treat (in press).
    • Breast Cancer Res Treat
    • Croker, A.K.1    Allan, A.L.2
  • 202
    • 33745635043 scopus 로고    scopus 로고
    • The stem-cell niche as an entity of action
    • Scadden D.T. The stem-cell niche as an entity of action. Nature 2006, 441:1075-1079.
    • (2006) Nature , vol.441 , pp. 1075-1079
    • Scadden, D.T.1
  • 203
    • 22344441829 scopus 로고    scopus 로고
    • Stem cell plasticity: A rare cell, not a rare event
    • Jang Y.Y., Sharkis S.J. Stem cell plasticity: A rare cell, not a rare event. Stem. Cell Res 2005, 1:45-51.
    • (2005) Stem. Cell Res , vol.1 , pp. 45-51
    • Jang, Y.Y.1    Sharkis, S.J.2
  • 204
    • 33646428091 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: The niche matters
    • Li L., Neaves W.B. Normal stem cells and cancer stem cells: The niche matters. Cancer Res 2006, 66:4553-4557.
    • (2006) Cancer Res , vol.66 , pp. 4553-4557
    • Li, L.1    Neaves, W.B.2
  • 205
    • 67449092765 scopus 로고    scopus 로고
    • Cancer stem cells and their niche
    • Iwasaki H., Suda T. Cancer stem cells and their niche. Cancer Sci 2009, 100:1166-1172.
    • (2009) Cancer Sci , vol.100 , pp. 1166-1172
    • Iwasaki, H.1    Suda, T.2
  • 206
    • 77953782543 scopus 로고    scopus 로고
    • The stem cell niche in health and malignancy
    • Burness M.L., Sipkins D.A. The stem cell niche in health and malignancy. Semin Cancer Biol 2010, 20:107-115.
    • (2010) Semin Cancer Biol , vol.20 , pp. 107-115
    • Burness, M.L.1    Sipkins, D.A.2
  • 208
    • 79955702339 scopus 로고    scopus 로고
    • Deadly teamwork: Neural cancer stem cells and the tumor microenvironment
    • Lathia J.D., Heddleston J.M., Venere M., et al. Deadly teamwork: Neural cancer stem cells and the tumor microenvironment. Cell Stem Cell 2011, 8:482-485.
    • (2011) Cell Stem Cell , vol.8 , pp. 482-485
    • Lathia, J.D.1    Heddleston, J.M.2    Venere, M.3
  • 209
    • 77954999143 scopus 로고    scopus 로고
    • Are all glioma cells cancer stem cells?
    • Cruz M., Siden Å., Tasat D.R., et al. Are all glioma cells cancer stem cells?. J Cancer Sci Ther 2010, 2:100-106.
    • (2010) J Cancer Sci Ther , vol.2 , pp. 100-106
    • Cruz, M.1    Siden, Å.2    Tasat, D.R.3
  • 210
    • 73049087467 scopus 로고    scopus 로고
    • TRRAP and the maintenance of stemness in gliomas
    • Charles N.A., Holland E.C. TRRAP and the maintenance of stemness in gliomas. Cell Stem Cell 2010, 6:6-7.
    • (2010) Cell Stem Cell , vol.6 , pp. 6-7
    • Charles, N.A.1    Holland, E.C.2
  • 211
    • 79957926996 scopus 로고    scopus 로고
    • The brain tumor microenvironment
    • Charles N.A., Holland E.C., Gilbertson R., et al. The brain tumor microenvironment. Glia 2011, 59:1169-1180.
    • (2011) Glia , vol.59 , pp. 1169-1180
    • Charles, N.A.1    Holland, E.C.2    Gilbertson, R.3
  • 212
    • 33846029123 scopus 로고    scopus 로고
    • A perivascular niche for brain tumor stem cells
    • Calabrese C., Poppleton H., Kocak M., et al. A perivascular niche for brain tumor stem cells. Cancer Cell 2007, 11:69-82.
    • (2007) Cancer Cell , vol.11 , pp. 69-82
    • Calabrese, C.1    Poppleton, H.2    Kocak, M.3
  • 213
    • 39449135834 scopus 로고    scopus 로고
    • PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
    • Hambardzumyan D., Becher O.J., Rosenblum M.K., et al. PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo. Genes Dev 2008, 22:436-448.
    • (2008) Genes Dev , vol.22 , pp. 436-448
    • Hambardzumyan, D.1    Becher, O.J.2    Rosenblum, M.K.3
  • 214
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • Keith B., Simon M.C. Hypoxia-inducible factors, stem cells, and cancer. Cell 2007, 129:465-472.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 215
    • 77956224494 scopus 로고    scopus 로고
    • Oxygen in stem cell biology: A critical component of the stem cell niche
    • Mohyeldin A., Garzón-Muvdi T., Quiñones-Hinojosa A. Oxygen in stem cell biology: A critical component of the stem cell niche. Cell Stem Cell 2010, 7:150-161.
    • (2010) Cell Stem Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzón-Muvdi, T.2    Quiñones-Hinojosa, A.3
  • 216
    • 77954414428 scopus 로고    scopus 로고
    • Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics
    • Lin Q., Yun Z. Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics. Cancer Biol Ther 2010, 9:949-956.
    • (2010) Cancer Biol Ther , vol.9 , pp. 949-956
    • Lin, Q.1    Yun, Z.2
  • 217
    • 77953958780 scopus 로고    scopus 로고
    • Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation
    • Yaromina A., Thames H., Zhou X., et al. Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation. Radiother Oncol 2010, 96:116-122.
    • (2010) Radiother Oncol , vol.96 , pp. 116-122
    • Yaromina, A.1    Thames, H.2    Zhou, X.3
  • 218
    • 33845226457 scopus 로고    scopus 로고
    • Radiation resistance and stem-like cells in brain tumors
    • Hambardzumyan D., Squatrito M., Holland E.C., et al. Radiation resistance and stem-like cells in brain tumors. Cancer Cell 2006, 10:454-456.
    • (2006) Cancer Cell , vol.10 , pp. 454-456
    • Hambardzumyan, D.1    Squatrito, M.2    Holland, E.C.3
  • 220
    • 36148995870 scopus 로고    scopus 로고
    • Influence of oxygen tension on CD133 phenotype in human glioma cell cultures
    • Platet N., Liu S.Y., Atifi M.E., et al. Influence of oxygen tension on CD133 phenotype in human glioma cell cultures. Cancer Lett 2007, 258:286-290.
    • (2007) Cancer Lett , vol.258 , pp. 286-290
    • Platet, N.1    Liu, S.Y.2    Atifi, M.E.3
  • 221
    • 77950838848 scopus 로고    scopus 로고
    • A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha
    • Seidel S., Garvalov B.K., Wirta V., et al. A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha. Brain 2010, 133:983-995.
    • (2010) Brain , vol.133 , pp. 983-995
    • Seidel, S.1    Garvalov, B.K.2    Wirta, V.3
  • 222
    • 80053515159 scopus 로고    scopus 로고
    • Glioma stem cell maintenance: The role of the microenvironment
    • Heddleston J.M., Hitomi M., Venere M., et al. Glioma stem cell maintenance: The role of the microenvironment. Curr Pharm Des 2011, 17:2386-2401.
    • (2011) Curr Pharm Des , vol.17 , pp. 2386-2401
    • Heddleston, J.M.1    Hitomi, M.2    Venere, M.3
  • 223
    • 77649273107 scopus 로고    scopus 로고
    • Hypoxia inducible factors in cancer stem cells
    • Heddleston J.M., Li Z., Lathia J.D., et al. Hypoxia inducible factors in cancer stem cells. Br J Cancer 2010, 102:789-795.
    • (2010) Br J Cancer , vol.102 , pp. 789-795
    • Heddleston, J.M.1    Li, Z.2    Lathia, J.D.3
  • 224
    • 70350225829 scopus 로고    scopus 로고
    • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    • Heddleston J.M., Li Z., McLendon R.E., et al. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 2009, 8:3274-3284.
    • (2009) Cell Cycle , vol.8 , pp. 3274-3284
    • Heddleston, J.M.1    Li, Z.2    McLendon, R.E.3
  • 225
    • 70149106164 scopus 로고    scopus 로고
    • HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
    • Bertout J.A., Majmundar A.J., Gordan J.D., et al. HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc Natl Acad Sci U S A 2009, 106:14391-14396.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 14391-14396
    • Bertout, J.A.1    Majmundar, A.J.2    Gordan, J.D.3
  • 226
    • 34047156190 scopus 로고    scopus 로고
    • HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    • Gordan J.D., Bertout J.A., Hu C.J., et al. HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 2007, 11:335-347.
    • (2007) Cancer Cell , vol.11 , pp. 335-347
    • Gordan, J.D.1    Bertout, J.A.2    Hu, C.J.3
  • 227
    • 75849160216 scopus 로고    scopus 로고
    • Human cancers converge at the HIF-2alpha oncogenic axis
    • Franovic A., Holterman C.E., Payette J., et al. Human cancers converge at the HIF-2alpha oncogenic axis. Proc Natl Acad Sci U S A 2009, 106:21306-21311.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 21306-21311
    • Franovic, A.1    Holterman, C.E.2    Payette, J.3
  • 228
    • 33751543273 scopus 로고    scopus 로고
    • Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
    • Tatum J.L., Kelloff G.J., Gillies R.J., et al. Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol 2006, 82:699-757.
    • (2006) Int J Radiat Biol , vol.82 , pp. 699-757
    • Tatum, J.L.1    Kelloff, G.J.2    Gillies, R.J.3
  • 229
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004, 14:198-206.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 230
    • 10644234769 scopus 로고    scopus 로고
    • The role of hypoxia-induced factors in tumor progression
    • Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 2004, 9(suppl 5):10-17.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 10-17
    • Vaupel, P.1
  • 231
    • 54049134838 scopus 로고    scopus 로고
    • Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis
    • Vaupel P. Hypoxia and aggressive tumor phenotype: Implications for therapy and prognosis. Oncologist 2008, 13(suppl 3):21-26.
    • (2008) Oncologist , vol.13 , Issue.SUPPL. 3 , pp. 21-26
    • Vaupel, P.1
  • 232
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • Vaupel P., Mayer A. Hypoxia in cancer: Significance and impact on clinical outcome. Cancer Metastasis Rev 2007, 26:225-239.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 233
    • 1642565876 scopus 로고    scopus 로고
    • Tumor hypoxia and malignant progression
    • Vaupel P., Mayer A., Höckel M. Tumor hypoxia and malignant progression. Methods Enzymol 2004, 381:335-354.
    • (2004) Methods Enzymol , vol.381 , pp. 335-354
    • Vaupel, P.1    Mayer, A.2    Höckel, M.3
  • 234
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • Quintana E., Shackleton M., Foster H.R., et al. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 2010, 18:510-523.
    • (2010) Cancer Cell , vol.18 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3
  • 235
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • Roesch A., Fukunaga-Kalabis M., Schmidt E.C., et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 2010, 141:583-594.
    • (2010) Cell , vol.141 , pp. 583-594
    • Roesch, A.1    Fukunaga-Kalabis, M.2    Schmidt, E.C.3
  • 236
    • 78049237405 scopus 로고    scopus 로고
    • Cancer stem cells versus phenotype-switching in melanoma
    • Hoek K.S., Goding C.R. Cancer stem cells versus phenotype-switching in melanoma. Pigment cell Melanoma Res 2010, 23:746-759.
    • (2010) Pigment cell Melanoma Res , vol.23 , pp. 746-759
    • Hoek, K.S.1    Goding, C.R.2
  • 237
    • 80052964920 scopus 로고    scopus 로고
    • Phenotypic plasticity and epithelial-mesenchymal transitions in cancer-And normal stem cells?
    • Scheel C., Weinberg R.A. Phenotypic plasticity and epithelial-mesenchymal transitions in cancer-And normal stem cells?. Int J Cancer 2011, 129:2310-2314.
    • (2011) Int J Cancer , vol.129 , pp. 2310-2314
    • Scheel, C.1    Weinberg, R.A.2
  • 238
    • 79953689605 scopus 로고    scopus 로고
    • Cancer stem cells and epithelial-to-mesenchymal transition (EMT)-phenotypic cells: Are they cousins or twins?
    • Kong D., Li Y., Wang Z., et al. Cancer stem cells and epithelial-to-mesenchymal transition (EMT)-phenotypic cells: Are they cousins or twins?. Cancers (Basel) 2011, 3:716-729.
    • (2011) Cancers (Basel) , vol.3 , pp. 716-729
    • Kong, D.1    Li, Y.2    Wang, Z.3
  • 239
    • 81255168182 scopus 로고    scopus 로고
    • Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: Distinct, overlapping or same populations
    • Floor S., van Staveren W.C., Larsimont D., et al. Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: Distinct, overlapping or same populations. Oncogene 2011, 30:4609-4621.
    • (2011) Oncogene , vol.30 , pp. 4609-4621
    • Floor, S.1    van Staveren, W.C.2    Larsimont, D.3
  • 240
    • 23844513413 scopus 로고    scopus 로고
    • Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis
    • Kucia M., Reca R., Miekus K., et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005, 23:879-894.
    • (2005) Stem Cells , vol.23 , pp. 879-894
    • Kucia, M.1    Reca, R.2    Miekus, K.3
  • 241
    • 77953090345 scopus 로고    scopus 로고
    • CXCL12 (SDF-1)/CXCR4 pathway in cancer
    • Teicher B.A., Fricker S.P. CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 2010, 16:2927-2931.
    • (2010) Clin Cancer Res , vol.16 , pp. 2927-2931
    • Teicher, B.A.1    Fricker, S.P.2
  • 243
    • 77954505691 scopus 로고    scopus 로고
    • Cancer stem cells as new therapeutic target to prevent tumour progression and metastasis
    • Mueller M.T., Hermann P.C., Heeschen C. Cancer stem cells as new therapeutic target to prevent tumour progression and metastasis. Front Biosci (Elite Ed) 2010, 2:602-613.
    • (2010) Front Biosci (Elite Ed) , vol.2 , pp. 602-613
    • Mueller, M.T.1    Hermann, P.C.2    Heeschen, C.3
  • 244
    • 42349093952 scopus 로고    scopus 로고
    • Cancer stem cells: Implications for the progression and treatment of metastatic disease
    • Croker A.K., Allan A.L. Cancer stem cells: Implications for the progression and treatment of metastatic disease. J Cell Mol Med 2008, 12:374-390.
    • (2008) J Cell Mol Med , vol.12 , pp. 374-390
    • Croker, A.K.1    Allan, A.L.2
  • 245
    • 56749106654 scopus 로고    scopus 로고
    • Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments
    • LaBarge M.A., Nelson C.M., Villadsen R., et al. Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb) 2009, 1:70-79.
    • (2009) Integr Biol (Camb) , vol.1 , pp. 70-79
    • LaBarge, M.A.1    Nelson, C.M.2    Villadsen, R.3
  • 246
    • 57649134966 scopus 로고    scopus 로고
    • Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells
    • Schieke S.M., Ma M., Cao L., et al. Mitochondrial metabolism modulates differentiation and teratoma formation capacity in mouse embryonic stem cells. J Biol Chem 2008, 283:28506-28512.
    • (2008) J Biol Chem , vol.283 , pp. 28506-28512
    • Schieke, S.M.1    Ma, M.2    Cao, L.3
  • 247
    • 79958173253 scopus 로고    scopus 로고
    • Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells
    • Smolkovα K., Plecitα-Hlavatα L., Bellance N., et al. Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells. Int J Biochem Cell Biol 2011, 43:950-968.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 950-968
    • Smolkovα, K.1    Plecitα-Hlavatα, L.2    Bellance, N.3
  • 248
    • 79953705886 scopus 로고    scopus 로고
    • Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?
    • Jose C., Bellance N., Rossignol R. Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?. Biochim Biophys Acta 2011, 1807:552-561.
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 552-561
    • Jose, C.1    Bellance, N.2    Rossignol, R.3
  • 250
    • 74249091150 scopus 로고    scopus 로고
    • The role of autophagy on the survival of dopamine neurons
    • Isidoro C., Biagioni F., Giorgi F.S., et al. The role of autophagy on the survival of dopamine neurons. Curr Top Med Chem 2009, 9:869-879.
    • (2009) Curr Top Med Chem , vol.9 , pp. 869-879
    • Isidoro, C.1    Biagioni, F.2    Giorgi, F.S.3
  • 251
    • 78149361025 scopus 로고    scopus 로고
    • Metabolic flexibility and cell hierarchy in metastatic cancer
    • Berridge M.V., Herst P.M., Tan A.S. Metabolic flexibility and cell hierarchy in metastatic cancer. Mitochondrion 2010, 10:584-588.
    • (2010) Mitochondrion , vol.10 , pp. 584-588
    • Berridge, M.V.1    Herst, P.M.2    Tan, A.S.3
  • 253
    • 77956419439 scopus 로고    scopus 로고
    • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
    • Bonuccelli G., Tsirigos A., Whitaker-Menezes D., et al. Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle 2010, 9:3506-3514.
    • (2010) Cell Cycle , vol.9 , pp. 3506-3514
    • Bonuccelli, G.1    Tsirigos, A.2    Whitaker-Menezes, D.3
  • 254
    • 34247468926 scopus 로고    scopus 로고
    • Chemokine networks and breast cancer metastasis
    • Karnoub A.E., Weinberg R.A. Chemokine networks and breast cancer metastasis. Breast Dis 2006, 26:75-85.
    • (2006) Breast Dis , vol.26 , pp. 75-85
    • Karnoub, A.E.1    Weinberg, R.A.2
  • 255
    • 0035964349 scopus 로고    scopus 로고
    • Variable beta-catenin expression in colorectal cancers indicates a tumor progression driven by the tumor environment
    • Brabletz T., Jung A., Reu S., et al. Variable beta-catenin expression in colorectal cancers indicates a tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A 2001, 98:10356-10361.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10356-10361
    • Brabletz, T.1    Jung, A.2    Reu, S.3
  • 256
    • 34648813274 scopus 로고    scopus 로고
    • Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer
    • Hlubek F., Brabletz T., Budczies J., et al. Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer. Int J Cancer 2007, 121:1941-1948.
    • (2007) Int J Cancer , vol.121 , pp. 1941-1948
    • Hlubek, F.1    Brabletz, T.2    Budczies, J.3
  • 257
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani S.A., Guo W., Liao M.J., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 258
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel A.P., Lièvre M., Thomas C., et al. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008, 3:e2888.
    • (2008) PLoS One , vol.3
    • Morel, A.P.1    Lièvre, M.2    Thomas, C.3
  • 259
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells-an integrated concept of malignant tumour progression
    • Brabletz T., Jung A., Spaderna S., et al. Opinion: Migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat Rev Cancer 2005, 5:744-749.
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3
  • 260
    • 79951813950 scopus 로고    scopus 로고
    • The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells
    • Brabletz S., Bajdak K., Meidhof S., et al. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J 2011, 30:770-782.
    • (2011) EMBO J , vol.30 , pp. 770-782
    • Brabletz, S.1    Bajdak, K.2    Meidhof, S.3
  • 261
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop-A motor of cellular plasticity in development and cancer?
    • Brabletz S., Brabletz T. The ZEB/miR-200 feedback loop-A motor of cellular plasticity in development and cancer?. EMBO Rep 2010, 11:670-677.
    • (2010) EMBO Rep , vol.11 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 262
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    • Schmalhofer O., Brabletz S., Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 2009, 28:151-166.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 263
    • 54049089608 scopus 로고    scopus 로고
    • MicroRNAs as regulators of epithelial-mesenchymal transition
    • Gregory P.A., Bracken C.P., Bert A.G., et al. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 2008, 7:3112-3118.
    • (2008) Cell Cycle , vol.7 , pp. 3112-3118
    • Gregory, P.A.1    Bracken, C.P.2    Bert, A.G.3
  • 264
    • 79960360062 scopus 로고    scopus 로고
    • E-cadherin loss associated with EMT promotes radioresistance in human tumor cells
    • Theys J., Jutten B., Habets R., et al. E-cadherin loss associated with EMT promotes radioresistance in human tumor cells. Radiother Oncol 2011, 99:392-397.
    • (2011) Radiother Oncol , vol.99 , pp. 392-397
    • Theys, J.1    Jutten, B.2    Habets, R.3
  • 265
    • 79952453864 scopus 로고    scopus 로고
    • Pancreatic cancer cells resistant to chemoradiotherapy rich in "stem-cell-like" tumor cells
    • Du Z., Qin R., Wei C., et al. Pancreatic cancer cells resistant to chemoradiotherapy rich in "stem-cell-like" tumor cells. Dig Dis Sci 2011, 56:741-750.
    • (2011) Dig Dis Sci , vol.56 , pp. 741-750
    • Du, Z.1    Qin, R.2    Wei, C.3
  • 266
    • 66149131111 scopus 로고    scopus 로고
    • Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells
    • Santisteban M., Reiman J.M., Asiedu M.K., et al. Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells. Cancer Res 2009, 69:2887-2895.
    • (2009) Cancer Res , vol.69 , pp. 2887-2895
    • Santisteban, M.1    Reiman, J.M.2    Asiedu, M.K.3
  • 267
    • 80053119731 scopus 로고    scopus 로고
    • The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas
    • Kim K.J., Lee K.H., Kim H.S., et al. The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas. Neuropathology 2011, 31:494-505.
    • (2011) Neuropathology , vol.31 , pp. 494-505
    • Kim, K.J.1    Lee, K.H.2    Kim, H.S.3
  • 268
    • 69349095324 scopus 로고    scopus 로고
    • + glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines
    • + glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines. Clin Cancer Res 2009, 15:5145-5153.
    • (2009) Clin Cancer Res , vol.15 , pp. 5145-5153
    • McCord, A.M.1    Jamal, M.2    Williams, E.S.3
  • 270
    • 33846287519 scopus 로고    scopus 로고
    • WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells
    • Woodward W.A., Chen M.S., Behbod F., et al. WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc Natl Acad Sci U S A 2007, 104:618-623.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 618-623
    • Woodward, W.A.1    Chen, M.S.2    Behbod, F.3
  • 271
    • 79958784379 scopus 로고    scopus 로고
    • Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction
    • Al-Assar O., Mantoni T., Lunardi S., et al. Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction. Cancer Biol Ther 2011, 11:1028-1035.
    • (2011) Cancer Biol Ther , vol.11 , pp. 1028-1035
    • Al-Assar, O.1    Mantoni, T.2    Lunardi, S.3
  • 272
    • 77956034139 scopus 로고    scopus 로고
    • Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment
    • Lagadec C., Vlashi E., Della Donna L., et al. Survival and self-renewing capacity of breast cancer initiating cells during fractionated radiation treatment. Breast Cancer Res 2010, 12:R13.
    • (2010) Breast Cancer Res , vol.12
    • Lagadec, C.1    Vlashi, E.2    Della Donna, L.3
  • 273
    • 79251613647 scopus 로고    scopus 로고
    • Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and non-stem cells
    • Boivin A., Hanot M., Malesys C., et al. Transient alteration of cellular redox buffering before irradiation triggers apoptosis in head and neck carcinoma stem and non-stem cells. PLoS One 2011, 6:e14558.
    • (2011) PLoS One , vol.6
    • Boivin, A.1    Hanot, M.2    Malesys, C.3
  • 274
    • 62349116134 scopus 로고    scopus 로고
    • In vivo imaging, tracking, and targeting of cancer stem cells
    • Vlashi E., Kim K., Lagadec C., et al. In vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst 2009, 101:350-359.
    • (2009) J Natl Cancer Inst , vol.101 , pp. 350-359
    • Vlashi, E.1    Kim, K.2    Lagadec, C.3
  • 275
    • 71549155909 scopus 로고    scopus 로고
    • Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
    • Saigusa S., Tanaka K., Toiyama Y., et al. Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann Surg Oncol 2009, 16:3488-3498.
    • (2009) Ann Surg Oncol , vol.16 , pp. 3488-3498
    • Saigusa, S.1    Tanaka, K.2    Toiyama, Y.3
  • 276
    • 79952453864 scopus 로고    scopus 로고
    • Pancreatic cancer cells resistant to chemoradiotherapy rich in "stem-cell-like" tumor cells
    • Du Z., Qin R., Wei C., et al. Pancreatic cancer cells resistant to chemoradiotherapy rich in "stem-cell-like" tumor cells. Dig Dis Sci 2011, 56:741-750.
    • (2011) Dig Dis Sci , vol.56 , pp. 741-750
    • Du, Z.1    Qin, R.2    Wei, C.3
  • 277
    • 33847369455 scopus 로고    scopus 로고
    • Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line
    • Chen M.S., Woodward W.A., Behbod F., et al. Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line. J Cell Sci 2007, 120:468-477.
    • (2007) J Cell Sci , vol.120 , pp. 468-477
    • Chen, M.S.1    Woodward, W.A.2    Behbod, F.3
  • 278
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown J.M., Attardi L.D. The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005, 5:231-237.
    • (2005) Nat Rev Cancer , vol.5 , pp. 231-237
    • Brown, J.M.1    Attardi, L.D.2
  • 279
    • 67650095390 scopus 로고    scopus 로고
    • The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells
    • Lomonaco S.L., Finniss S., Xiang C., et al. The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer 2009, 125:717-722.
    • (2009) Int J Cancer , vol.125 , pp. 717-722
    • Lomonaco, S.L.1    Finniss, S.2    Xiang, C.3
  • 280
    • 40449086885 scopus 로고    scopus 로고
    • Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
    • Apel A., Herr I., Schwarz H., et al. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008, 68:1485-1494.
    • (2008) Cancer Res , vol.68 , pp. 1485-1494
    • Apel, A.1    Herr, I.2    Schwarz, H.3
  • 281
    • 79960356284 scopus 로고    scopus 로고
    • Autophagy contributes to resistance of tumor cells to ionizing radiation
    • Chaachouay H., Ohneseit P., Toulany M., et al. Autophagy contributes to resistance of tumor cells to ionizing radiation. Radiother Oncol 2011, 99:287-292.
    • (2011) Radiother Oncol , vol.99 , pp. 287-292
    • Chaachouay, H.1    Ohneseit, P.2    Toulany, M.3
  • 282
    • 74949118681 scopus 로고    scopus 로고
    • The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
    • Rouschop K.M., van den Beucken T., Dubois L., et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest 2010, 120:127-141.
    • (2010) J Clin Invest , vol.120 , pp. 127-141
    • Rouschop, K.M.1    van den Beucken, T.2    Dubois, L.3
  • 283
    • 80053302394 scopus 로고    scopus 로고
    • Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity
    • Zhuang W., Li B., Long L., et al. Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity. Int J Cancer 2011, 129:2720-2731.
    • (2011) Int J Cancer , vol.129 , pp. 2720-2731
    • Zhuang, W.1    Li, B.2    Long, L.3
  • 284
    • 78651359429 scopus 로고    scopus 로고
    • Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy
    • Zhuang W., Li B., Long L., et al. Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy. Brain Res 2011, 1371:7-15.
    • (2011) Brain Res , vol.1371 , pp. 7-15
    • Zhuang, W.1    Li, B.2    Long, L.3
  • 285
    • 80052164677 scopus 로고    scopus 로고
    • Kill one bird with two stones: Potential efficacy of BCR-ABL and autophagy inhibition in CML
    • Helgason G.V., Karvela M., Holyoake T.L. Kill one bird with two stones: Potential efficacy of BCR-ABL and autophagy inhibition in CML. Blood 2011, 118:2035-2043.
    • (2011) Blood , vol.118 , pp. 2035-2043
    • Helgason, G.V.1    Karvela, M.2    Holyoake, T.L.3
  • 286
    • 77957681100 scopus 로고    scopus 로고
    • ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy
    • Dewaele M., Maes H., Agostinis P. ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy 2010, 6:838-854.
    • (2010) Autophagy , vol.6 , pp. 838-854
    • Dewaele, M.1    Maes, H.2    Agostinis, P.3
  • 287
    • 64749093574 scopus 로고    scopus 로고
    • Association of reactive oxygen species levels and radioresistance in cancer stem cells
    • Diehn M., Cho R.W., Lobo N.A., et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009, 458:780-783.
    • (2009) Nature , vol.458 , pp. 780-783
    • Diehn, M.1    Cho, R.W.2    Lobo, N.A.3
  • 288
    • 48649096069 scopus 로고    scopus 로고
    • Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity
    • Prevo R., Deutsch E., Sampson O., et al. Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity. Cancer Res 2008, 68:5915-5923.
    • (2008) Cancer Res , vol.68 , pp. 5915-5923
    • Prevo, R.1    Deutsch, E.2    Sampson, O.3
  • 289
    • 0346457085 scopus 로고    scopus 로고
    • Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy
    • Taneja N., Davis M., Choy J.S., et al. Histone H2AX phosphorylation as a predictor of radiosensitivity and target for radiotherapy. J Biol Chem 2004, 279:2273-2280.
    • (2004) J Biol Chem , vol.279 , pp. 2273-2280
    • Taneja, N.1    Davis, M.2    Choy, J.S.3
  • 290
    • 16644392782 scopus 로고    scopus 로고
    • Detection of DNA damage in individual cells by analysis of histone H2AX phosphorylation
    • Olive P.L. Detection of DNA damage in individual cells by analysis of histone H2AX phosphorylation. Methods Cell Biol 2004, 75:355-373.
    • (2004) Methods Cell Biol , vol.75 , pp. 355-373
    • Olive, P.L.1
  • 291
    • 33845874094 scopus 로고    scopus 로고
    • Cancer stem cells and radiotherapy: New insights into tumor radioresistance
    • Diehn M., Clarke M.F. Cancer stem cells and radiotherapy: New insights into tumor radioresistance. J Natl Cancer Inst 2006, 98:1755-1757.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1755-1757
    • Diehn, M.1    Clarke, M.F.2
  • 292
    • 77649257221 scopus 로고    scopus 로고
    • Selective targeting of radiation-resistant tumor-initiating cells
    • Zhang M., Atkinson R.L., Rosen J.M. Selective targeting of radiation-resistant tumor-initiating cells. Proc Natl Acad Sci U S A 2010, 107:3522-3527.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3522-3527
    • Zhang, M.1    Atkinson, R.L.2    Rosen, J.M.3
  • 293
    • 62549142665 scopus 로고    scopus 로고
    • Comparative analysis of DNA repair in stem and nonstem glioma cell cultures
    • Ropolo M., Daga A., Griffero F., et al. Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. Mol Cancer Res 2009, 7:383-392.
    • (2009) Mol Cancer Res , vol.7 , pp. 383-392
    • Ropolo, M.1    Daga, A.2    Griffero, F.3
  • 294
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret E., Ginestier C., Iovino F., et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009, 69:1302-1313.
    • (2009) Cancer Res , vol.69 , pp. 1302-1313
    • Charafe-Jauffret, E.1    Ginestier, C.2    Iovino, F.3
  • 295
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz O.H., Valdez R., Theisen B.K., et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006, 441:475-482.
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3
  • 296
    • 78149284013 scopus 로고    scopus 로고
    • Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer
    • Schramek D., Leibbrandt A., Sigl V., et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature 2010, 468:98-102.
    • (2010) Nature , vol.468 , pp. 98-102
    • Schramek, D.1    Leibbrandt, A.2    Sigl, V.3
  • 297
    • 65949121610 scopus 로고    scopus 로고
    • Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells
    • Sauvageot C.M., Weatherbee J.L., Kesari S., et al. Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. Neuro Oncol 2009, 11:109-121.
    • (2009) Neuro Oncol , vol.11 , pp. 109-121
    • Sauvageot, C.M.1    Weatherbee, J.L.2    Kesari, S.3
  • 298
    • 34248550985 scopus 로고    scopus 로고
    • Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors
    • Folkins C., Man S., Xu P., et al. Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res 2007, 67:3560-3564.
    • (2007) Cancer Res , vol.67 , pp. 3560-3564
    • Folkins, C.1    Man, S.2    Xu, P.3
  • 299
    • 79251591038 scopus 로고    scopus 로고
    • Glioblastoma, cancer stem cells and hypoxia
    • Bar E.E. Glioblastoma, cancer stem cells and hypoxia. Brain Pathol 2011, 21:119-129.
    • (2011) Brain Pathol , vol.21 , pp. 119-129
    • Bar, E.E.1
  • 300
    • 68049144956 scopus 로고    scopus 로고
    • Tumor vascular changes mediated by inhibition of oncogenic signaling
    • Qayum N., Muschel R.J., Im J.H., et al. Tumor vascular changes mediated by inhibition of oncogenic signaling. Cancer Res 2009, 69:6347-6354.
    • (2009) Cancer Res , vol.69 , pp. 6347-6354
    • Qayum, N.1    Muschel, R.J.2    Im, J.H.3
  • 301
    • 45749106028 scopus 로고    scopus 로고
    • Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer
    • Brunner T.B., Geiger M., Grabenbauer G.G., et al. Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer. J Clin Oncol 2008, 26:2699-2706.
    • (2008) J Clin Oncol , vol.26 , pp. 2699-2706
    • Brunner, T.B.1    Geiger, M.2    Grabenbauer, G.G.3
  • 302
    • 34547913802 scopus 로고    scopus 로고
    • The carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage
    • Mesker W.E., Junggeburt J.M., Szuhai K., et al. The carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage. Cell Oncol 2007, 29:387-398.
    • (2007) Cell Oncol , vol.29 , pp. 387-398
    • Mesker, W.E.1    Junggeburt, J.M.2    Szuhai, K.3
  • 303
    • 77952243411 scopus 로고    scopus 로고
    • The proportion of tumour cells is an independent predictor for survival in colorectal cancer patients
    • West N.P., Dattani M., McShane P., et al. The proportion of tumour cells is an independent predictor for survival in colorectal cancer patients. Br J Cancer 2011, 102:1519-1523.
    • (2011) Br J Cancer , vol.102 , pp. 1519-1523
    • West, N.P.1    Dattani, M.2    McShane, P.3
  • 304
    • 77954667472 scopus 로고    scopus 로고
    • Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma
    • Evers P., Lee P.P., DeMarco J., et al. Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma. BMC Cancer 2010, 10:384.
    • (2010) BMC Cancer , vol.10 , pp. 384
    • Evers, P.1    Lee, P.P.2    DeMarco, J.3
  • 305
    • 80051703750 scopus 로고    scopus 로고
    • (18)F-FDG PET-guided salvage neoadjuvant radiochemotherapy of adenocarcinoma of the esophagogastric junction: The MUNICON II trial
    • Meyer zum Büschenfelde C.M., Herrmann K., Schuster T., et al. (18)F-FDG PET-guided salvage neoadjuvant radiochemotherapy of adenocarcinoma of the esophagogastric junction: The MUNICON II trial. J Nucl Med 2011, 52:1189-1196.
    • (2011) J Nucl Med , vol.52 , pp. 1189-1196
    • Meyer zum Büschenfelde, C.M.1    Herrmann, K.2    Schuster, T.3
  • 306
    • 79959343003 scopus 로고    scopus 로고
    • Adaptive dose painting by numbers for head-and-neck cancer
    • Duprez F., De Neve W., De Gersem W., et al. Adaptive dose painting by numbers for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2011, 80:1045-1055.
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 1045-1055
    • Duprez, F.1    De Neve, W.2    De Gersem, W.3
  • 307
    • 79960116484 scopus 로고    scopus 로고
    • Adaptive radiotherapy for locally advanced non-small-cell lung cancer does not underdose the microscopic disease and has the potential to increase tumor control
    • Guckenberger M., Richter A., Wilbert J., et al. Adaptive radiotherapy for locally advanced non-small-cell lung cancer does not underdose the microscopic disease and has the potential to increase tumor control. Int J Radiat Oncol Biol Phys 2011, 81:e275-e282.
    • (2011) Int J Radiat Oncol Biol Phys , vol.81
    • Guckenberger, M.1    Richter, A.2    Wilbert, J.3
  • 308
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer E.A., Therasse P., Bogaerts J., et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer 2009, 45:228-247.
    • (2009) Eur J Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 309
    • 66149139452 scopus 로고    scopus 로고
    • From RECIST to PERCIST: Evolving considerations for PET response criteria in solid tumors
    • Wahl R.L., Jacene H., Kasamon Y., et al. From RECIST to PERCIST: Evolving considerations for PET response criteria in solid tumors. J Nucl Med 2009, 50(suppl 1):122S-150S.
    • (2009) J Nucl Med , vol.50 , Issue.SUPPL. 1
    • Wahl, R.L.1    Jacene, H.2    Kasamon, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.