PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

Genes and Development

Volumn 22, Issue 4, 2008, Pages 436-448

  Hambardzumyan, Dolores ^a   Becher, Oren J ^a   Rosenblum, Marc K ^a   Pandolfi, Pier Paolo ^b   Manova Todorova, Katia ^a   Holland, Eric C ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Medulloblastoma; p53; PI3K Akt; PTEN

Indexed keywords

PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER MODEL; CANCER STEM CELL; CELL CYCLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CEREBELLUM; CONTROLLED STUDY; DESENSITIZATION; DNA DAMAGE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; IRRADIATION; MEDULLOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIATION EXPOSURE; RADIATION RESPONSE; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BRAIN; BRAIN NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; HEDGEHOG PROTEINS; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; MEDULLOBLASTOMA; MICE; MICE, KNOCKOUT; NEOPLASTIC STEM CELLS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; PTEN PHOSPHOHYDROLASE; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; WHOLE-BODY IRRADIATION;

EID: 39449135834     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1627008     Document Type: Article

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