Neurosphere formation is an independent predictor of clinical outcome in malignant glioma

Stem Cells

Volumn 27, Issue 4, 2009, Pages 980-987

  Laks, Dan R ^a   Masterman Smith, Michael ^a   Visnyei, Koppany ^a   Angenieux, Brigitte ^a   Orozco, Nicholas M ^a   Foran, Ian ^a   Yong, William H ^a   Vinters, Harry V ^a   Liau, Linda M ^a   Lazareff, Jorge A ^a   Mischel, Paul S ^a   Cloughesy, Timothy F ^a   Horvath, Steve ^a   Kornblum, Harley I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain tumor stem cell; Cancer; Cancer stem cell; Glioblastoma; Human glioma; Neurosphere; Progression free survival

Indexed keywords

BEVACIZUMAB; CARBOPLATIN; ERLOTINIB; KI 67 ANTIGEN; LOMUSTINE; TAMOXIFEN; TEMOZOLOMIDE;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER GROWTH; CARCINOGENICITY; CELL ASSAY; CELL CULTURE; CELL POPULATION; CELL PROLIFERATION; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; MALE; MORTALITY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PREDICTOR VARIABLE; XENOGRAFT;

ADOLESCENT; ADULT; AGED; ANIMALS; BRAIN NEOPLASMS; CHILD; FEMALE; GLIOMA; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MICE; MICE, SCID; MIDDLE AGED; NEOPLASTIC STEM CELLS; PROGNOSIS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; TUMOR CELLS, CULTURED;

EID: 65749087298     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.15     Document Type: Article

References (27)

1. Buckner JC, Brown PD, O'Neill BP et al. Central nervous system tumors. Mayo Clin Proc 2007;82:1271-1286. (Pubitemid 47502884)
2. Stupp R, Mason WP, van den Bent MJ et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-996. (Pubitemid 40349501)
3. Reynolds BA, Tetzlaff W, Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci 1992;12:4565-4574.
4. Reynolds BA, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 1992;255:1707-1710. (Pubitemid 23042428)
5. Galli R, Binda E, Orfanelli U et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004;64:7011-7021. (Pubitemid 39331011)
6. Hemmati HD, Nakano I, Lazareff JA et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 2003;100: 15178-15183. (Pubitemid 37518036)
7. Buckner JC, Brown PD, O'Neill BP et al. Central nervous system tumors. Mayo Clin Proc 2007;82:1271-1286.
8. Singh SK, Clarke ID, Terasaki M et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-5828. (Pubitemid 37187480)
9. Lee J, Kotliarova S, Kotliarov Y et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006;9:391-403. (Pubitemid 43668737)
10. Singh SK, Hawkins C, Clarke ID et al. Identification of human brain tumour initiating cells. Nature 2004;432:396-401. (Pubitemid 39551674)
11. Kleihues P, Louis DN, Scheithauer BW et al. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002;61: 215-225; discussion 226-219. (Pubitemid 34212595)
12. Vescovi AL, Galli R, Reynolds BA. Brain tumour stem cells. Nat Rev Cancer 2006;6:425-436.
13. + tumor cells in clinically relevant mouse models of medulloblastoma and glioma. Stem Cells 2008;26:1414-1424.
14. Mangiola A, Lama G, Giannitelli C et al. Stem cell marker nestin and c-Jun NH2-terminal kinases in tumor and peritumor areas of glioblastoma multiforme: Possible prognostic implications. Clin Cancer Res 2007;13:6970-6977. (Pubitemid 350276877)
15. Zeppernick F, Ahmadi R, Campos B et al. Stem cell marker CD133 affects clinical outcome in glioma patients. Clin Cancer Res 2008;14: 123-129.
16. Phillips HS, Kharbanda S, Chen R et al. Molecular subclasses of highgrade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006;9:157-173. (Pubitemid 43357943)
17. Beier D, Wischhusen J, Dietmaier W et al. CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors. Brain Pathol 2008;18:370-377.
18. Singh SK, Clarke ID, Hide T et al. Cancer stem cells in nervous system tumors. Oncogene 2004;23:7267-7273. (Pubitemid 39382160)
19. Joo KM, Kim SY, Jin X et al. Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas. Lab Invest 2008;88:808-815.
20. Nakano I, Masterman-Smith M, Saigusa K et al. Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. J Neurosci Res 2008;86:48-60.
21. Piccirillo SG, Reynolds BA, Zanetti N et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006;444:761-765.
22. Cifone MA, Fidler IJ. Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma. Proc Natl Acad Sci USA 1980;77:1039-1043. (Pubitemid 10105052)
23. Freedman VH, Shin SI. Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium. Cell 1974;3:355-359.
24. Shin SI, Freedman VH, Risser R et al. Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro. Proc Natl Acad Sci USA 1975;72: 4435-4439.
25. Colburn NH, Bruegge WF, Bates JR et al. Correlation of anchorageindependent growth with tumorigenicity of chemically transformed mouse epidermal cells. Cancer Res 1978;38:624-634. (Pubitemid 8311406)
26. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57-70. (Pubitemid 30046295)
27. Bouvier-Labit C, Chinot O, Ochi C et al. Prognostic significance of Ki67, p53 and epidermal growth factor receptor immunostaining in human glioblastomas. Neuropathol Appl Neurobiol 1998;24: 381-388. (Pubitemid 28479484)