Acidic stress promotes a glioma stem cell phenotype

Cell Death and Differentiation

Volumn 18, Issue 5, 2011, Pages 829-840

  Hjelmeland, A B ^a   Wu, Q ^a   Heddleston, J M ^a   Choudhary, G S ^b   MacSwords, J ^a   Lathia, J D ^a   McLendon, R ^c   Lindner, D ^a   Sloan, A ^b   Rich, J N ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

acidic microenvironment; cancer stem cell; glioma; pH

Indexed keywords

ANGIOGENIC FACTOR; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXYGEN; TUMOR MARKER;

ACIDIC STRESS; ACIDITY; ARTICLE; CANCER CELL CULTURE; CANCER STEM CELL; CELL HETEROGENEITY; CELL RENEWAL; CELL STRESS; CONTROLLED STUDY; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PARACRINE SIGNALING; PH; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

ACIDOSIS; ANGIOGENESIS INDUCING AGENTS; ANTIGENS, DIFFERENTIATION; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; GLUCOSE TRANSPORTER TYPE 1; HOMEODOMAIN PROTEINS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASM TRANSPLANTATION; NEOPLASTIC STEM CELLS; NERVE TISSUE PROTEINS; OCTAMER TRANSCRIPTION FACTOR-3; PHENOTYPE; SERPINS; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC; TUMOR MARKERS, BIOLOGICAL; TUMOR MICROENVIRONMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79954423356     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.150     Document Type: Article

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