Metabolic flexibility and cell hierarchy in metastatic cancer

Mitochondrion

Volumn 10, Issue 6, 2010, Pages 584-588

  Berridge, Michael V ^a   Herst, Patries M ^a   Tan, An S ^a  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

Author keywords

Aerobic glycolysis; Cancer; Metabolism; Metastasis; Mitochondrial respiration; Self renewal

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; LACTIC ACID; MITOCHONDRIAL DNA; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE 1; UNCLASSIFIED DRUG;

AEROBIC GLYCOLYSIS; AEROBIC METABOLISM; CANCER CELL; CELL DIFFERENTIATION; CELL ENERGY; CELL GROWTH; CELL METABOLISM; CELL POPULATION; CELL PROLIFERATION; CELL RENEWAL; GLYCOLYSIS; HUMAN; LEUKEMIA CELL; LUNG TUMOR; MELANOMA CELL; METASTASIS; METASTASIS POTENTIAL; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; TUMOR CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

ENERGY METABOLISM; GLYCOLYSIS; HOMEOSTASIS; HUMANS; MITOCHONDRIA; NEOPLASM METASTASIS; NEOPLASMS;

EID: 78149361025     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2010.08.002     Document Type: Review

References (59)

1. Al-Hajj M., Wicha M.S., Benito-Hernandez A., Morrison S.J., Clarke M.F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 2003, 100:3983-3988.
2. Azevedo F.A., Carvalho L.R., Grinberg L.T., Farfel J.M., Ferretti R.E., Leite R.E., Jacob Filho W., Lent R., Herculano-Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J. Comp. Neurol. 2009, 513:532-541.
3. Berridge M.V., Tan A.S. Effects of mitochondrial gene deletion on tumorigenicity of metastatic melanoma: reassessing the Warburg effect. Rejuvenation Res. 2009, 13:139-141.
4. Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3:730-737.
5. Brand K. Aerobic glycolysis by proliferating cells: protection against oxidative stress at the expense of energy yield. J. Bioenerg. Biomembr. 1997, 29:355-364.
6. Cardenas-Navia L.I., Mace D., Richardson R.A., Wilson D.F., Shan S., Dewhirst M.W. The pervasive presence of fluctuating oxygenation in tumors. Cancer Res. 2008, 68:5812-5819.
7. DeBerardinis R.J., Lum J.J., Hatzivassiliou G., Thompson C.B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
8. Denko N.C. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat. Rev. Cancer 2008, 8:705-713.
9. Dunn G.P., Old L.J., Schreiber R.D. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004, 21:137-148.
10. Elstrom R.L., Bauer D.E., Buzzai M., Karnauskas R., Harris M.H., Plas D.R., Zhuang H., Cinalli R.M., Alavi A., Rudin C.M., Thompson C.B. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res. 2004, 64:3892-3899.
11. Fantin V.R., St-Pierre J., Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell 2006, 9:425-434.
12. Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 2004, 4:891-899.
13. Gladden L.B. Lactate metabolism: a new paradigm for the third millennium. J. Physiol. 2004, 558:5-30.
14. Godinot C., de Laplanche E., Hervouet E., Simonnet H. Actuality of Warburg's views in our understanding of renal cancer metabolism. J. Bioenerg. Biomembr. 2007, 39:235-241.
15. Gottschalk S., Anderson N., Hainz C., Eckhardt S.G., Serkova N.J. Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin. Cancer Res. 2004, 10:6661-6668.
16. Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
17. Herst P.M., Berridge M.V. Cell surface oxygen consumption: a major contributor to cellular oxygen consumption in glycolytic cancer cell lines. Biochim. Biophys. Acta 2007, 1767:170-177.
18. Herst P.M., Tan A.S., Scarlett D.J., Berridge M.V. Cell surface oxygen consumption by mitochondrial gene knockout cells. Biochim. Biophys. Acta 2004, 1656:79-87.
19. Herst P.M., Levine D.M., Berridge M.V. Mitochondrial gene knockout HL60rho(0) cells show preferential differentiation into monocytes/macrophages. Leuk. Res. 2005, 29:1163-1170.
20. Indo H.P., Davidson M., Yen H.C., Suenaga S., Tomita K., Nishii T., Higuchi M., Koga Y., Ozawa T., Majima H.J. Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 2007, 7:106-118.
21. Ischenko I., Seeliger H., Schaffer M., Jauch K.W., Bruns C.J. Cancer stem cells: how can we target them?. Curr. Med. Chem. 2008, 15:3171-3184.
22. Ishikawa T., Nakagawa H. Human ABC transporter ABCG2 in cancer chemotherapy and pharmacogenomics. J. Exp. Ther. Oncol. 2009, 8:5-24.
23. Ji J., Black K.L., Yu J.S. Glioma stem cell research for the development of immunotherapy. Neurosurg 2010, 21:159-166.
24. Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006, 3:177-185.
25. King M.P., Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989, 246:500-503.
26. Kulawiec M., Safina A., Desouki M.M., Still I., Matsui S., Bakin A., Singh K.K. Tumorigenic transformation of human breast epithelial cells induced by mitochondrial DNA depletion. Cancer Biol. Ther. 2008, 7:1732-1743.
27. Li C., Heidt D.G., Dalerba P., Burant C.F., Zhang L., Adsay V., Wicha M., Clarke M.F., Simeone D.M. Identification of pancreatic cancer stem cells. Cancer Res. 2007, 67:1030-1037.
28. Lim E., Vaillant F., Wu D., Forrest N.C., Pal B., Hart A.H., Asselin-Labat M.L., Gyorki D.E., Ward T., Partanen A., Feleppa F., Huschtscha L.I., Thorne H.J., Fox S.B., Yan M., French J.D., Brown M.A., Smyth G.K., Visvader J.E., Lindeman G.J. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat. Med. 2009, 15:907-913.
29. Lou H., Dean M. Targeted therapy for cancer stem cells: the patched pathway and ABC transporters. Oncogene 2007, 26:1357-1360.
30. Magda D., Lecane P., Prescott J., Thiemann P., Ma X., Dranchak P.K., Toleno D.M., Ramaswamy K., Siegmund K.D., Hacia J.G. mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft. BMC Genomics 2008, 9:521-540.
31. Mangia S., Simpson I.A., Vannucci S.J., Carruthers A. The in vivo neuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation. J. Neurochem. 2009, 109:55-62.
32. Marin-Hernandez A., Gallardo-Perez J.C., Ralph S.J., Rodriguez-Enriquez S., Moreno-Sanchez R. HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms. Mini Rev. Med. Chem. 2009, 9:1084-1101.
33. Moreno-Sanchez R., Rodriguez-Enriquez S., Marin-Hernandez A., Saavedra E. Energy metabolism in tumor cells. FEBS J. 2007, 274:1393-1418.
34. Nakashima R.A., Paggi M.G., Pedersen P.L. Contributions of glycolysis and oxidative phosphorylation to adenosine 5'-triphosphate production in AS-30D hepatoma cells. Cancer Res. 1984, 44:5702-5706.
35. O'Brien C.A., Pollett A., Gallinger S., Dick J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
36. Papandreou I., Cairns R.A., Fontana L., Lim A.L., Denko N.C. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006, 3:187-197.
37. Pecqueur C., Bui T., Gelly C., Hauchard J., Barbot C., Bouillaud F., Ricquier D., Miroux B., Thompson C.B. Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB J. 2008, 22:9-18.
38. Pellerin L., Magistretti P.J. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl Acad. Sci. USA 1994, 91:10625-10629.
39. Pellerin L., Bouzier-Sore A.K., Aubert A., Serres S., Merle M., Costalat R., Magistretti P.J. Activity-dependent regulation of energy metabolism by astrocytes: an update. Glia 2007, 55:1251-1262.
40. Ricci-Vitiani L., Lombardi D.G., Pilozzi E., Biffoni M., Todaro M., Peschle C., De Maria R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007, 445:111-115.
41. Rich P. Chemiosmotic coupling: the cost of living. Nature 2003, 421:583.
42. Rodda D.J., Chew J.L., Lim L.H., Loh Y.H., Wang B., Ng H.H., Robson P. Transcriptional regulation of nanog by OCT4 and SOX2. J. Biol. Chem. 2005, 280:24731-24737.
43. Samudio I., Fiegl M., McQueen T., Clise-Dwyer K., Andreeff M. The Warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation. Cancer Res. 2008, 68:5198-5205.
44. Samudio I., Fiegl M., Andreeff M. Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism. Cancer Res. 2009, 69:2163-2166.
45. Scarlett D.-J.G., Herst P.M., Tan A.S., Prata C., Berridge M.V. Mitochondrial gene-knockout (ro) cells: a versatile model for exploring the secrets of trans-plasma membrane electron transport. Biofactors 2004, 20:213-220.
46. Schmidt H., Siems W., Muller M., Dumdey R., Rapoport S.M. ATP-producing and consuming processes of Ehrlich mouse ascites tumor cells in proliferating and resting phases. Exp. Cell Res. 1991, 194:122-127.
47. Semenza G.L. HIF-1 mediates the Warburg effect in clear cell renal carcinoma. J. Bioenerg. Biomembr. 2007, 39:231-234.
48. Simpson I.A., Carruthers A., Vannucci S.J. Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J. Cereb. Blood Flow Metab. 2007, 27:1766-1791.
49. Singh S.K., Clarke I.D., Terasaki M., Bonn V.E., Hawkins C., Squire J., Dirks P.B. Identification of a cancer stem cell in human brain tumors. Cancer Res. 2003, 63:5821-5828.
50. Sonveaux P., Vegran F., Schroeder T., Wergin M.C., Verrax J., Rabbani Z.N., De Saedeleer C.J., Kennedy K.M., Diepart C., Jordan B.F., Kelley M.J., Gallez B., Wahl M.L., Feron O., Dewhirst M.W. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Invest. 2008, 118:3930-3942.
51. Takehara T., Teramura T., Onodera Y., Kishigami S., Matsumoto K., Saeki K., Fukuda K., Hosoi Y. Potential existence of stem cells with multiple differentiation abilities to three different germ lineages in mouse neurospheres. Stem Cells Dev. 2009, 18:1433-1440.
52. Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
53. Wang T., Marquardt C., Foker J. Aerobic glycolysis during lymphocyte proliferation. Nature 1976, 261:702-705.
54. Warburg O. Heavy Metal Prosthetic Groups and Enzyme Action 1949, Oxford University Press, London.
55. Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
56. Xu Q., Liu G., Yuan X., Xu M., Wang H., Ji J., Konda B., Black K.L., Yu J.S. Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens. Stem Cells 2009, 27:1734-1740.
57. Yamagata M., Hasuda K., Stamato T., Tannock I.F. The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase. Br. J. Cancer 1998, 77:1726-1731.
58. Yu M., Shi Y., Wei X., Yang Y., Zhou Y., Hao X., Zhang N., Niu R. Depletion of mitochondrial DNA by ethidium bromide treatment inhibits the proliferation and tumorigenesis of T47D human breast cancer cells. Toxicol. Lett. 2007, 170:83-93.
59. Zu X.L., Guppy M. Cancer metabolism: facts, fantasy, and fiction. Biochem. Biophys. Res. Commun. 2004, 313:459-465.