CD133+ and CD133- glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles

Cancer Research

Volumn 67, Issue 9, 2007, Pages 4010-4015

  Beier, Dagmar ^a   Hau, Peter ^a   Proescholdt, Martin ^a   Lohmeier, Annette ^a   Wischhusen, Jörg ^b   Oefner, Peter J ^a   Aigner, Ludwig ^a   Brawanski, Alexander ^a   Bogdahn, Ulrich ^a   Beier, Christoph P ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STEM CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL LINEAGE; CELL PROLIFERATION; GLIOBLASTOMA; MOUSE; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD; BRAIN NEOPLASMS; CELL GROWTH PROCESSES; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GLIOBLASTOMA; GLYCOPROTEINS; HUMANS; MICE; MICE, NUDE; PEPTIDES; TUMOR CELLS, CULTURED; TUMOR STEM CELLS;

EID: 34249332411     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-4180     Document Type: Article

References (17)

1. Fan X, Salford LG, Widegren B. Glioma stem cells: evidence and limitation. Semin Cancer Biol 2007;17: 214-8.
2. Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature 2004;432: 396-401.
3. Galli R, Binda E, Orfanelli U, et al. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 2004;64:7011-21.
4. Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A 2003;100:15178-83.
5. Yuan X, Curtin J, Xiong Y, et al. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 2004;23:9392-400.
6. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414: 105-11.
7. Phillips HS, Kharbanda S, Chen R, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006;9:157-73.
8. Bao S, Wu Q, McLendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444: 756-60.
9. Wachs FP, Couillard-Despres S, Engelhardt M, et al. High efficacy of clonal growth and expansion of adult neural stem cells. Lab Invest 2003;83:949-62.
10. Singh SK, Clarke ID, Terasaki M, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-8.
11. Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 2002;39:193-206.
12. Kondo T, Setoguchi T, Taga T. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci U S A 2004; 101:781-6.
13. Lee J, Kotliarova S, Kotliarov Y, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006;9:391-403.
14. Kleihues P, Ohgaki H. Primary and secondary glioblastomas: from concept to clinical diagnosis. J Neurooncol 1999;1:44-51.
15. Uhrbom L, Dai C, Celestino JC, Rosenblum MK, Fuller GN, Holland EC. Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res 2002;62:5551-8.
16. Fomchenko EI, Holland EC. Stem cells and brain cancer. Exp Cell Res 2005;306:323-9.
17. Uchida N, Buck DW, He D, et al. Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A 2000;97:14720-5.