Breast cancer stem-like cells show dominant homologous recombination due to a larger S-G2 fraction

Cancer Biology and Therapy

Volumn 11, Issue 12, 2011, Pages 1028-1035

  Al Assar, Osama ^a   Mantoni, Tine ^a   Lunardi, Serena ^a   Kingham, Guy ^a   Helleday, Thomas ^a   Brunner, Thomas B ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Breast cancer; Cancer stem cells; Cancer stem like cells; Cell cycle; Homologous recombination; Ionizing radiation; Non homologous end joining

Indexed keywords

CD24 ANTIGEN; CYCLIN D; CYCLIN E; HISTONE H2AX; RAD51 PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER STEM CELL; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; DNA REPAIR; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IONIZING RADIATION; PHENOTYPE;

BENZOFURANS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; FEMALE; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; NEOPLASTIC STEM CELLS; RAD51 RECOMBINASE; RADIATION TOLERANCE; RECOMBINATION, GENETIC;

EID: 79958784379     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.11.12.15699     Document Type: Article

References (33)

1. Frank NY, Schatton T, Frank MH. The therapeutic promise of the cancer stem cell concept. J Clin Invest 2010; 120:41-50.
2. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006; 66:9339-44. (Pubitemid 44623625)
3. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997; 3:730-7. (Pubitemid 27298715)
4. Al-Assar O, Muschel RJ, Mantoni TS, McKenna WG, Brunner TB. Radiation response of cancer stem-like cells from established human cell lines after sorting for surface markers. Int J Radiat Oncol Biol Phys 2009; 75:1216-25.
5. Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, Chambon P, et al. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 2008; 452:650-3. (Pubitemid 351483363)
6. Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM. WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proceedings of the Nat Acad Sci USA 2007; 104:618-23. (Pubitemid 46123074)
7. Wang J, Wakeman TP, Lathia JD, Hjelmeland AB, Wang XF, White RR, et al. Notch promotes radioresistance of glioma stem cells. Stem Cells 2010; 28:17-28.
8. Eyler CE, Foo WC, LaFiura KM, McLendon RE, Hjelmeland AB, Rich JN. Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells 2008; 26:3027-36.
9. Bao S, Wu Q, Li Z, Sathornsumetee S, Wang H, McLendon RE, et al. Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res 2008; 68:6043-8.
10. Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, et al. Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009; 138:592-603.
11. Ponti D, Costa A, Zaffaroni N, Pratesi G, Petrangolini G, Coradini D, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005; 65:5506-11. (Pubitemid 40911148)
12. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, et al. Cyclin-dependent kinases: a family portrait. Nat Cell Biol 2009; 11:1275-6.
13. Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, et al. Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells. Cancer Res 2010; 70:5389-98.
14. Adimoolam S, Sirisawad M, Chen J, Thiemann P, Ford JM, Buggy JJ. HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination. Proc Nat Acad Sci USA 2007; 104:19482-7.
15. Stingl J, Eirew P, Ricketson I, Shackleton M, Vaillant F, Choi D, et al. Purification and unique properties of mammary epithelial stem cells. Nature 2006; 439:993-7. (Pubitemid 43292419)
16. Coco Martin JM, Balkenende A, Verschoor T, Lallemand F, Michalides R. Cyclin D1 overexpression enhances radiation-induced apoptosis and radiosensitivity in a breast tumor cell line. Cancer Res 1999; 59:1134-40. (Pubitemid 29135977)
17. + breast cancer-initiating cells to radiation. J Natl Cancer Inst 2006; 98:1777-85.
18. Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, et al. Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells. Br J Cancer 2010; 102:206-12.
19. Jeggo P, Lavin MF. Cellular radiosensitivity: how much better do we understand it? Int J Rad Biol 2009; 85:1061-81.
20. Mah LJ, El-Osta A, Karagiannis TC. gammaH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 2010; 24:679-86.
21. Hartlerode AJ, Scully R. Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J 2009; 423:157-68.
22. Tan TL, Essers J, Citterio E, Swagemakers SM, de Wit J, Benson FE, et al. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation. Curr Biol 1999; 9:325-8. (Pubitemid 29181840)
23. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444:756-60. (Pubitemid 44949604)
24. Deihn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, et al. Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature 2009; 458:780-3.
25. Karimi-Busheri F, Rasouli-Nia A, Mackey JR, Weinfeld M. Senescene evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res 2010; 12:31.
26. + glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines. Clin Cancer Res 2009; 15:5145-53.
27. Ropolo M, Daga A, Griffero F, Foresta M, Casartelli G, Zunino A, et al. Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. Mol Cancer Res 2009; 7:383-92.
28. Branzei D, Vanoli F, Foiani M. SUMOylation regulates Rad18-mediated template switch. Nature 2008; 456:915-20.
29. You Z, Bailis JM. DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints. Trends Cell Biol 2010; 20:402-9.
30. Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res 2003; 63:6008-15. (Pubitemid 37187504)
31. Buggy JJ, Cao ZA, Bass KE, Verner E, Balasubramanian S, Liu L, et al. CRA-024781: a novel synthetic inhibitor of histone deacetylase enzymes with antitumor activity in vitro and in vivo. Mol Cancer Ther 2006; 5:1309-17. (Pubitemid 43881324)
32. Banuelos CA, Banath JP, MacPhail SH, Zhao J, Reitsema T, Olive PL. Radiosensitization by the histone deacetylase inhibitor PCI-24781. Clin Cancer Res 2007; 13:6816-26. (Pubitemid 350206820)
33. Zhang B, Strauss AC, Chu S, Li M, Ho Y, Shiang KD, et al. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell 2010; 17:427-42.