β1 integrin as a molecular therapeutic target

International Journal of Radiation Biology

Volumn 83, Issue 11-12, 2007, Pages 753-760

  Cordes, Nils ^a   Park, Catherine C ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Beta1 integrin; Ionizing radiation; Radiotherapy; Tumor

Indexed keywords

BETA1 INTEGRIN; BIBX 1382BS; CASPASE 8; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ETOPOSIDE; INTERLEUKIN 1; KALININ; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PROCASPASE 8; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; INTEGRIN; RADIOSENSITIZING AGENT;

APOPTOSIS; BREAST CANCER; BREAST DUCT; CELL INTERACTION; CELL PROLIFERATION; CELL PROTECTION; CYTOTOXICITY; DISEASE COURSE; DNA DAMAGE; DNA INTEGRATION; DRUG EFFICACY; DRUG MECHANISM; EXTRACELLULAR MATRIX; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VIVO STUDY; IONIZING RADIATION; KERATINOCYTE; LUNG SMALL CELL CANCER; METASTASIS; MICROENVIRONMENT; MOLECULAR THERAPY; MORPHOGENESIS; MYOEPITHELIOMA; PRIORITY JOURNAL; PROGNOSIS; RADIOTHERAPY; SHORT SURVEY; ANIMAL; BIOLOGICAL MODEL; BREAST TUMOR; CELL SURVIVAL; DRUG ANTAGONISM; FEMALE; NEOPLASM; PATHOLOGY; PHYSIOLOGY; RADIATION DOSE; RADIATION EXPOSURE; RADIOBIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD29; BREAST NEOPLASMS; CELL SURVIVAL; EXTRACELLULAR MATRIX; FEMALE; HUMANS; INTEGRINS; MODELS, BIOLOGICAL; NEOPLASMS; PROGNOSIS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RADIOBIOLOGY; SIGNAL TRANSDUCTION;

EID: 36849053853     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000701639694     Document Type: Short Survey

References (70)

1. Adriance MC, Inman JL, Petersen OW, Bissell MJ. 2005. Myoepithelial cells: Good fences make good neighbors. Breast Cancer Research 7:190-197.
2. Aoudjit F, Vuori K. 2001. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene 20:4995-5004.
3. Barcellos-Hoff MH. 1993. Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Research 53:3880-3886.
4. Barcellos-Hoff MH, Park C, Wright EG. 2005. Radiation and the microenvironment - tumorigenesis and therapy. Nature Reviews Cancer 5:867-875.
5. Baumann M, Krause M, Zips D, Eicheler W, Dorfler A, Ahrens J, Petersen C, Bruchner K, Hilberg F. 2003. Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse. International Journal of Radiation Biology 79:547-559.
6. Berry MG, Gui GP, Wells CA, Carpenter R. 2004. Integrin expression and survival in human breast cancer. European Journal of Surgery and Oncology 30:484-489.
7. Bissell MJ, Weaver VM, Lelievre SA, Wang F, Petersen OW, Schmeichel KL. 1999. Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Research 59:1757-1763s; discussion 1763s-1764s.
8. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS, Baselga J, Youssoufian H, Amellal N, Rowinsky EK, Ang KK. 2006. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. New England Journal of Medicine 354:567-578.
9. Briand P, Petersen OW, Van Deurs B. 1987. A new diploid nontumorigenic human breast epithelial cell line isolated and propagated in chemically defined medium. In Vitro Cell and Developmental Biology 23:181-188.
10. Cheng JC, Chou CH, Kuo ML, Hsieh CY. 2006. Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway. Oncogene 25:7009-7018.
11. Chiarugi P, Pani G, Giannoni E, Taddei L, Colavitti R, Raugei G, Symons M, Borrello S, Galeotti T, Ramponi G. 2003. Reactive oxygen species as essential mediators of cell adhesion: the oxidative inhibition of a FAK tyrosine phosphatase is required for cell adhesion. Journal of Cell Biology 161:933-944.
12. Choi SH, Cho KJ, Nam SY, Lee SW, Kang J, Kim SY. 2006. Clinical significance of beta1 integrin expression as a prediction marker for radiotherapy in early glottic carcinoma. Laryngoscope 116:1228-1231.
13. Cordes N. 2004. Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity. Cancer Research 64:5683-5692.
14. Cordes N, Beinke C. 2004. Fibronectin alters cell survival and intracellular signaling of confluent A549 cultures after irradiation. Cancer Biology & Therapy 3:47-53.
15. Cordes N, Meineke V. 2003. Cell adhesion-mediated radio-resistance (CAM-RR). Extracellular matrix-dependent improvement of cell survival in human tumor and normal cells in vitro. Strahlentherapie & Onkologie 179:337-344.
16. Cordes N, Seidler J, Durzok R, Geinitz H, Brakebusch C. 2006. beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury. Oncogene 25:1378-1390.
17. Cordes N, van Beuningen D. 2004. Arrest of human lung fibroblasts in G2 phase after irradiation is regulated by converging phosphatidylinositol-3 kinase and beta1-integrin signaling in vitro. International Journal of Radiation Oncology Biology Physics 58:453-462.
18. Damiano JS, Cress AE, Hazlehurst LA, Shtil AA, Dalton WS. 1999. Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 93:1658-1667.
19. Debnath J, Brugge JS. 2005. Modelling glandular epithelial cancers in three-dimensional cultures. Nature Reviews Cancer 5:675-688.
20. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. 1998. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proceedings of the National Academy of Science of the United States of America 95:11211-11216.
21. Diehl JA, Cheng M, Roussel MF, Sherr CJ. 1998. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes & Development 12:3499-3511.
22. Eke I, Sandfort V, Mischkus A, Baumann M, Cordes N. 2006. Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin. Radiotherapy and Oncology 80:178-184.
23. Elliott BE, Ekblom P, Pross H, Niemann A, Rubin K. 1994. Anti-beta 1 integrin IgG inhibits pulmonary macrometastasis and the size of micrometastases from a murine mammary carcinoma. Cell Adhesion & Communcation 1:319-332.
24. Estrugo D, Fischer A, Hess F, Scherthan H, Belka C, Cordes N. 2007. Ligand Bound beta1 Integrins Inhibit Procaspase-8 for Mediating Cell Adhesion-Mediated Drug and Radiation Resistance in Human Leukemia Cells. PLoS ONE 2:e269.
25. Fujita S, Watanabe M, Kubota T, Teramoto T, Kitajima M. 1995. Alteration of expression in integrin beta 1-subunit correlates with invasion and metastasis in colorectal cancer. Cancer Letters 91:145-149.
26. Fuks Z, Vlodavsky I, Andreeff M, McLoughlin M, Haimovitz-Friedman A. 1992. Effects of extracellular matrix on the response of endothelial cells to radiation in vitro. European Journal of Cancer 28A:725-731.
27. Girling AC, Hanby AM, Millis RR. 1990. Radiation and other pathological changes in breast tissue after conservation treatment for carcinoma. Journal of Clinical Pathology 43:152-156.
28. Gonzalez MA, Pinder SE, Wencyk PM, Bell JA, Elston CW, Nicholson RI, Robertson JF, Blamey RW, Ellis IO. 1999. An immunohistochemical examination of the expression of E-cadherin, alpha- and beta/gamma-catenins, and alpha2- and beta1-integrins in invasive breast cancer. Journal of Pathology 187:523-529.
29. Hazlehurst LA, Landowski TH, Dalton WS. 2003. Role of the tumor microenvironment in mediating de novo resistance to drugs and physiological mediators of cell death. Oncogene 22:7396-7402.
30. Hehlgans S, Haase M, Cordes N. 2007. Signalling via integrins: implications for cell survival and anticancer strategies. Biochimica et Biophysica Acta 1775:163-180.
31. Hess F, Estrugo D, Fischer A, Belka C, Cordes N. 2007. Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells. Oncogene 26:1372-1384.
32. Hodkinson PS, Elliott T, Wong WS, Rintoul RC, Mackinnon AC, Haslett C, Sethi T. 2006. ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase. Cell Death & Differentation 13:1776-1788.
33. Howlett AR, Bailey N, Damsky C, Petersen OW, Bissell MJ. 1995. Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma. Journal of Cell Science 108 (Pt 5):1945-1957.
34. Hynes RO. 2002. Integrins: Bidirectional, allosteric signaling machines. Cell 110:673-687.
35. Jacks T, Weinberg RA. 2002. Taking the study of cancer cell survival to a new dimension. Cell 111:923-925.
36. Jones JL, Critchley DR, Walker RA. 1992. Alteration of stromal protein and integrin expression in breast - a marker of premalignant change? Journal of Pathology 167:399-406.
37. Jonjic N, Lucin K, Krstulja M, Iternicka Z, Mustac E. 1993. Expression of beta-1 integrins on tumor cells of invasive ductal breast carcinoma. Pathology Research and Practise 189:979-984.
38. Kremer CL, Schmelz M, Cress AE. 2006. Integrin-dependent amplification of the G2 arrest induced by ionizing radiation. Prostate 66:88-96.
39. Lanzafame S, Emmanuele C, Torrisi A. 1996. Correlation of alpha 2 beta 1 integrin expression with histological type and hormonal receptor status in breast carcinomas. Pathology Research and Practise 192:1031-1038.
40. Lee JW, Juliano RL. 2002. The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cells. Biochimica et Biophysica Acta 1542:23-31.
41. Legate KR, Montanez E, Kudlacek O, Fassler R. 2006. ILK, PINCH and parvin: The tIPP of integrin signalling. Nature Reviews Molecular Cell Biology 7:20-31.
42. Leith JT, Michelson S. 1990. Tumor radiocurability: Relationship to intrinsic tumor heterogeneity and to the tumor bed effect. Invasion and Metastasis 10:329-351.
43. Li N, Zhang Y, Naylor MJ, Schatzmann F, Maurer F, Wintermantel T, Schuetz G, Mueller U, Streuli CH, Hynes NE. 2005. Beta1 integrins regulate mammary gland proliferation and maintain the integrity of mammary alveoli. EMBO Journal 24:1942-1953.
44. Marconi A, Atzei P, Panza C, Fila C, Tiberio R, Truzzi F, Wachter T, Leverkus M, Pincelli C. 2004. FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes. Journal of Cell Science 117:5815-5823.
45. Mechtersheimer G, Munk M, Barth T, Koretz K, Moller P. 1993. Expression of beta 1 integrins in non-neoplastic mammary epithelium, fibroadenoma and carcinoma of the breast. Virchows Archiv of Pathology, Anatomy & Histopathology 422:203-210.
46. Moore GH, Schiller JE, Moore GK. 2004. Radiation-induced histopathologic changes of the breast: the effects of time. American Journal of Surgery & Pathology 28:47-53.
47. Moro L, Venturino M, Bozzo C, Silengo L, Altruda F, Beguinot L, Tarone G, Defilippi P. 1998. Integrins induce activation of EGF receptor: Role in MAP kinase induction and adhesion-dependent cell survival. EMBO Journal 17:6622-6632.
48. Okamura M, Yamaji S, Nagashima Y, Nishikawa M, Yoshimoto N, Kido Y, Iemoto Y, Aoki I, Ishigatsubo Y. 2007. Prognostic value of integrin beta1-ILK-pAkt signaling pathway in non-small cell lung cancer. Human Pathology 38:1081-1091.
49. Onoda JM, Piechocki MP, Honn KV. 1992. Radiation-induced increase in expression of the alpha IIb beta 3 integrin in melanoma cells: Effects on metastatic potential. Radiation Research 130:281-288.
50. Park CC, Henshall-Powell RL, Erickson AC, Talhouk R, Parvin B, Bissell MJ, Barcellos-Hoff MH. 2003. Ionizing radiation induces heritable disruption of epithelial cell interactions. Proceedings of the National Academy of Science of the United States of America 100:10728-10733.
51. Park CC, Zhang H, Pallavicini M, Gray JW, Baehner F, Park CJ, Bissell MJ. 2006. Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Research 66:1526-1535.
52. Pawlik TM, Keyomarsi K. 2004. Role of cell cycle in mediating sensitivity to radiotherapy. International Journal of Radiation Oncology Biology Physics 59:928-942.
53. Pignatelli M, Cardillo MR, Hanby A, Stamp GW. 1992. Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors. Human Pathology 23:1159-1166.
54. Pignatelli M, Hanby AM, Stamp GW. 1991. Low expression of beta 1, alpha 2 and alpha 3 subunits of VLA integrins in malignant mammary tumours. Journal of Pathology 165:25-32.
55. Schatzmann F, Marlow R, Streuli CH. 2003. Integrin signaling and mammary cell function. Journal of Mammary Gland Biology and Neoplasia 8:395-408.
56. Schnitt SJ, Connolly JL, Harris JR, Cohen RB. 1984. Radiation-induced changes in the breast. Human Pathology 15:545-550.
57. Sethi T, Rintoul RC, Moore SM, MacKinnon AC, Salter D, Choo C, Chilvers ER, Dransfield I, Donnelly SC, Strieter R, Haslett C. 1999. Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo. Nature Medicine 5:662-668.
58. Shain KH, Landowski TH, Dalton WS. 2002. Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines. Journal of Immunology 168:2544-2553.
59. Shaw LM. 1999. Integrin function in breast carcinoma progression. Journal of Mammary Gland Biology and Neoplasia 4:367-376.
60. Stevenson AF, Lange CS. 1997. Extracellular matrix (ECM) and cytoskeletal modulation of cellular radiosensitivity. Acta Oncologica 36:599-606.
61. Toulany M, Kasten-Pisula U, Brammer I, Wang S, Chen J, Dittmann K, Baumann M, Dikomey E, Rodemann HP. 2006. Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radio-sensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. Clinical Cancer Research 12:4119-4126.
62. Vlodavsky I, Lui GM, Gospodarowicz D. 1980. Morphological appearance, growth behavior and migratory activity of human tumor cells maintained on extracellular matrix versus plastic. Cell 19:607-616.
63. Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. 1998. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology. Proceedings of the National Academy of Science of the United States of America 95:14821-14826.
64. Wang JL, Sun Y, Wu S. 2000. Gamma-irradiation induces matrix metalloproteinase II expression in a p53-dependent manner. Molecular Carcinogenesis 27:252-258.
65. White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U, Muller WJ. 2004. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 6:159-170.
66. Wild-Bode C, Weller M, Rimner A, Dichgans J, Wick W. 2001. Sublethal irradiation promotes migration and invasiveness of glioma cells: Implications for radiotherapy of human glioblastoma. Cancer Research 61:2744-2750.
67. Yao ES, Zhang H, Chen YY, Lee B, Chew K, Moore D, Park C. 2007. Increased beta1 integrin is associated with decreased survival in invasive breast cancer. Cancer Research 67:659-664.
68. Younes MN, Kim S, Yigitbasi OG, Mandal M, Jasser SA, Dakak Yazici Y, Schiff BA, El-Naggar A, Bekele BN, Mills GB, Myers JN. 2005. Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer. Molecular Cancer Therapy 4:1146-1156.
69. Zhang H, Ozaki I, Mizuta T, Matsuhashi S, Yoshimura T, Hisatomi A, Tadano J, Sakai T, Yamamoto K. 2002. Beta 1-integrin protects hepatoma cells from chemotherapy induced apoptosis via a mitogen-activated protein kinase dependent pathway. Cancer 95:896-906.
70. Zutter MM, Krigman HR, Santoro SA. 1993. Altered integrin expression in adenocarcinoma of the breast. Analysis by in situ hybridization. American Journal of Pathology 142:1439-1448.