Are all glioma cells cancer stem cells?

Journal of Cancer Science and Therapy

Volumn 2, Issue 4, 2010, Pages 100-106

  Mabel, Cruz ^a   Åke, Siden ^a,b   Ruth, Tasat Deborah ^c   Sebastian, Yakisich J ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSIDAD NACIONAL DE SAN MARTÍN   (Argentina)

Author keywords

Cancer; Glioma; Proliferation; Stem cell theory; Stem cells; Stemness

Indexed keywords

ARTICLE; ASTROCYTOMA; CANCER STEM CELL; CELL CULTURE; CELL DIVISION; CELL POPULATION; CELL PROLIFERATION; CYTOLOGY; EPENDYMOMA; GLIOBLASTOMA; GLIOMA; GLIOMA CELL; HUMAN; KINETICS; MEDULLOBLASTOMA; PHENOTYPE;

EID: 77954999143     PISSN: None     EISSN: 19485956     Source Type: Journal    
DOI: 10.4172/1948-5956.1000032     Document Type: Article

References (45)

1. Al-Hajj M, Clarke MF (2004) Self-renewal and solid tumor stem cells. Oncogene 23: 7274-7282.
2. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, et al. (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444: 756-760.
3. Benda P, Lightbody J, Sato G, Levine L, Sweet W (1968) Differentiated rat glial cell strain in tissue culture. Science 161: 370-371.
4. Bexell D, Gunnarsson S, Siesjö P, Bengzon J, Darabi A (2009) CD133+ and nestin+ tumor-initiating cells dominate in N29 and N32 experimental gliomas. Int J Cancer 125: 15-22.
5. Blagosklonny MV (2007) Cancer stem cell and cancer stemloids: from biology to therapy. Cancer Biol Ther 6: 1684-1690.
6. Brehar FM, Bleotu C, Stefan LM, Buzgariu W, Chivu M, et al. (2009) Isolation and partial characterization of a new human glioblastoma cell line. Chirurgia (Bucur) 104: 453-461.
7. Charles N, Ozawa T, Squatrito M, Bleau AM, Brennan CW, et al. (2010) Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells. Cell Stem Cell 6: 141-152.
8. Charles NA, Holland EC (2010) TRRAP and the maintenance of stemness in gliomas. Cell Stem Cell 6: 6-7.
9. Chen R, Nishimura MC, Bumbaca SM, Kharbanda S, Forrest WF, et al. (2010) A hierarchy of self-renewing tumor-initiating cell types in glioblastoma. Cancer Cell 17: 362-375.
10. Chua C, Zaiden N, Chong KH, See SJ, Wong MC, et al. (2008) Characterization of a side population of astrocytoma cells in response to temozolomide. J Neurosurg 109: 856-866.
11. Fong D, Yeh A, Naftalovich R, Choi TH, Chan MM (2010) Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: Towards targeting of cancer stem cells with phytochemicals. Cancer Lett 293: 65-72.
12. Fukaya R, Ohta S, Yamaguchi M, Fujii H, Kawakami Y, et al. (2010) Isolation of cancer stem-like cells from a side population of a human glioblastoma cell line, SK-MG-1. Cancer Lett 291: 150-157.
13. Galli R, Binda E, Orfanelli U, Cipelletti B, Gritti A, et al. (2004) Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64: 7011-7021.
14. Griguer CE, Oliva CR, Gobin E, Marcorelles P, Benos DJ, et al. (2008) CD133 is a marker of bioenergetic stress in human glioma. PLoS ONE 3: e3655.
15. Gupta PB, Chaffer CL, Weinberg RA (2009) Cancer stem cells: mirage or reality? Nat Med 15: 1010-1012.
16. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57-70.
17. Heddleston JM, Li Z, McLendon RE, Hjelmeland AB, Rich JN (2009) The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 8: 3274-3284.
18. Hill RP (2006) Identifying cancer stem cells in solid tumors: case not proven. Cancer Res 66: 1891-1895.
19. Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, et al. (2002) Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 39: 193-206.
20. Kelly JJ, Stechishin O, Chojnacki A, Lun X, Sun B, et al. (2009) Proliferation of human glioblastoma stem cells occurs independently of exogenous mitogens. Stem Cells 27: 1722-1733.
21. Kim Y, Lin Q, Zelterman D, Yun Z (2009) Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Cancer Res 69: 9271-9280.
22. Kondo T, Setoguchi T, Taga T (2004) Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Proc Natl Acad Sci USA 101: 781-786.
23. Leychkis Y, Munzer SR, Richardson JL (2009) What is stemness? Stud Hist Philos Biol Biomed Sci 40: 312-320.
24. Martínez-Climent JA, Andreu EJ, Prosper F (2006) Somatic stem cells and the origin of cancer. Clin Transl Oncol 8: 647-663.
25. McBride S, Meleady P, Baird A, Dinsdale D, Clynes M (1998) Human lung carcinoma cell line DLKP contains 3 distinct subpopulations with different growth and attachment properties. Tumor Biol 19: 88-103.
26. McCord AM, Jamal M, Williams ES, Camphausen K, Tofilon PJ (2009) CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines. Clin Cancer Res 15: 5145-5153.
27. Nicolis SK (2007) Cancer stem cells and "stemness" genes in neuro-oncology. Neurobiol Dis 25: 217-229.
28. Osmond TL, Broadley KW, McConnell MJ (2010) Glioblastoma cells negative for the anti-CD133 antibody AC133 express a truncated variant of the CD133 protein. Int J Mol Med 25: 883-888.
29. Platet N, Mayol JF, Berger F, Hérodin F, Wion D (2007) Fluctuation of the SP/non-SP phenotype in the C6 glioma cell line. FEBS Lett 581: 1435-1440.
30. Prestegarden L, Svendsen A, Wang J, Sleire L, Skaftnesmo KO, et al. (2010) Glioma cell populations grouped by different cell type markers drive brain tumor growth. Cancer Res 70: 4274-4279.
31. Qiang L, Yang Y, Ma YJ, Chen FH, Zhang LB, et al. (2009) Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. Cancer Lett 279: 13-21.
32. Ropolo M, Daga A, Griffero F, Foresta M, Casartelli G, et al. (2009) Comparative analysis of DNA repair in stem and nonstem glioma cell cultures. Mol Cancer Res 7: 383-392.
33. Rubin H (2002) The disparity between human cell senescence in vitro and lifelong replication in vivo. Nat Biotechnol 20: 675-681.
34. Seidel S, Garvalov BK, Wirta V, von Stechow L, Schänzer A, et al. (2010) A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha. Brain 133: 983-995.
35. Setoguchi T, Taga T, Kondo T (2004) Cancer stem cells persist in many cancer cell lines. Cell Cycle 3: 414-415.
36. Shen G, Shen F, Shi Z, Liu W, Hu W, et al. (2008) Identification of cancer stemlike cells in the C6 glioma cell line and the limitation of current identification methods. In Vitro Cell Dev Biol Anim 44: 280-289.
37. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, et al. (2003) Identification of a cancer stem cell in human brain tumors. Cancer Res 63: 5821-5828.
38. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, et al. (2004) Identification of human brain tumor initiating cells. Nature 432: 396-401.
39. Soeda A, Park M, Lee D, Mintz A, Androutsellis-Theotokis A, et al. (2009) Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene 28: 3949-3959.
40. Withers HR, Lee SP (2006) Modeling growth kinetics and statistical distribution of oligometastases. Semin Radiat Oncol 16: 111-119.
41. Yakisich JS (2009) Theoretical basis for the measurement of small differences in the length of the cell cycle between two cell populations. The Open Biology Journal 2: 95-100.
42. Yi L, Zhou ZH, Ping YF, Chen JH, Yao XH (2007) Isolation and characterization of stem cell-like precursor cells from primary human anaplastic oligoastrocytoma. Mod Pathol 20: 1061-1068.
43. Yuan X, Curtin J, Xiong Y, Liu G, Waschsmann-Hogiu S, et al. (2004) Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23: 9392-9400.
44. Zheng X, Shen G, Yang X, Liu W (2007) Most C6 cells are cancer stem cells: evidence from clonal and population analyses. Cancer Res 67: 3691-3697.
45. Zhou XD, Wang XY, Qu FJ, Zhong YH, Lu XD, et al. (2009) Detection of cancer stem cells from the C6 glioma cell line. J Int Med Res 37: 503-510.